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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Biochemical Phenomena (14):
Recent article
Biochemical Phenomena
Abstract
We aim to integrate structural, biochemical, and functional aspects of this bewildering and ancient family of glycan-binding proteins and discuss their implications in physiologic and pathologic settings....
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PMID: 21848324
PDF is available here.
PDF is available here.
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Kidney International (78)10 2010
Abstract
Abstract
We describe the bioinorganic aspects of angiogenesis which contribute to a better understanding of the molecular mechanisms and regulation of angiogenesis. In particular, the role of metals, especially copper, metalloproteinases, and the current status on the imaging of angiogenesis targeting VEGF o...
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PMID: 20535417
PDF is available here.
PDF is available here.
Abstract
We developed an approach that utilizes physiologically based pharmacokinetic (PBPK) modeling coupled with Monte Carlo simulation to generate a virtual population, complete with associated patient characteristics and PK data, for population PK analysis. For this work, we used a previously published P...
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PMID: 20803616
PDF is available here.
PDF is available here.
Seminars in Nephrology (29)4 2009
Abstract
Abnormalities of kidney and urinary tract development are the most common cause of end-stage kidney failure in childhood in the United States. Over the past 20 years, the advent of mutant and transgenic mice and the manipulation of gene expression in other animal models has resulted in major advance...
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PMID: 19615554
PDF is available here.
PDF is available here.
Biochemical Society transactions (37)Pt 1 2009
Abstract
We know more about STIV than other viruses infecting members of the Archaea domain. Like most viruses isolated from crenarchaeal hosts, STIV has little in common with viruses that infect eukaryotic and bacterial hosts and should be considered the founding member of a new virus family. However, despi...
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PMID: 19143613
PDF is available here.
PDF is available here.
Biochemical Society transactions (37)Pt 1 2009
Abstract
We have analysed the two proteins, MBA (membrane-bound AAA) 1 and MBA2, by computational and experimental means. They appear to be monophyletic and to share a common ancestor with the Cdc48 clade. Both are membrane-bound and active as nucleotidases upon heterologous expression in Escherichia coli. T...
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PMID: 19143614
PDF is available here.
PDF is available here.
Biochemical Journal (417)2 2009
Abstract
We show that alternative promoter usage of the mouse Twf2 gene generates two isoforms, which differ from each other only at their very N-terminal region. Of these isoforms, Twf2a is predominantly expressed in non-muscle tissues, whereas expression of Twf2b is restricted to heart and skeletal muscle....
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PMID: 18837697
PDF is available here.
PDF is available here.
Abstract
Plants absorb a number of elements from soil, some of which have no known biological function and some are known to be toxic at low concentrations. As plants constitute the foundation of the food chain, some concerns have been raised about the possibility of toxic concentrations of c...
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PMID: 19433308
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)46 2008
Abstract
We propose a model of substrate binding in AaManA in which Glu282 interacts with the axial OH-C(2) in-2 subsites. Based on sequence comparisons, the enzyme was assigned to a new glycoside hydrolase family (GH113) that belongs to clan GH-A....
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PMID: 18755688
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)46 2008
Abstract
We find that the C-terminal domain of human Tgs1 can function in lieu of the yeast protein in vivo. We present a biochemical characterization of the human Tgs1 guanine-N2 methyltransferase reaction and identify individual amino acids required for methyltransferase activity in vitro and in vivo....
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PMID: 18775984
PDF is available here.
PDF is available here.
Abstract
We evaluated 40 bisaryl molecules based on 10 unique linker substructures to determine how these linkages influence inhibitor potency and selectivity. These linkers connect one unsubstituted aromatic ring to either a 3,5-X 2 or a 3,5-X 2-4-OH phenyl substructure (X = Br or CH 3). Coconsideration of...
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PMID: 18811132
PDF is available here.
PDF is available here.
Abstract
We picked TERS experiments with emphasis on its application in life sciences. Based on these experiments, the future perspective of this analytical method and its limitations is discussed....
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PMID: 19343661
PDF is available here.
PDF is available here.
Chemistry & Biology (15)9 2008
Abstract
The biological significance of protein and lipid glycosylation is well established. For example, cells respond to environmental stimuli by altering glycan structures on their surfaces, and cancer cells evade normal growth regulation in part by remodeling their surface glycans. In general, glycan che...
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PMID: 18804025
PDF is available here.
PDF is available here.
Abstract
A review of the literature pertinent to interpretation of biochemistry data and quality control (QC) and proficiency testing data from 2 biochemistry analyzers was used to determine clinical quality requirements for biochemistry assays, characterize the performance of and calculate sigma metrics for...
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PMID: 18776084
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1781)9 2008
Abstract
We believe that the seminal event was the linking of the investigational drug, FTY720 (fingolimod), to S1P signaling. This realization profoundly altered understanding of S1P biology, revealing both that S1P is prominent in lymphocyte trafficking and that mimicking S1P signaling with an agonist drug...
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PMID: 18638568
PDF is available here.
PDF is available here.
YAKUGAKU ZASSHI (128)8 2008
Abstract
We present recent examples including (a) enzymatic formation of a "supra-natural" hexacyclic polyprenoid as well as heteroaromatic ring containing cyclic polyprenoids by bacterial squalene: hopene cyclase from Alicyclobacillus acidocaldarius, and (b) enzymatic cyclization of 22,23-dihydro-2,3-oxidos...
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PMID: 18670176
PDF is available here.
PDF is available here.
Lab On a Chip (8)8 2008
Abstract
We describe the construction and assembly of the devices using the MAB methodology, and demonstrate common microfluidic applications including laminar flow development, valve control, and cell culture....
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PMID: 18651080
PDF is available here.
PDF is available here.
Abstract
We discuss several examples of the ultraslow component, its possible origin and implications in biology. We show that the ultrafast (approximately 1 ps) component arises from an extended hydrogen bond network while the ultraslow component originates from binding of a water molecule to a biological m...
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PMID: 18566703
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to evaluate the effects of acute exposure to various doses of fenitrothion (FNT) on level of serum glucose, total protein, triglycerides (TG), total cholesterol (TC) and some hematological parameters. The study was conducted on 8-week-old male Wistar rats that divided into...
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PMID: 18819630
PDF is available here.
PDF is available here.
Protein-protein docking by simulating the process of association subject to biochemical constraints.
Abstract
We present a computational procedure for modeling protein-protein association and predicting the structures of protein-protein complexes. The initial sampling stage is based on an efficient Brownian dynamics algorithm that mimics the physical process of diffusional association. Relevant biochemical...
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PMID: 18186463
PDF is available here.
PDF is available here.
Biodegradation (19)3 2008
Abstract
We have previously reported the formation of a nicotinamide adenine dinucleotide (NAD(+))-Cr(III) complex after enzymatic reduction of chromate. Although the NAD(+)-Cr(III) complex was stable under sterile conditions, microbial cells were identified as precipitates in a non-sterile NAD(+)-Cr(III) so...
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PMID: 17701280
PDF is available here.
PDF is available here.
Biodegradation (19)3 2008
Abstract
The influence of biochemical composition of different co-substrates added to raw sludge during co-composting process was studied. The physical properties of the composting mass and their influence on the biological activity were also investigated. Three treatments composed of mixtures of raw sludge...
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PMID: 17674125
PDF is available here.
PDF is available here.
Abstract
Pepsin-solubilized collagen (PSC) was conjugated with carboxymethyl dextran (CMD) using cyanogen bromide to obtain a PSC-CMD film having improved physical properties, physiological properties, and cell affinity. The conjugation was confirmed by the loss of the alpha- and beta-subunit chains and the...
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PMID: 18540095
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)21 2008
Abstract
We show that the 21 gene regulon specifying the pdu organelle and propanediol utilization enzymes from Citrobacter freundii is fully functional when cloned in Escherichia coli, both producing metabolosomes and allowing propanediol utilization. Genetic manipulation of the level of specific shell prot...
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PMID: 18332146
PDF is available here.
PDF is available here.
Biochemistry (Washington) (47)16 2008
Abstract
We expressed in Escherichia coli proteins from Arabidopsis thaliana (At), humans (Hs), and the yeast Saccharomyces cerevisiae (Sc), purified them to near homogeneity, and compared their properties. Consistent with the multiple divergent amino acids within mostly conserved polymerase domains, the pol...
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PMID: 18366182
PDF is available here.
PDF is available here.
Abstract
Journal of Physical Chemistry B (112)14 2008
Abstract
We develop a theory for subdiffusion-limited bimolecular enzyme kinetics. As in normal diffusion, the statistics of the reaction times depend on the ratio between the distance to the target and the reaction rate in a scale invariant manner. Contrary to some studies, we find no critical value of alph...
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PMID: 18345656
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)15 2008
Abstract
Using chemistry and microfluidics to understand the spatial dynamics of complex biological networks.
Abstract
We describe chemical concepts and microfluidic tools developed for network-level investigations of the spatial dynamics of these networks. Modular approaches can be used to simplify these networks by separating them into modules, and simple experimental or computational models can be created by repl...
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PMID: 18217723
PDF is available here.
PDF is available here.
Abstract
Bioresource Technology (99)6 2008
Abstract
Both dilute and concentrated vinasse can be spread on agricultural fields or used as organic fertilizer. The effects of different characteristics of the original raw material on the biochemical composition of vinasse and their C and N mineralization in soil were investigated. Vinasse samples were ob...
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PMID: 17582760
PDF is available here.
PDF is available here.
Abstract
Journal of Biological Chemistry (283)13 2008
Abstract
We isolated two diaphanous-related formins, mDia1 and Daam1, in platelet extracts by GTP-RhoA affinity column chromatography. We characterized them by a novel assay, where beads coated with the FH1-FH2-DAD domains of either mDia1 or Daam1 were incubated with platelet cytosol, and the assembled actin...
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PMID: 18218625
PDF is available here.
PDF is available here.
Abstract
Abstract
In this study, we detected LPS in plasma of individuals exposed to high levels of LPS at their workplace. This finding is supported by elevated levels of several inflammatory cytokines among the workers, significantly exceeding that of the non-exposed control group. To the best of our knowledge, thi...
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PMID: 17855504
PDF is available here.
PDF is available here.
Journal of Contaminant Hydrology (96)1-4 2008
Abstract
This paper uses the findings from a column study to develop a reactive model for exploring the interactions occurring in leachate-contaminated soils. The changes occurring in the concentrations of acetic acid, sulphate, suspended and attached biomass, Fe(II), Mn(II), calcium, carbonate ions, and pH...
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PMID: 17996980
PDF is available here.
PDF is available here.
Abstract
We review the latest contributions of our group to this subject and report new results for systems studied previously, grouping them in single pi bonds, chains and aromatic rings. The dynamics of ethylene and substituted ethylenes is discussed mainly in connection to the competition between the two...
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PMID: 18183311
PDF is available here.
PDF is available here.
Biomedical Microdevices (10)1 2008
Abstract
We present sequential fluidic manipulations with nanoliter-sized droplets, based on the precise control of wettability and the capillary pressure of a microchannel. The microfluidic chip we have developed successfully performed biochemical reactions and can dispense a droplet of a few hundred nanoli...
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PMID: 17610068
PDF is available here.
PDF is available here.
Abstract
We focus on systems developed for biocatalysis and biosensors for toxicity screening. Enzyme-poly(L-lysine) (PLL) films, especially when stabilized by crosslinking, can be used for biocatalysis at unprecedented high temperatures or in acidic or basic solutions on electrodes or sub-micron sized beads...
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PMID: 18092072
PDF is available here.
PDF is available here.
Abstract
Abstract
We discuss recent developments in SERS spectroscopy and their impact on different research fields....
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PMID: 18000657
PDF is available here.
PDF is available here.
Abstract
Here we present an analysis that investigates how simple biochemical motifs that involve multiple stages of regulation can be constructed to differentially process signals that persist at different time scales. We compute the dynamic, frequency dependent gain within these networks and resulting powe...
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PMID: 19091071
PDF is available here.
PDF is available here.
Abstract
We investigate the temporal hierarchy in biochemical reaction networks focusing on: (1) the elucidation of the existence of "pools" (i.e., aggregate variables) formed from component concentrations and (2) the determination of their composition and interactions over different time scales. To date the...
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PMID: 18787685
PDF is available here.
PDF is available here.
Ethnicity & Disease (18)1 2008
Abstract
Thirteen (40.6%) patients presented with diabetic ketoacidosis (DKA), 11 (34.4%) with hyperglycemic hyperosmolar state (HHS), while 8 (25%) had normo-osmolar nonketotic hyperglycemic state (NNHS). The mean glucose level at presentation in HHS was statistically significantly higher than in DKA and NN...
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PMID: 18447095
PDF is available here.
PDF is available here.
Methods in Enzymology (448) 2008
Abstract
We describe here protocols for the construction of bacterial LSm coexpression vectors, expression and purification of LSm proteins and subcomplexes, and the in vitro reconstitution of fully functional human LSm1-7 and LSm2-8 heptameric complexes....
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PMID: 19111171
PDF is available here.
PDF is available here.
Physical Chemistry (59) 2008
Abstract
We characterize self-assembled monolayers and multilayers using nanografting to place unknown molecules into a matrix with known structure or vice versa. The availability of an internal standard in situ allows the unknown structures to be imaged and quantified. The same approaches are applied to rev...
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PMID: 18031212
PDF is available here.
PDF is available here.
Physical Biology (5)2 2008
Abstract
We provide an example of a biological process, adaptation, where simulations are argued to approach closer to biology. Adaptation is a common feature of sensory systems, and a plausible component of other biochemical networks because it rescales upstream signals to facilitate downstream processing....
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PMID: 18577806
PDF is available here.
PDF is available here.
Biosystems (91)1 2008
Abstract
We assessed these two methods by computational knockout experiments. We examined a simple pathway model and found that the extreme pathway method led to misguided conclusions in specific cases, while optimization analysis calculated the correct knockout effects. We also investigated the Escherichia...
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PMID: 18082935
PDF is available here.
PDF is available here.
Annals of Clinical Biochemistry (45)Pt 1 2008
Abstract
Although adding clinical interpretative comments is very time-consuming for senior laboratory staff, there is overwhelming support of this activity among our GPs and nurse practitioner users; therefore, our local policy of routinely adding clinical comments will remain for the foreseeable future....
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PMID: 18275680
PDF is available here.
PDF is available here.
Annals of Clinical Biochemistry (45)Pt 1 2008
Abstract
We report self-prescribed high dose of vitamin D3 over 5-6 years by two men. Subject 1 had been taking 100 microg/day for 3 years followed by 3 years of 200 microg/day. Serum 25(OH)D concentrations averaged 130 nmol/L while taking 100 microg/day of vitamin D3. While taking 200 microg/day of vitamin...
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PMID: 18275686
PDF is available here.
PDF is available here.
Abstract
Understanding the function of biomolecules is crucially dependent on observing the dynamics of their biosynthesis, distribution, and metabolism in their native environment at the cellular and organismal levels rather than their behavior in the isolated samples. Small bioorthogonal functional groups...
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PMID: 18154263
PDF is available here.
PDF is available here.
Journal of Biotechnology (132)4 2007
Abstract
Systems biology is an integrative science that aims at the global characterization of biological systems. Huge amounts of data regarding gene expression, proteins activity and metabolite concentrations are collected by designing systematic genetic or environmental perturbations. Then the challenge i...
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PMID: 17870200
PDF is available here.
PDF is available here.
Natural Product Reports (24)6 2007
Abstract
Over the last 20 years myxobacteria have made their way from highly exotic organisms to one of the major sources of microbial natural products with interesting biological activities. Recent progress towards achieving a better understanding of the genetics and the biochemistry of myxobacterial second...
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PMID: 18033576
PDF is available here.
PDF is available here.
Mathematical Biosciences (210)1 2007
Abstract
We refer to this framework as the Stochastic Cooperativity Paradigm (SCP). In this approach, the focus of attention is placed on the fact that in systems with the size and link density of GRN ( approximately 25000 and approximately 100, respectively), the confluence of all the factors which are nece...
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PMID: 17617426
PDF is available here.
PDF is available here.
Iubmb Life (59)11 2007
Abstract
Abstract
Abstract
Abstract
We review experiments that have begun to identify specific molecules that influence vascular remodeling and therefore may serve as mediators for the phenomena. More comprehensive analyses of the specific molecular pathways in the vessels that determine constant flow may provide new therapeutic appro...
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PMID: 17541029
PDF is available here.
PDF is available here.