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Molecular Weight (0):
Recent article
Molecular Weight
Abstract
Our purification scheme led to a 30-fold purification of this activity, with the removal of more than 99.9% of total protein. While Ado was the preferred substrate, inosine and guanosine were also cleaved, with 43% and 32% of the Ado activity, respectively. Our data suggest that M. smegmatis express...
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PMID: 21821769
PDF is available here.
PDF is available here.
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Acta Biomaterialia (7)10 2011
Abstract
The quest for synthetic materials to repair load-bearing bone lost because of trauma, cancer, or congenital bone defects requires the development of porous, high-performance scaffolds with exceptional mechanical strength. However, the low mechanical strength of porous bioactive ceram...
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PMID: 21745606
PDF is available here.
PDF is available here.
Abstract
Copper complex with Curtis macrocyclic tetramine is offered as reagent for extraction-photometric determination of nonsteroidal anti-inflammatory drugs (NSAIDs), belonging to the class of aromatic carboxylic acids. The studies indicate that this method is suitable for quantitative determination of NS...
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PMID: 21928706
PDF is available here.
PDF is available here.
Biomacromolecules (12)9 2011
Abstract
Polyhydroxyalkanoates (PHA) synthesis genes phbC and orfZ cloned from Ralstonia eutropha H16 were transformed into beta-oxidation weakened Pseudomonas putida KTOY08ΔGC, a mutant of P. putida KT2442. The recombinant P. putida strain termed KTHH06 was able to produce a short-chain-len...
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PMID: 21863836
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1812)9 2011
Abstract
These results suggest that the TLR-4 and TLR-2 play an important role in the arthritis mechanism and the interaction/block of HA at high molecular mass may reduce inflammation and cartilage injury....
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PMID: 21723389
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1814)9 2011
Abstract
We show that this protein has a general affinity for single-stranded DNA (ssDNA) as documented by Electrophoretic Mobility Shift Assay (EMSA). The apparent molecular weight of the monomer is about 12.7kDa as measured by HPLC-SEC. Moreover, isoelectrofocusing showed an isoelectric point for pV(VGJΦ)...
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PMID: 21586349
PDF is available here.
PDF is available here.
Abstract
We report that the resistance to the Bt toxin Cry1Ac in the cabbage looper, Trichoplusia ni, evolved in greenhouses, is associated with differential alteration of two midgut aminopeptidases N, APN1 and APN6, conferred by a trans-regulatory mechanism. Biochemical, proteomic, and molecular analyses sh...
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PMID: 21844358
PDF is available here.
PDF is available here.
Abstract
The present study aimed to evaluate the protective and curative effects of the 15 KD protein isolated from the seeds of Peganum harmala L. against carbon tetrachloride (CCl4) induced oxidative stress in rats.
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PMID: 21845799
PDF is available here.
PDF is available here.
Ukrainskij biokhimicheskij zhurnal/Ukrayins'kij biokhimichnij zhurnal/Ukrainian biochemical journal (82)6 2011
Abstract
I preparations homogeneous in SDS-PAAG test were obtained by the affinity chromatography on the synthesized sorbent L-arginine-macroporous glass. Some physico-chemical characteristics of the isolated arginase preparation have been estimated: thermo- and pH-stability, temperature- and pH-optima of th...
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PMID: 21805858
PDF is available here.
PDF is available here.
Abstract
Fibrillar aggregates of beta-amyloid peptide (Abeta) are major constituents of the senile plaques found in the brains of patients suffering from Alzheimer's disease (AD). Previous studies have shown that spontaneous isomerization or racemization of aspartyl residues in Abeta peptides...
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PMID: 21812329
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1814)7 2011
Abstract
We show that while the anchor helix is one of the first targets to be cut, this occurs in the same time-frame as several potentially inactivating cleavages in Domain III. Thus autolytic activation would overlap with inactivation. We also show that the small subunit does not dissociate from the large...
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PMID: 21549862
PDF is available here.
PDF is available here.
Abstract
In this work, the effect of molecular weight (MW) of surface grafted poly(N-isopropylacrylamide) (PNIPAAm) on protein adsorption and cell adhesion was investigated systematically. PNIPAAm-grafted polyurethane (PU) surfaces of varying graft MW were prepared via conventional radical polymerization. The...
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PMID: 21093225
PDF is available here.
PDF is available here.
Abstract
Our results showed that 76% and 93% of these patients had elevated IgM and IgG against r47b, respectively, and 98% and 100% had elevated IgM and IgG against r56s, respectively. The kinetics of antibody responses against r47b and r56s can be grouped into three patterns. In the first type of response,...
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PMID: 21508168
PDF is available here.
PDF is available here.
Abstract
Our results indicated that occludin small-interfering RNA (siRNA) transfection causes an increase in transepithelial flux of various-sized probes, including urea, mannitol, inulin, and dextran, across the Caco-2 monolayers, without affecting the transepithelial resistance. The increase in relative f...
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PMID: 21415414
PDF is available here.
PDF is available here.
Abstract
We have developed a new, broad-specificity "xyloglucan glycosynthase", selected from active-site mutants of a bacterial endoxyloglucanase, which catalyzed the synthesis of high molar mass polysaccharides, with complex side-chain structures, from suitable glycosyl fluoride donor substrates. The produ...
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PMID: 21618981
PDF is available here.
PDF is available here.
Abstract
Densities and molar excess volumes of the solutions of pyridine or nicotine in liquid polyethylene glycol, PEG200 and PEG400, have been determined at several temperatures. The experimental molar excess volumes are negative, thus indicating strong attractive interactions between the components, as cou...
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PMID: 21604799
PDF is available here.
PDF is available here.
Abstract
We have developed what we believe to be a novel set of methods to characterize these undulations and extract the underlying profiles in the large systems. Our approach first obtains an undulation reference surface for each frame in the simulation and subsequently isolates the long-wavelength undulat...
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PMID: 21539778
PDF is available here.
PDF is available here.
Abstract
We examine the widely used assumption that most proteins have dn/dc values in a very narrow range, and reappraise the prediction of dn/dc of unmodified proteins based on their amino acid composition. Applying this approach in large scale to the entire set of known and predicted human proteins, we ob...
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PMID: 21539801
PDF is available here.
PDF is available here.
Abstract
Dihydroartemisinin (DHA) is a poorly water-soluble drug that displays low bioavailability after oral administration. Attempts have been made to improve the solubility of DHA. Yet, no information is available concerning improved bioavailability. This study aimed to improve the water solubility of DHA...
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PMID: 21656361
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1811)5 2011
Abstract
We recently observed that plasma PLTP specific activity is inversely correlated with high-density lipoprotein (HDL) level and particle size in healthy adults. The purpose of this study was to evaluate the factors that contribute to the variation in plasma PLTP specific activity. Analysis of the spec...
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PMID: 21303701
PDF is available here.
PDF is available here.
Abstract
These results suggest that CH₃ SAM surfaces were the least proinflammatory of all SAM surfaces. Overall, similar trends were observed in the profiles of proteins eluted from surfaces exposed to filtered 10% HS or 1% HP. However, the unique profiles of adsorbed proteins on different SAM surface che...
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PMID: 21509932
PDF is available here.
PDF is available here.
Abstract
Abstract
Polyphenol oxidase (PPO) purified using DEAE-cellulose and Biogel P-100 column chromatography from banana pulp showed 12.72-fold activity and 2.49% yield. The optimum temperature and pH were found to be 30 degrees C and 7.0, respectively for its activity. Catechol was found to be a suitable substrate...
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PMID: 21598798
PDF is available here.
PDF is available here.
Abstract
Our results support the hypothesis that failure of proteasomal and non-proteasomal proteolytic clearance mechanisms leads to tau accumulation and progressive neurofibrillary degeneration in AD....
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PMID: 21577325
PDF is available here.
PDF is available here.
Abstract
Urinary peptidome changes and discrimination for potential renal glomerular and tubular damage after 6 wk of fenofibrate treatment were evaluated in 26 healthy subjects.
Peptide profiling was performed in urine samples before and after treatment using high-resolution...
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PMID: 21360683
PDF is available here.
PDF is available here.
médecine/sciences (27)4 2011
Abstract
Biochimica et Biophysica Acta (1808)9 2011
Abstract
The serotonin (5-HT(1A)) receptor, a G-protein-coupled receptor (GPCR), plays important roles in serotonergic signaling in the central nervous system. The third intracellular loop (ICL3) of the 5-HT(1A) receptor has been shown to be important for the regulation of this receptor through interactions w...
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PMID: 21640070
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1812)7 2011
Abstract
We used an incisional wound healing model in genetically diabetic mice to test the effects of systemic injection of HA. Diabetic (n=56) and normoglycemic (n=56) mice were subjected to incision and randomized (8 groups of 7 animals each) to receive HA at different doses, 7.5, 15 and 30mg/kg/i.p., or...
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PMID: 21447385
PDF is available here.
PDF is available here.
Abstract
We report the identification and characterization of a native high molecular weight zinc-binding multiprotein complex from HuSP by utilizing 2-DE followed by MS. Twenty-six proteins representing isoforms and/or fragments of 11 different proteins were found to be assembled in this complex. Prostate-s...
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PMID: 21404442
PDF is available here.
PDF is available here.
Abstract
Radical cations of selected low molecular-weight silicon model compounds were obtained by photoinduced electron transfer. These radical cations react readily with a variety of nucleophiles, regularly used in monolayer fabrication onto hydrogen-terminated silicon. From time-resolved kinetics, it was c...
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PMID: 21405139
PDF is available here.
PDF is available here.
Abstract
DNA three-way junctions are frequently used in nanoarchitectures. Ligand-dependent designs that provide well-characterized building blocks for structure-switching DNA nanodevices are presented.
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PMID: 21401129
PDF is available here.
PDF is available here.
Abstract
We isolated a novel lectin from Carica papaya seeds, named C. papaya lectin (CPL). Purification of the lectin involved ammonium sulfate fractionation and DEAE anion exchange and repeated gel filtration chromatography. Inhibition of CPL causing hemagglutination on human erythrocytes showed that the l...
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PMID: 21405109
PDF is available here.
PDF is available here.
Abstract
Two series of polyphilic molecules composed of a rigid and linear p-terphenyl core, terminated at both ends with polar glycerol groups capable of hydrogen bonding, and two branched swallow tail-type lateral chains, composed of a fluorinated and a nonfluorinated branch or two fluorinated branches, wer...
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PMID: 21391683
PDF is available here.
PDF is available here.
Abstract
The foam of sparkling wines is a key parameter of their quality. However, the compounds that are directly involved in foam formation and stabilization are not yet completely established. In this work, seven sparkling wines were produced in Bairrada appellation (Portugal) under different conditions an...
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PMID: 21375299
PDF is available here.
PDF is available here.
Abstract
The objective of this study was to synthesize and characterize novel hyperbranched poly(acrylic acid)s via atom-transfer radical polymerization (ATRP) technique and tether the photo-curable methacrylate onto the poly(acrylic acid), use these polymers to formulate the resin-modified glass-ionomer ceme...
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PMID: 21377199
PDF is available here.
PDF is available here.
Abstract
A novel gene (designated as tan410) encoding tannase was isolated from a cotton field metagenomic library by functional screening. Sequence analysis revealed that tan410 encoded a protein of 521 amino acids. SDS-PAGE and gel filtration chromatography analysis of purified tannase suggested that Tan410...
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PMID: 21388130
PDF is available here.
PDF is available here.
Abstract
Pore formation and pore closure in poly(D,L-lactide-co-glycolide)-based drug delivery systems are two important processes as they control the release of the encapsulated drug. The phenomenon pore closure was investigated by studying the effects of the pH and the temperature of the re...
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PMID: 21094192
PDF is available here.
PDF is available here.
Abstract
We report the results of an experimental study of the microstructure of dispersions of Carbopol ETD 2050, a model yield-stress fluid. Using two different light scattering instruments, measurements were made over three decades in scattering wave vector, from 0.02 to 25 μm^{-1}. These measurements re...
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PMID: 21517498
PDF is available here.
PDF is available here.
Abstract
We expose a known rubber material to controlled dosages of γ radiation and utilize a newly developed multiquantum nuclear-magnetic-resonance technique to characterize the MWD as a function of radiation. We show that such data along with mechanical stress-strain measurements are amenable to accurate...
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PMID: 21517517
PDF is available here.
PDF is available here.
Abstract
We lack insight into the impact of structure and size for their capacity to affect immune responses.
This study addresses the importance of chemical structure, size, origin and presence of contaminants for the capacity of both dietary and non-food NSP to modulate DC. Of 28 NSP produc...
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PMID: 20938988
PDF is available here.
PDF is available here.
Acta Biologica Hungarica (62)1 2011
Abstract
A thermostable xylanase was purified and characterized from the thermophilic fungus Rhizomucor miehei (Cooney & Emerson) Schipper. The enzyme was purified to homogeneity by ammonium sulfate precipitation, sephadex G-100 gel filtration and diethylaminoethyl cellulose anion exchange chromatography with...
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PMID: 21388922
PDF is available here.
PDF is available here.
Abstract
We investigated the avidity (quality of the antibody) using urea....
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PMID: 21560402
PDF is available here.
PDF is available here.
Abstract
Glucoamylase from Aspergillus niger is an industrially important biocatalyst that is utilized in the mass production of glucose from raw starch or soluble oligosaccharides. The G1 isoform consists of a catalytic domain and a starch-binding domain connected by a heavily glycosylated linker region. Th...
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PMID: 21301084
PDF is available here.
PDF is available here.
Abstract
The haemopexin fold is present in almost all life forms and is utilized for carrying out diverse physiological functions. The structure of CP4, a haemopexin-fold protein from cow pea (Vigna unguiculata), was determined at 2.1 Å resolution. The protein exists as a monomer both in solution and in t...
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PMID: 21301085
PDF is available here.
PDF is available here.
Abstract
CTP synthase catalyzes the last committed step in de novo pyrimidine-nucleotide biosynthesis. Active CTP synthase is a tetrameric enzyme composed of a dimer of dimers. The tetramer is favoured in the presence of the substrate nucleotides ATP and UTP; when saturated with nucleotide, the tetramer comp...
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PMID: 21301086
PDF is available here.
PDF is available here.
Abstract
During fatty-acid biosynthesis, enoyl-acyl carrier protein (enoyl-ACP) reductase catalyzes the reduction of trans-2-enoyl-ACP to fully saturated acyl-ACP via the ubiquitous fatty-acid synthase system. NADH-dependent enoyl-ACP reductase (FabI) from Pseudomonas aeruginosa has been purified and crystal...
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PMID: 21301088
PDF is available here.
PDF is available here.
Abstract
Phospholipases D are the major dermonecrotic component of Loxosceles venom and catalyze the hydrolysis of phospholipids, resulting in the formation of lipid mediators such as ceramide-1-phosphate and lysophosphatidic acid which can induce pathological and biological responses. Phospholipases D can b...
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PMID: 21301094
PDF is available here.
PDF is available here.
Abstract
In cancer tissue, altered glycosylation of proteins is observed. There are some typical changes; for example, sialyl-Lewis(a/x) glycoforms are more abundant in many types of cancers. The current study investigated the differences in glycosylation of proteins between neoplastic and healthy human saliv...
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PMID: 21288176
PDF is available here.
PDF is available here.
Abstract
A family of biodegradable poly(amine-co-esters) was synthesized in one step via enzymatic copolymerization of diesters with amino-substituted diols. Diesters of length C(4) -C(12) (i.e., from succinate to dodecanedioate) were successfully copolymerized with diethanolamines with eithe...
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PMID: 21171165
PDF is available here.
PDF is available here.
YAKUGAKU ZASSHI (131)2 2011
Abstract
Sperminated pullulans (SP) having different molecular weights (MWs) were prepared, and the enhancing effect on the pulmonary absorption of insulin in rats was examined. SP acted as enhancers of insulin absorption when a 0.1% solution was applied with insulin simultaneously and their enhancing effects...
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PMID: 21297376
PDF is available here.
PDF is available here.
Abstract
An oxalate oxidase was purified to apparent homogeneity from the leaves of 10-days old seedlings of forage Sorghum (Sorghum vulgare var. KH-105). The enzyme had a Mr of 124 kDa with two identical subunits, an optimum pH of 4.5, optimum temperature of 37 degrees C and activation energ...
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PMID: 21469601
PDF is available here.
PDF is available here.
Biopolymers (95)4 2011
Abstract
A water soluble acidic heteropolysaccharide named WAF was isolated from Auricularia auricula-judae by extracting with 0.9% NaCl solution. By using gas chromatography, gas chromatography-mass spectrometry, and NMR, its chemical structure was determined to be composed of a backbone of α-(1→3)-linked...
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PMID: 21280017
PDF is available here.
PDF is available here.
Abstract
We prepared grape seed extracts, from two different varieties, containing high amounts of polyphenols but little resveratrol. Their neuroprotective effects were investigated using primary culture of neonatal mouse hippocampal neurons treated with an excitotoxic concentration of glutamate. Koshu, a w...
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PMID: 21283677
PDF is available here.
PDF is available here.
Abstract
We also evaluated the biocompatibility of both microfilms. Eighteen eyes (9 rabbits) were surgically implanted with one type of microfilm in each eye. Serial anterior-segment optical coherence tomography (AS-OCT) scans together with serial slit-lamp microscopy allowed us to measure thickness and cro...
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PMID: 21799878
PDF is available here.
PDF is available here.
Abstract
We present studies on the interaction of JHBP with low molecular weight proteins (LMWP) in the hemolymph. Using ligand blotting we found that JHBP interacts with a protein of about 44 kDa. To identify the protein that preferentially binds JHBP, a LMWP fraction was applied to a Sepharose-bound JHBP a...
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PMID: 21403916
PDF is available here.
PDF is available here.
Abstract
We found that αA-crystallin-derived peptide, (66)SDRDKFVIFLDVKHF(80), which accumulates in the aging lens, can inhibit the chaperone activity of α-crystallin and cause aggregation and precipitation of lens crystallins. Age-related change in the concentration of αA-(66-80) peptide was estimated by...
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PMID: 21552534
PDF is available here.
PDF is available here.
Abstract
We investigated the anterior pituitary production of N-terminal prolactin-derived fragments along the estrous cycle and the involvement of estrogens in this process. In addition, we studied the effects of a recombinant vasoinhibin, 16 kDa prolactin, on anterior pituitary apoptosis and proliferation....
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PMID: 21760910
PDF is available here.
PDF is available here.
Abstract
We have previously suggested, based on Small Angle X-ray Scattering data, that recombinant murine proNGF has features typical of an intrinsically unfolded protein. Using complementary biophysical techniques, we show here new evidence that clarifies and widens this hypothesis through a detailed compa...
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PMID: 21818348
PDF is available here.
PDF is available here.
Abstract
In our earlier studies 34 kDa outer membrane protein (OMP) of Shigella flexneri 2a has been identified as an efficient immunostimulant.
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PMID: 21818362
PDF is available here.
PDF is available here.
Abstract
We reported in vitro culture conditions for this bacterium which, in contrast to typical methods, yielded a bacterial phenotype that mimics that of the bacterium's mammalian, extracellular phase.
SDS-PAGE and carbohydrate analysis of differentially-cultivated F. tularensis LVS reveal...
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PMID: 21799828
PDF is available here.
PDF is available here.