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Promoter Regions, Genetic (2):
Recent article
Promoter Regions, Genetic
Abstract
We employed an olfactory sensory neuron (OSN)-specific gene manipulation system in combination with in vivo imaging of transparent zebrafish embryos. Knockdown of PTPσ enhanced the accumulation of synaptic vesicles in the axon terminals of OSNs. The exaggerated accumulation of synaptic vesicles was...
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PMID: 21812780
PDF is available here.
PDF is available here.
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Abstract
Attempts to determine the clinical significance of BRCA1/2 mutations in ovarian cancer have produced conflicting results.
To determine the relationships between BRCA1/2 deficiency (ie, mutation and promoter hypermethylation) and overall survival (OS), progression-free...
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PMID: 21990299
PDF is available here.
PDF is available here.
Abstract
The incidence and mortality of gastric and colorectal cancers are among the highest malignant tumors in China. The aim of this study is to investigate whether variations of the human oxoguanine glycosylase 1 (hOGG1) gene are related to the risk of gastric and colorectal cancers in the Chinese populat...
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PMID: 21822670
PDF is available here.
PDF is available here.
Abstract
We report that TAF1B, a subunit of human Pol I basal transcription factor SL1, is structurally related to TFIIB/TFIIB-like proteins, through predicted amino-terminal zinc ribbon and cyclin-like fold domains. SL1, essential for Pol I recruitment to the ribosomal RNA gene promoter, also has an essenti...
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PMID: 21921199
PDF is available here.
PDF is available here.
Abstract
We show that BIKDD, a constitutively active mutant form of proapoptotic gene, BIK, effectively induces apoptosis of breast cancer cells and synergizes with lapatinib. Most importantly, BikDD significantly reduces BCICs through co-antagonism of its binding partners Bcl-2, Bcl-xL, and Mcl-1, suggestin...
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PMID: 21907925
PDF is available here.
PDF is available here.
Abstract
We characterized an E-box motif (RBE1) within the core promoter that was previously implicated in both transcriptional activation and repression. We show that RBE1 is a binding site for the RBF-2 transcription factor complex (USF1, USF2, and TFII-I), previously shown to bind an upstream viral elemen...
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PMID: 21813151
PDF is available here.
PDF is available here.
Abstract
We showed that the ghrelin promoter operates under the control of somatostatin but not under that of IFNγ.
Gastric infection and inflammation is associated with increased IFNγ expression and reduced ghrelin expression. IFNγ does not directly control ghrelin expression but inhibits...
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PMID: 21912454
PDF is available here.
PDF is available here.
Abstract
We found that HIF subunits and HIF2α in particular were normally expressed in the mediobasal hypothalamus of mice. Hypothalamic HIF was up-regulated by glucose to mediate the feeding control of hypothalamic glucose sensing. Two underlying molecular pathways were identified, including suppression of...
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PMID: 21814490
PDF is available here.
PDF is available here.
Abstract
We used genome sequence information to carry out phylogenetic classification of 864 TetR family members with a special focus on TetR regulators in Geobacteraceae, an environmentally important family of delta-Proteobacteria. The genome of Geobacter sulfurreducens, a model representative of Geobactera...
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PMID: 21699403
PDF is available here.
PDF is available here.
Abstract
We studied the effects of the application of retinoic acid, a ligand of a nuclear receptor, and of butyric acid, an inhibitor of histone deacetylase activity, on the expression of mRNA of prestin and Gata-3 in the organotypic culture of the organ of Corti of newborn rats using RT-PCR. Application of...
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PMID: 21344672
PDF is available here.
PDF is available here.
Abstract
We conclude the following: i) overexpression of ΔNp63 contributes to salivary tumorigenesis, ii) ΔNp63 plays a dominant negative effect on the TA isoform in the modulation of cell migration and invasion, and iii) the ΔN isoform plays an oncogenic role and may represent an attractive target for th...
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PMID: 21703418
PDF is available here.
PDF is available here.
Abstract
Abstract In nature the foodborne pathogen Listeria monocytogenes lives as a saprophyte where it can contaminate preharvest produce. This environment can present many stresses such as ultraviolet light, variations in temperature and humidity, and oxidative stress from growing plant ma...
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PMID: 21381923
PDF is available here.
PDF is available here.
Abstract
We examined genome-wide DNA methylation and gene expression in HPV(+) and HPV(-) SCC cell lines. We used two platforms: the Illumina Infinium Methylation BeadArray and tiling arrays, and confirmed illustrative examples with pyrosequencing and quantitative PCR. These analyses indicate that HPV(+) cel...
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PMID: 21613826
PDF is available here.
PDF is available here.
Abstract
We characterized the promoter region of the hST3Gal V gene. Functional analysis of the 5'-flanking region of the hST3Gal V gene revealed that the -177 to -83 region functions as the VPA-inducible promoter and that the CREB/ATF binding site at -143 is crucial for VPA-induced expression of hST3Gal V i...
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PMID: 21699754
PDF is available here.
PDF is available here.
Acta Medica Okayama (65)3 2011
Abstract
We constructed an attenuated adenovirus 5 vector (Telomelysin, OBP-301), in which the hTERT promoter element drives expression of E1 genes. Since only tumor cells that express telomerase activity would activate this promoter, the hTERT proximal promoter would allow for preferential expression of vir...
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PMID: 21709712
PDF is available here.
PDF is available here.
Abstract
We have found evidences that genome-wide changes in nucleosome occupancy play a critical role in controlling the rigorous parasite replication in infected red blood cells. However, the role of nucleosome positioning at remarkable locations such as transcriptional start sites (TSS) was not investigat...
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PMID: 20708104
PDF is available here.
PDF is available here.
Abstract
Our findings suggest that different IL-10 gene polymorphisms may lead to an imbalance between the pro-inflammatory and anti-inflammatory cytokine responses which may in turn influence the susceptibility to HCV infection....
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PMID: 21727647
PDF is available here.
PDF is available here.
PLoS Genetics (7)6 2011
Abstract
We recently identified miR-146a as a negative regulator of the interferon pathway and linked the abnormal activation of this pathway to the underexpression of miR-146a in SLE patients. To explore why the expression of miR-146a is reduced in SLE patients, we conducted short parallel sequencing of pot...
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PMID: 21738483
PDF is available here.
PDF is available here.
PLoS Genetics (7)6 2011
Abstract
We investigate how chromatin structure is modified following UV irradiation to facilitate DNA repair in yeast. Using a combination of chromatin immunoprecipitation to measure histone acetylation levels, histone acetylase occupancy in chromatin, MNase digestion, or restriction enzyme endonuclease acc...
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PMID: 21698136
PDF is available here.
PDF is available here.
Oral Oncology (47)7 2011
Abstract
We explored the expression of CHD5 in 65 patients with laryngeal squamous cell carcinoma (LSCC) using real-time PCR, immunohistochemistry and Western blotting. DNA methylation was detected using bisulfate-specific sequencing. The potential function of CHD5 was determined using MTT, apoptosis and tra...
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PMID: 21636313
PDF is available here.
PDF is available here.
Abstract
P-glycoprotein (P-gp) mediates efflux of xenobiotics and bacterial toxins from the intestinal mucosa into the lumen. Dysregulation of P-gp has been implicated in inflammatory bowel disease. Certain probiotics have been shown to be effective in treating inflammatory bowel disease. However, direct effe...
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PMID: 21350189
PDF is available here.
PDF is available here.
Abstract
We have validated in vivo the newly developed 450,000 (450K) cytosine microarray (Illumina). The 450K microarray includes CpG and CNG sites, CpG islands/shores/shelves/open sea, non-coding RNA (microRNAs and long non-coding RNAs) and sites surrounding the transcription start sites (-200 bp to -1,500...
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PMID: 21593595
PDF is available here.
PDF is available here.
Abstract
We report that the microRNA-10b gene (miR-10b) was silenced in gastric cancer cells by promoter methylation. In this study, using a methylation array and bisulfate pyrosequencing analysis, we found that miR-10b promoter CpGs were heavily methylated in gastric cancers. Clinicopathologic data showed...
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PMID: 21562367
PDF is available here.
PDF is available here.
Abstract
We applied either MeTA or a conventional DNA demethylating agent, 5-aza-cytidine (Aza-CR), to human embryonic kidney cell line 293T and analyzed gene expression profiles by microarray: 138 and 202 genes that are upregulated 5-fold or more were identified by MeTA and Aza-CR, respectively. The top ten...
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PMID: 21586901
PDF is available here.
PDF is available here.
Abstract
We have hypothesized that Brg1 and Brm form distinct complexes in regulating gene expression in an animal model of cardiac hypertophy. We have identified that the hypertrophic myocardium is characterized by profound morphological changes associated with increased expression of ANP (Nppa), BNP (Nppb)...
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PMID: 21586902
PDF is available here.
PDF is available here.
Abstract
We have recently demonstrated that Tet1 is specifically expressed in murine embryonic stem (ES) cells and is required for ES cell maintenance. Using chromatin immunoprecipitation coupled with high-throughput DNA sequencing, here we show in mouse ES cells that Tet1 is preferentially bound to CpG-rich...
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PMID: 21451524
PDF is available here.
PDF is available here.
Abstract
We extensively characterize alternative first exons of the mouse GR to reveal homology to the rat and human. We further find that, although most promoters are broadly expressed in various tissues, transcription of individual promoters can be differentially regulated by growth factor- and depolarizat...
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PMID: 21527501
PDF is available here.
PDF is available here.
Abstract
We investigate whether GRα isoform-specific differences in the regulation of antiapoptotic genes contribute to this resistant phenotype. We now show that GRα-D, unlike the other receptor isoforms, does not inhibit the activity of a nuclear factor κB (NF-κB)-responsive reporter gene and does not...
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PMID: 21527497
PDF is available here.
PDF is available here.
Abstract
We show that Drosophila STAT (STAT92E) functions as a general transcription factor that, together with the transcription factor Zelda, induces transcription of a large number of early-transcribed zygotic genes during the MZT. STAT92E is present in the early embryo as a maternal product and is active...
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PMID: 21637778
PDF is available here.
PDF is available here.
Abstract
Triple-negative breast cancer (TNBC) occurs in approximately 15% of all breast cancer patients, and the incidence of TNBC is greatly increased in BRCA1 mutation carriers. This study aimed to assess the impact of BRCA1 promoter methylation with respect to breast cancer subtypes in spo...
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PMID: 21593597
PDF is available here.
PDF is available here.
Abstract
We report that transcription of RunX1T1 was confirmed to be positively regulated by SMAD4 in IOSE cells and epigenetically silenced in a panel of ovarian cancer cell lines by promoter hypermethylation and histone methylation at H3 lysine 9. SMAD4 depletion increased repressive histone modifications...
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PMID: 21540640
PDF is available here.
PDF is available here.
Abstract
We have fused the promoterless lux operon luxCDABE to the promoter regions of Anabaena sp. PCC 7120 phoA genes putatively encoding alkaline phosphatases, phoA (all2843) and phoA-like (alr5291) and to the promoter region of one operon putatively encoding a high affinity phosphate transporter pst1 (al...
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PMID: 21533636
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
Today the treatment of inherited diseases holds a major field in gene therapy, and gamma -retroviral vectors are often the preferred tool for stable introduction of the therapeutic gene(s) into the host cell genome. In many cases, the newly introduced gene has to be constitutively expressed, since e...
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PMID: 19110630
PDF is available here.
PDF is available here.
Abstract
We have recently demonstrated that exposure to a suboptimal diet during early development leads to abnormal epigenetic regulation of a promoter-enhancer interaction at the gene encoding HNF-4α, a key transcription factor required for pancreatic β-cell differentiation and glucose homeostasis. In ad...
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PMID: 21623004
PDF is available here.
PDF is available here.
PLoS Genetics (7)5 2011
Abstract
We use an integrative analysis and evolutionary conservation to identify features that predict when the loss of a regulatory interaction is detrimental in the extensively mapped transcription network of budding yeast. Properties such as the strength of an interaction, location and context in a promo...
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PMID: 21637788
PDF is available here.
PDF is available here.
Abstract
I (highly-differentiated group) were higher than that in grade II (moderate-differentiated group) and grade III (poorly-differentiated group) (P < 0.05); and the methylation rates at CpG_3, CpG_8 and CpG_14.15.16 loci in ER(+) PR(+) HER2(-) group were lower than that in ER(-) PR(-) HER2(+) group (P...
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PMID: 21756827
PDF is available here.
PDF is available here.
Abstract
We have shown that TIF1γ was a tumor suppressor in mouse and human chronic myelomonocytic leukemia (CMML). Loss of Tif1g in mouse HSCs favored the expansion of the granulo-monocytic progenitor compartment. Furthermore, Tif1g deletion induced the age-dependent appearance of a cell-autonomous myelopr...
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PMID: 21537084
PDF is available here.
PDF is available here.
Abstract
To explore the influence of arsenic pollution caused by coal-burning on methylation (promoter and exon 5) and mutation (exon 5) of human p53 gene, and to analyze the relationship between methylation, mutation and arsenism.
According to the diagnostic criteria of endem...
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PMID: 21756780
PDF is available here.
PDF is available here.
Abstract
We addressed the question of the influence of the locus structure and epigenetic modifications of the target locus on its susceptibility for being paramutated by trans-acting small RNA molecules. Silencing was induced by crossing a 35S promoter silencer locus 271 with two different 35S-driven transg...
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PMID: 21521939
PDF is available here.
PDF is available here.
Abstract
Hypertrophy occurs in urinary bladder wall smooth muscle (BSM) in men with partial bladder outlet obstruction (PBOO) caused by benign prostatic hyperplasia (BPH) and in animal models of PBOO. Hypertrophied BSM from the rabbit model exhibits down-regulation of caveolin-1, a structural and functional p...
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PMID: 21514437
PDF is available here.
PDF is available here.
Abstract
In colorectal cancer (CRC), DNA methylation anomalies define distinct subgroups termed CpG island methylator phenotype 1 (CIMP1), CIMP2, and CIMP-negative. The role of this classification in predicting recurrence and disease-free survival (DFS) in resected stage III CRC was evaluated.
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PMID: 21509761
PDF is available here.
PDF is available here.
Abstract
The aim of the current study was to catalog genomic and epigenomic abnormalities in newly diagnosed glioblastoma patients and determine the correlation among clinical, genetic, and epigenetic profiles and clinical outcome.
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PMID: 21472719
PDF is available here.
PDF is available here.
Cell Metabolism (13)4 2011
Abstract
We tested whether deletion of PARP-2, an alternative NAD(+)-consuming enzyme, impacts on NAD(+) bioavailability and SIRT1 activity. Our results indicate that PARP-2 deficiency increases SIRT1 activity in cultured myotubes. However, this increase was not due to changes in NAD(+) levels, but to an inc...
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PMID: 21459329
PDF is available here.
PDF is available here.
Abstract
We previously showed that Dicer, an RNaseIII endonuclease required for microRNA (miRNA) biogenesis, is absolutely essential for Sertoli cells to mature, survive, and ultimately sustain germ cell development. Here, using isotope-coded protein labeling, a technique for protein relative quantification...
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PMID: 20467044
PDF is available here.
PDF is available here.
Epigenetics (6)4 2011
Abstract
We have investigated promoter methylation of the Insr, Igf1 and Igf1r genes in skeletal and cardiac muscles of normal and diabetic db/db mice. No differences in Insr promoter methylation were found in the heart and skeletal muscles and no methylation was detected in the Igf1 promoter in skeletal mus...
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PMID: 21474992
PDF is available here.
PDF is available here.
Molecular Therapy (19)4 2011
Abstract
We found that integrating retroviral vector particles induce stable interleukin-10 (IL-10) production in murine (BALB/c H-2(d)) transduced B cells. This requires a novel mechanism whereby the interaction of retroviral vector particle with its cognate cellular receptor activates intracellular signali...
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PMID: 21157434
PDF is available here.
PDF is available here.
Epigenetics (6)4 2011
Abstract
We previously described an extensive methylation-acetylation switch on cell cycle promoters using a single nucleosome ChIP assay. A key issue is how PTMs are locally positioned. We report an analysis on the role of the NF-Y CCAAT transcription factor on histone acetylation. Whereas H3K9 and H3K14 ac...
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PMID: 21304275
PDF is available here.
PDF is available here.
Abstract
We performed a genome-wide DNA methylation study in CD4+ T cells in lupus patients compared to normal healthy controls. Cytosine methylation was quantified in 27,578 CG sites located within the promoter regions of 14,495 genes. We identified 236 hypomethylated and 105 hypermethylated CG sites in lup...
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PMID: 21436623
PDF is available here.
PDF is available here.
Abstract
We report that TLTs arising during inflammation in mice and humans in a variety of tissues (eg, pancreas, kidney, liver, and salivary gland) contain stromal cell networks consisting of podoplanin(+) T-zone fibroblastic reticular cells (TRCs), distinct from follicular dendritic cells. Similar to lymp...
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PMID: 21435450
PDF is available here.
PDF is available here.
Abstract
RNA interference (RNAi) mediated by short hairpin-RNA (shRNA) expressing plasmids can induce specific and long-term knockdown of specific mRNAs in eukaryotic cells. To develop a vector-based RNAi model for Schistosoma mansoni, the schistosome U6 gene promoter was employed to drive expression of shRNA...
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PMID: 21447344
PDF is available here.
PDF is available here.
Abstract
Abstract
We report generation of transgenic (Tg) mice with targeted Elovl4 expression driven by an epidermal-specific involucrin promoter. In homozygous Stgd3 mice, this transgene reinstates both epidermal Elovl4 expression and synthesis of two missing epidermal lipid groups: C28-C36 acylceramides and (O-lin...
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PMID: 21429867
PDF is available here.
PDF is available here.
Abstract
We show here that Mpk1 additionally serves a function in transcription elongation that is also independent of its catalytic activity. This function is mediated by an interaction between Mpk1 and the Paf1 subunit of the Paf1C elongation complex. A mutation in Paf1 that blocks this interaction causes...
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PMID: 21376235
PDF is available here.
PDF is available here.
Abstract
We question this separation. We study an example of two interacting repressilators (artificial regulatory oscillators based on cyclic repression). We show that changing the cooperativity of transcription repression (Hill coefficient) and reaction timescales dramatically alter synchronization propert...
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PMID: 21517519
PDF is available here.
PDF is available here.
Abstract
PROCR haplotype 3 (H3) and FOXA2 rs1055080 were associated with PC levels in the family but only PROCR H3 was also associated with plasma levels in the healthy individuals. Carriers of both variants had higher PC levels than carriers of only PROCR H3 in the family but not in healthy individuals, sug...
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PMID: 21392254
PDF is available here.
PDF is available here.
Abstract
In the first study, 255 GCs were classified into N-TF 44%, G-TF 31%, GI-TF 3%, and I-TF 2%. The TF type did not strictly accord with the mucin phenotype, classified by MUC2/5AC/6/CD10 expression. EBV status was the only factor related to both the TF and mucin phenotype classifications (P<0.0001, <0....
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PMID: 21487519
PDF is available here.
PDF is available here.
Behavior Genetics (41)2 2011
Abstract
Our results confirm previous findings of an interaction between the MAOA-VNTR polymorphism and self-reported maltreatment. Results for boys and girls differ according to MAOA-VNTR genotype and direction of phenotypic expression....
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PMID: 20734127
PDF is available here.
PDF is available here.
Abstract
Interleukin (IL)-10 is an immunoregulatory cytokine, levels of which can be influenced by single nucleotide polymorphisms (SNPs) in the promoter. Some, but not all previous studies have shown associations of IL10 SNPs with HIV-1 disease progression, using markers such as viral load or CD4 count. Ther...
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PMID: 21560494
PDF is available here.
PDF is available here.
Mucosal Immunology (4)2 2011
Abstract
We generated transgenic mice that constitutively express TL1A in T cells or dendritic cells. These mice spontaneously develop IL-13-dependent inflammatory small bowel pathology that strikingly resembles the intestinal response to nematode infections. These changes were dependent on the presence of a...
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PMID: 20980995
PDF is available here.
PDF is available here.
Clinical Cancer Research (17)7 2011
Abstract
To address the association between sequence variants within the MGMT (O(6)-methylguanine-DNA methyltransferase) promoter-enhancer region and methylation of MGMT in premalignant lesions from smokers and lung adenocarcinomas, their biological effects on gene regulation, and targeting MGMT for therapy....
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PMID: 21355081
PDF is available here.
PDF is available here.