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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Signal Transduction (6):
Recent article
Signal Transduction
Biochemical Pharmacology (82)11 2011
Abstract
We analyzed the effects of IFN-α2b and TGF-β1 treatments on Wnt/β-catenin pathway, Smads proteins levels, β-catenin/TCF4/Smads interaction and proliferation and apoptotic death in HepG2/C3A and Huh7 cell lines. IFN-α2b and TGF-β1 attenuated Wnt/β-catenin signal by decreasing β-catenin and Fr...
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PMID: 21843516
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
We have discovered that other cellular stressors are integrated with glucocorticoid signaling through a new hormone-independent phosphorylation site, Ser134, on the human glucocorticoid receptor (GR). Ser134 phosphorylation is induced by a variety of stress-activating stimuli in a p38 mitogen-activa...
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PMID: 21930780
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth fa...
|
PMID: 22120177
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurrent gene rearrangements involving genes enc...
|
PMID: 22101766
PDF is available here.
PDF is available here.
Nature Medicine (17)12 2011
Abstract
We identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tu...
|
PMID: 22081024
PDF is available here.
PDF is available here.