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Freund's Adjuvant (0):
Recent article
Freund's Adjuvant
Abstract
We have tested the effect of a novel anti-inflammatory peptide (KGHYAERVG, termed IIIM1) on experimental autoimmune encephalitis (EAE), an animal model of MS. Our findings demonstrate significant reduction in neurological score following oral administration of IIIM1. Structural studies revealed that...
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PMID: 20434883
PDF is available here.
PDF is available here.
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Journal of Neuroscience (30)26 2010
Abstract
We investigated the hippocampal TRPV1 (transient receptor potential vanilloid 1) expression in ovariectomized rats that received 17-beta-estradiol substitution and found that 17-beta-estradiol enhanced the mechanical allodynia of inflamed temporomandibular joint (TMJ) induced by complete Freund's ad...
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PMID: 20592193
PDF is available here.
PDF is available here.
Journal of Neuroimmunology (223)1-2 2010
Abstract
We consider the shifting valence of 'allergic' and 'autoimmune' in conceptions of experimental encephalomyelitis (EE). Ehrlich's dismissal of the relevance to disease of autoimmunity resulted in its 'long struggle for recognition' notwithstanding the convincing attribution in 1904 of the hemolysis o...
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PMID: 20427093
PDF is available here.
PDF is available here.
Anesthesiology (112)6 2010
Abstract
The data of this study suggest that NR1 siRNA has potential therapeutic value in the treatment of inflammatory pain induced or maintained by peripheral nociceptor activity and support the potential application of this method to the study of nociceptive processes and target the validation of pain-ass...
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PMID: 20463582
PDF is available here.
PDF is available here.
Abstract
Trichuris muris is a laboratory model for the human whipworm Trichuris trichiura which infects approximately 1 billion people in tropical and sub-tropical countries. The development of a vaccine would control trichuriasis by promoting the acquisition of immunity during childhood, thereby reducing fa...
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PMID: 19968992
PDF is available here.
PDF is available here.
Journal of Ethnopharmacology (128)3 2010
Abstract
The extract showed significant antinociceptive effects in persistent pain induced by CFA and on neuropathic pain induced by PLSN. The effects of Dioscorea bulbifera persisted for 5 days after two administrations in CFA-induced hypernociception. Dioscorea bulbifera significantly inhibited acute LPS-i...
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PMID: 20152893
PDF is available here.
PDF is available here.
Abstract
These results indicate that the full spectrum of marmoset experimental autoimmune encephalomyelitis can be induced by sensitization against a single MOG peptide in incomplete Freund adjuvant lacking microbial compounds for innate immune activation and by eliciting antigen-specific T-cell cytolytic a...
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PMID: 20448482
PDF is available here.
PDF is available here.
[Cross-protective effect of the Cp39 adhesive proteins against avian Pasteurella multicida in mice].
Abstract
SDS-PAGE indicated that the Cp39 protein was expressed in vitro and in vivo grown P. multocida. Mice immunized with rCp39, native Cp39 or capsular proteins from in vivo and in vitro grown strain C48-3 were protected completely against the challenge with the homologous strain C48-3, while 60 - 80% pr...
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PMID: 20499641
PDF is available here.
PDF is available here.
Abstract
We cloned gts from the genome of SC19, and inserted it into prokaryotic expression plasmid pET28a-gts. The recombinant vector was transformed into E. coli BL21. Induced by IPTG, one 58 kD protein, was expressed and purified by using Ni - NTA column (Novagen). The purity of rGtS was 93.3% and the con...
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PMID: 20499650
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
We examined whether fucoidan affected the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) in rats. EAE was induced in Lewis rats that were immunized with guinea-pig myelin basic protein (MBP) and complete Freund's adjuvant. Fucoidan (50 mg/kg, daily) was administered to rats wit...
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PMID: 19655293
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
We examined whether fucoidan affected the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) in rats. EAE was induced in Lewis rats that were immunized with guinea-pig myelin basic protein (MBP) and complete Freund's adjuvant. Fucoidan (50 mg/kg, daily) was administered to rats wit...
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PMID: 19655293
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
We examined whether fucoidan affected the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) in rats. EAE was induced in Lewis rats that were immunized with guinea-pig myelin basic protein (MBP) and complete Freund's adjuvant. Fucoidan (50 mg/kg, daily) was administered to rats wit...
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PMID: 19655293
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
We examined whether fucoidan affected the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) in rats. EAE was induced in Lewis rats that were immunized with guinea-pig myelin basic protein (MBP) and complete Freund's adjuvant. Fucoidan (50 mg/kg, daily) was administered to rats wit...
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PMID: 19655293
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
We examined whether fucoidan affected the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) in rats. EAE was induced in Lewis rats that were immunized with guinea-pig myelin basic protein (MBP) and complete Freund's adjuvant. Fucoidan (50 mg/kg, daily) was administered to rats wit...
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PMID: 19655293
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
We examined whether fucoidan affected the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) in rats. EAE was induced in Lewis rats that were immunized with guinea-pig myelin basic protein (MBP) and complete Freund's adjuvant. Fucoidan (50 mg/kg, daily) was administered to rats wit...
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PMID: 19655293
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
We examined whether fucoidan affected the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) in rats. EAE was induced in Lewis rats that were immunized with guinea-pig myelin basic protein (MBP) and complete Freund's adjuvant. Fucoidan (50 mg/kg, daily) was administered to rats wit...
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PMID: 19655293
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
We examined whether fucoidan affected the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) in rats. EAE was induced in Lewis rats that were immunized with guinea-pig myelin basic protein (MBP) and complete Freund's adjuvant. Fucoidan (50 mg/kg, daily) was administered to rats wit...
|
PMID: 19655293
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
We examined whether fucoidan affected the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) in rats. EAE was induced in Lewis rats that were immunized with guinea-pig myelin basic protein (MBP) and complete Freund's adjuvant. Fucoidan (50 mg/kg, daily) was administered to rats wit...
|
PMID: 19655293
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
We examined whether fucoidan affected the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) in rats. EAE was induced in Lewis rats that were immunized with guinea-pig myelin basic protein (MBP) and complete Freund's adjuvant. Fucoidan (50 mg/kg, daily) was administered to rats wit...
|
PMID: 19655293
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
We examined whether fucoidan affected the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) in rats. EAE was induced in Lewis rats that were immunized with guinea-pig myelin basic protein (MBP) and complete Freund's adjuvant. Fucoidan (50 mg/kg, daily) was administered to rats wit...
|
PMID: 19655293
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
We examined whether fucoidan affected the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) in rats. EAE was induced in Lewis rats that were immunized with guinea-pig myelin basic protein (MBP) and complete Freund's adjuvant. Fucoidan (50 mg/kg, daily) was administered to rats wit...
|
PMID: 19655293
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
We examined whether fucoidan affected the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) in rats. EAE was induced in Lewis rats that were immunized with guinea-pig myelin basic protein (MBP) and complete Freund's adjuvant. Fucoidan (50 mg/kg, daily) was administered to rats wit...
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PMID: 19655293
PDF is available here.
PDF is available here.
Abstract
We have observed strong antibody responses in mice without the coadministration of any additional adjuvant by noncovalently assembling a T and B cell epitope peptide into nanofibers using a short C-terminal peptide extension. Self-assembling peptides have been explored recently as scaffolds for tiss...
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PMID: 20080728
PDF is available here.
PDF is available here.
Abstract
Strychnos potatorum Linn (Loganiaceae) is a moderate sized tree found in southern and central parts of India, Sri Lanka and Burma. In traditional system of medicine, Strychnos potatorum Linn seeds were used for various ailments including inflammation, diabetes etc. To investigate the folkloric use o...
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PMID: 20939932
PDF is available here.
PDF is available here.
Molecular Pain (6)1 2010
Abstract
We have previously used the rat 4 day Complete Freund's Adjuvant (CFA) model to screen compounds with potential to reduce osteoarthritic pain. The aim of this study was to identify genes altered in this model of osteoarthritic pain and use this information to infer analgesic potential of compounds b...
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PMID: 20846436
PDF is available here.
PDF is available here.
Abstract
Quality control and quality assurance procedures are discussed for the agreed benchmark standard Freund's complete adjuvant (FCA). In addition, the use of the incomplete adjuvant (FIA) in the preparation of antisera is discussed. A major problem is the use of a safe and suitable mineral oil in FCA a...
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PMID: 20099121
PDF is available here.
PDF is available here.
Abstract
This study investigated possible implication of nitric oxide and prostanoids in anaphylactic reaction in small mesenteric and coronary arteries. MATERIAL AND METHODS. Isolated arteries from guinea pigs, sensitized with 0.5 mL of horse serum or sham-sensitized, were challenged with 1% of horse serum...
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PMID: 20234162
PDF is available here.
PDF is available here.
Abstract
The development of autoimmune myocarditis in rats after a single hypodermic injection of rat myosin mixed with a complete Freund's adjuvant (CFA) (400 microg/kg in 200 microl) was studied. The rats from the control group were injected with only CFA. The titer of antibodies to myosin, infiltration of...
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PMID: 21077370
PDF is available here.
PDF is available here.
Abstract
Premna corymbosa (Burm.f.) Rottl. & Willd. (Verbenaceae) is a small tree used in traditional medicine for rheumatic disorders and it is the one of the ingredient in many ayurvedic preparations available in the market for inflammatory disorder uses. The aim of this work was to evaluate the acute toxi...
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PMID: 20506686
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To study the effect of geniposide-acid(GA) on the anti-inflammatory action for adjuvant-induced arthritis (AA) rats and the proliferation of synoviocytes in AA rats and the feasible mechanism of apoptosis in vitro. METHOD: Forty-eight health male Wistar rats were divided randomly into six...
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PMID: 20222429
PDF is available here.
PDF is available here.
Abstract
We observed the rat common condition, weighed the rat body weight weekly, measured the degree of swelling of voix pedis every 4 days, weighed the thymus and spleen on the end of life, and measured the contents of cell factor TNF-alpha, IL-2, and IL-6 in rat blood serum. RESULT: As far as the arthros...
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PMID: 20353012
PDF is available here.
PDF is available here.
Abstract
We conclude that the lymphatic system plays an important role in the maintenance of the prooxidant-antioxidant balance under these pathological conditions....
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PMID: 20396744
PDF is available here.
PDF is available here.
Abstract
The subconjunctival injection of the alpha-MSH expression vector ACTH1-17 plasmid is effective in suppressing EAU. The suppressive activity is dependent on MC5r expression, and possibly works though alpha-MSH antagonism of inflammation than on alpha-MSH directly modulating immune cells. The results...
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PMID: 19426838
PDF is available here.
PDF is available here.
Parasitology (54)03 2009
Abstract
Evaluation of protective immunity of 28KD-GST as a vaccine against experimental Schistosoma mansoni.
Abstract
Schistosoma mansoni GST was purified from adult worm homogenates by affinity chromatography. SDS-PAGE analysis of the purified antigen revealed that SmGST has molecular weight around 28 KD was used as a vaccine in a dose of 25 and 35 microg. Eleven groups of BALB/c mice of 10 mice each were vaccinat...
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PMID: 19795747
PDF is available here.
PDF is available here.
Endocrinology (150)8 2009
Abstract
A greater incidence of temporomandibular joint (TMJ) pain is reported in females, suggesting that gonadal hormones may play a role in this condition. However, the exact roles of 17beta-estradiol (E2) and progesterone (P4) in TMJ pain are not completely known. Two experiments were performed to determ...
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PMID: 19359384
PDF is available here.
PDF is available here.
Muscle & Nerve (40)2 2009
Abstract
We examined the mRNA and protein expression of AChR-alpha as well as the pattern of alpha-bungarotoxin labeling in muscle tissue from EAMG mice with varying disease severity. AChR-alpha expression was increased considerably in endplates from mice with severe EAMG, but it was distinct and greatly in...
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PMID: 19609914
PDF is available here.
PDF is available here.
Abstract
Much of modern biology and biochemistry relies on the availability of highly specific antibodies for use in such ubiquitous techniques as immunohistochemistry, ELISAs, immunoprecipitation, and immunoblotting. Thus, the generation of large quantities of specific antibodies directed against proteins o...
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PMID: 19575471
PDF is available here.
PDF is available here.
Abstract
We investigated qualitative and quantitative changes in rat hind limb muscles caused by complete Freund's adjuvant (CFA)-induced knee joint pain. One week after CFA injection, muscle atrophy was induced only on the CFA-injected side. Wet weight of the rectus femoris (RF) and soleus (SOL) muscles wer...
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PMID: 19555394
PDF is available here.
PDF is available here.
Abstract
The pain thresholds to irradiation of the rats in Group 650 nm LI and Group CLI were significantly higher than those in Group MC and Group SI (P < 0.01), and the mast cell degranulation rate in Group 650 nm LI and Group CLI were also significantly higher than that in Group MC and Group SI (P < 0.001...
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PMID: 19563196
PDF is available here.
PDF is available here.
Abstract
We have investigated the efficacy and mechanism of curcumin against EAE. The treatment of Lewis rats with curcumin significantly reduced the clinical severity of EAE, and had a dramatic reduction in the number of inflammatory cells infiltration in the spinal cord. The proliferation of the MBP-reacti...
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PMID: 19539560
PDF is available here.
PDF is available here.
Abstract
Experimental autoimmune encephalomyelitis (EAE) is a Th17-mediated autoimmune disease and an animal model for multiple sclerosis (MS). Complete Freund's adjuvant (CFA) contains pathogen-associated molecular patterns (PAMPs) that bind toll-like receptors (TLRs), and is necessary to induce EAE. Upstre...
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PMID: 19211042
PDF is available here.
PDF is available here.
Abstract
We calculated that in 1 month one hen could produce more than 100 liters of antibody detection reagents or enough antibody to neutralize approximately 11.6 million mouse lethal doses of botulinum toxin. Utilization of an egg antibody platform is potentially rapid (28 to 70 days) and scalable to kilo...
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PMID: 19517727
PDF is available here.
PDF is available here.
Abstract
Lornoxicam exhibits strong analgesic but weak antipyretic effects in rats with paw inflammation. Such a separation of effects is related to its efficacy in the reduction of PGE2 levels in the paw and brain hypothalamus....
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PMID: 19405999
PDF is available here.
PDF is available here.
Abstract
We observed the differences among the foot joint destruction process of CIA to elucidate further the pathological process of this model. CIA was induced in male Wistar rat immunized with bovine type II collagen and Freund's incomplete adjuvant. Radiological studies were performed 1, 2, 4, 6, and 8 m...
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PMID: 18982329
PDF is available here.
PDF is available here.
Abstract
These results show that FK506-mPEG may be practically applicable as a prodrug for the immunosuppressant FK506....
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PMID: 19407973
PDF is available here.
PDF is available here.
The Journal of Pain (10)3 2009
Abstract
We used isobolographic analysis to examine the in vivo effects of the combination of the Nav1.8 blocker A-803467 [5-(4-Chloro-phenyl)-furan-2-carboxylic acid (3,5-dimethoxy-phenyl)-amide] with 2 structurally distinct TRPV1 antagonists, A-840257 [1-(1H-Indazol-4-yl)-3-([R]-4-piperidin-1-yl-indan-1-yl...
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PMID: 19070548
PDF is available here.
PDF is available here.
Congenital Anomalies (49)1 2009
Abstract
Maternal diabetes mellitus is associated with increased fetal teratogenesis, including cardiovascular defects. Non-specific maternal immune stimulation with Freund's complete adjuvant (FCA) or interferon gamma (IFNγ) has been associated with protection against birth malformations. Using a diabetic m...
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PMID: 19243410
PDF is available here.
PDF is available here.
Abstract
Maternal diabetes can induce a number of developmental abnormalities in both laboratory animals and humans, including deformities of the face and palate. The incidence of birth defects in newborns of women with diabetes is approximately 3 to 5 times higher than among nondiabetics. In mice, nonspecif...
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PMID: 19089897
PDF is available here.
PDF is available here.
Abstract
I (beta(2)-GP I)-specific antibodies (Abs) was detected in all groups but with specific, context-related properties. Analysis of pregnancy-related pathology (anti-beta(2)-GP I Abs-associated) showed differences in the pathological potential of the induced immune response. It was demonstrated that se...
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PMID: 19291092
PDF is available here.
PDF is available here.
Abstract
We generated mice with an Nmur1 deletion and then profiled the responses of these mice in a cutaneous inflammation model utilizing complete Freund's adjuvant (CFA). We report here that mice lacking Nmur1 had normal inflammation responses with moderate changes in serum cytokines compared to Nmur1(+/+...
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PMID: 19070594
PDF is available here.
PDF is available here.
Journal of Immunology (182)2 2009
Abstract
We investigated the contribution made by plasmacytoid DCs (pDCs) in the spontaneous breach of tolerance to arthritis-related self proteins, including rheumatoid factor, citrullinated peptide, and type II collagen observed in a novel arthritis model. Selective pDC depletion in vivo enhanced the sever...
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PMID: 19124739
PDF is available here.
PDF is available here.
Modern Rheumatology (19)5 2009
Abstract
We assessed the in vitro effects of imatinib on the proliferation of RA synovial fibroblast-like cells (RASFs) using a MTT assay. Intracellular signaling of PDGF was evaluated by Western blot analysis. Platelet-derived growth factor was found to induce a significant proliferation of RASFs, while ima...
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PMID: 19568828
PDF is available here.
PDF is available here.
Malaria Journal (8)1 2009
Abstract
AFCo1 significantly enhanced the IgG and T-cell response against MSP4 and MSP5, with a potency equivalent to CFA, with the response being characterized by both IgG1 and IgG2a isotypes, increased interferon gamma production and a strong DTH response, consistent with the ability of AFCo1 to induce Th1...
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PMID: 19250541
PDF is available here.
PDF is available here.
Abstract
Serum BLG-specific IgG1 and IgE concentrations were significantly higher in germ-free mice during the primary immune response and IgE production persisted longer in germ-free mice. Furthermore, secretion of BLG-specific IgA was evidenced only in feces from germ-free mice while, in contrast, fecal Ig...
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PMID: 18716405
PDF is available here.
PDF is available here.
Neuroendocrinology Letters (30 Suppl 1) 2009
Abstract
The beneficial effect of sesame oil on markers of oxidative stress accompanying AA was demonstrated by decrease of plasma TBARS and decrease of GGT activity in the joint and spleen tissues. Level of protein carbonyls, TAC in plasma and activity of NAGA in serum and in the kidney were improved, yet n...
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PMID: 20027138
PDF is available here.
PDF is available here.
Abstract
Experimental autoimmune encephalomyelitis (EAE), an animal model of Multiple Sclerosis, is induced after injection of PLP(139-151) myelin peptide in complete Freund's adjuvant into SJL/J mice. During EAE, T cells and macrophages infiltrate the brain, produce cytokines IL-17, IFN-gamma, TNF-alpha, or...
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PMID: 19022403
PDF is available here.
PDF is available here.
Transplantation (87)2 2009
Abstract
Our results demonstrated that CFA treatment ameliorates autoimmunity in diabetic NOD mice by up-regulating CD4=CD25+Foxp3+ regulatory T cells and increasing TGF-beta1 production. Exendin-4 enhanced the effect of CFA on reversing diabetes in NOD mice by stimulating beta-cell replication....
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PMID: 19155973
PDF is available here.
PDF is available here.
Abstract
We evaluated the effect of the co-administration of chitosan in the tolerance to type II collagen (CII) using an experimental model of arthritis. Rats were fed diluent (acetic acid), 1 mg CII, 1 mg chitosan or 1 mg CII + 1 mg chitosan during 5 days before immunization with CII in Freund's complete a...
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PMID: 19076832
PDF is available here.
PDF is available here.
Abstract
We examined the hypothesis that the upregulation of the NR1 subunit of the NMDA receptor (NR1) in the trigeminal subnucleus caudalis (Sp5c) following inflammation of the temporomandibular joint (TMJ) region would be regulated by interleukin-6 (IL-6) and the nuclear factor-kappa B (NF-kappaB). Inflam...
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PMID: 19058915
PDF is available here.
PDF is available here.