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Repetitive Sequences, Amino Acid (1):
Recent article
Repetitive Sequences, Amino Acid
Abstract
We have investigated which portion of Tg is engaged in this late stage of its maturation. First, we demonstrate that this event is linked to oxidation involving region I. Introduction of the Tg-C1245R mutation in the hinge (identical to that causing human goitrous hypothyroidism) inhibits this matur...
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PMID: 21816825
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
We report here identification of missense CDON mutations in human HPE. These mutations diminish CDON's ability to support SHH-dependent gene expression in cell-based signaling assays. The mutations occur outside the SHH-binding domain of CDON, and the encoded variant CDON proteins do not display def...
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PMID: 21802063
PDF is available here.
PDF is available here.
Abstract
We have expanded the recognition of Pumilio and FBF homology protein (PUF) repeats beyond adenine, guanine and uracil and evolved them to specifically bind cytosine. These repeat sequences can be used to create PUF domains capable of selectively binding RNA targets of diverse sequence and structure....
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PMID: 21572425
PDF is available here.
PDF is available here.
Abstract
Glioblastoma is a complex multifactorial disorder that has swift and devastating consequences. Few genes have been consistently identified as prognostic biomarkers of glioblastoma survival. The goal of this study was to identify general and clinical-dependent biomarker genes and biological processes...
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PMID: 21649900
PDF is available here.
PDF is available here.
EMBO Journal (29)21 2010
Abstract
We report the crystal structure of Schizosaccharomyces pombe Cut9 (Cdc16/Apc6) in complex with Hcn1 (Cdc26), showing that Cdc16/Cut9 is a contiguous TPR superhelix of 14 TPR units. A C-terminal block of TPR motifs interacts with Hcn1, whereas an N-terminal TPR block mediates Cdc16/Cut9 self-associat...
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PMID: 20924356
PDF is available here.
PDF is available here.
Infection and Immunity (78)9 2010
Abstract
Chlamydia trachomatis is the leading cause of infectious blindness worldwide and is the most commonly reported pathogen causing sexually transmitted infections. Tarp (translocated actin recruiting phosphoprotein), a type III secreted effector that mediates actin nucleation, is central to C. trachoma...
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PMID: 20605986
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)30 2010
Abstract
We report the crystal structure of a complex between the Pseudomonas translocator chaperone PcrH and a short region from the minor translocator PopD. PcrH displays a 7-helical tetratricopeptide repeat fold that harbors the PopD peptide within its concave region, originally believed to be involved in...
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PMID: 20385547
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
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PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
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PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
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PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
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PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
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PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
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PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Molecular Microbiology (77)1 2010
Abstract
We showed the gene in all tested pneumococci and identified that the observed differences in the molecular mass of PavB rely on the number of repeats, ranging from five to nine SSURE. PavB interacted with fibronectin and plasminogen in a dose-dependent manner as shown by using various SSURE peptides...
|
PMID: 20444103
PDF is available here.
PDF is available here.
Arthritis & Rheumatism (62)7 2010
Abstract
Release of interleukin-1beta (IL-1beta), but not CXCL1 and tumor necrosis factor alpha, was impaired in Cryo(DeltaLRR Z/DeltaLRR Z) and Cryo(-Z/-Z) mouse bone marrow-derived macrophages compared with WT mouse bone marrow-derived macrophages in response to not only MSU crystals but also other known s...
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PMID: 20506351
PDF is available here.
PDF is available here.
Abstract
We have determined the crystal structure of the complex between the C-terminal domain (CTD) of alpha-COP and full-length epsilon-COP, two components of the B-subcomplex, at a 2.9 A resolution. The alpha-COP(CTD) x epsilon-COP heterodimer forms a rod-shaped structure, in which epsilon-COP adopts a te...
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PMID: 20534429
PDF is available here.
PDF is available here.
Biochemistry (Washington) (49)24 2010
Alanine scanning mutagenesis of HIV-1 gp41 heptad repeat 1: insight into the gp120-gp41 interaction.
Abstract
On the basis of mutagenesis, biochemical, and structural studies, heptad repeat 1 of HIV gp41 (HR1) has been shown to play numerous critical roles in HIV entry, including interacting with gp120 in prefusion states and interacting with gp41 heptad repeat 2 (HR2) in the fusion state. Moreover, HR1 is...
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PMID: 20481578
PDF is available here.
PDF is available here.
Abstract
A simple and efficient protein sequence analysis strategy was developed to predict the number and location of structural repeats in the TOR protein. This strategy uses multiple HHpred alignments against proteins of known 3D structure to enable protein repeats referenced from the 3D structure to be t...
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PMID: 20060908
PDF is available here.
PDF is available here.
EMBO Reports (11)5 2010
Abstract
We have developed ultrathin FG domain films that reproduce the mode of attachment and the density of FG repeats in NPCs, and that exhibit a thickness that corresponds to the nanoscopic dimensions of the native permeability barrier. By using a combination of biophysical characterization techniques, w...
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PMID: 20379223
PDF is available here.
PDF is available here.
Abstract
We explored byssus cuticle chemistry by means of in situ resonance Raman spectroscopy and demonstrated that the cuticle is a polymeric scaffold stabilized by catecholato-iron chelate complexes having an unusual clustered distribution. Consistent with byssal cuticle chemistry and mechanics, we presen...
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PMID: 20203014
PDF is available here.
PDF is available here.
Abstract
During the last years the low-molecular non-peptidic regulators of the polypeptide hormones receptors containing LGR-repeats were identified. In the review the data on the structure and the molecular mechanisms of action of these regulators as agonists and antagonists of the luteiniz...
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PMID: 20695210
PDF is available here.
PDF is available here.
Abstract
We present the high resolution crystal structure of TMC353121, a potent inhibitor of respiratory syncytial virus (RSV), bound at a hydrophobic pocket of the 6HB formed by amino acid residues from both HR1 and HR2 heptad-repeats. Binding of TMC353121 stabilizes the interaction of HR1 and HR2 in an al...
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PMID: 19966279
PDF is available here.
PDF is available here.
Abstract
We found that glutamine repeats occur more often than expected by amino acid abundance among 3,400 head development genes in T. dalmanni and D. melanogaster. Furthermore, glutamine repeats occur disproportionately in transcription factors. Loci with glutamine repeats exhibit heterozygosities and all...
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PMID: 20663190
PDF is available here.
PDF is available here.
BMC Microbiology (10) 2010
Abstract
Here we describe a novel LRR domain, or nested repeat observed in 134 proteins from 54 bacterial species. This novel LRR domain has 21 residues with the consensus sequence of LxxLxLxxNxLxxLDLxx(N/L/Q/x)xx or LxxLxCxxNxLxxLDLxx(N/L/x)xx. This LRR domain is characterized by a nested periodicity; it co...
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PMID: 20825685
PDF is available here.
PDF is available here.
Abstract
We demonstrated that a cell polarity-regulating kinase, PAR-1b, interacts with the utrophin-DG complex, and positively regulates the interaction between utrophin and DG. In this study, we demonstrate that the 8th and 9th spectrin-like repeats (R8 and R9) of utrophin cooperatively form a PAR-1b-inter...
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PMID: 19945424
PDF is available here.
PDF is available here.
Abstract
Direct binding of WD40 repeat of Embryonic Ectoderm Development (EED) in the Polycomb Repressor Complex 2 (PRC2) to the histone H3 tail regulates the H3K27 methyltrasnferase activity of PRC2. The binding activity is required for the methylation of H3K27 over long distance of a Drosop...
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PMID: 20008334
PDF is available here.
PDF is available here.
Abstract
We present results from real-time binding kinetic experiments, demonstrating that IkappaBalpha increases the dissociation rate of NF-kappaB from the DNA in a highly efficient kinetic process. Analysis of various IkappaB mutant proteins shows that this process requires the C-terminal PEST sequence an...
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PMID: 19887633
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1793)10 2009
Abstract
We consider how the nuclear pore complex (NPC), a large nanopore mediating the traffic between genetic material and protein synthesizing apparatus, is functionalized to carry out a set of transport functions. A major parameter of NPC functionalization is a lining of it external and internal surfaces...
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PMID: 19596381
PDF is available here.
PDF is available here.
Abstract
Biochemical Journal (422)1 2009
Abstract
We isolated the full-length cDNA and studied the role of human SCUBE2 in the HH signalling cascade. When overexpressed, recombinant human SCUBE2 manifests as a secreted surface-anchored glycoprotein. Deletion mapping analysis defines the critical role of the spacer region and/or cysteine-rich repeat...
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PMID: 19480626
PDF is available here.
PDF is available here.