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Enhancer Elements, Genetic (3):
Recent article
Enhancer Elements, Genetic
Abstract
We identified GATA4 as a transcription factor expressed in osteoblasts and directly regulated by 17β-estradiol in this cell type but not in breast cancer cells, another estrogen-responsive tissue. Chromatin immunoprecipitation sequencing (chromatin immunoprecipitation sequencing) reveals that estro...
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PMID: 21566084
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
We have recently demonstrated that exposure to a suboptimal diet during early development leads to abnormal epigenetic regulation of a promoter-enhancer interaction at the gene encoding HNF-4α, a key transcription factor required for pancreatic β-cell differentiation and glucose homeostasis. In ad...
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PMID: 21623004
PDF is available here.
PDF is available here.
Abstract
We identify molecular events particularly likely to produce significant regulatory changes in humans: complete deletion of sequences otherwise highly conserved between chimpanzees and other mammals. We confirm 510 such deletions in humans, which fall almost exclusively in non-coding regions and are...
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PMID: 21390129
PDF is available here.
PDF is available here.
Abstract
We demonstrate that Tbx6-dependent regulation of Sox2 determines the fate of axial stem cells. In wild-type embryos, enhancer N1 of the neural primordial gene Sox2 is activated in the caudal lateral epiblast, and the cells staying in the superficial layer sustain N1 activity and activate Sox2 expres...
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PMID: 21331042
PDF is available here.
PDF is available here.
Abstract
The hepatic nuclear factor HNF4α is a versatile transcription factor and controls expression of many genes in development, metabolism and disease. To delineate its regulatory gene network in colon cancer and to define novel gene targets a comprehensive genome-wide scan was carried out at a resolutio...
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PMID: 21829439
PDF is available here.
PDF is available here.
Abstract
We defined the important residues and domains of the Arabidopsis YUC1 FMO, a key enzyme in auxin biosynthesis. We previously showed that simultaneous inactivation of YUC1 and its homologue YUC4 caused severe defects in vascular and floral development. We mutagenized the yuc4 mutant and screened for...
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PMID: 21205174
PDF is available here.
PDF is available here.
EMBO Journal (29)24 2010
Abstract
We show that FoxO1 promotes inflammation by enhancing Tlr4-mediated signalling in mature macrophages. By means of chromatin immunoprecipitation (ChIP) combined with massively parallel sequencing (ChIP-Seq), we show that FoxO1 binds to multiple enhancer-like elements within the Tlr4 gene itself, as w...
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PMID: 21045807
PDF is available here.
PDF is available here.
Nature Genetics (42)9 2010
Abstract
What is the best way to identify regulatory DNA sequences such as enhancers, promoters, insulators and silencers? A new study shows that specific binding by a coactivator protein identifies enhancers that are invisible to common detection methods based on evolutionary constraint....
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PMID: 20802475
PDF is available here.
PDF is available here.
Genetika (Moskva) (46)9 2010
Abstract
The transcriptional domain of chicken alpha-globin genes was shown to contain the non-globin coding erythroid-specific TMEM8 gene inducible upon terminal differentiation of erythroblasts. Acquirement by the chicken TMEM8 gene of the erythroid-specific expression correlates with its approachment to t...
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PMID: 21061608
PDF is available here.
PDF is available here.
Journal of Immunology (185)4 2010
Abstract
We found that thapsigargin-induced ER stress augmented recruitment of IFN regulatory factor-3, CREB binding protein/p300, and transcriptional machinery to the murine ifnb1 promoter during LPS stimulation. Although full synergistic IFN-beta production requires X-box binding protein 1 (XBP-1), this UP...
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PMID: 20660350
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)33 2010
Abstract
The CDX2 transcription factor is known to play a crucial role in inhibiting proliferation, promoting differentiation and the expression of intestinal specific genes in intestinal cells. The overall effect of CDX2 in intestinal cells has previously been investigated in conditional knock-out mice, rev...
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PMID: 20551321
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)33 2010
Abstract
We have previously demonstrated that both intron 10 and the alternatively spliced exon 11 contain regulatory sequences that affect insulin receptor splicing both positively and negatively and that these sequences bind the serine/arginine-rich (SR) proteins SRp20 and SF2/ASF and the CELF protein CUG-...
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PMID: 20519504
PDF is available here.
PDF is available here.
Developmental Biology (344)1 2010
Abstract
We report the expression of Six1 in the horseshoe-shaped mouse ectoderm surrounding the anterior neural plate in a pattern broadly similar to that of non-mammalian vertebrates. To elucidate the identity of Six1-positive mouse ectoderm, we searched for enhancers responsible for Six1 expression by in...
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PMID: 20471971
PDF is available here.
PDF is available here.
Abstract
Selector proteins are transcription factors that coordinate the formation and identity of organs and appendages. The proper formation of these tissues requires the selector proteins to regulate the expression of a large set of genes. Many selector proteins are involved in regulating multiple develop...
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PMID: 20725144
PDF is available here.
PDF is available here.
Cancer Letters (294)1 2010
Abstract
We aimed to demonstrate that alpha-fetoprotein (AFP)-producing cells in cholangiocarcinomas possessed cancer stem cell (CSC)-like properties. AFP enhancer/promoter-driven EGFP gene was transfected into human cholangiocarcinoma cell lines. One cell line, RBE, expressed both AFP and EGFP. Clonal analy...
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PMID: 20149523
PDF is available here.
PDF is available here.
Abstract
We tested this hypothesis by generating a deficiency that removes two newly discovered enhancers of shavenbaby (svb, a transcript of the ovo locus), a gene encoding a transcription factor that directs development of Drosophila larval trichomes. At optimal temperatures for embryonic development, this...
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PMID: 20512118
PDF is available here.
PDF is available here.
Abstract
We have identified a distal upstream enhancer, 4E, of ADH4. In HepG2 human hepatoma cells, 4E increased the activity of an ADH4 basal promoter by 50-fold. 4E was cell-specific, as no enhancer activity was detected in a human lung cell line, H1299. We have narrowed the enhancer activity to a 565 bp r...
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PMID: 20363298
PDF is available here.
PDF is available here.
Molecular Therapy (18)7 2010
Abstract
We made use of one of the most promising gene therapy vector platforms, the adeno-associated viral (AAV) vector system, and the COL4A3-deficient mice, a genetic mouse model of renal tubulointerstitial fibrosis, to develop a novel bidirectional treatment strategy to prevent renal fibrosis. By compari...
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PMID: 20424598
PDF is available here.
PDF is available here.
Abstract
We have evaluated GL67A gene transfer to the murine nasal epithelium of wild-type and CF knockout mice to assess this tissue as a test site for gene transfer agents. The plasmids used were regulated by either (1) the commonly used short-acting cytomegalovirus promoter/enhancer or (2) the ubiquitin C...
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PMID: 19648474
PDF is available here.
PDF is available here.
ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification.
Abstract
We now show that, in addition to the known chromosome 14 translocation, ATM-deficient mouse thymic lymphomas routinely contain a centromeric fragment of chromosome 14 that spans up to the 5' boundary of the Tcra/d locus, at which position a 500-kb or larger region centromeric to Tcra/d is routinely...
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PMID: 20566716
PDF is available here.
PDF is available here.
Abstract
We implicate Drifter/Ventral veinless (Dfr/Vvl), a class III POU domain transcription factor, in tissue-specific regulation of the innate immune defense of Drosophila. We show that Dfr/Vvl is highly expressed in a range of immunocompetent tissues, including the male ejaculatory duct, where its prese...
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PMID: 20457811
PDF is available here.
PDF is available here.
Journal of Immunology (184)12 2010
Abstract
We have analyzed the nucleosome organization of accessible and inaccessible Tcrb and Tcra alleles in primary murine thymocytes in vivo. We identified highly positioned arrays of nucleosomes at Dbeta, Jbeta, and Jalpha segments and obtained evidence indicating that positioning is established at least...
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PMID: 20483751
PDF is available here.
PDF is available here.
Regulation of Sox2 in the pre-placodal cephalic ectoderm and central nervous system by enhancer N-4.
Abstract
The development of various tissues originating from the cephalic placodes is accompanied by the expression of the Sox2 gene. This Sox2 expression initiates in the pre-placodal cephalic ectoderm, and is regulated by enhancer N-4, which also regulates Sox2 in the embryonic central nervous system (CNS)...
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PMID: 20507355
PDF is available here.
PDF is available here.
Developmental Biology (342)1 2010
Abstract
In the mouse, the Otx2 gene has been shown to play essential roles in the visceral endoderm during anterior-posterior axis formation and head induction. While these are primary processes in vertebrate embryogenesis, the visceral endoderm is a tissue unique to mammals. Two enhancers (VE and CM) have...
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PMID: 20353765
PDF is available here.
PDF is available here.
Abstract
To explore the role of activation of glucagon-like peptide 1 receptor (GLP-1R) and its relative cell signaling pathway in the cytoprotection of geniposide.
Cell viability was determined by MTT assay. Knockdown of the Glp-1r gene was carried out with shRNA. The levels...
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PMID: 20364157
PDF is available here.
PDF is available here.
Oncology Reports (23)5 2010
Abstract
We generated thymic lymphoma cell lines from EbetaR/Rp53-/- (EP) double mutant mice where the T cell receptor (TCR) beta enhancer (Ebeta) was deleted, and the p53 gene was inactivated. Here, we characterized the EP cell lines to study the roles of the Ebeta and p53 on TCRbeta rearrangements during l...
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PMID: 20372865
PDF is available here.
PDF is available here.
Abstract
We have now analyzed the regulatory significance of the region upstream of the SHOX gene. By comparative genomic analyses, we identified several conserved non-coding elements, which subsequently were tested in an in ovo enhancer assay in both chicken limb bud and cornea, where SHOX is also expressed...
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PMID: 19997128
PDF is available here.
PDF is available here.
Developmental Biology (340)2 2010
Abstract
We used sequence conservation around the Hox4 genes to analyze all fish:human conserved non-coding sequences by reporter assays in stable zebrafish transgenesis. Thirty-four elements were functionally tested in GFP reporter gene constructs and more than 100 F1 lines were analyzed to establish a corr...
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PMID: 20144609
PDF is available here.
PDF is available here.
Abstract
We isolated two similar but distinct AG second intron/enhancers from tobacco (NtAGI-1 and NtAGI-2) and analyzed their ability to drive floral organ-specific expression in plants through the creation of forward- and reverse-oriented chimeric promoters, fNtAGIP1, rNtAGIP1, fNtAGIP2 and rNtAGIP2. Analy...
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PMID: 20182740
PDF is available here.
PDF is available here.
Abstract
We propose a framework that complements existing methodologies for prospective enhancer identification. The methods in this work are derived from two key insights: (i) that chromatin modification signatures can discriminate proximal and distally located regulatory regions and (ii) the notion of prom...
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PMID: 20401945
PDF is available here.
PDF is available here.
médecine/sciences (26)4 2010
Abstract
Abstract
Transgenic expression of the human angiotensinogen (HAGT) gene directed by the mouse kidney androgen-regulated protein (Kap) gene promoter is proximal tubule cell-specific and androgen-regulated in vivo. The same Kap promoter fragment did not support similar regulation of other genes, but a transgen...
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PMID: 20153828
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
We generated 18 cardiac enhancer trap (CET) transgenic zebrafish lines. They exhibit EGFP expression in defined cell types--the endocardium, myocardium, and epicardium--or in anatomical regions of the heart--the atrium, ventricle, valves, or bulbus arteriosus. Most of these expression domains are ma...
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PMID: 20063419
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
We generated 18 cardiac enhancer trap (CET) transgenic zebrafish lines. They exhibit EGFP expression in defined cell types--the endocardium, myocardium, and epicardium--or in anatomical regions of the heart--the atrium, ventricle, valves, or bulbus arteriosus. Most of these expression domains are ma...
|
PMID: 20063419
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
We generated 18 cardiac enhancer trap (CET) transgenic zebrafish lines. They exhibit EGFP expression in defined cell types--the endocardium, myocardium, and epicardium--or in anatomical regions of the heart--the atrium, ventricle, valves, or bulbus arteriosus. Most of these expression domains are ma...
|
PMID: 20063419
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
We generated 18 cardiac enhancer trap (CET) transgenic zebrafish lines. They exhibit EGFP expression in defined cell types--the endocardium, myocardium, and epicardium--or in anatomical regions of the heart--the atrium, ventricle, valves, or bulbus arteriosus. Most of these expression domains are ma...
|
PMID: 20063419
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
We generated 18 cardiac enhancer trap (CET) transgenic zebrafish lines. They exhibit EGFP expression in defined cell types--the endocardium, myocardium, and epicardium--or in anatomical regions of the heart--the atrium, ventricle, valves, or bulbus arteriosus. Most of these expression domains are ma...
|
PMID: 20063419
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
We generated 18 cardiac enhancer trap (CET) transgenic zebrafish lines. They exhibit EGFP expression in defined cell types--the endocardium, myocardium, and epicardium--or in anatomical regions of the heart--the atrium, ventricle, valves, or bulbus arteriosus. Most of these expression domains are ma...
|
PMID: 20063419
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
We generated 18 cardiac enhancer trap (CET) transgenic zebrafish lines. They exhibit EGFP expression in defined cell types--the endocardium, myocardium, and epicardium--or in anatomical regions of the heart--the atrium, ventricle, valves, or bulbus arteriosus. Most of these expression domains are ma...
|
PMID: 20063419
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
We generated 18 cardiac enhancer trap (CET) transgenic zebrafish lines. They exhibit EGFP expression in defined cell types--the endocardium, myocardium, and epicardium--or in anatomical regions of the heart--the atrium, ventricle, valves, or bulbus arteriosus. Most of these expression domains are ma...
|
PMID: 20063419
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
We generated 18 cardiac enhancer trap (CET) transgenic zebrafish lines. They exhibit EGFP expression in defined cell types--the endocardium, myocardium, and epicardium--or in anatomical regions of the heart--the atrium, ventricle, valves, or bulbus arteriosus. Most of these expression domains are ma...
|
PMID: 20063419
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
We generated 18 cardiac enhancer trap (CET) transgenic zebrafish lines. They exhibit EGFP expression in defined cell types--the endocardium, myocardium, and epicardium--or in anatomical regions of the heart--the atrium, ventricle, valves, or bulbus arteriosus. Most of these expression domains are ma...
|
PMID: 20063419
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
We generated 18 cardiac enhancer trap (CET) transgenic zebrafish lines. They exhibit EGFP expression in defined cell types--the endocardium, myocardium, and epicardium--or in anatomical regions of the heart--the atrium, ventricle, valves, or bulbus arteriosus. Most of these expression domains are ma...
|
PMID: 20063419
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
We generated 18 cardiac enhancer trap (CET) transgenic zebrafish lines. They exhibit EGFP expression in defined cell types--the endocardium, myocardium, and epicardium--or in anatomical regions of the heart--the atrium, ventricle, valves, or bulbus arteriosus. Most of these expression domains are ma...
|
PMID: 20063419
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
We generated 18 cardiac enhancer trap (CET) transgenic zebrafish lines. They exhibit EGFP expression in defined cell types--the endocardium, myocardium, and epicardium--or in anatomical regions of the heart--the atrium, ventricle, valves, or bulbus arteriosus. Most of these expression domains are ma...
|
PMID: 20063419
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
We generated 18 cardiac enhancer trap (CET) transgenic zebrafish lines. They exhibit EGFP expression in defined cell types--the endocardium, myocardium, and epicardium--or in anatomical regions of the heart--the atrium, ventricle, valves, or bulbus arteriosus. Most of these expression domains are ma...
|
PMID: 20063419
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
We generated 18 cardiac enhancer trap (CET) transgenic zebrafish lines. They exhibit EGFP expression in defined cell types--the endocardium, myocardium, and epicardium--or in anatomical regions of the heart--the atrium, ventricle, valves, or bulbus arteriosus. Most of these expression domains are ma...
|
PMID: 20063419
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
We generated 18 cardiac enhancer trap (CET) transgenic zebrafish lines. They exhibit EGFP expression in defined cell types--the endocardium, myocardium, and epicardium--or in anatomical regions of the heart--the atrium, ventricle, valves, or bulbus arteriosus. Most of these expression domains are ma...
|
PMID: 20063419
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
We generated 18 cardiac enhancer trap (CET) transgenic zebrafish lines. They exhibit EGFP expression in defined cell types--the endocardium, myocardium, and epicardium--or in anatomical regions of the heart--the atrium, ventricle, valves, or bulbus arteriosus. Most of these expression domains are ma...
|
PMID: 20063419
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
We generated 18 cardiac enhancer trap (CET) transgenic zebrafish lines. They exhibit EGFP expression in defined cell types--the endocardium, myocardium, and epicardium--or in anatomical regions of the heart--the atrium, ventricle, valves, or bulbus arteriosus. Most of these expression domains are ma...
|
PMID: 20063419
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
We generated 18 cardiac enhancer trap (CET) transgenic zebrafish lines. They exhibit EGFP expression in defined cell types--the endocardium, myocardium, and epicardium--or in anatomical regions of the heart--the atrium, ventricle, valves, or bulbus arteriosus. Most of these expression domains are ma...
|
PMID: 20063419
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
We generated 18 cardiac enhancer trap (CET) transgenic zebrafish lines. They exhibit EGFP expression in defined cell types--the endocardium, myocardium, and epicardium--or in anatomical regions of the heart--the atrium, ventricle, valves, or bulbus arteriosus. Most of these expression domains are ma...
|
PMID: 20063419
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
We generated 18 cardiac enhancer trap (CET) transgenic zebrafish lines. They exhibit EGFP expression in defined cell types--the endocardium, myocardium, and epicardium--or in anatomical regions of the heart--the atrium, ventricle, valves, or bulbus arteriosus. Most of these expression domains are ma...
|
PMID: 20063419
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
We generated 18 cardiac enhancer trap (CET) transgenic zebrafish lines. They exhibit EGFP expression in defined cell types--the endocardium, myocardium, and epicardium--or in anatomical regions of the heart--the atrium, ventricle, valves, or bulbus arteriosus. Most of these expression domains are ma...
|
PMID: 20063419
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
We generated 18 cardiac enhancer trap (CET) transgenic zebrafish lines. They exhibit EGFP expression in defined cell types--the endocardium, myocardium, and epicardium--or in anatomical regions of the heart--the atrium, ventricle, valves, or bulbus arteriosus. Most of these expression domains are ma...
|
PMID: 20063419
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
We generated 18 cardiac enhancer trap (CET) transgenic zebrafish lines. They exhibit EGFP expression in defined cell types--the endocardium, myocardium, and epicardium--or in anatomical regions of the heart--the atrium, ventricle, valves, or bulbus arteriosus. Most of these expression domains are ma...
|
PMID: 20063419
PDF is available here.
PDF is available here.
Developmental Dynamics (239)3 2010
Abstract
We generated 18 cardiac enhancer trap (CET) transgenic zebrafish lines. They exhibit EGFP expression in defined cell types--the endocardium, myocardium, and epicardium--or in anatomical regions of the heart--the atrium, ventricle, valves, or bulbus arteriosus. Most of these expression domains are ma...
|
PMID: 20063419
PDF is available here.
PDF is available here.
Abstract
We identified nuclear factor-kappaB (NF-kappaB) to activate PU.1 expression through a novel site within the URE. We found sequence variations of this particular NF-kappaB site in 4 of 120 AML patients. These variant NF-kappaB sequences failed to mediate activation of PU.1. Moreover, the synergistic...
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PMID: 19966852
PDF is available here.
PDF is available here.
Abstract
We used the classic example of the duplicated zebrafish sox11a and -b loci to test the duplication, degeneration, complementation (DDC) model of genome evolution through whole genome duplication. While recent reports have demonstrated sub-partitioning of regulatory sequences in duplicated regions, a...
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PMID: 20039180
PDF is available here.
PDF is available here.
Biochemistry (New York) (75)2 2010
Abstract
We have revealed evolutionarily conserved regions in a 4500-bp DNA sequence 5'-adjacent to the survivin (BIRC5) gene. In the transcribed region of the BIRC5 gene we have detected and characterized in detail a 3'-fragment of the CpG island that stimulated in enhancer-like way the gene promoter activi...
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PMID: 20367605
PDF is available here.
PDF is available here.