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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Synaptic Transmission (0):
Recent article
Synaptic Transmission
Abstract
We find that release of glutamate from synaptic vesicles along axons of mouse dorsal root ganglion neurons in culture promotes myelin induction by stimulating formation of cholesterol-rich signaling domains between oligodendrocytes and axons, and increasing local synthesis of the major protein in th...
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PMID: 21817014
PDF is available here.
PDF is available here.
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Abstract
Journal of Neuroscience (31)37 2011
Abstract
We used functional multineuron calcium imaging to monitor the spike outputs from thousands of CA1 neurons in response to the stimulation of two independent sites of the dentate gyrus in rat hippocampal networks ex vivo. Only pyramidal cells were analyzed based on post hoc immunostaining. Some CA1 py...
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PMID: 21917800
PDF is available here.
PDF is available here.
Brain research (1410) 2011
Abstract
These results suggest that erythropoietin decreases the excitatory neurotransmitter release probability and may in this way protect the synapses from toxic levels of glutamate. Erythropoietin perfusion increased the expression of long-term potentiation in the hippocampus which is considered as basic...
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PMID: 21803333
PDF is available here.
PDF is available here.
Abstract
Dysfunction of inhibitory synaptic transmission can destroy the balance between excitatory and inhibitory synaptic inputs in neurons, thereby inducing epileptic activity. The aim of the paper is to investigate the effects of successive excitatory inputs on the epileptic activity indu...
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PMID: 21887845
PDF is available here.
PDF is available here.
Abstract
We discuss the role of AD-linked calcium signaling alterations in neurons and how this may be linked to synaptic dysfunctions at both early and late stages of the disease....
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PMID: 21786198
PDF is available here.
PDF is available here.
Abstract
Introduction: Oxidative stress is an essential component of neuronal death in Parkinson's disease (PD). Clinically, progression of PD is also characterised by onset of motor complications (MC). MC results from the peripheral and central degree of fluctuations of levodopa (LD) and of...
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PMID: 21480824
PDF is available here.
PDF is available here.
Abstract
We review the morphological and physiological aspects of the development of the VCN-MNTB pathway and its calyceal termination, along with potential mechanisms that give rise to its precision. During embryonic development, VCN axons grow towards the midline, cross the midline into the region of the p...
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PMID: 21093567
PDF is available here.
PDF is available here.
Abstract
We review the cellular signaling networks that regulate the activity of transcription factors during brain development and discuss the functional roles of specific activity-regulated transcription factors in specific stages of synapse formation, refinement, and maturation. Interestingly, a number of...
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PMID: 21555405
PDF is available here.
PDF is available here.
Abstract
We review the cellular signaling networks that regulate the activity of transcription factors during brain development and discuss the functional roles of specific activity-regulated transcription factors in specific stages of synapse formation, refinement, and maturation. Interestingly, a number of...
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PMID: 21555405
PDF is available here.
PDF is available here.
Abstract
We developed a computational model of glutamatergic signaling at a prototypical dendritic spine to examine the patterns of NMDAR subtype activation at temporal and spatial resolutions that are difficult to obtain experimentally. We demonstrate that NMDAR subtypes have different dynamic ranges of act...
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PMID: 21738464
PDF is available here.
PDF is available here.
Abstract
We found that the EEG relative power in the beta band was higher in the aged than that in the young rats. After administration of baclofen, there was a slower increase in the relative power in the delta band in the aged than that in the young rats. Moreover, there was no significant difference betwe...
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PMID: 21574046
PDF is available here.
PDF is available here.
Abstract
We will review the data about the connections of POP with conventional neurotransmitter systems and provide an overview of the role of POP in neurotransmission....
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PMID: 21222629
PDF is available here.
PDF is available here.
Abstract
We think about iGluR function. Recently, a number of novel transmembrane proteins have been uncovered that may also serve as iGluR auxiliary proteins. Here we review pivotal developments in our understanding of the role of TARPs in AMPA receptor trafficking and gating, and provide an overview of how...
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PMID: 21521608
PDF is available here.
PDF is available here.
Abstract
Abstract
We hypothesize that dysregulation of immune-related genes modifies synaptic functions and stability in this region....
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PMID: 21091092
PDF is available here.
PDF is available here.
médecine/sciences (27)4 2011
Abstract
Neuropharmacology (60)5 2011
Abstract
We discuss recent findings on the physiology and plasticity of inputs to interneurons in the basolateral amygdala, the primary input station. These interneurons are a heterogeneous group of cells that can be separated on immunohistochemical and electrophysiological grounds. Glutamatergic inputs to t...
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PMID: 21093462
PDF is available here.
PDF is available here.
Physiological Reviews (91)2 2011
Abstract
We review how neuronal activity regulates both axon morphology and axonal function on a long-term time scale during development and adulthood....
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PMID: 21527732
PDF is available here.
PDF is available here.
Brain research (1382) 2011
Abstract
We report that either deafferentation or reduction of sensory input by nares occlusion significantly reduced GAD67 protein and the number of SA cells expressing GAD67. However, neither manipulation altered GAD65 protein or the number of GAD65 PG cells. These findings show that sensory experience str...
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PMID: 21276774
PDF is available here.
PDF is available here.
Autism Research (4)1 2011
Abstract
We review the existing data on the phenotypes of mice carrying mutations in genes associated with ASD including neuroligin, neurexin and Shank mutant mice as well as the Fmr1, Mecp2, Ube3a, Nf1, Pten and Tsc1/Tsc2 mutant mice. The diversity and complexity of the phenotype of these mouse models refle...
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PMID: 21328568
PDF is available here.
PDF is available here.
Abstract
There is a widespread presence of both adenosine (P1) and P2 nucleotide receptors in the brain on both neurones and glial cells. Adenosine receptors play a major role in presynaptic neuromodulation, while P2X receptors are involved in fast synaptic transmission and synaptic plasticit...
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PMID: 21401499
PDF is available here.
PDF is available here.
Neural plasticity (2011) 2011
Abstract
We summarize recent data concerning the functional role of GABA in building up and refining neuronal circuits early in development and the molecular mechanisms regulating the E/I balance. A dysfunction of the GABAergic signaling early in development leads to a severe E/I unbalance in neuronal circui...
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PMID: 21766041
PDF is available here.
PDF is available here.
Neural plasticity (2011) 2011
Abstract
We provide new insights to better face with this "double coin" condition in the attempt to optimize the functional recovery of patients....
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PMID: 21766043
PDF is available here.
PDF is available here.
Neural plasticity (2011) 2011
Abstract
We review some of the sophisticated ways in which this ionic driving force can vary within neuronal circuits. This driving force for GABA(A)Rs is subject to tight spatial control, with the distribution of Cl⁻ transporter proteins and channels generating regional variation in the strength of GABA(A...
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PMID: 21766044
PDF is available here.
PDF is available here.
Neural plasticity (2011) 2011
Abstract
We review homeostatic plasticity of GABAergic neurons and their synaptic connections. We propose a simplistic model for homeostatic plasticity of GABAergic components of the circuitry (GABAergic synapses onto excitatory neurons, excitatory connections onto GABAergic neurons, cellular excitability of...
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PMID: 21876819
PDF is available here.
PDF is available here.
Abstract
We report here that presynaptic NMDA receptors are present on GABAergic terminals in developing (postnatal day (PND) 12-15) but not older (PND21-25) rat frontal cortex. Using MK-801 in the recording pipette to block postsynaptic NMDA receptors, evoked and miniature IPSCs were recorded in layer II/II...
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PMID: 21365001
PDF is available here.
PDF is available here.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] (Chapter 6) 2011
Abstract
Synaptic plasticity is the process by which the brain alters the strength of its synaptic connections, a fundamental function of the brain that enables individuals to learn from experience. The study of synaptic plasticity often involves the application of standard in vitro electroph...
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PMID: 21207366
PDF is available here.
PDF is available here.
Nature Neuroscience (13)12 2010
Abstract
We found that the same vesicles participate in active and spontaneous release....
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PMID: 21102450
PDF is available here.
PDF is available here.
Nature Neuroscience (13)12 2010
Abstract
We found that cross-depletion of spontaneously or actively recycling synaptic vesicle pools occurred on stimulation in rat hippocampal neurons and identified the recycling pool as a major source of spontaneous release....
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PMID: 21102448
PDF is available here.
PDF is available here.
Abstract
The human brain contains more than 100 trillion (10(14)) synaptic connections, which form all of its neural circuits. Neuroscientists have long been interested in how this complex synaptic web is weaved during development and remodelled during learning and disease. Recent studies hav...
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PMID: 21068831
PDF is available here.
PDF is available here.
Abstract
Abstract
We show that mice lacking Mecp2 from GABA (γ-aminobutyric acid)-releasing neurons recapitulate numerous Rett syndrome and autistic features, including repetitive behaviours. Loss of MeCP2 from a subset of forebrain GABAergic neurons also recapitulates many features of Rett syndrome. MeCP2-deficient...
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PMID: 21068835
PDF is available here.
PDF is available here.
Abstract
We introduce a novel system for recognition of partially occluded and rotated images. The system is based on a hierarchical network of integrate-and-fire spiking neurons with random synaptic connections and a novel organization process. The network generates integrated output sequences that are used...
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PMID: 21047704
PDF is available here.
PDF is available here.
Abstract
The optic tectum of zebrafish is involved in behavioral responses that require the detection of small objects. The superficial layers of the tectal neuropil receive input from retinal axons, while its deeper layers convey the processed information to premotor areas. Imaging with a genetically encode...
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PMID: 21030657
PDF is available here.
PDF is available here.
Abstract
Dopamine modulation of excitatory neurotransmission is critical in the control of movement, emotion and reward. In the striatum, medium size spiny neurons (MSNs) are responsible for the integration of cortical and thalamic information that flows through parallel, partly overlapping,...
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PMID: 20632967
PDF is available here.
PDF is available here.
Abstract
We find that, in both exogenous and native preparations, gain-of-function missense mutations underlying Familial Hemiplegic Migraine type 1 (FHM-1) occlude CDF of P/Q-type Ca(2+) channels. In FHM-1 mutant mice, the alteration of P/Q-type channel CDF correlates with reduced short-term synaptic facili...
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PMID: 20937883
PDF is available here.
PDF is available here.
Implant Dentistry (19)5 2010
Abstract
More than 70% of dentists have experienced patients with postoperative paresthesia/dysesthesia or anesthesia as a result of dental procedures. The most common nerve affected is the mandibular nerve, which may be injured during either implant surgery or bone grafting procedures. However, no organized...
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PMID: 20881808
PDF is available here.
PDF is available here.
Learning & Memory (17)10 2010
Abstract
We recorded from the hippocampus in vivo while rats underwent a brief period of EE. There was no detectable EE-induced change in synaptic efficacy in the dentate gyrus in vivo, but there was an increase in cellular excitability. In slices prepared from the same animals, we failed to observe any evid...
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PMID: 20861169
PDF is available here.
PDF is available here.
Neuroreport (21)13 2010
Abstract
We examined the effect of 2'-3'-O-(4-benzoylbenzoyl)-adenosine-5'-triphosphate (Bz-ATP), a P2X7 receptor agonist, on action potential-independent glutamate release from nerve terminals attached to mechanically isolated immature hilar neurons. Bz-ATP increased spontaneous excitatory postsynaptic curr...
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PMID: 20639779
PDF is available here.
PDF is available here.
Abstract
The Drosophila larval neuromuscular junction (NMJ) shares many structural and functional similarities to synapses in other animals, including humans. These include the basic feature of synaptic transmission as well as the molecular mechanisms regulating the synaptic vesicle cycle. Because of its lar...
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PMID: 20810635
PDF is available here.
PDF is available here.
Abstract
The Drosophila larval neuromuscular junction (NMJ) shares many structural and functional similarities to synapses in other animals, including humans. These include the basic feature of synaptic transmission, as well as the molecular mechanisms regulating the synaptic vesicle cycle. Because of its la...
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PMID: 20810636
PDF is available here.
PDF is available here.
Neuromolecular Medicine (12)3 2010
Abstract
We examined synaptic function in the hippocampus of aged mice deficient for the Parkinson's disease-linked protein, parkin. Surprisingly, heterozygous but not homozygous parkin-deficient mice exhibited impairments in basal excitatory synaptic strength. Similarly heterozygous mice exhibited broad def...
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PMID: 20232175
PDF is available here.
PDF is available here.
Fitoterapia (81)6 2010
Abstract
Bergamot (Citrus bergamia, Risso) is a fruit most knowledgeable for its essential oil (BEO) used in aromatherapy to minimize symptoms of stress-induced anxiety and mild mood disorders and cancer pain though the rational basis for such applications awaits to be discovered. The behavioural and EEG spe...
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PMID: 20093169
PDF is available here.
PDF is available here.
Neuroscience (169)3 2010
Abstract
We tested the hypothesis that activation of the glutamatergic input to a neuron leads to an endocannabinoid-mediated suppression of the GABAergic afferent input to the same neuron. Spontaneous postsynaptic currents (sPSCs) were recorded with patch-clamp techniques in Purkinje cells in mouse cerebell...
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PMID: 20553815
PDF is available here.
PDF is available here.
Brain research (1349) 2010
Abstract
We have examined the effect of 5HT on electrical synapses possessing variable coupling strengths. While 5HT decreased electrical coupling at synapses with weak electrical connectivity, synapses with strong electrical coupling were less affected by 5HT treatment, as follows from the equations used fo...
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PMID: 20599836
PDF is available here.
PDF is available here.
Biochemical Pharmacology (80)4 2010
Abstract
We report that the type 1 ryanodine receptor (RyR1) is a molecular target that responds to nanomolar (-)-epigallocatechin-3-gallate (EGCG) and (-)-epicatechin-3-gallate (ECG). Single channel analyses demonstrate EGCG (5-10nM) increases channel open probability (Po) twofold, by lengthening open dwell...
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PMID: 20471964
PDF is available here.
PDF is available here.
Abstract
We review recent studies further indicating that inhibition from parvalbumin-positive GABA neurons is necessary to produce gamma oscillations in cortical circuits; provide an update on postmortem studies documenting that deficits in the expression of glutamic acid decarboxylase67, which accounts for...
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PMID: 20556669
PDF is available here.
PDF is available here.
Abstract
Inhibitory neurotransmission to the longitudinal muscle is more prominent in the neonatal than in the adult guinea pig ileum.
Inhibitory neuromuscular transmission was investigated using in vitro ileal longitudinal muscle myenteric plexus (LMMP) preparations made from neonatal (< or =48 h postnatal)...
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PMID: 20482699
PDF is available here.
PDF is available here.
Abstract
We call this interaction cross-inhibition. Cross-inhibition did not occur in HEK-293 cells expressing alpha3beta4 nAChRs and a C-terminal tail truncated P2X2 receptor (P2X2TR) (P > 0.05, n = 8). Intracellular application of the C-terminal tail of the P2X2 receptor blocked nAChR-P2X receptor cross-in...
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PMID: 20426799
PDF is available here.
PDF is available here.
Abstract
We have modelled aspects of AD in Drosophila melanogaster to shed light on these processes and to further our understanding of the relationship between tau and amyloid in this disease....
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PMID: 20658990
PDF is available here.
PDF is available here.
Physical Review E (82)2 Pt 1 2010
Abstract
We perform a weighted network analysis to understand the effect of neurosurgery on the characteristics of functional brain networks. Statistically significant changes in network features have been discovered in the beta (13-30 Hz) band after neurosurgery: the link weight correlation around nodes and...
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PMID: 20866854
PDF is available here.
PDF is available here.
Abstract
Excitatory synapses are located in confined chemical spaces called the dendritic spines. These are atypical femtoliter-order microdomains where the behavior of even single molecules may have important biological consequences. Powerful chemical biological techniques have now been deve...
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PMID: 20644538
PDF is available here.
PDF is available here.
Abstract
Salient stimuli redirect attention and suppress ongoing motor activity. This attentional shift is thought to rely upon thalamic signals to the striatum to shift cortically driven action selection, but the network mechanisms underlying this interaction are unclear. Using a brain slice...
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PMID: 20670836
PDF is available here.
PDF is available here.
EMBO Journal (29)15 2010
Abstract
We used cultured autaptic hippocampal neurons from Snap-25 null mice rescued with mutants challenging the C-terminal, N-terminal and middle domains of the SNARE-bundle to dissect out the involvement of these domains in neurotransmission. We report that the stabilities of two different sub-domains of...
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PMID: 20562829
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)30 2010
Abstract
We were interested in the role of the C. elegans protein WSP-1 in the adult nematode. In this report, we show that a deletion mutant of wsp-1 exhibits a strong sensitivity to the neuromuscular inhibitor aldicarb. Transgenic rescue experiments demonstrated that neuronal expression of WSP-1 rescued th...
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PMID: 20501656
PDF is available here.
PDF is available here.
NeuroImage (51)4 2010
Abstract
To date, the majority of neurovascular coupling studies focused on the thalamic afferents' activity in layer IV and the corresponding large spiking activity as responsible for functional hyperemia. This paper highlights the role of the secondary and late cortico-cortical transmission in neurovascula...
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PMID: 20350606
PDF is available here.
PDF is available here.
Abstract
We measured movement of individual actin molecules within living spines. Velocity of single actin molecules along filaments, an index of filament polymerization rate, was highly heterogeneous within individual spines. Most strikingly, molecular velocity was elevated in discrete, well-separated foci...
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PMID: 20624594
PDF is available here.
PDF is available here.
Abstract
We demonstrate that deletion of the filamentous protein Septin 5 imparts immature synapses with striking morphological and functional features reminiscent of mature synapses. This includes synaptic vesicles tightly localized to active zones, resistance to the slow Ca(2+) buffer EGTA and a reduced nu...
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PMID: 20624595
PDF is available here.
PDF is available here.
Abstract
We will examine how these long-lasting neuroadaptations may drive the pathology of psychostimulant addiction. Finally, we review clinical trials that highlight antagonists at excitatory AMPA receptors as promising targets against cocaine abuse....
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PMID: 20624588
PDF is available here.
PDF is available here.