Abstract
We describe how CLEVER is used and offer advice in interpreting the results....
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PMID: 20981533
PDF is available here.
Abstract
Aromatase (CYP19) inhibitors have emerged as promising candidates for the treatment of estrogen-dependent breast cancer. In this study, a series of androstenedione derivatives with CYP19 inhibitory activity was subjected to a molecular docking study followed by quantitative structure-activity relatio...
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PMID: 21054398
PDF is available here.
Abstract
The effects of clay dose and mixing energy on the efficiency of vegetable oil sedimentation by clay are investigated. The sedimentation efficiency increased with increasing clay dose to a maximum of about 80% of added oil. The maximum sedimentation efficiency was achieved at a lower clay dose, and t...
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PMID: 21121454
PDF is available here.
Abstract
Crystallization of L-cystine is a critical step in the pathogenesis of cystine kidney stones. Treatments for this disease are somewhat effective but often lead to adverse side effects. Real-time in situ atomic force microscopy (AFM) reveals that L-cystine dimethylester (L-CDME) and L-cystine methyle...
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PMID: 20947757
PDF is available here.
Abstract
Coxsackie and adenovirus receptor (CAR) is the primary cellular receptor for group B coxsackieviruses and most adenovirus serotypes and plays a crucial role in adenoviral gene therapy. Recent discovery of the interaction between junctional adhesion molecule-like protein (JAML) and CA...
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PMID: 20813955
PDF is available here.
Abstract
Chromatography technology was employed to clarify the mechanism of interaction between multi-wall carbon nanotubes (MWCNT) and proteins. A column (16x100 mm) was packed with purified MWCNT, and various proteins were eluted with phosphate buffered saline (PBS) with and without gradient systems. It wa...
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PMID: 20610879
PDF is available here.
Abstract
GMTA expanded significantly more than WMTA; however, varying the WP ratio did not affect the setting expansion.
Published by Elsevier Inc....
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PMID: 20647100
PDF is available here.
Abstract
Chitosan was isolated and purified from the mycelia of Rhizomucor miehei and Mucor racemosus. To characterize the extracted materials, their FTIR spectra were compared with that of shrimp chitosan. Final degree of deacetylation which determined by (1)H NMR was obtained as 98.6% for chitosan from R....
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PMID: 20471417
PDF is available here.
Abstract
This study indicated that storage temperature might influence surface hardness and microstructure of WMTA.
Copyright 2010 American Association of Endodontists. Published by Elsevier Inc. All rights reserved....
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PMID: 20647108
PDF is available here.
Abstract
In this study, potato and bean starches were treated by gamma-irradiation up to 50kGy. Molecular structure and physicochemical properties of irradiated potato and bean starches were investigated. Microscopic observation under scanning electron microscope (SEM) and polarized microscope showed that so...
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PMID: 20438750
PDF is available here.
Abstract
We focused on quantification of activity of 3,4,6-substituted-2-quinolone derivatives with reference to structural properties. The multi-variant regression expressions were developed through sequential multiple linear regression technique, considering adjustable correlation coefficient (r(adj)(2))....
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PMID: 20537436
PDF is available here.
Abstract
Dried blood spot (DBS) sampling could potentially become the preferred blood collection technique in toxicological and clinical studies. Autoradiography was performed to study compound distribution within a dbs under different conditions using five papers, 31ETF, Grade 226, 903(®),...
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PMID: 21083347
PDF is available here.
Justin B Siegel,
Alexandre Zanghellini,
Helena M Lovick,
Gert Kiss,
Abigail R Lambert,
Jennifer L St Clair,
Jasmine L Gallaher,
Donald Hilvert,
Michael H Gelb,
Barry L Stoddard,
Kendall N Houk,
Forrest E Michael and
David Baker
Abstract
We describe the de novo computational design and experimental characterization of enzymes catalyzing a bimolecular Diels-Alder reaction with high stereoselectivity and substrate specificity. X-ray crystallography confirms that the structure matches the design for the most active of the enzymes, and...
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PMID: 20647463
PDF is available here.
Abstract
We report on the marked similarity between the self-assembly of metal nanoparticles and reaction-controlled step-growth polymerization. The nanoparticles act as multifunctional monomer units, which form reversible, noncovalent bonds at specific bond angles and organize themselves into a colloidal po...
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PMID: 20616274
PDF is available here.
Abstract
There is an increasing demand for composite resins with both strong antibacterial activity and satisfactory mechanical properties. This study tested the hypothesis that the new antibacterial agent tetrapod-like zinc oxide whisker (T-ZnOw) could simultaneously enhance the antibacterial activity and m...
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PMID: 20439932
PDF is available here.
Abstract
Secondary caries and restoration fracture remain common problems in dentistry. This study tested the hypothesis that combining nano-CaF(2) and glass fillers would yield nanocomposites with high mechanical properties and F release. Novel CaF(2) nanoparticles (56-nm) were synthesized via spray-drying...
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PMID: 20439933
PDF is available here.
Abstract
The analysis of circulating metabolites is driven by the need to complete a comprehensive PK/PD exploration of the activity of a drug. When detected and identified, circulating metabolites should be considered from their concentration, structure (relationship to parent and known stru...
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PMID: 21083236
PDF is available here.
Abstract
We describe some of the physico-mechanical characteristics of tumor-associated ECMs believed to play important roles in regulating epithelial tumorigenic behaviors.
Copyright © 2010 Elsevier Ltd. All rights reserved....
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PMID: 20452434
PDF is available here.
Abstract
A series of 1-(aryloxypropyl)-4-(chloroaryl) piperazines have been synthesized and the target compounds evaluated for atypical antipsychotic activity in apomorphine induced mesh climbing and stereotypy assays in mice. The compounds 11 and 12 have emerged as important lead compounds showing potential...
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PMID: 20207451
PDF is available here.
Abstract
We have determined the experimental logP values of a set of 25 lamellarins, given it is the single most important parameter in determining multiple ADMET parameters. We also discuss the relationship between this natural product class, natural product derivatives in development and on the market, ora...
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PMID: 20167395
PDF is available here.
Abstract
We examined the ability of these scoring functions to discriminate between active and inactive compounds over receptor-based focused libraries. Our results demonstrated that the employed here empirical scoring functions were more appropriate for the pocket of predominant hydrophobic nature while the...
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PMID: 20227800
PDF is available here.
Abstract
An electronic tongue (ET) comprising 18 potentiometric chemical sensors was applied to the quantitative analysis of beer. Fifty Belgian and Dutch beers of different types were measured using the ET. The same samples were analyzed using conventional analytical techniques with respect to the main phys...
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PMID: 20188892
PDF is available here.
Abstract
We explored byssus cuticle chemistry by means of in situ resonance Raman spectroscopy and demonstrated that the cuticle is a polymeric scaffold stabilized by catecholato-iron chelate complexes having an unusual clustered distribution. Consistent with byssal cuticle chemistry and mechanics, we presen...
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PMID: 20203014
PDF is available here.
Abstract
We highlight recent developments and inventions made by introducing the fourth dimension of time in electron microscopy. Today, ultrafast electron microscopy (4D UEM) enables a resolution that is 10 orders of magnitude better than that of conventional microscopes, which are limited by the video-came...
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PMID: 20378810
PDF is available here.
Abstract
OBJECTIVE: To study the chemical constituents of the leaf of Clausena lansium (Lour.) Skeels. METHOD: The compounds were isolated by various chromatographic techniques and their structures were elucidated by their physicochemical properties and the analysis of their spectroscopic data. RESULT: Seven...
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PMID: 20617679
PDF is available here.
Abstract
Under similar laboratory conditions, the physiochemical properties and erosion potentials on enamel surfaces differed between some, but not all, beverages available in the UK and the US.
Copyright 2009 Elsevier Ltd. All rights reserved....
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PMID: 19962418
PDF is available here.
Abstract
Hyaluronan (HA) is a key component of the extra-cellular matrix and is involved in several mechanisms of the wound healing process. It is highly hygroscopic and is involved in the visco-elasticity of the skin. The properties of this molecule depend on its molecular weight. Native high molecular weig...
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PMID: 20435254
PDF is available here.
Abstract
We first review the similarities and differences between the physicochemical properties of GAGs and other statistical chain polyelectrolytes of both natural and abioitic origin. Since the biofunctionality and regulation of the structures of GAGs is intimately connected with interactions with their c...
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PMID: 20444439
PDF is available here.
Abstract
We report here two self-replicating peptide-derived macrocycles that emerge from a small dynamic combinatorial library and compete for a common feedstock. Replication is driven by nanostructure formation, resulting from the assembly of the peptides into fibers held together by beta sheets. Which of...
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PMID: 20299594
PDF is available here.
Abstract
Effects of sintering temperature on the physical and compositional properties of alpha-TCP foam fabricated using the polyurethane foam method were examined. When a polyurethane foam coated with alpha-TCP slurry was sintered at 1,400-1,550 degrees C, alpha-TCP foam having basically the same fully int...
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PMID: 20379025
PDF is available here.
Abstract
Our strategy and methodology offer significant and practical improvements over other methodologies....
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PMID: 19452259
PDF is available here.
Abstract
These results showed that the prepared tacrolimus-loaded NP are good possible candidates as a lymphatic delivery system of tacrolimus.
Copyright (c) 2009 Elsevier B.V. All rights reserved....
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PMID: 19703559
PDF is available here.
Abstract
This study determined if a standardized condensation force and dwell time per condensation pressure point could reliably bond new amalgam to older amalgam without applying extrinsic Hg. A stabilization jig was created to hold 15 friction-fit 1-inch diameter (25 mm) cylindrical resin specimen blocks...
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PMID: 20533632
PDF is available here.
Abstract
We have determined the physicochemical properties and crystal structure of cytochrome c(554) at 1.8 A in order to help elucidate its function. The physicochemical properties and the tertiary structure of cytochrome c(554) resemble those of dimeric cytochrome c(552) from Pseudomonas nautica, but the...
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PMID: 20460700
PDF is available here.
Abstract
The objective of this study is to prepare a non-viral carrier of gene expression from the polysaccharide dextran and evaluate the effect of amine compounds introduced to dextran on the level of gene expression. Dextran with a molecular weight of 74 x 10(3) was cationized by the chemical introduction...
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PMID: 20092686
PDF is available here.
Abstract
Energy and structural parameters of monochromanes and trimethylphenols derivatives have been chracterized through the employment of semiempirical methods of quantum chemistry. The correlation has been proved between antiradical, hepatoprotective properties of these compounds and energy and structura...
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PMID: 20684230
PDF is available here.
Abstract
For the same radiant exposure, conversion, RPmax and stress increased with photoinitiator concentration (P < 0.001). When the low concentration group exposed to 32 J/cm2 was compared with the high and intermediate groups (exposed to 16 J/cm2), RPmax still increased with the photoinitiator concentrat...
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PMID: 19824555
PDF is available here.
Abstract
We calculated physicochemical effects for the bonds reacting in the substrate of these enzymatic reactions. These descriptors allow the definition of similarities within these reactions and thus can serve as a method for the classification of enzyme reactions. To foster an understanding of the inves...
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PMID: 19445497
PDF is available here.
Abstract
Electron capture dissociation (ECD) and electron transfer dissociation (ETD) of doubly protonated electron affinity (EA)-tuned peptides were studied to further illuminate the mechanism of these processes. The model peptide FQpSEEQQQTEDELQDK, containing a phosphoserine residue, was converted to EA-tun...
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PMID: 19331417
PDF is available here.
Abstract
OBJECTIVE: To investigate the physicochemical constants such as equilibrium solubility and apparent partition coefficients (Papp), and study the effects of temperature, pH value and antioxidants on the stability of breviscapine solution. METHOD: The equilibrium solubility of breviscapine in various...
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PMID: 19623977
PDF is available here.
Abstract
Tobramycin was spray dried at different temperatures from different water to isopropanol feed ratios (0:100-20:80) in order to obtain dry powder formulations for inhalation. The spray-dried powders were characterized for their physicochemical properties including crystallinity, morphology, density,...
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PMID: 18752304
PDF is available here.
Abstract
Poly(lactide-co-glycolide) (PLGA) has been widely used for bone tissue regeneration. However, it lacks hydrophilicity, bioactivity and sufficient mechanical strength and its acidic degradation by-products can lead to pH decrease in the vicinity of the implants. Mesoporous bioactive glass (MBG) with...
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PMID: 19203787
PDF is available here.
Abstract
Higher amine ratios led to improved polymer properties, but also produced more yellowing in resin composites with CQ and CQ-PPD. The use of PPD alone was not advantageous for producing good final properties when compared to CQ and CQ-PPD....
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PMID: 18848352
PDF is available here.
Abstract
The spatial distribution of nano-dynamic-mechanical properties varied significantly enabling four distinguishable matrix, filler-cluster and inter-phase regions to be identified. Proceeding from matrix to filler-cluster locations, complex-moduli increased linearly and loss-factors decreased linearly...
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PMID: 19124150
PDF is available here.
Abstract
MALDI in combination with high-energy collision-induced dissociation (CID) performed by tandem time-of-flight mass spectrometry (TOF/RTOF) is a relatively new technology for the structural analysis of various classes of biomolecules as e.g., peptides, carbohydrates, glycoconjugate drugs and lipids....
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PMID: 19199883
PDF is available here.
Abstract
The operating principles and some applications of atmospheric pressure desorption electrospray ionization (DESI) and surface activated chemical ionization (SACI) methods are described in detail. The former technique allows one to obtain information on the chemical composition (in terms of organic co...
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PMID: 19199882
PDF is available here.
Abstract
The mechanism of interaction of nanocrystals of hydroxyapatite with Staphylococcus aureus bacteria has been investigated. It was shown that the growth of bacteria and their colonies both in the presence and absence of hydroxyapatite nanocrystals can be described using the Fokker-Planck equation. It...
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PMID: 20067185
PDF is available here.
Abstract
Complexation with HBenBCD may be an effective way to increase the bioavailability of glyburide....
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PMID: 19126293
PDF is available here.
Abstract
The association of drugs with chylomicrons is a complex process, which involves the lipophilic core as well as surface apoproteins. The in-silico model based on multiple physicochemical properties of the drugs is able to predict successfully the degree of association with chylomicrons....
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PMID: 19126294
PDF is available here.
Abstract
We investigated the distribution of Legionella at seventeen WWTPs throughout Taiwan. Legionella were detected in 10 of the 17 WWTPs (58.8%) and 25 of 41 samples (61.0%). In the integrated, hospital, industrial and domestic wastewater systems were 13/18 (72.2%), 7/12 (58.3%), 2/7 (28.6%) and 3/4 (75....
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PMID: 19717918
PDF is available here.
Abstract
A battery of bioassays, including biological toxicity as well as in vitro mouse spleen lymphoproliferative responses and cytokine production, was conducted to compare the effectiveness of tertiary treatment methods such as coagulation (Coag) and absorption on granular activated carbon (GAC) and disi...
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PMID: 19759452
PDF is available here.