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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Base Sequence (5):
Recent article
Base Sequence
Abstract
Sanger, or dideoxynucleotide sequencing, is an important tool for biomolecular research. An important trend in DNA sequencing is to find new and innovative ways to provide high-quality, reliable sequences in a more efficient manner, using automated capillary electrophoresis. The Apol...
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PMID: 21738437
PDF is available here.
PDF is available here.
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Abstract
We show using highly sensitive competition experiments that selection of resistant bacteria occurs at extremely low antibiotic concentrations. Thus, for three clinically important antibiotics, drug concentrations up to several hundred-fold below the minimal inhibitory concentration of susceptible ba...
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PMID: 21811410
PDF is available here.
PDF is available here.
Abstract
We studied the effects of the application of retinoic acid, a ligand of a nuclear receptor, and of butyric acid, an inhibitor of histone deacetylase activity, on the expression of mRNA of prestin and Gata-3 in the organotypic culture of the organ of Corti of newborn rats using RT-PCR. Application of...
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PMID: 21344672
PDF is available here.
PDF is available here.
Mitochondrion (11)4 2011
Abstract
We have generated a cell line, EB delta1, with multiple mtDNA deletions, that is respiration-defective and generates high levels of superoxide, a reactive oxygen species. Treatment of EB delta1 with tagged polycistronic (pc) RNAs, encoding parts of the mitochondrial proteome, bound to a multi-subuni...
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PMID: 21496501
PDF is available here.
PDF is available here.
Mitochondrion (11)4 2011
Abstract
Mutations in mitochondrial DNA (mtDNA) generate multi-system disorders due to failure of ATP production. A cybrid containing a 1.9-kb mtDNA deletion from a patient with Kearns Sayre Syndrome is respiration-defective and grows glycolytically. When treated with a ribonucleoprotein (RNP...
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PMID: 21406250
PDF is available here.
PDF is available here.
Abstract
Thirty-three Triatoma sanguisuga (LeConte) adults and nymphs were collected during June and July 2009, at five sites on Cumberland Island and two sites on Sapelo Island, Georgia, to assess genetic diversity within and between sites. All but three specimens were found in a peridomestic habitat. The en...
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PMID: 21845939
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1812)7 2011
Abstract
We analyzed an osteoblast primary culture derived from the cervical vertebrae of a mandibuloacral dysplasia type A patient bearing the homozygous R527H LMNA mutation. Mandibuloacral dysplasia type A osteoblasts showed nuclear abnormalities typical of laminopathic cells, but they proliferated in cult...
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PMID: 21419220
PDF is available here.
PDF is available here.
Abstract
The Hepatitis Delta Virus (HDV) ribozyme, which is well adapted to the environment of the human cell, is an excellent candidate for the future development of gene-inactivation systems. On top of this, a new generation of HDV ribozymes now exists that benefits from the addition of a s...
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PMID: 21793786
PDF is available here.
PDF is available here.
Abstract
Twenty-one species of Chaetomium known from Iran were compared on the basis of morphological and molecular characters. Six new species are recognized, five isolated from cereals and one from nematode cysts. A combined sequence dataset of the ITS region, partial LSU rDNA, and β-tubul...
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PMID: 21307161
PDF is available here.
PDF is available here.
Abstract
We know little about the phylogeny and diversity of Tuber species in Japan. We have collected 186 new Tuber ascoma samples in Japan over a 10-year period. The identities and phylogenies of the samples were analyzed by using sequences of four nuclear loci, i.e., internal transcribed spacer (ITS) and...
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PMID: 21307163
PDF is available here.
PDF is available here.
Abstract
We identified a novel mutation in SIX1 (p.E125K) in a Tunisian family with variable HI and preauricular pits. This mutation is located at the same position as the mutation identified in the Catwhesel (Cwe) mouse. No renal and branchial defects were observed in our family nor in Cwe/+ mice. A homolog...
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PMID: 21700001
PDF is available here.
PDF is available here.
Abstract
We analyzed nucleotide diversity of the glycophorin gene family in 15 African populations with different levels of malaria exposure. High levels of nucleotide diversity and gene conversion were found at these genes. We observed divergent patterns of genetic variation between these duplicated genes a...
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PMID: 21664997
PDF is available here.
PDF is available here.
Abstract
I and Subgroup Id. The 22 isolates could be further subdivided into 2 groups: Id1 (n = 20) and Id2 (n = 2). A marker (a non-conservative nucleotide substitution) for the Id1 SVCV group was identified. It was specifically found in all sequences of Id1 isolates when testing SVCV originating from diffe...
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PMID: 21848117
PDF is available here.
PDF is available here.
Abstract
We describe the development and validation of a rapid, sensitive and specific real-time reverse transcription quantitative PCR assay (RT-qPCR) that amplifies sequence from representative isolates of all VHSV genotypes (I, II, III and IV). The pan-specific VHSV RT-qPCR assay reliably detects 100 copi...
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PMID: 21848118
PDF is available here.
PDF is available here.
Abstract
RNA regulation has been increasingly recognized as a potential and perhaps overlooked genetics of higher organisms. Noncoding RNAs (ncRNA) may play various catalytic and regulatory roles in the genetic operating system. Recent studies using comparative genomics and molecular genetics show evidence of...
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PMID: 21041153
PDF is available here.
PDF is available here.
Abstract
We have previously shown that RAD50 is involved in mitotic nonhomologous integration but not in homologous integration. However, the role of Rad50 in nonhomologous integration has not previously been examined. In the current work, we report that the rad50∆ mutation caused a tenfold decrease in the...
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PMID: 21512733
PDF is available here.
PDF is available here.
Abstract
We show that FrsA converts pyruvate to acetaldehyde and carbon dioxide in a cofactor-independent manner and that its pyruvate decarboxylation activity is enhanced by the dephosphorylated form of IIA(Glc) (d-IIA(Glc)). Crystal structures of FrsA and its complex with d-IIA(Glc) revealed residues requi...
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PMID: 21623357
PDF is available here.
PDF is available here.
Abstract
We report an immunostimulatory long double-stranded RNA (dsRNA) structure with the ability to trigger RNAi-mediated specific target gene silencing, termed as long interfering dsRNA (liRNA). liRNA targeting Survivin mRNA not only efficiently and specifically triggered target gene silencing via RNAi,...
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PMID: 21749291
PDF is available here.
PDF is available here.
Abstract
Epigenetic modifications of N-terminal histone tails, especially histone H3, are important for the regulation of the target genes in chromatin. Specific methods for detection of these modifications in histone H3 N-terminal peptides are valuable tools for diagnostic and therapeutic...
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PMID: 21749292
PDF is available here.
PDF is available here.
Abstract
We propose that the selected RNA aptamer is a potential cancer imaging agent by targeting malignant cells overexpressing the ErbB2 receptor....
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PMID: 21749294
PDF is available here.
PDF is available here.
Abstract
A sol-gel microarray system was developed for a protein interaction assay with high activity. Comparing to 2-dimensional microarray surfaces, sol-gel can offer a more dynamic and broad range for proteins. In the present study, this sol-gel-integrated protein array was used in binding...
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PMID: 21749295
PDF is available here.
PDF is available here.
Abstract
We theoretically discuss the relationship between diffusivity and hydrated structures of DNA fragments in water solvent using molecular dynamics methods. In particular, influence of base pair substitutions on the diffusivity is investigated, focusing on an adenine-thymine (AT) rich B-DNA decamer 5'-...
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PMID: 20853125
PDF is available here.
PDF is available here.
Abstract
We reported the presence of imported trichinellosis in a Thai worker returning from Malaysia, who presented with progressive generalized muscle hypertrophy and weakness after eating wild boar meat. This work analyzed a partial small subunit of a mitochondrial ribosomal RNA gene of Trichinella larvae...
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PMID: 21633039
PDF is available here.
PDF is available here.
Abstract
Polydnaviruses are a group of double-stranded DNA viruses and are symbiotically associated with some ichneumonoid wasps. As proviruses, the replication of polydnaviruses occurs in the female reproductive organ at the pupal stage. This study analyzed the effects of two developmental h...
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PMID: 21699752
PDF is available here.
PDF is available here.
Abstract
We reported a microarray platform to detect miRNA expression. In this study, we evaluated the sensitivity and specificity of our microarray platform. After systematic analysis, we determined an optimized hybridization condition with high sensitivity and specificity for miRNA detection. Our results w...
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PMID: 21632556
PDF is available here.
PDF is available here.