Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Repetitive Sequences, Nucleic Acid (3):
Recent article
Repetitive Sequences, Nucleic Acid
Abstract
We show that the edges of the rDNA array are exceptionally susceptible to meiotic DSBs, revealing an inherent heterogeneity in the rDNA array. We find that this localized DSB susceptibility necessitates a border-specific protection system consisting of the meiotic ATPase Pch2 and the origin recognit...
|
PMID: 21822291
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
The results of intraspecies heterogeneity analysis of 4 bifidobacterial species, B. longum, B. animalis subsp. lactics, B. bifidum and B. dentium colonizing intestines of people of different age groups are presented in the paper. A high level of intraspecies variability has been revealed for all spec...
|
PMID: 21809682
PDF is available here.
PDF is available here.
Abstract
We have previously shown that RAD50 is involved in mitotic nonhomologous integration but not in homologous integration. However, the role of Rad50 in nonhomologous integration has not previously been examined. In the current work, we report that the rad50∆ mutation caused a tenfold decrease in the...
|
PMID: 21512733
PDF is available here.
PDF is available here.
Abstract
We provide an updated analysis of the evolutionary relationships between CRISPR-Cas systems and Cas proteins. Three major types of CRISPR-Cas system are delineated, with a further division into several subtypes and a few chimeric variants. Given the complexity of the genomic architectures and the ex...
|
PMID: 21552286
PDF is available here.
PDF is available here.
PLoS Biology (9)6 2011
Abstract
We employ population genomics data from Escherichia coli, Saccharomyces paradoxus, and Drosophila to provide evidence suggesting that it is not the indels per se but the sequence in which indels occur that causes the accumulation of nucleotide substitutions. We found that about two-thirds of indels...
|
PMID: 21697975
PDF is available here.
PDF is available here.
Abstract
We provide the first genome sequence for S. agalactiae isolated from a cow diagnosed with clinical mastitis (strain FSL S3-026). Comparison to eight S. agalactiae genomes obtained from human disease isolates revealed 183 genes specific to the bovine strain. Subsequent polymerase chain reaction (PCR)...
|
PMID: 21536150
PDF is available here.
PDF is available here.
Abstract
We report here on the existence of a high-level compositional organization of isochores in the human genome. By using a segmentation algorithm incorporating the long-range correlations existing in human DNA, we find that every chromosome is composed of a few huge segments (~ 10^{7} bp) of relatively...
|
PMID: 21517526
PDF is available here.
PDF is available here.
Molecular Cell (41)2 2011
Abstract
We asked if, during B cell activation, AID also induces DNA breaks at genes other than IgH genes. Using a nonbiased genome-wide approach, we have identified hundreds of reproducible, AID-dependent DSBs in mouse splenic B cells shortly after induction of CSR in culture. Most interestingly, AID induce...
|
PMID: 21255732
PDF is available here.
PDF is available here.
Abstract
We compared the performance of specific algorithms for the clustering of interspersed repeats and found that only a particular combination of algorithms detected TE families with good recovery of the reference sequences. We then applied a new procedure for reconciling the different clustering result...
|
PMID: 21304975
PDF is available here.
PDF is available here.
Abstract
The combination of gene annotation information and sequence motif-orientated computational candidate gene prediction methods highlight an added benefit in generating a list of plausible candidate genes, as has been demonstrated for XLMR. Reviewers: This article was reviewed by Dr Barbara Bardoni (no...
|
PMID: 21668950
PDF is available here.
PDF is available here.
Epigenetics (6)1 2011
Abstract
We examined global DNA methylation in WBC (measured in three repetitive elements, LINE1, Sat2 and Alu, by MethyLight and in LINE1 by pyrosequencing) in 51 girls ages 6-17. Compared to girls without a family history of breast cancer, methylation levels were lower for all assays in girls with a family...
|
PMID: 20930546
PDF is available here.
PDF is available here.
Abstract
We demonstrate that the model can handle statistically biased sequences and distantly related sequences where conventional knowledge discovery tools often fail....
|
PMID: 21431607
PDF is available here.
PDF is available here.
Cytogenetic and Genome Research (132)1-2 2011
Abstract
We aimed to characterize TEs to help elucidate their impact on the genomic architecture, diversity and evolution of chromosomes in the D. buzzatii cluster of species (repleta group).
A full TE element of D. buzzatii, named PERI, was identified in a BAC clone available in GenBank. PERI was further an...
|
PMID: 20938165
PDF is available here.
PDF is available here.
Cytogenetic and Genome Research (132)1-2 2011
Abstract
Karyotype and cytogenetic characteristics of 2 species of giant trahiras, Hopliasintermedius, São Francisco river basin, and Hopliasaimara, Arinos river (Amazon basin), were examined by conventional (C-banding, Ag-NOR, DAPI/CMA(3) double-staining) and fluorescent in situ hybridization (FISH) with 5...
|
PMID: 20924165
PDF is available here.
PDF is available here.
Molecular characteristics of "Mycobacterium canettii" the smooth Mycobacterium tuberculosis bacilli.
Abstract
We have collected 59 SmTB isolates of which 14 were newly recovered since previous reports, and performed extensive phenotypical and genotypical characterization. We take advantage of these investigations to review the current knowledge of "M. canettii". Their characteristics and the apparent lack o...
|
PMID: 20692377
PDF is available here.
PDF is available here.
Abstract
We show that pericentric satellites undergo a transient peak in expression precisely at the time of chromocenter formation. This transcription is regulated in a strand-specific manner in time and space and is strongly biased by the parental asymmetry. The transcriptional upregulation follows a devel...
|
PMID: 20951352
PDF is available here.
PDF is available here.
Epigenetics (5)7 2010
Abstract
We recently performed a genome-wide survey for endogenous targets silenced by MOM1 and identified loci that are concentrated around centromeres and rich in sequences homologous to the 24-nt small interfering RNAs (siRNAs) that accumulate in wild type plants. Further and independent analyses indicate...
|
PMID: 21464619
PDF is available here.
PDF is available here.
Chromosome Research (18)6 2010
Abstract
We investigated. Only very low amounts of the Fat element were detected on the chromosomes of two other barley species, Hordeum geniculatum and Hordeum chilense, with different genome compositions. The chromosomes of other cereal species exhibited distinct hybridisation patterns with the Fat probe,...
|
PMID: 20717716
PDF is available here.
PDF is available here.
Mycopathologia (170)3 2010
Abstract
Twelve simple sequence repeat (SSRs) loci were used to evaluate genetic diversity of 109 isolates of Macrophomina phaseolina collected from different geographical regions and host species throughout the United States (US). Genetic diversity was assessed using Nei's minimum genetic distance, and the...
|
PMID: 20352493
PDF is available here.
PDF is available here.
Abstract
We sequenced the 138-mega-base pair genome of V. carteri and compared its approximately 14,500 predicted proteins to those of its unicellular relative Chlamydomonas reinhardtii. Despite fundamental differences in organismal complexity and life history, the two species have similar protein-coding pot...
|
PMID: 20616280
PDF is available here.
PDF is available here.
Abstract
Cytogenetic and Genome Research (129)1-3 2010
Abstract
We now can detect smaller chromosomal and DNA rearrangements, diminutions and amplifications of repeats and changes of the epigenetic status of introgressed regions.
Copyright 2010 S. Karger AG, Basel....
|
PMID: 20628252
PDF is available here.
PDF is available here.
Abstract
CA88 is the first long nuclear repetitive DNA sequence identified in the blood fluke, Schistosoma mansoni. The assembled S. mansoni sequence, which contains the CA88 repeat, has 8,887 nucleotides and at least three repeat units of approximately 360 bp. In addition, CA88 also possesses an internal CA...
|
PMID: 20721481
PDF is available here.
PDF is available here.
Abstract
In the present study, the authors investigated the effects of shiftwork exposure on DNA methylation using peripheral blood DNA from subjects working in two chemical plants in Northern Italy. The investigation was designed to evaluate (a) DNA methylation changes in Alu and long interspersed nuclear e...
|
PMID: 20636218
PDF is available here.
PDF is available here.
Abstract
Unbiased longitudinal studies are needed to understand the distributed neurodegenerative changes of Huntington's disease (HD). They may also provide tools for assessing disease-modifying interventions. The authors investigated the progression of regional atrophy in premanifest and ea...
|
PMID: 19955112
PDF is available here.
PDF is available here.
Parasitology Research (107)2 2010
Abstract
Diphyllobothrium latum is a widespread intestinal parasite, which has a great clinical relevance, but there are no sequences of its nuclear genome. In this paper, a repetitive element in the D. latum genome is firstly described. The adult D. latum was obtained in the result of expulsion from intesti...
|
PMID: 20440623
PDF is available here.
PDF is available here.
Archives of Microbiology (192)7 2010
Abstract
We identified two more YclJ-regulated genes, yycA and yfjR, using bioinformatic analysis of the B. subtilis genome, and it was shown that YclJ binds to those promoters and controls the expression of those genes....
|
PMID: 20512483
PDF is available here.
PDF is available here.
Biosystems (100)3 2010
Abstract
We study, how short-range correlations in Eukaryotic genomes change under elimination of various classes of repetitive DNA. Our main result is that a residual correlation pattern, common to most mammalian species, emerges under elimination of all repetitive DNA, suggesting features of an ancestral c...
|
PMID: 20350581
PDF is available here.
PDF is available here.
Abstract
The configuration hyperspace of canonical and oxidized 14-mers of B-DNA comprising telomere repeat units d(ApGpGpGpTpT) was sampled over 40 ns via molecular dynamic (MD) simulations. The energetic and structural consequences of TRF1 binding to telomere B-DNA were compared with non-complexed systems....
|
PMID: 20464436
PDF is available here.
PDF is available here.
Journal of Physical Chemistry B (114)16 2010
Abstract
Our results also indicate that the presence of the thymine 5-methyl group is necessary for calibrating the backbone conformation and the basepair and dinucleotide step geometry of the core A-tract as well as the flanking CA/TG and the neighboring GC/GC steps, as observed in free and protein-bound DN...
|
PMID: 20373819
PDF is available here.
PDF is available here.
Abstract
We genotyped families of cystic fibrosis sib pairs homozygous for F508del-CFTR who represent extreme clinical phenotypes at informative microsatellite markers spanning a 38 Mb region between CFTR and 7qtel. Recombination events on both parental chromosomes were compared between siblings with concord...
|
PMID: 20051989
PDF is available here.
PDF is available here.
Abstract
A semiautomated, repetitive-sequence-based PCR (rep-PCR) instrument (DiversiLab system) was evaluated in comparison with pulsed-field gel electrophoresis (PFGE) to investigate an outbreak of Serratia marcescens infections in a neonatal intensive care unit (NICU). A selection of 36 epidemiologically...
|
PMID: 20237095
PDF is available here.
PDF is available here.
Abstract
We termed the protein Metnase (also called SETMAR). Metnase methylates histone H3 lysine 36 (H3K36), improves the integration of foreign DNA, and enhances DNA double-strand break (DSB) repair by the non-homologous end joining (NHEJ) pathway, potentially dependent on its interaction with DNA Ligase I...
|
PMID: 20309721
PDF is available here.
PDF is available here.
Abstract
We consider possible explanations for why selection acting against NAHR has not eliminated hotspots from repeat DNA including mechanistic constraints, possible benefits to repeat DNA from recruiting hotspots and rapid evolution of the recombination machinery. I suggest that rapid evolution of hotspo...
|
PMID: 20308096
PDF is available here.
PDF is available here.
Abstract
A moderately repetitive sequence was identified and designated as PS1227. Southern blot analysis indicated 34 distinct bands ranging in size from 1.5 kb-23 kb, of which 21 were polymorphic among 49 isolates examined. Analysis of single-zoospore progenies showed that the PS1227 fingerprint pattern wa...
|
PMID: 20560357
PDF is available here.
PDF is available here.
Biological Bulletin (218)2 2010
Abstract
We detected telomerase activity in host nuclear extracts prepared from two scleractinian corals, Madracis auretenra and Madracis decactis, and also in cultured Symbiodinium, the symbiotic algae that live within corals. Sequencing the TRAP reaction products indicated that the telomeric DNA repeat seq...
|
PMID: 20413788
PDF is available here.
PDF is available here.
Abstract
Since the derivation of the first human embryonic stem cell (hESC) line in 1998, there has been substantial interest in the potential of these cells for regenerative medicine and cell therapy and in the use of hESCs carrying clinically relevant genetic mutations as models for disease research and th...
|
PMID: 20178004
PDF is available here.
PDF is available here.
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics (27)2 2010
Abstract
The expanded repeats at the MJD locus were confirmed by molecular technique. The proband had 43 CAG repeats at the MJD locus. He had two sons with 41 and 64 repeats in the expanded allele respectively. CONCLUSION: A 43 CAG repeat allele was unstable upon inter-generational transmission. The change o...
|
PMID: 20376803
PDF is available here.
PDF is available here.
Abstract
A novel genotyping method for toxigenic Vibrio cholerae O1 El Tor and O139 was developed. The method was designed to amplify DNA sequences "sandwiched" between any given pair of repetitive sequences, "V. cholera repeats (VCR)", in highly polymorphic "integron island" of ca. 125 kb in the small chrom...
|
PMID: 19900536
PDF is available here.
PDF is available here.
Abstract
The nuclear ribosomal locus coding for the large subunit is represented in tandem arrays in the plant genome. These consecutive gene blocks, consisting of several regions, are widely applied in plant phylogenetics. The regions coding for the subunits of the rRNA have the lowest rate of evolution. Al...
|
PMID: 19626457
PDF is available here.
PDF is available here.
Abstract
We reported previously that the polymorphic polypyrimidine CCTTT-microsatellite in the regulatory region of nitric oxide synthase 2 (NOS2) bound nuclear proteins in vitro. In the present work, we aimed to characterize and investigate a potential regulatory role of the CCTTT-microsatellite in NOS2 ex...
|
PMID: 19669598
PDF is available here.
PDF is available here.
Abstract
Leukocyte telomere length is associated with diseases of aging, but there is limited knowledge of diet and lifestyle determinants.
|
PMID: 20219960
PDF is available here.
PDF is available here.
Abstract
We used direct nucleotide sequencing to genotype the entire exogenous coding region of the androgen receptor in ten commonly used prostate cancer cell lines. Our analysis confirmed the presence or absence of several known SNPs in the cell lines studied. We also assayed the number of CAG-repeat and G...
|
PMID: 20061791
PDF is available here.
PDF is available here.
Psychological Medicine (40)3 2010
Abstract
Besides muscular symptomatology, there is significant CTG-dependent involvement of the CNS in adult DM1 patients. Our data indicate that the cognitive impairment predominantly affects the fronto-parietal lobe....
|
PMID: 19627641
PDF is available here.
PDF is available here.
Abstract
We have cloned and sequenced PCR amplicons from seven American polyploid species to generate 164 new 5S rRNA gene sequences. These sequences were analysed along with the more than 2000 5S rDNA sequences previously generated from the majority of species in Hordeum to provide a comprehensive picture o...
|
PMID: 20237596
PDF is available here.
PDF is available here.
Biochemical Genetics (48)1-2 2010
Abstract
The genetic diversity of 116 barley accessions, representing five Chinese eco-geographic populations, was studied using simple sequence repeat (SSR) markers. The 21 SSR loci revealed 128 alleles with an average of 6.1 alleles per locus. The highest values of proportion of polymorphic...
|
PMID: 20094841
PDF is available here.
PDF is available here.
Biochemical Genetics (48)1-2 2010
Abstract
The genetic diversity of 116 barley accessions, representing five Chinese eco-geographic populations, was studied using simple sequence repeat (SSR) markers. The 21 SSR loci revealed 128 alleles with an average of 6.1 alleles per locus. The highest values of proportion of polymorphic...
|
PMID: 20094841
PDF is available here.
PDF is available here.
Biochemical Genetics (48)1-2 2010
Abstract
The genetic diversity of 116 barley accessions, representing five Chinese eco-geographic populations, was studied using simple sequence repeat (SSR) markers. The 21 SSR loci revealed 128 alleles with an average of 6.1 alleles per locus. The highest values of proportion of polymorphic...
|
PMID: 20094841
PDF is available here.
PDF is available here.
Biochemical Genetics (48)1-2 2010
Abstract
The genetic diversity of 116 barley accessions, representing five Chinese eco-geographic populations, was studied using simple sequence repeat (SSR) markers. The 21 SSR loci revealed 128 alleles with an average of 6.1 alleles per locus. The highest values of proportion of polymorphic...
|
PMID: 20094841
PDF is available here.
PDF is available here.
Biochemical Genetics (48)1-2 2010
Abstract
The genetic diversity of 116 barley accessions, representing five Chinese eco-geographic populations, was studied using simple sequence repeat (SSR) markers. The 21 SSR loci revealed 128 alleles with an average of 6.1 alleles per locus. The highest values of proportion of polymorphic...
|
PMID: 20094841
PDF is available here.
PDF is available here.
Abstract
Previous studies have reported the increased sensitivity of PCR targeting AF146527 over that of PCR targeting the B1 gene for diagnosis of toxoplasmosis. The present study suggests that the AF146527 element was absent in 4.8% of human Toxoplasma gondii-positive samples tested. The data argue that th...
|
PMID: 19940050
PDF is available here.
PDF is available here.
Abstract
We have defined the mechanism of CRISPR self/non-self discrimination. In Staphylococcus epidermidis, target/crRNA mismatches at specific positions outside of the spacer sequence license foreign DNA for interference, whereas extended pairing between crRNA and CRISPR DNA repeats prevents autoimmunity....
|
PMID: 20072129
PDF is available here.
PDF is available here.
Abstract
We investigated its effect on repetitive sequences and selected gene loci, Oct-4, Sall3, Per1, Clu, Dpep1 and Igf2r, including tissue-dependent and differentially methylated regions, by treating mouse NIH/3T3 fibroblast cells with concentrations of 5azadC ranging from 0.001 to 5 microM. Demethylatio...
|
PMID: 19996551
PDF is available here.
PDF is available here.
Abstract
Gene duplications alter the genetic constitution of organisms and can be a driving force of molecular evolution in humans and the great apes. In this context, the study of genomic disorders has uncovered the essential role played by the genomic architecture, especially low copy repeats (LCRs) or seg...
|
PMID: 20080665
PDF is available here.
PDF is available here.
PLoS Genetics (6)12 2010
Abstract
We systematically analyze NAHR between Ty retrotransposons using a genome-wide approach that exploits unique features of Saccharomyces cerevisiae purebred and Saccharomyces cerevisiae/Saccharomyces bayanus hybrid diploids. We find that DNA double-strand breaks (DSBs) induce NAHR-dependent rearrangem...
|
PMID: 21151956
PDF is available here.
PDF is available here.
Abstract
Francisella tularensis subspecies tularensis consists of two separate populations A1 and A2. This report describes the complete genome sequence of NE061598, an F. tularensis subspecies tularensis A1 isolated in 1998 from a human with clinical disease in Nebraska, United States of Ame...
|
PMID: 20140244
PDF is available here.
PDF is available here.
BMC Plant Biology (10) 2010
Abstract
We propose that ctg1034 is located within the heterochromatic C-band region of deletion bin 3BL7 based on the identification of heterochromatic tandem repeats and presence of significant matches to chromodomain-containing gypsy LTR retrotransposable elements. We also speculate that this location, am...
|
PMID: 20507561
PDF is available here.
PDF is available here.
BMC Genomics (11) 2010
Abstract
We report the distribution of these two types of sRNAs among the different classes of wheat TEs, the regions targeted within the TEs, and their impact on the methylation patterns of the targeted regions.
We constructed an sRNA library from hexaploid wheat and developed a database that included our l...
|
PMID: 20584339
PDF is available here.
PDF is available here.
Abstract
The genome of stallion (Spanish breed) and donkey (Spanish endemic Zamorano-Leonés) were compared using whole comparative genomic in situ hybridization (W-CGH) technique, with special reference to the variability observed in the Y chromosome. Results show that these diverging genomes still share so...
|
PMID: 20353909
PDF is available here.
PDF is available here.
Abstract
We investigate the effects of improved spatial locality on certain post-construction operations on suffix trees. We used a maximal exact repeat finding algorithm, MERF, on which software REPuter is based, as an example, and conducted experiments on the 16 chromosomes of the yeast Saccharomyces cerev...
|
PMID: 20865526
PDF is available here.
PDF is available here.