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Permeability (2):
Recent article
Permeability
Abstract
We state that the in vitro bovine corneal epithelial primary culture model is useful for ocular studies....
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PMID: 21928720
PDF is available here.
PDF is available here.
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Abstract
In 2009, the Bovine Corneal Opacity and Permeability (BCOP) test was accepted by the regulatory bodies for the identification of corrosive and severe ocular irritants (Global Harmonised System [GHS] Category 1). However, no in vitro test is currently accepted for the differentiation of ocular irritan...
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PMID: 21942548
PDF is available here.
PDF is available here.
Abstract
We identify a specific subset of centrosomal proteins that are recruited to the cell cortex by DP upon epidermal differentiation. These include Lis1 and Ndel1, which are centrosomal proteins that regulate microtubule organization and anchoring in other cell types. This recruitment was mediated by a...
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PMID: 21844209
PDF is available here.
PDF is available here.
Abstract
Similar multicellular structures can evolve within the same organism that may have different evolutionary histories, be controlled by different regulatory pathways, and play similar but nonidentical roles. In the human fungal pathogen Candida albicans, a quite extraordinary example of this has occurr...
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PMID: 21829325
PDF is available here.
PDF is available here.
Abstract
We provide new evidence that orientin from bamboo leaves (Phyllostachys nigra) protect H9c2 cardiomyocytes against ischemia/reperfusion (I/R) injury through the mitochondrial apoptotic pathway. A previous work has identified that orientin could protect myocardium against ischemia/reperfusion injury....
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PMID: 21283956
PDF is available here.
PDF is available here.
Abstract
Our hypothesis is that the experimental protocols influence the mechanical properties of both annulus fibrosus and nucleus pulposus. IVD extracted from bovine tails were tested in unconfined compression stress-relaxation experiments according to six different protocols, where for each protocol, the...
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PMID: 21823745
PDF is available here.
PDF is available here.
Abstract
We hypothesized that higher permeability scaffolds will enhance bone regeneration for a given cell seeding density. We manufactured poly-ɛ-caprolactone scaffolds, designed to have the same internal pore design and either a low permeability (0.688×10(-7)m(4)/N-s) or a high permeability (3.991×10(-...
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PMID: 21395465
PDF is available here.
PDF is available here.
Abstract
We examined the effects of the OR ligand thymol on ion transport in human and rat colonic epithelia using an Ussing chamber. In the mucosal-submucosal preparations, the mucosal addition of thymol evoked anion secretion concentration dependently. In addition, dextran (4 kDa) permeability was enhanced...
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PMID: 21372164
PDF is available here.
PDF is available here.
Abstract
We hypothesized that MUC17 has a role in protection of the intestinal mucosa against luminal pathogens. Human intestinal cell lines were transfected by electroporation (Caco-2 and HT 29/19A) and by retroviral expression vector (LS174T, a cell line with high levels of MUC17 expression) using MUC17 si...
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PMID: 21393431
PDF is available here.
PDF is available here.
Abstract
Our results indicated that occludin small-interfering RNA (siRNA) transfection causes an increase in transepithelial flux of various-sized probes, including urea, mannitol, inulin, and dextran, across the Caco-2 monolayers, without affecting the transepithelial resistance. The increase in relative f...
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PMID: 21415414
PDF is available here.
PDF is available here.
Abstract
Among the exotoxins produced by Staphylococcus aureus and Streptococcus pyogenes, the superantigens (SAgs) are the most potent T-cell activators known to date. SAgs are implicated in several serious diseases including toxic shock syndrome (TSS), Kawasaki disease, and sepsis. However, the immunopathog...
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PMID: 21641398
PDF is available here.
PDF is available here.
Abstract
We discuss, production, characterization and in-vivo evaluation of nevirapine nanosuspensions. Laser diffraction showed that the average particles size was 457 nm. Following single-dose administration, the plasma gamma concentration profiles showed fast release. Macrophage uptake studies confirmed e...
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PMID: 21699078
PDF is available here.
PDF is available here.
Abstract
We prepared a liposomal hydrogel of adenosylcobalamin (AdCbl), a vitamin B12 derivative, and investigated possible beneficial effects of AdCbl on atopic dermatitis using an NC/Nga murine atopic dermatitis model. AdCbl was loaded into liposomes prepared by a thin film hydration method using a pH grad...
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PMID: 21699082
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to evaluate the effect of hypertension and its reverse on serum nitric oxide (NO) concentration and endothelial permeability in two-kidney one-clip (2K1C) hypertensive rats. 28 male Wistar rats were divided into four groups: 1) 2K1C for 12 weeks; 2) sham-cli...
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PMID: 21613665
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1813)5 2011
Abstract
We here demonstrate that upon mitochondrial outer membrane permeabilization physiological expression levels of XIAP are sufficient to selectively prolong the release of dimeric but not monomeric Smac. Elevating the expression of XIAP further extended the release duration of dimeric Smac and resulted...
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PMID: 21354220
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1808)9 2011
Abstract
We iteratively performed atomistic molecular dynamics simulations and biophysical measurements to probe the interaction of a cyclic antimicrobial peptide and its inactive linear analogue with model membranes. We establish that, relative to the linear peptide, the cyclic one binds stronger to negativ...
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PMID: 21586269
PDF is available here.
PDF is available here.
Abstract
We demonstrate how the intrinsically hybrid nature of MOFs enables the self-completing growth of thin MOF layers. Moreover, these layers can be shaped as hollow capsules that demonstrate selective permeability directly related to the micropore size of the MOF crystallites forming the capsule wall. S...
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PMID: 21505497
PDF is available here.
PDF is available here.
Abstract
Atherosclerosis is an inflammatory process occurring in arterial tissue, involving the subintimal accumulation of LDL. Measurement of the rate at which LDL and other lipoproteins, such as HDL and VLDL, enter and exit the tissue can provide insight into the mechanisms involved in the development of at...
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PMID: 21508256
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1816)1 2011
Abstract
We review here new insights and challenges in understanding Claudin function in normal physiology and cancer....
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PMID: 21515339
PDF is available here.
PDF is available here.
Abstract
The poor solubility and wettability of Candesartan cilexetil (CAN) leads to poor dissolution and hence, low bioavailability after oral administration. The aim of the present study was to improve the solubility and dissolution rate and hence the permeability of CAN by preparing solid...
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PMID: 21453263
PDF is available here.
PDF is available here.
Abstract
To evaluate the effects of carprofen and meloxicam on conductance and permeability to mannitol and on the histologic appearance of sections of canine gastric mucosa.
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PMID: 21453160
PDF is available here.
PDF is available here.
Abstract
The objective of the present study was to determine the intestinal absorption of sulpiride incorporated into SMEDDS by means of single-pass intestinal perfusion method (SPIP) in rat and to compare the effective permeability coefficient obtained with that of drug solution and micellar...
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PMID: 21454158
PDF is available here.
PDF is available here.
Abstract
To prepare ursolic acid ethosomes and investigate the penetration characteristics of ursolic ethosomes as a transdermal vehicle.
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PMID: 21809568
PDF is available here.
PDF is available here.
Abstract
We have evaluated the use of allometry for prediction of CL/F and AUC. In this paper we describe the evaluation of different allometric scaling approaches for the prediction of C(max), V(z)/F and t(½) after oral drug administration in man....
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PMID: 21456631
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1808)9 2011
Abstract
We studied an impact of visible light in combination with a photosensitizer on translocation of various substances across artificial (vesicular and planar) bilayer lipid membranes (BLMs). Along with induction of carboxyfluorescein leakage from liposomes, pronounced stimulation of lipid flip-flop bet...
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PMID: 21663731
PDF is available here.
PDF is available here.
Abstract
To assess whether glutamate plays a similar role to glutamine in preserving gut wall integrity.
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PMID: 21472123
PDF is available here.
PDF is available here.
Abstract
To elucidate the effect and underlying mechanisms of omeprazole action on Mg(2+) transport across the intestinal epithelium.
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PMID: 21472124
PDF is available here.
PDF is available here.
Abstract
The permeability of gases through uncompressed cork was investigated. More than 100 samples were assessed from different plank qualities to provide a picture of the permeability distribution. A novel technique based on a mass spectrometer leak detector was used to directly measure the helium flow thr...
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PMID: 21434693
PDF is available here.
PDF is available here.
Abstract
We report generation of transgenic (Tg) mice with targeted Elovl4 expression driven by an epidermal-specific involucrin promoter. In homozygous Stgd3 mice, this transgene reinstates both epidermal Elovl4 expression and synthesis of two missing epidermal lipid groups: C28-C36 acylceramides and (O-lin...
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PMID: 21429867
PDF is available here.
PDF is available here.
Abstract
To investigate the role of intestinal mucosal blood flow (IMBF) and motility in the damage of intestinal mucosal barrier in rats with traumatic brain injury.
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PMID: 21350716
PDF is available here.
PDF is available here.
Abstract
The initial seeding density is a critical variable in functional tissue engineering. A sufficient number of cells uniformly distributed throughout the scaffold is a key requirement to achieve homogeneous extra cellular matrix (ECM) deposition in vitro. However, high initial se...
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PMID: 21275843
PDF is available here.
PDF is available here.
Current Protocols in Toxicology (Chapter 20) 2011
Abstract
The Caco-2 cell system, a well characterized intestinal in vitro model, makes it possible to evaluate the ability of chemicals to cross the intestinal barrier, as well as to study their transport mechanisms. Permeability values estimated with this model correlate well with human in v...
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PMID: 21400683
PDF is available here.
PDF is available here.
Abstract
To adapt a simple gravimetric method to measuring the permeability of adhesive resin films to liquid water, and to compare this to the water vapor permeability of the same resins.
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PMID: 21469402
PDF is available here.
PDF is available here.
Abstract
Zanamivir is currently used for the treatment of H1N1 and H5N1 influenza viruses. Due to its highly hydrophilic property, zanamivir has poor oral bioavailability. Liposomal formulations are known to improve oral absorption of hydrophilic drugs. The present study investigates the effe...
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PMID: 21235479
PDF is available here.
PDF is available here.
Abstract
In this study agarose-alginate scaffolds are synthesized using cryogelation technology in different formats like monolith, sheet, discs, and beads, and show amiable mechanical strength like soft tissue properties and high interconnected macroporous degradable architecture. In cell-ma...
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PMID: 21077225
PDF is available here.
PDF is available here.
Abstract
We conclude that SCI is followed by compromised BTB integrity by as early as 72 hours post-injury in rats and is accompanied by a substantial immune response within the testis. Furthermore, our results indicate that the BTB remains compromised and testis immune cell infiltration persists for months...
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PMID: 21298060
PDF is available here.
PDF is available here.
Abstract
We introduced the concept of cycle flux to derive exact solutions of experimental observables from the permeation model. There are multiple cyclic paths on the model, and random transitions complete the cycles. The rate of cycle completion is called the cycle flux. The net flux is generated by a com...
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PMID: 21304994
PDF is available here.
PDF is available here.
Abstract
We hypothesized that GCC signaling mediates regulation of intestinal barrier function....
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PMID: 21305056
PDF is available here.
PDF is available here.
Abstract
Various derivatives of decanoic acid (CD) have been synthesized and evaluated against Gram positive B. subtilis, S. aureus and Gram negative E. coli bacteria as well a sagainst fungi C. albicans and A. niger. Quantitative structure activity relationship (QSAR) models for antimicrobial activities were...
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PMID: 21485292
PDF is available here.
PDF is available here.
Abstract
Our model was validated against experimental data for calcium release and thrombin-, histamine-, and VEGF-mediated MLC activation. The simulated effects of PAR-1, Rho GTPase, ROCK, VEGF and VEGFR2 over-expression on MLC activation, and the collective modulation by thrombin and histamine are consiste...
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PMID: 21756365
PDF is available here.
PDF is available here.
Abstract
A novel arginine-rich chitosan (CS) derivates mimicked cell penetration peptides; N-Arginine chitosan (N-Arg-CS) was prepared by two reaction methods involving activated L-arginine and the amine group on the chitosan. FTIR spectra showed that arginine was chemically coupled with CS. Elemental analysi...
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PMID: 21829153
PDF is available here.
PDF is available here.
Abstract
Splanchnic hypoperfusion is common in various pathophysiological conditions and often considered to lead to gut dysfunction. While it is known that physiological situations such as physical exercise also result in splanchnic hypoperfusion, the consequences of flow redistribution at the expense of abd...
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PMID: 21811592
PDF is available here.
PDF is available here.
Abstract
In the present study, the possible interactions between celecoxib and some excipients (colloidal silicon dioxide (Aerosil), microcrystalline cellulose (Avicel PH 102), lactose anhydrous, magnesium stearate, cross-povidone and talc) were evaluated by examining the pure drug or drug-excipient powder mi...
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PMID: 21648198
PDF is available here.
PDF is available here.
British Journal of Nutrition (105)2 2011
Abstract
We aimed to determine the effects of enteral supplementation of a prebiotic mixture consisting of neutral oligosaccharides (short-chain galacto-oligosaccharides (SCGOS)/long-chain fructo-oligosaccharides (LCFOS)) and acidic oligosaccharides (AOS) on intestinal permeability of preterm infants as meas...
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PMID: 20863418
PDF is available here.
PDF is available here.
Abstract
Abstract
Taking alkaloids and iridoid as the study, relationships of quantitative molecular structure and transmission rate on UF membrane were developed initially at exploring the mechanism of UF in Chinese herb decoction and to lay a foundation for the optimal design of membrane technology in the production...
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PMID: 21506407
PDF is available here.
PDF is available here.
Abstract
We aimed to study the effects of gliadin and various intestinal bacterial strains on mucosal barrier integrity, gliadin translocation, and cytokine production.
Changes in gut mucosa were assessed in the intestinal loops of inbred Wistar-AVN rats that were reared under germ-free condi...
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PMID: 21249146
PDF is available here.
PDF is available here.
Abstract
These results indicate that the limonene microemulsion system is a promising tool for the percutaneous delivery of curcumin.
Copyright © 2010 Elsevier B.V. All rights reserved....
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PMID: 20828994
PDF is available here.
PDF is available here.
Abstract
The computational platform ENVIRONMENT, developed to simulate stochastically reaction systems in varying compartmentalized conditions [Mavelli and Ruiz-Mirazo: Philos Trans R Soc Lond B Biol Sci 362:1789-1802, 2007; Physical Biology 7(3): 036002, 2010], is here applied to study the dynamic properties...
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PMID: 21431610
PDF is available here.
PDF is available here.
Abstract
We have reported that NIK-specific siRNA in cationic liposomes was shown to suppress the expression of NIK and the proliferation of HCC cells (Cho et al., 2009). More improved suppression of NIK, followed by the improved antiproliferative effect on Hep3B cells, was achieved when 5-FU was co-treated...
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PMID: 21468918
PDF is available here.
PDF is available here.
Medicinski arhiv (65)1 2011
Abstract
In this work, effect of phentolamine as antagonist of alpha-1 adrenergic receptor in patients with bronchial asthma and with obstructive chronic bronchitis was studied. Parameters of the lung function are determined by body plethysmography. Raw and ITGV were registered and SRaw was calculated as well...
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PMID: 21534442
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)2 2011
Abstract
Dermal absorption of mucopolysaccharide polysulfate (MPS, the active ingredient of Hirudoid") in human and minipig was investigated by using 14C-labeled MPS. Three types of human and minipig skin samples were used: intact, dried and tape-stripped. At 24 h after application of 14C-MPS...
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PMID: 21428242
PDF is available here.
PDF is available here.
Abstract
We report the design of a novel pyrrolopyrimidine-based scaffold for such α-helix mimetics with increased conformational rigidity. We also developed a facile solid-phase synthetic route that is amenable to divergent synthesis of a large library. Using a fluorescence polarization-based assay, we ide...
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PMID: 21171592
PDF is available here.
PDF is available here.
British Journal of Nutrition (104)12 2010
Abstract
We showed that dietary Ca decreases whereas dietary short-chain fructo-oligosaccharides (scFOS) increase intestinal permeability in rats. However, it is unknown how and where in the gastrointestinal tract Ca and scFOS exert their effects. Rats were fed a Western low-Ca control diet, or a similar die...
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PMID: 20691137
PDF is available here.
PDF is available here.
Abstract
Hypothermic circulatory arrest increases permeability of the blood brain barrier in watershed areas.
Abstract
We tested the hypothesis that the BBB is disrupted by HCA.
Forty-one piglets (mean weight 11 kg) were randomly allocated to acute and survival experiments. Five groups (25 piglets, 5 per group) underwent acute studies: anesthesia alone (control); CPB at 37°C with full-flow (FF); CPB at 25°C with v...
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PMID: 21095352
PDF is available here.
PDF is available here.
Macromolecular Bioscience (10)11 2010
Abstract
The successful replacement of large-scale cartilage defects or osteoarthritic lesions using tissue-engineering approaches will likely require composite biomaterial scaffolds that have biomimetic mechanical properties and can provide cell-instructive cues to control the growth and dif...
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PMID: 20857388
PDF is available here.
PDF is available here.
Abstract
We sought to determine whether the treatment of mice with Salp15 during EAE induction would prevent the generation of proinflammatory T cell responses and the development of the disease. Surprisingly, Salp15-treated mice developed more severe EAE than control animals. The treatment of EAE-induced mi...
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PMID: 20920474
PDF is available here.
PDF is available here.
Abstract
By means of numerical simulations and epidemic analysis, the transition point of the stochastic asynchronous susceptible-infected-recovered model on a square lattice is found to be c0=0.1765005(10), where c is the probability a chosen infected site spontaneously recovers rather than tries to infect...
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PMID: 21230514
PDF is available here.
PDF is available here.
Abstract
This paper presents a comprehensive performance study of polylactic acid (PLA) biocomposites, obtained by solvent casting, containing a novel silver-based antimicrobial layered silicate additive for use in active food packaging applications. The silver-based nanoclay showed strong antimicrobial acti...
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PMID: 20711905
PDF is available here.
PDF is available here.