Abstract
We also need strategies for to increase the therapeutic ratio i.e. Increase lung deposition without increasing systemic side effects. Another challenge is to design and to perform clinical trials, targeting effects in SA, proving the clinical importance of SA treatment in a large number of patients....
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PMID: 21501394
PDF is available here.
Abstract
The influence of sea-land breezes (SLBs) on the spatial distribution and temporal variation of particulate matter (PM) in the atmosphere was investigated over coastal Taiwan. PM was simultaneously sampled at inland and offshore locations during three intensive sampling periods. The intensive PM sampl...
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PMID: 21516932
PDF is available here.
Abstract
We report on a case of fungus ball in a 20-year-old female with refractory chronic rhinosinusitis (RCRS) and bronchial asthma due to the black yeast Exophiala oligosperma which was confirmed by mycological and molecular (sequences of ITS rDNA) investigations. Exophiala oligosperma has previously not...
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PMID: 21528779
PDF is available here.
Abstract
The new generation nebuliser PARI eFlow® rapid allows a highly efficient aerosol delivery at reduced inhalation time. However, lung function data during long-term use of this device are not available until now.
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PMID: 21463983
PDF is available here.
Abstract
Samples of airborne PM with different size were collected by cascade impactor (Andersen) in Beijing during the Beijing Olympics. Organic carbon (OC) and elemental carbon (EC) in particles were determined by DRI Model 2001 A t carbon analyzer of USA. PM (56%), OC (55%) and EC (73%) were associated wit...
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PMID: 21528548
PDF is available here.
Abstract
The droplets exhaled by an index patient with infectious disease such as influenza or tuberculosis may be the carriers of contagious agents. Indoor environments such as the airliner cabins may be susceptible to infection from such airborne contagious agents. The present investigation computed the tr...
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PMID: 21208287
PDF is available here.
Abstract
In this study, single-particle characterization of aerosol particles collected at an underground shopping area was performed for the first time. A quantitative single-particle analytical technique, low-Z particle electron probe X-ray microanalysis, was used to characterize a total of 7900 individual...
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PMID: 20846210
PDF is available here.
Abstract
The spray drying technique was used to obtain the roxithromycin containing microcapsules with high taste masking efficiency. Eudragit L30D-55 was chosen as a barrier coating. The taste was evaluated by an electronic tongue, and taste-masking effect in water lasted at least several dozen hours.
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PMID: 21796943
PDF is available here.
Abstract
This study aims to evaluate the effect of combining the confidingly preferred modality of radiofrequency (RF) application with intranasal corticosteroid spray treatment on the efficacy of RF and on the number of sessions in patients with hypertrophy of inferior turbinate.
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PMID: 21303311
PDF is available here.
Abstract
We had searched a substance that inactivated sweat antigen adopting histamine release test. And we found that tannic acid which selected by screening various natural products inactivated sweat antigen....
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PMID: 21346405
PDF is available here.
Abstract
We oxidized n-pentanal, n-octanal, n-undecanal and n-tridecanal with OH radicals at high NO(x). The C(n-1) aldehyde molar yields after the peroxyl radical + NO reaction were 69 ± 15, 36 ± 10, 16 ± 5 and 4 ± 1%, respectively. Complementary structure-activity relationship calculations of important...
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PMID: 20856967
PDF is available here.
Abstract
We evaluated differences in airway versus systemic inflammatory responses to primary versus secondary organic particle components, particle size fractions, and the potential of particles to induce cellular production of reactive oxygen species.
A total of 60 elderly subjects contributed up to 12 wee...
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PMID: 20811287
PDF is available here.
Abstract
Chemical tracer methods for determining contributions to primary organic aerosol (POA) are fairly well established, whereas similar techniques for secondary organic aerosol (SOA), inherently complicated by time-dependent atmospheric processes, are only beginning to be studied. Laboratory chamber exp...
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PMID: 21141432
PDF is available here.
Abstract
To obtain the characteristic factors or signatures of particulate polycyclic aromatic hydrocarbons (PAHs) to help identify the sources of particulate PAHs in the atmosphere, different carbonaceous aerosols were generated by burning different fossil fuels and biomass under different conditions in the...
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PMID: 21141424
PDF is available here.
Abstract
Electronic cigarettes (e-cigarettes) aerosolize nicotine and produce a vapor that emulates that of cigarettes but purportedly has fewer traditional toxins than secondhand smoke. Although e-cigarettes are widely sold online and by retailers, new research suggests that they may contain unexpected toxi...
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PMID: 21041581
PDF is available here.
Annele Virtanen,
Jorma Joutsensaari,
Thomas Koop,
Jonna Kannosto,
Pasi Yli-Pirilä,
Jani Leskinen,
Jyrki M Mäkelä,
Jarmo K Holopainen,
Ulrich Pöschl,
Markku Kulmala,
Douglas R Worsnop and
Ari Laaksonen
Abstract
We present experimental evidence that they can be solid under ambient conditions. We investigated biogenic SOA particles formed from oxidation products of VOCs in plant chamber experiments and in boreal forests within a few hours after atmospheric nucleation events. On the basis of observed particle...
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PMID: 20944744
PDF is available here.
Abstract
Our results indicate that in vitro simulated drug delivery using this method of recording using a flow chamber, closely approximates ex vivo total drug delivery. This technique allows for recording of breathing on patients while they are using spacers, with minimum increase in dead space or resistan...
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PMID: 20455768
PDF is available here.
Abstract
Our aim was to investigate the potential of the DustGun aerosol technology integrated with the isolated, perfused, and ventilated lung of the rat (IPL) to study the pulmonary disposition of an inhaled model biopharmaceutical, the 40-kDa protein horseradish peroxidase (HRP).
The DustGun aerosol techn...
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PMID: 20455769
PDF is available here.
Abstract
Droplet evaporation has been known to bias cascade impactor measurement of aerosols generated by jet nebulizers. Previous work suggests that vibrating mesh nebulizers behave differently from jet nebulizers. Unlike jet nebulizers, vibrating mesh nebulizers do not rely on compressed air to generate dr...
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PMID: 20455771
PDF is available here.
Abstract
Nasal continuous positive airway pressure (nCPAP) is an accepted mode of respiratory support for preterm infants with respiratory insufficiency. To avoid potential sequelae of endotracheal (ET) intubation and mechanical ventilation, prophylactic aerosolization of surfactant delivered via nCPAP has b...
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PMID: 20455772
PDF is available here.
Abstract
Our study suggests that the use of prefilled dry powder inhalers as well as inhalation instruction increases correct inhalation technique. Simultaneous use of different types of inhalation devices has to be discouraged....
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PMID: 20804428
PDF is available here.
Abstract
The relative importance of different routes of influenza transmission, including the role of bioaerosols, and ability of masks and/or hand hygiene to prevent transmission, remains poorly understood. Current evidence suggests that infectious virus is not typically released from adults after 5 days of...
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PMID: 20923613
PDF is available here.
Abstract
These results may have infection control implications for other airborne infections, such as severe acute respiratory syndrome and tuberculosis, as well as for pandemic influenza infection....
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PMID: 20923611
PDF is available here.
Abstract
In order to fulfil the EU-limitations of fine dust and traffic-produced gases Cologne installed 2008 one of the first German environmental zones, from which stepwise vehicles with too high emissions will be locked out. Verification of effectiveness and the research on further strategies to reduce fi...
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PMID: 20542442
PDF is available here.
Abstract
To report a case of recurrent Stenotrophomonas maltophilia ventilator-associated pneumonia (VAP) that was successfully treated with doxycycline and aerosolized colistin.
A 28-year-old male was admitted with a severe head injury and required mechanical ventilation. The patient developed S. maltophili...
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PMID: 20736426
PDF is available here.
Abstract
These results demonstrate that NP inhalations produce rapid increases in plasma nicotine concentrations, provide satisfaction and are well tolerated. At the 20 μg/puff dose, peak nicotine concentrations were higher than with the Nicotrol/Nicorette nicotine vapor inhaler cartridge. Further trials of...
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PMID: 20939642
PDF is available here.
Abstract
Real-world particulate emission measurements usually include a fresh nanoparticle mode called the nucleation mode. The formation of the nucleation mode during mixing, dilution, and cooling of diesel exhaust is discussed based on existing experimental and modeling data. The further evolution of the n...
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PMID: 21090552
PDF is available here.
Abstract
This paper presents the measurement of airborne particle properties with use of a dedicated sampling protocol and a measurement setup directly installed in the exhaust line of vehicles and engines. The sampling system dilutes a small part of the exhaust directly at the tailpipe without the need of e...
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PMID: 21090550
PDF is available here.
Abstract
The Coordinating Research Council convened two Real-Time PM Measurement Workshops in December 2008 and March 2009 to take an intensive look at the current status and future directions of combustion aerosol measurement. The purpose was to examine the implications of parallel rapid developments over t...
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PMID: 21090546
PDF is available here.
Abstract
Transmission of respiratory infectious diseases in humans, for instance influenza, occurs by several modes. Respiratory droplets provide a vector of transmission of an infectious pathogen that may contribute to different transmission modes. An epidemiological model incorporating the dynamics of inha...
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PMID: 20164087
PDF is available here.
Abstract
Contaminated environmental surfaces are important reservoirs in the transmission of many human pathogens. Although several options exist for disinfecting contaminated environmental surfaces, few are compatible with use on both hard smooth non-porous (hard) and soft porous surfaces (soft) while still...
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PMID: 20574884
PDF is available here.
Abstract
Aerosol and gaseous pollution measurements were carried out at an urban background site in the south of Italy located near an industrial complex. Collection of 24 h samples of PM10 and PM2.5 and successive chemical quantification of metals were performed. Data were compared with measurements taken a...
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PMID: 20559588
PDF is available here.
Abstract
We measured the effects of filtration and deflection achieved with surgical masks and N95 respirators.
We constructed a chamber designed to produce radiolabeled wet aerosols simulating contaminated particles exhaled during tidal breathing (source). Particles within the chamber were exposed to either...
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PMID: 20736113
PDF is available here.
Abstract
We examined the systemic and local effects of aerosol gemcitabine on lung and pulmonary metastasis in this relevant large-animal tumor model using serial laboratory and arterial blood gas analysis and histopathology and immunohistochemistry, respectively.
Six hundred seventy-two 1-h doses of aerosol...
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PMID: 19803732
PDF is available here.
Abstract
The Staccato system employs a thermal vaporization technology to generate pure drug aerosols with a particle size optimized for alveolar deposition, leading to rapid absorption of the drug into the systemic circulation. Unlike most traditional aerosol-generation techniques, the particle size of the...
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PMID: 20528148
PDF is available here.
Abstract
We have demonstrated that the cell surface Fas expression, the Fas/FasL signaling pathway, and the constitutive expression of FasL in the lung microenvironment play a critical role in the metastatic potential of OS cells. Here we review the status of Fas expression in two sets of OS cells, human SAO...
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PMID: 20528149
PDF is available here.
Abstract
Acquisition of Pseudomonas aeruginosa, the most prevalent organism isolated from cystic fibrosis (CF) airways, is associated with an accelerated clinical deterioration and reduced survival. Strategies to chronically suppress P. aeruginosa infections in individuals with CF have evolved over the last...
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PMID: 20658904
PDF is available here.
Abstract
Pseudomonas aeruginosa is a common and important pathogen in people with cystic fibrosis (CF). With the advent of modern genotyping, a number of clonal strains of P. aeruginosa have been identified, some of which are associated with increased morbidity. The route of cross-infection between people wi...
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PMID: 20658913
PDF is available here.
Abstract
Netilmicin is a semi-synthetic aminoglycoside antibiotic used against a broad spectrum of Gram-negative bacteria. A reversed-phase high-performance liquid chromatographic method has been developed to determine the composition of netilmicin sulfate and to estimate its related substances without pre-...
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PMID: 20819288
PDF is available here.
Abstract
We investigated PM(2.5) nitrite, nitrate, sulfate, chloride, sodium, ammonium, calcium, and magnesium ions using a URG 9000-D aerosol ion monitor with 1-h time-resolution and detection limit of 0.1 microg/m(3). The gas phase is separated from the aerosol phase with a liquid diffusion parallel-plate...
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PMID: 20819279
PDF is available here.
Abstract
In this study, epirubicin (EPI)-loaded solid lipid nanoparticles (EPI-SLNs) were successfully prepared as an inhalable formulation for treatment of lung cancer. The physicochemical properties and in vitro pulmonary deposition of EPI-SLNs was studied. Pharmacokinetics were studied in rats by inhalati...
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PMID: 20824958
PDF is available here.
Abstract
We describe here, the development of the design and the protocol for this device. By testing aerosol formulations of budesonide and salbutamol sulphate, respectively, reproducible deposition of aerosol particles on, and the integrity of, the pulmonary cell monolayer could be demonstrated.
2010 FRAME...
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PMID: 20822321
PDF is available here.
Abstract
The major objective of this study was: discriminatory assessment of dry powder aerosol performance using standardized entrainment tubes (SETs) and lactose-based formulations with two model drugs. Drug/lactose interactive physical mixtures (2%w/w) were prepared. Their properties were...
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PMID: 20198688
PDF is available here.
Abstract
The objectives of this study were: systematic investigation of dry powder aerosol performance using standardized entrainment tubes (SETs) and lactose-based formulations with two model drugs; mechanistic evaluation of performance data by powder aerosol deaggregation equation (PADE). T...
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PMID: 20222025
PDF is available here.
Abstract
The relationship between physicochemical properties of drug/carrier blends and aerosol drug powder delivery was evaluated. Four pulmonary drugs each representing the major pulmonary therapeutic classes and with a different pharmacological action were employed. Specifically, the four...
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PMID: 20229601
PDF is available here.
Abstract
Aerosolization performance of dry powder blends of drugs for the treatment of asthma or chronic obstructive pulmonary diseases have been reported in three previous articles. In vitro aerosolization was performed at defined shear stresses (0.624-13.143 N/m(2)). Formulations were chara...
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PMID: 20232454
PDF is available here.
Abstract
We discard the initial assumption, and extended the Monte Carlo simulation study to examine the influence of both input variable variation and product performance measurement variation on the uncertainty in DOE model coefficients. The Monte Carlo simulations presented in this article illustrate the...
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PMID: 20564385
PDF is available here.
Abstract
Our results suggest that nasal deposition of albuterol aerosol generated by a pneumatic nebulizer in 9-month-old infants may be significantly affected by changes in TV, ranging between 50 to 200 mL, whereas total lung deposition may not be affected. These results also predict that environmental loss...
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PMID: 20496045
PDF is available here.
Abstract
We investigated the condensed-phase reactions of biogenic VOCs with C double bond C bonds (limonene, C(10)H(16), and terpineol, C(10)H(18)O) catalyzed by sulfuric acid by both bulk solution (BS) experiments and gas-particle (GP) experiments using a flow cell reactor. Product analysis by gas chromato...
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PMID: 20550185
PDF is available here.
Abstract
We use it to quantify organic nitrates in secondary organic aerosol generated from high-NO(x) photooxidation of limonene, alpha-pinene, Delta-3-carene, and tridecane. In these experiments the organic nitrate moiety is observed to be 6-15% of the total SOA mass....
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PMID: 20575535
PDF is available here.
Abstract
We demonstrate the first evidence of nitrogenated organic aerosol production by extreme ultraviolet-vacuum ultraviolet irradiation of a N(2)/CH(4) gas mixture. The ultrahigh-mass-resolution study with laser desorption ionization-Fourier transform-ion cyclotron resonance mass spectrometry of N(2)/CH(...
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PMID: 20616074
PDF is available here.