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Suspensions (0):
Recent article
Suspensions
Abstract
Background and Objective: The primary objective of this study was to characterize the pharmacokinetic profile of pantoprazole delayed-release granules in infants and children aged 1 month to
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PMID: 21740077
PDF is available here.
PDF is available here.
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Abstract
The effect of temperature stresses on Cefaclor suspensions under different storage conditions for a duration of 14 days was tested. The degradation of Cefaclor was determined on the 2nd, 7th and 14th day after reconstitution using a sensitive and precise Reversed phase High Performance Liquid Chromat...
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PMID: 21715263
PDF is available here.
PDF is available here.
Abstract
Nevirapine is a poorly water-soluble antiretroviral drug. Intravenous nevirapine nanosuspensions (NS) (457 ± 10 nm) were prepared by high-pressure homogenization. NS were surface modified by stabilizer adsorption, e.g., serum albumin, polysaccharide and polyethylene glycol (PEG) 1000. The NS were ch...
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PMID: 21094278
PDF is available here.
PDF is available here.
Abstract
We discuss, production, characterization and in-vivo evaluation of nevirapine nanosuspensions. Laser diffraction showed that the average particles size was 457 nm. Following single-dose administration, the plasma gamma concentration profiles showed fast release. Macrophage uptake studies confirmed e...
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PMID: 21699078
PDF is available here.
PDF is available here.
Abstract
Abstract
Nonmagnetic microparticles (e.g., cells, polymer beads) immersed in a magnetic fluid (ferrofluid) under a nonuniform magnetic field experience a magnetophoretic force in the direction of decreasing magnetic field strength. This phenomenon was exploited in the development of a continu...
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PMID: 21608138
PDF is available here.
PDF is available here.
Abstract
Functionalized iron oxide nanoparticles have attracted an increasing interest in the last 10 years as contrast agents for MRI. One challenge is to obtain homogeneous and stable aqueous suspensions of iron oxide nanoparticles without aggregates. Iron oxide nanoparticles with sizes aro...
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PMID: 21698771
PDF is available here.
PDF is available here.
Abstract
Dihydroartemisinin (DHA) is a poorly water-soluble drug that displays low bioavailability after oral administration. Attempts have been made to improve the solubility of DHA. Yet, no information is available concerning improved bioavailability. This study aimed to improve the water solubility of DHA...
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PMID: 21656361
PDF is available here.
PDF is available here.
Abstract
The polymorphic and pseudopolymorphic forms of CG-400549, a novel FabI inhibitor with potent in vivo activity were prepared and characterized by differential scanning calorimetry (DSC), powder X-ray diffractometry (PXRD) and thermogravimetric analysis (TG). Seven crystal forms of CG-400549, one anhyd...
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PMID: 21656363
PDF is available here.
PDF is available here.
Abstract
The potential of positively charged polymeric nanoparticles in improving therapeutic efficacy of meloxicam (MLX), a poorly water-soluble anti-inflammatory agent was evaluated. MLX loaded positively charged nanoparticles were prepared by using poly-epsilon-caprolactone (PCL) as a biodegradable polymer...
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PMID: 21699066
PDF is available here.
PDF is available here.
Abstract
We present a kinetic model for flowing active suspensions and analyze the behavior of a suspension subjected to a weak steady shear. Asymptotic solutions are sought in Deborah number expansions. At the leading order, we explore the steady states and perform their stability analysis. We predict the r...
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PMID: 21517529
PDF is available here.
PDF is available here.
Abstract
We measured Brownian displacements of microspheres exposed to light of varying intensities and wavelengths. Displacements were consistently diminished in an intensity-dependent and wavelength-dependent fashion, and center-to-center distances between microspheres were shifted to higher values. We con...
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PMID: 21287689
PDF is available here.
PDF is available here.
Abstract
We describe successful scaled-up production of ESCs on microcarriers in a stirred culture system in a serum-free medium. Cells expanded on CultiSpher S, Cytodex 3, and Collagen microcarriers showed superior cell-fold expansions of 439, 193, and 68, respectively, without excessive agglomeration, comp...
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PMID: 21538971
PDF is available here.
PDF is available here.
Abstract
The objective of this work was to develop and evaluate reconstitutable suspensions of ibuprofen-loaded microspheres prepared with an acrylic polymer (Eudragit RS-PM). The microspheres were prepared by the quasi-emulsion solvent diffusion technique. To prepare reconstitutable suspension formulation, t...
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PMID: 21796942
PDF is available here.
PDF is available here.
Abstract
We present a detailed AFM study on multilayered dry lipid films prepared from aqueous vesicle suspensions. Different preparation techniques were applied in order to optimize the preparation of homogeneous lipid films of various film thicknesses. Suspensions of preformed DOPC/DPPC vesicles were adsor...
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PMID: 20832257
PDF is available here.
PDF is available here.
Abstract
Peculiarities of breathing of cultures of cells producing biologically active compounds (isoprenoids and alkaloids) were investigated in order to optimize productivity of culture growth and biosynthesis. It had been revealed that studied cultures of cells of Dioscorea deltoidea Wall (producer of furi...
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PMID: 21442926
PDF is available here.
PDF is available here.
Ugeskrift for laeger (172)50 2010
Abstract
We wanted to test whether we, by using data on thousands of prescriptions, could answer a prosaic yet very timely question: Which penicillin is most widely accepted?
By use of the Odense PharmacoEpidemiological Database (OPED) we extracted data on all penicillin prescriptions issued to children in t...
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PMID: 21156107
PDF is available here.
PDF is available here.
Abstract
We report the physico-chemical characterisation of fatty acid stabilised aqueous magnetic fluids, which are ideal systems for studying the influence of nanoparticle aggregation on the emergent magnetic resonance properties of the suspensions. Stable colloids of superparamagnetic magnetite, Fe(3)O(4)...
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PMID: 20922236
PDF is available here.
PDF is available here.
Analyst (Cambridge UK) (135)11 2010
Abstract
Using an aqueous two-phase system comprised of dextran and polyethylene glycol, this article describes the stable spatial patterning of sub-microlitre droplets of bacterial suspensions. Microdroplets of different types of bacterial populations are positioned and maintained adjacent to each other wit...
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PMID: 20838666
PDF is available here.
PDF is available here.
Farmacia Hospitalaria (35)1 2010
Abstract
The final concentration at 6 months for both the 2.5% and 5% carbamazapine suspensions was 22.9 and 45.9mg/ml respectively, with calculated richness values between 90 and 110% fulfilling USP23 NF18 requirements. No changes in physical properties and no culture growth were observed during the study p...
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PMID: 20933450
PDF is available here.
PDF is available here.
Abstract
The formulation variables required for the production of spray-dried oily core nanocapsules (NCs) with targeted size and drug payload were optimized using a Box-Behnken experimental design. These NCs were characterized for size, morphology, encapsulation efficiency (EE%) and drug release kinetics, cr...
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PMID: 20928871
PDF is available here.
PDF is available here.
Lab On a Chip (10)18 2010
Abstract
We report an approach utilizing a suspended nanoparticle crystal (S-NPC) as an electrical read-out biosensor based on a nanofluidic electrokinetics principle. As a preliminary demonstration, streptavidin-modified S-NPC with a particle diameter of 520 nm was used to detect biotin in a PBS buffer. The...
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PMID: 20544114
PDF is available here.
PDF is available here.
Cold Spring Harbor Protocols (2010)9 2010
Abstract
We describe a protocol for FISH in solution that can be performed entirely in suspension, in a microcentrifuge tube format, prior to microscopy. This protocol can be applied to both gram-positive and -negative cells, as well as complex microbial assemblages. The method employs a rapid technique for...
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PMID: 20810640
PDF is available here.
PDF is available here.
Nanotechnology (21)34 2010
Abstract
We investigated the covalent biofunctionalization of magnetic nanoparticles based on carbodiimide activation. An important aspect in the covalent biofunctionalization of nanoparticles has been neglected, namely pre-concentration. Exploiting the electrostatic attraction forces between a protein and t...
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PMID: 20683138
PDF is available here.
PDF is available here.
Pharmaceutical Research (27)8 2010
Abstract
A computational fluid dynamics (CFD) study examined the impact of particle size on dissolution rate and residence of intravitreal suspension depots of Triamcinolone Acetonide (TAC).
A model for the rabbit eye was constructed using insights from high-resolution NMR ima...
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PMID: 20467888
PDF is available here.
PDF is available here.
Abstract
We have demonstrated phototoxic effects of curcumin in selected aqueous preparations against both gram-positive Enterococcus faecalis and Streptococcus intermedius and gram-negative Escherichia coil bacteria in vitro. One of the most efficient preparations was curcumin in polyethylene glycol (PEG 40...
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PMID: 20824961
PDF is available here.
PDF is available here.
Abstract
In this study the effects of an aqueous suspension of a commercial preparation of the mushroom Coprinus comatus on oxidative stress induced in rats by alloxane and carbon tetrachloride was examined. The effects were estimated from changes in the biochemical parameters (xanthine oxidase, glutathione...
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PMID: 20657376
PDF is available here.
PDF is available here.
Abstract
The anomalous acidic properties of the coarse grades of anhydrous calcium hydrogen phosphate are commented and a tentative elucidation of this is proposed.
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PMID: 20662325
PDF is available here.
PDF is available here.
Abstract
Poorly water-soluble compounds are difficult to develop as drug products using conventional formulation techniques and are frequently abandoned early in discovery. In the present study, a nanoprecipitation-high-frequency ultrasonication technique was adapted to produce drug nanosuspensions. The form...
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PMID: 20662313
PDF is available here.
PDF is available here.
Journal of Hazardous Materials (178)1-3 2010
Abstract
This paper reports arsenic methylation in betaine-nontronite clay-water suspensions under environmental conditions. Two nontronites (<0.05 mm), NAu-1 (green color, Al-enriched) and NAu-2 (brown color, Al-poor, contains tetrahedral Fe) from Uley Mine - South Australia were selected for this study. Be...
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PMID: 20189716
PDF is available here.
PDF is available here.
Abstract
We investigated (i) the impact of SWNT concentration on cell growth and biofilm formation, (ii) toxic effects of SWNTs on mature biofilms, and (iii) formation of biofilm on SWNT-coated surfaces. The results show that at the initial stage of biofilm formation, SWNTs come into contact with bacterial c...
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PMID: 20465305
PDF is available here.
PDF is available here.
Abstract
We present an approach to gain well-dispersed nanoparticles in physiological media. Therefore, a step-by-step procedure is demonstrated on two different tungsten carbide nanopowders which can be transferred to other powders. The procedure includes a comprehensive powder characterization, followed by...
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PMID: 20795896
PDF is available here.
PDF is available here.
Abstract
Solid dispersions of artemether (ARM), a poorly soluble drug, were prepared using polyvinylpyrrolidone (PVPK25, MW 25000) and polyethyleneglycol (PEG4000, MW 4000) as excipients. These dispersions were studied by physical mixture, freeze-drying, and melting methods. They were characterized by X-ray...
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PMID: 20607495
PDF is available here.
PDF is available here.
Abstract
PX-18 is a new highly potent phospholipase A(2) inhibitor with a poor aqueous solubility. Therefore, it was formulated as nanosuspensions with an active content of 1% (w/w), 5% (w/w) and 10% (w/w) using high-pressure homogenization. By contact angle measurements on compressed discs of PX-18, Tween 8...
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PMID: 20214969
PDF is available here.
PDF is available here.
Abstract
The aims of this study were to investigate and characterize the physico-chemical properties of beclomethasone dipropionate (BDP) crystallized from tricholoromonofluoromethane (CFC-11). Physical interactions in a model pressurised metered dose inhaler (pMDI) system and changes in surface energy after...
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PMID: 20184946
PDF is available here.
PDF is available here.
The Journal of Chemical Physics (132)17 2010
Abstract
We parametrize the SRD fluid to provide a one to one match in the shear viscosity of a Lennard-Jones fluid and present viscosity measurements for a range of such parameters. We demonstrate how to apply the Müller-Plathe reverse perturbation method for determining the shear viscosity of the SRD flui...
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PMID: 20459155
PDF is available here.
PDF is available here.
Abstract
We demonstrate the preparation of a highly stable BLM that retains significant fluidity by using a mixture of polymerizable and nonpolymerizable phospholipids. Alamethicin, a voltage-gated peptide channel for which membrane fluidity is required for activity, was reconstituted into mixed BLMs prepare...
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PMID: 20441163
PDF is available here.
PDF is available here.
Abstract
The work describes a study of the oxidation power of N-doped and undoped anatase TiO(2), as well as TiO(2) Degussa P25 suspensions for photocatalytic degradation of the herbicides RS-2-(4-chloro-o-tolyloxy)propionic acid (mecoprop) and 3,6-dichloro-pyridine-2-carboxylic acid (clopyralid) using visib...
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PMID: 20657461
PDF is available here.
PDF is available here.
Lab Animal (39)5 2010
Abstract
To assess a drug's toxic or carcinogenic effects on neonatal and adult mice and rats, researchers often carry out oral gavage studies. Whether dosed singly or in various combinations, provided as soluble solutions or as colloidal suspensions, the drug must be delivered in accurate and precise doses....
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PMID: 20410899
PDF is available here.
PDF is available here.
Abstract
We present a theory of the effective viscosity eta(s) of a concentrated suspension of uncharged polymer-coated spherical particles, which are termed uncharged spherical soft particles, in a liquid of viscosity eta on the basis of a cell model. These particles consist of the uncharged particle core o...
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PMID: 20000425
PDF is available here.
PDF is available here.
Abstract
An unknown impurity (degradation product) present at a level below 0.1% in the initial sample was increased to 0.25% in 50 degrees C 3 M stability samples of lamivudine, zidovudine and nevirapine tablets for oral suspension, as detected by gradient reverse phase HPLC. This degradation product was is...
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PMID: 20503923
PDF is available here.
PDF is available here.
Abstract
Particle/binder/solvent systems are widely used in many applications and have long been studied. Understanding and controlling polymer adsorption in these complex material systems are important to achieve successful final performance. In this study, the effect of polymer adsorption on film formation...
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PMID: 20096848
PDF is available here.
PDF is available here.
Abstract
Formulation of a new Prednisolone acetate (1%) ophthalmic suspension to obtain a better contactibility of the drug at the site of action. The formulation was evaluated and optimized based on physiological, physicochemical and pharmaceutical parameters and prepared aseptically, keeping particle size...
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PMID: 20363691
PDF is available here.
PDF is available here.
Methods in Molecular Biology (633)633 2010
Abstract
Limited understanding of the cell biology of the breast and breast cancer hampers our ability to develop new therapeutic approaches. Mouse models of mammary gland development and tumourigenesis are key to developing new insights into the biology of both the normal and diseased tissues. Recent advanc...
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PMID: 20204626
PDF is available here.
PDF is available here.
Physical Review Letters (104)9 2010
Abstract
We relate these macroscopic measurements to the orientation of individual swimming cells under flow and discuss our results in the light of several existing models....
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PMID: 20367014
PDF is available here.
PDF is available here.
Abstract
Meloxicam gel was designed based on the matching of the solubility parameter (delta) of the drug with that of the polymer and subsequently with skin for improved dermal delivery of meloxicam. The delta of meloxicam (11.48 (cal/cm(3))(0.5)) determined by solubility measurement was matched statistical...
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PMID: 20077041
PDF is available here.
PDF is available here.
Planta Medica (76)4 2010
Abstract
The Mexican species GALPHIMIA GLAUCA (Cav.) Kuntze (Malphigiaceae) synthesises a family of sedative and anxiolytic nor-secofriedelanes, designated as galphimines. These active principles accumulate at low concentration in the aerial parts of plants from wild populations. Transformed calluses and cel...
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PMID: 19809970
PDF is available here.
PDF is available here.
Abstract
We demonstrate a proof-of-concept digital electrospray. This system consists of a 61-nozzle array microfabricated in silicon and a 61-element digital extractor fabricated using flexible polyimide substrates. "Digital" refers to the state of each electrospray source that can be tuned either on or off...
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PMID: 20370220
PDF is available here.
PDF is available here.
Abstract
A specific, fast and sensitive high performance liquid chromatography coupled to an electro spray tandem triple quadrupole mass spectrometer (LC-MS/MS) assay was developed for the determination of nimesulide in human plasma using carbamazepine as the internal standard. The lower limit of quantificat...
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PMID: 20197019
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To investigate the effects of light on baicalin,baicalein accumulation and related genes expression in suspension cultures of Scutellaria baicalensis. METHOD: The content of baicalin, baicalein in suspension cultures of S. baicalensis was determined by HPLC. The related genes expression w...
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PMID: 20545186
PDF is available here.
PDF is available here.
Physical Review Letters (104)6 2010
Abstract
We use a mesoscopic simulation technique to study the effect of short-ranged interparticle attractions on the steady-state sedimentation of colloidal suspensions. Attractions increase the average sedimentation velocity v(s) compared to the pure hard-sphere case, and for strong enough attractions, a...
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PMID: 20366858
PDF is available here.
PDF is available here.
Ecotoxicology (19)2 2010
Abstract
Groups of the mussel Perna perna were transplanted to two points and at three different depths in the coastal region close to the Itajaí-Açu River mouth, an impacted river in the south of Brazil. With the objective of evaluating the physiology changes in the organisms in relation t...
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PMID: 19795207
PDF is available here.
PDF is available here.
Ecotoxicology (19)2 2010
Abstract
Groups of the mussel Perna perna were transplanted to two points and at three different depths in the coastal region close to the Itajaí-Açu River mouth, an impacted river in the south of Brazil. With the objective of evaluating the physiology changes in the organisms in relation t...
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PMID: 19795207
PDF is available here.
PDF is available here.
Ecotoxicology (19)2 2010
Abstract
Groups of the mussel Perna perna were transplanted to two points and at three different depths in the coastal region close to the Itajaí-Açu River mouth, an impacted river in the south of Brazil. With the objective of evaluating the physiology changes in the organisms in relation t...
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PMID: 19795207
PDF is available here.
PDF is available here.
Ecotoxicology (19)2 2010
Abstract
Groups of the mussel Perna perna were transplanted to two points and at three different depths in the coastal region close to the Itajaí-Açu River mouth, an impacted river in the south of Brazil. With the objective of evaluating the physiology changes in the organisms in relation t...
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PMID: 19795207
PDF is available here.
PDF is available here.
Ecotoxicology (19)2 2010
Abstract
Groups of the mussel Perna perna were transplanted to two points and at three different depths in the coastal region close to the Itajaí-Açu River mouth, an impacted river in the south of Brazil. With the objective of evaluating the physiology changes in the organisms in relation t...
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PMID: 19795207
PDF is available here.
PDF is available here.
Ecotoxicology (19)2 2010
Abstract
Groups of the mussel Perna perna were transplanted to two points and at three different depths in the coastal region close to the Itajaí-Açu River mouth, an impacted river in the south of Brazil. With the objective of evaluating the physiology changes in the organisms in relation t...
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PMID: 19795207
PDF is available here.
PDF is available here.
Ecotoxicology (19)2 2010
Abstract
Groups of the mussel Perna perna were transplanted to two points and at three different depths in the coastal region close to the Itajaí-Açu River mouth, an impacted river in the south of Brazil. With the objective of evaluating the physiology changes in the organisms in relation t...
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PMID: 19795207
PDF is available here.
PDF is available here.
Ecotoxicology (19)2 2010
Abstract
Groups of the mussel Perna perna were transplanted to two points and at three different depths in the coastal region close to the Itajaí-Açu River mouth, an impacted river in the south of Brazil. With the objective of evaluating the physiology changes in the organisms in relation t...
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PMID: 19795207
PDF is available here.
PDF is available here.
Ecotoxicology (19)2 2010
Abstract
Groups of the mussel Perna perna were transplanted to two points and at three different depths in the coastal region close to the Itajaí-Açu River mouth, an impacted river in the south of Brazil. With the objective of evaluating the physiology changes in the organisms in relation t...
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PMID: 19795207
PDF is available here.
PDF is available here.