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All › Chemical Actions and Uses › Pharmacologic Actions › Physiological Effects of Drugs › Central Nervous System Depressants

Central Nervous System Depressants (4)

Articles on Central Nervous System Depressants

  1. The prevalence of drugs in injured drivers.
    Olaf H OH Drummer, Irene I Kourtis, ... Dimitri D Gerostamoulos

    Forensic Sci Int 215(1-3):14-7 (2012) PMID 21377816

    In mid 2009 Victoria introduced compulsory drug testing of blood taken from all injured drivers taken to hospital. Δ(9)-Tetrahydrocannabinol (THC), methylamphetamine (MA) and 3,4-methylenedioxy-methylamphetamine (MDMA) are prohibited and if drivers are positive to any amount an auto...
  2. Causality between polyhexamethyleneguanidine occurrence in unrecorded alcohol and cholestatic hepatitis outbreak in Russia.
    Dirk W DW Lachenmeier, Yulia B YB Monakhova, ... Jürgen J Rehm

    Clin Toxicol (Phila) 50(2):154-5; author reply 156 (2012) PMID 22216917

  3. Event-specific drinking among college students.
    Clayton C Neighbors, David C DC Atkins, ... Lindsey M LM Rodriguez

    Psychol Addict Behav 25(4):702-7 (2011) PMID 21639597

    College represents a period of risk for heavy drinking and experiencing unwanted consequences associated with drinking. Previous research has identified specific events, including holidays (e.g., New Years), school breaks (e.g., Spring Break) and personally relevant events (e.g., 21s...
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  4. In vitro metabolism of tiletamine, zolazepam and nonbenzodiazepine sedatives: Identification of target metabolites for equine doping control...
    Susanna J SJ Fenwick and James P JP Scarth

    Drug Test Anal 3(10):705-16 (2011) PMID 21916022

    I metabolite information was provided by incubation with equine liver S9 fraction. In vitro techniques were chosen in order to reduce the ethical and financial issues surrounding the study of so many compounds, none of which are licensed for use in horses in the UK. Several metabolites of each drug...
  5. Deficiency of insulin-like growth factor 1 reduces vulnerability to chronic alcohol intake-induced cardiomyocyte mechanical dysfunction: rol...
    Wei W Ge, Qun Q Li, ... Jun J Ren

    J Cell Mol Med 15(8):1737-46 (2011) PMID 20731752

    I (IGF-1) levels are closely associated with cardiac performance although the role of IGF-1 in alcoholic cardiac dysfunction is unknown. This study was designed to evaluate the impact of severe liver IGF-1 deficiency (LID) on chronic alcohol-induced cardiomyocyte contractile and intracellular Ca(2+)...
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  6. Impaired GABA and glycine transmission triggers cardinal features of rapid eye movement sleep behavior disorder in mice.
    Patricia L Brooks and John H Peever

    J Neurosci 31(19):7111-21 (2011) PMID 21562273

    We show that transgenic mice with deficient glycine and GABA transmission have a behavioral, motor, and sleep phenotype that recapitulates the cardinal features of RBD. Specifically, we show that mice with impaired glycine and GABA(A) receptor function exhibit REM motor behaviors, non-REM muscle twi...
  7. Ethanol Preconditioning Reduces Hepatic I/R Injury by Inhibiting the Complement System Activation
    Zheng-Wei Ma, Xiao-Bin Feng, ... Jia-Hong Dong

    J Surg Res 166(2):10 (2011) PMID 19854450

    Ethanol preconditioning (EtOH-PC) refers to a phenomenon in which cerebral, intestinal, and myocardial tissues are protected from the deleterious effects of ischemia/reperfusion (I/R) by prior ingestion of ethanol at low to moderate levels. Whether EtOH-PC can offer protective effect...
  8. Alcohol withdrawal during hospitalization.
    Vicky A VA Keys

    Am J Nurs 111(1):40-4; quiz 45-6 (2011) PMID 21191232

    OVERVIEW: For a chronic drinker, sudden alcohol withdrawal because of an unexpected hospitalization can lead to escalating withdrawal symptoms and even death if unrecognized and untreated. Nurses need to be aware of the prevalence of alcohol abuse in the United States and consider the possibility of...
  9. Upregulation of cannabinoid type 1 receptors in dopamine D2 receptor knockout mice is reversed by chronic forced ethanol consumption.
    Panayotis K Thanos, Vanessa Gopez, ... Nora D Volkow

    Alcohol Clin Exp Res 35(1):19-27 (2011) PMID 20958329

    We monitored the drinking patterns and locomotor activity of Drd2+/+ and Drd2-/- mice consuming either water or a 20% (v/v) ethanol solution (forced ethanol intake) for 6 months and used the selective CB1 receptor antagonist [³H]SR141716A to quantify CB1R levels in different brain regions with in v...
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  10. Variants of contextual fear conditioning are differentially impaired in the juvenile rat by binge ethanol exposure on postnatal days 4-9.
    Nathen J NJ Murawski and Mark E ME Stanton

    Behav Brain Res 212(2):133-42 (2010) PMID 20385174

    We report that rats exposed to a high binge dose of ethanol (5.25g/kg/day) over postnatal days [PD] 4-9 failed to demonstrate the CPFE when preexposed to the conditioning context on PD31, relative to sham-intubated and undisturbed controls (Experiment 1). Neonatal alcohol disrupted conditioned freez...