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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
G-Quadruplexes (0):
Recent article
G-Quadruplexes
Molecular BioSystems (7)9 2011
Abstract
We report a general pH-responsive, DNA-directed assay for the design of a reversible assembly of GO-GO and GO-AuNPs hybrid using human telomeric G-quadruplex and i-motif DNA....
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PMID: 21748191
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
We studied the effect of Mg(2+) on G-quadruplex DNA with CD, FRET, EMSA, and PCR-stop assay. We found that various G-quadruplexes could be differentiated through simultaneous addition of both K(+) and Mg(2+), which could be used for selective identification of G-quadruplexes in promoter oncogene but...
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PMID: 20971074
PDF is available here.
PDF is available here.
Molecular BioSystems (6)12 2010
Abstract
We researched the role of alternative DNA structure in cytosine methylation using quadruplex DNA as a case study. Our findings from analysis of 2.1 million CpGs in humans, across 12 tissues from the Human Epigenome Project (HEP), revealed a striking correlation within each tissue: CpGs with low meth...
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PMID: 20877913
PDF is available here.
PDF is available here.
Abstract
We show that ATRX binds to tandem repeat (TR) sequences in both telomeres and euchromatin. Genes associated with these TRs can be dysregulated when ATRX is mutated, and the change in expression is determined by the size of the TR, producing skewed allelic expression. This reveals the characteristics...
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PMID: 21029860
PDF is available here.
PDF is available here.
Analyst (Cambridge UK) (135)11 2010
Abstract
We report a molecular recognition between adenosine and its aptamer, which leads to the formation of a four-stranded tetraplex structures (G-quartet) of the aptamer. It is found that the formed G-quartet could induce the side-by-side self-assembly of gold nanorods (AuNRs) owing to the electrostatic...
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PMID: 20830327
PDF is available here.
PDF is available here.
Abstract
A short route, involving a tetramolecular condensation reaction and a Pd/C catalyst-H(2)-mediated reductive N-heteroannulation as the key-steps, has been found for the synthesis of some new penta- and heptacyclic indolo- (12), quinolino- (13) and indoloquinolinocarbazole (11) derivatives. HF-DFT (B3...
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PMID: 20734015
PDF is available here.
PDF is available here.
Abstract
A label-free detection of K(+) was developed using G-quadruplex DNA (c-Myc) modulated fluorescence enhancement of tetrakis-(diisopropylguanidino) zinc phthalocyanine (Zn-DIGP). Upon the addition of increasing concentrations of potassium, a detection limit of 0.8 μM for K(+) was easily achieved. Com...
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PMID: 20804164
PDF is available here.
PDF is available here.
FEBS Journal (277)17 2010
Abstract
We discuss the connections of G-quadruplex nucleic acids to human genetic diseases and cancer based on the recent literature....
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PMID: 20670277
PDF is available here.
PDF is available here.
FEBS Journal (277)17 2010
Abstract
We examine the diversity of G-quadruplex and i-motif structures in promoter elements and attempt to categorize the different types of arrangements in which they are found. For the c-Myc G-quadruplex and Bcl-2 i-motif, we summarize recent biological and structural studies....
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PMID: 20670278
PDF is available here.
PDF is available here.
Chemical Communications (46)31 2010
Abstract
Anionic phthalocyanines inhibited efficiently telomerase activity even in the presence of excess double-stranded DNA (dsDNA) because of their selective binding to telomere G-quadruplex, although low selectivity of a typical cationic ligand, TMPyP4, to the G-quadruplex allowed telomerase reaction und...
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PMID: 20596577
PDF is available here.
PDF is available here.
Chemical Communications (46)31 2010
Abstract
A bis-guanylhydrazone derivative of diimidazo[1,2-a:1,2-c]pyrimidine has unexpectedly been found to be a potent stabiliser of several quadruplex DNAs, whereas there is no significant interaction with duplex DNA. Molecular modeling suggests that the guanylhydrazone groups play an active role in quadr...
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PMID: 20582382
PDF is available here.
PDF is available here.
Abstract
This study was performed to evaluate how the loss of a guanine base affects the structure and stability of the three-tetrad G-quadruplex of 5'-dG(3)(TTAG(3))(3), the basic quadruplex-forming unit of the human telomere DNA. None of the 12 possible abasic sites hindered the formation of quadruplexes,...
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PMID: 20643102
PDF is available here.
PDF is available here.
Analyst (Cambridge UK) (135)8 2010
Abstract
We report a label-free fluorescence turn-on approach for the selective sensing of potassium. A properly selected G-rich oligonucleotide (oligo-Y) folded into stable quadruplex structure when mixed with potassium in an aqueous solution. Single-stranded nucleic acid specific nuclease was subsequently...
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PMID: 20585688
PDF is available here.
PDF is available here.
Biochemical Journal (430)1 2010
Abstract
These results suggest a distinction between the determinants of G4 DNA binding and the ssDNA interactions required for helicase action and that hPif1 may act on G4 substrates by binding alone or as a resolvase. Human Pif1 could therefore have a role in processing G4 structures that arise in the sing...
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PMID: 20524933
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)29 2010
Abstract
We found that MAZ specifically binds to the duplex and quadruplex conformations of the GA-element, whereas PARP-1 shows specificity only for the G-quadruplex. On the basis of fluorescence resonance energy transfer melting and polymerase stop assays we saw that MAZ stabilizes the KRAS quadruplex. Whe...
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PMID: 20457603
PDF is available here.
PDF is available here.
Advanced Materials (FRG) (22)25 2010
Abstract
Advanced Materials (FRG) (22)25 2010
Abstract
Advanced Materials (FRG) (22)25 2010
Abstract
Abstract
A series of 24-membered macrocyclic hexaoxazoles containing one or two aminoalkyl substituents was synthesized and evaluated for cytotoxicity and for their ability to selectively stabilize G-quadruplex DNA and RNA. The most cytotoxic analog 4a, with IC(50) values of 25 and 130 nM using KB3-1 and RPM...
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PMID: 20409709
PDF is available here.
PDF is available here.
Abstract
The study of DNA G-quadruplex stabilizers has enjoyed a great momentum in the late years due to their application as anticancer agents. The recognition of the grooves of these structural motifs is expected to result in a higher degree of selectivity over other DNA structures. Therefore, to achieve a...
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PMID: 20394365
PDF is available here.
PDF is available here.
Chemical Communications (46)16 2010
Abstract
We demonstrate a strategy for label-free protein detection through monitoring the Surface Enhanced Raman Spectrum of an aptamer probe attached to a gold nanoshell. Low limit of detection and minimal non-specific binding show potential for in vitro and in vivo assays.
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PMID: 20369187
PDF is available here.
PDF is available here.
Abstract
We developed a reverse transcriptase based method (RTase stop assay) to characterize quadruplex formations in guanine-rich RNAs with high sensitivity and specificity. By using the RTase stop assay, we also revealed a plausible structural polymorphism in biologically important RNAs. The RTase stop as...
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PMID: 20206514
PDF is available here.
PDF is available here.
Abstract
We report a novel strategy of using G-quadruplex as a drug carrier to target cancer cells for photodynamic therapy (PDT). A G-quadruplex forming AS1411 aptamer could be physically conjugated with six molecules of porphyrin derivative, 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin (TMPyP4), t...
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PMID: 20166743
PDF is available here.
PDF is available here.
Abstract
Molecular dynamics (MD) simulations of four-stranded G-quadruplex DNA complexes formed by the sequence d(TTAGGG)(4) and the TQMP ligand are presented. The TQMP complex was examined both in two possible binding modes (diagonal loop and parallel loop positions). Simulations show that the G-quadruplex...
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PMID: 19969395
PDF is available here.
PDF is available here.
FEBS Journal (277)5 2010
Abstract
FEBS Journal (277)5 2010
Abstract
Thermodynamic and kinetic studies complement high-resolution structures of G-quadruplexes. Such studies are essential for a thorough understanding of the mechanisms that govern quadruplex folding and conformational changes in quadruplexes. This perspective article reviews representat...
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PMID: 19951355
PDF is available here.
PDF is available here.
FEBS Journal (277)5 2010
Abstract
Telomeres play an important role in cellular aging and cancer. Human telomeric DNA and RNA G-rich sequences are capable of forming a four-stranded structure, known as the G-quadruplex. Such a structure might be important for telomere biology and a good target for drug design. This mi...
|
PMID: 19951353
PDF is available here.
PDF is available here.
FEBS Journal (277)5 2010
Abstract
The 3'-ends of human chromosomal DNA terminate in short single-stranded guanine-rich tandem-repeat sequences. In cancer cells, these are associated with the telomere-maintenance enzyme telomerase together with the end-binding protein hPOT1. Small molecules that can compete with these...
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PMID: 19951354
PDF is available here.
PDF is available here.
FEBS Journal (277)5 2010
Abstract
FEBS Journal (277)5 2010
Abstract
Thermodynamic and kinetic studies complement high-resolution structures of G-quadruplexes. Such studies are essential for a thorough understanding of the mechanisms that govern quadruplex folding and conformational changes in quadruplexes. This perspective article reviews representat...
|
PMID: 19951355
PDF is available here.
PDF is available here.
FEBS Journal (277)5 2010
Abstract
Telomeres play an important role in cellular aging and cancer. Human telomeric DNA and RNA G-rich sequences are capable of forming a four-stranded structure, known as the G-quadruplex. Such a structure might be important for telomere biology and a good target for drug design. This mi...
|
PMID: 19951353
PDF is available here.
PDF is available here.
FEBS Journal (277)5 2010
Abstract
The 3'-ends of human chromosomal DNA terminate in short single-stranded guanine-rich tandem-repeat sequences. In cancer cells, these are associated with the telomere-maintenance enzyme telomerase together with the end-binding protein hPOT1. Small molecules that can compete with these...
|
PMID: 19951354
PDF is available here.
PDF is available here.
FEBS Journal (277)5 2010
Abstract
FEBS Journal (277)5 2010
Abstract
Thermodynamic and kinetic studies complement high-resolution structures of G-quadruplexes. Such studies are essential for a thorough understanding of the mechanisms that govern quadruplex folding and conformational changes in quadruplexes. This perspective article reviews representat...
|
PMID: 19951355
PDF is available here.
PDF is available here.
FEBS Journal (277)5 2010
Abstract
Telomeres play an important role in cellular aging and cancer. Human telomeric DNA and RNA G-rich sequences are capable of forming a four-stranded structure, known as the G-quadruplex. Such a structure might be important for telomere biology and a good target for drug design. This mi...
|
PMID: 19951353
PDF is available here.
PDF is available here.
FEBS Journal (277)5 2010
Abstract
The 3'-ends of human chromosomal DNA terminate in short single-stranded guanine-rich tandem-repeat sequences. In cancer cells, these are associated with the telomere-maintenance enzyme telomerase together with the end-binding protein hPOT1. Small molecules that can compete with these...
|
PMID: 19951354
PDF is available here.
PDF is available here.
FEBS Journal (277)5 2010
Abstract
FEBS Journal (277)5 2010
Abstract
Thermodynamic and kinetic studies complement high-resolution structures of G-quadruplexes. Such studies are essential for a thorough understanding of the mechanisms that govern quadruplex folding and conformational changes in quadruplexes. This perspective article reviews representat...
|
PMID: 19951355
PDF is available here.
PDF is available here.
FEBS Journal (277)5 2010
Abstract
Telomeres play an important role in cellular aging and cancer. Human telomeric DNA and RNA G-rich sequences are capable of forming a four-stranded structure, known as the G-quadruplex. Such a structure might be important for telomere biology and a good target for drug design. This mi...
|
PMID: 19951353
PDF is available here.
PDF is available here.
FEBS Journal (277)5 2010
Abstract
The 3'-ends of human chromosomal DNA terminate in short single-stranded guanine-rich tandem-repeat sequences. In cancer cells, these are associated with the telomere-maintenance enzyme telomerase together with the end-binding protein hPOT1. Small molecules that can compete with these...
|
PMID: 19951354
PDF is available here.
PDF is available here.
FEBS Journal (277)5 2010
Abstract
FEBS Journal (277)5 2010
Abstract
Thermodynamic and kinetic studies complement high-resolution structures of G-quadruplexes. Such studies are essential for a thorough understanding of the mechanisms that govern quadruplex folding and conformational changes in quadruplexes. This perspective article reviews representat...
|
PMID: 19951355
PDF is available here.
PDF is available here.
FEBS Journal (277)5 2010
Abstract
Telomeres play an important role in cellular aging and cancer. Human telomeric DNA and RNA G-rich sequences are capable of forming a four-stranded structure, known as the G-quadruplex. Such a structure might be important for telomere biology and a good target for drug design. This mi...
|
PMID: 19951353
PDF is available here.
PDF is available here.
FEBS Journal (277)5 2010
Abstract
The 3'-ends of human chromosomal DNA terminate in short single-stranded guanine-rich tandem-repeat sequences. In cancer cells, these are associated with the telomere-maintenance enzyme telomerase together with the end-binding protein hPOT1. Small molecules that can compete with these...
|
PMID: 19951354
PDF is available here.
PDF is available here.
FEBS Journal (277)5 2010
Abstract
FEBS Journal (277)5 2010
Abstract
Thermodynamic and kinetic studies complement high-resolution structures of G-quadruplexes. Such studies are essential for a thorough understanding of the mechanisms that govern quadruplex folding and conformational changes in quadruplexes. This perspective article reviews representat...
|
PMID: 19951355
PDF is available here.
PDF is available here.
FEBS Journal (277)5 2010
Abstract
Telomeres play an important role in cellular aging and cancer. Human telomeric DNA and RNA G-rich sequences are capable of forming a four-stranded structure, known as the G-quadruplex. Such a structure might be important for telomere biology and a good target for drug design. This mi...
|
PMID: 19951353
PDF is available here.
PDF is available here.
FEBS Journal (277)5 2010
Abstract
The 3'-ends of human chromosomal DNA terminate in short single-stranded guanine-rich tandem-repeat sequences. In cancer cells, these are associated with the telomere-maintenance enzyme telomerase together with the end-binding protein hPOT1. Small molecules that can compete with these...
|
PMID: 19951354
PDF is available here.
PDF is available here.
FEBS Journal (277)5 2010
Abstract
FEBS Journal (277)5 2010
Abstract
Thermodynamic and kinetic studies complement high-resolution structures of G-quadruplexes. Such studies are essential for a thorough understanding of the mechanisms that govern quadruplex folding and conformational changes in quadruplexes. This perspective article reviews representat...
|
PMID: 19951355
PDF is available here.
PDF is available here.
FEBS Journal (277)5 2010
Abstract
Telomeres play an important role in cellular aging and cancer. Human telomeric DNA and RNA G-rich sequences are capable of forming a four-stranded structure, known as the G-quadruplex. Such a structure might be important for telomere biology and a good target for drug design. This mi...
|
PMID: 19951353
PDF is available here.
PDF is available here.
FEBS Journal (277)5 2010
Abstract
The 3'-ends of human chromosomal DNA terminate in short single-stranded guanine-rich tandem-repeat sequences. In cancer cells, these are associated with the telomere-maintenance enzyme telomerase together with the end-binding protein hPOT1. Small molecules that can compete with these...
|
PMID: 19951354
PDF is available here.
PDF is available here.
FEBS Journal (277)5 2010
Abstract
FEBS Journal (277)5 2010
Abstract
Thermodynamic and kinetic studies complement high-resolution structures of G-quadruplexes. Such studies are essential for a thorough understanding of the mechanisms that govern quadruplex folding and conformational changes in quadruplexes. This perspective article reviews representat...
|
PMID: 19951355
PDF is available here.
PDF is available here.
FEBS Journal (277)5 2010
Abstract
Telomeres play an important role in cellular aging and cancer. Human telomeric DNA and RNA G-rich sequences are capable of forming a four-stranded structure, known as the G-quadruplex. Such a structure might be important for telomere biology and a good target for drug design. This mi...
|
PMID: 19951353
PDF is available here.
PDF is available here.
FEBS Journal (277)5 2010
Abstract
The 3'-ends of human chromosomal DNA terminate in short single-stranded guanine-rich tandem-repeat sequences. In cancer cells, these are associated with the telomere-maintenance enzyme telomerase together with the end-binding protein hPOT1. Small molecules that can compete with these...
|
PMID: 19951354
PDF is available here.
PDF is available here.
FEBS Journal (277)5 2010
Abstract
FEBS Journal (277)5 2010
Abstract
Thermodynamic and kinetic studies complement high-resolution structures of G-quadruplexes. Such studies are essential for a thorough understanding of the mechanisms that govern quadruplex folding and conformational changes in quadruplexes. This perspective article reviews representat...
|
PMID: 19951355
PDF is available here.
PDF is available here.
FEBS Journal (277)5 2010
Abstract
Telomeres play an important role in cellular aging and cancer. Human telomeric DNA and RNA G-rich sequences are capable of forming a four-stranded structure, known as the G-quadruplex. Such a structure might be important for telomere biology and a good target for drug design. This mi...
|
PMID: 19951353
PDF is available here.
PDF is available here.
FEBS Journal (277)5 2010
Abstract
The 3'-ends of human chromosomal DNA terminate in short single-stranded guanine-rich tandem-repeat sequences. In cancer cells, these are associated with the telomere-maintenance enzyme telomerase together with the end-binding protein hPOT1. Small molecules that can compete with these...
|
PMID: 19951354
PDF is available here.
PDF is available here.