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Microscopy, Electron, Transmission (2):
Recent article
Microscopy, Electron, Transmission
Biochimica et Biophysica Acta (1808)11 2011
Abstract
We show that the negatively charged phospholipid phosphatidylserine (PS) is exposed in the outer leaflet of their plasma membrane not only in tumor cell lines, but also in metastases and primary cultures thereof, which contrasts with a lack of PS exposure by differentiated non-tumorigenic counterpar...
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PMID: 21810406
PDF is available here.
PDF is available here.
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Abstract
We present six design rules that can be used to deliberately prepare nine distinct colloidal crystal structures, with control over lattice parameters on the 25- to 150-nanometer length scale. These design rules outline a strategy to independently adjust each of the relevant crystallographic paramete...
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PMID: 21998382
PDF is available here.
PDF is available here.
Abstract
These results indicate that F. alocis has virulence properties that may enhance its ability to survive and persist in the periodontal pocket and may play an important role in infection-induced periodontal disease....
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PMID: 21825062
PDF is available here.
PDF is available here.
FEBS Journal (278)19 2011
Abstract
Through its capability to transiently pack and unpack our genome, chromatin is a key player in the regulation of gene expression. Single-molecule approaches have recently complemented conventional biochemical and biophysical techniques to decipher the complex mechanisms ruling chroma...
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PMID: 21810177
PDF is available here.
PDF is available here.
Abstract
We present a mouse model in which a polyclonal sheep anti-mouse podocyte Ab caused subepithelial immune complex formation. Mice developed a nephrotic syndrome with severe edema, proteinuria, hypoalbuminemia, and elevated cholesterol and triglycerides. Development of proteinuria was biphasic: an init...
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PMID: 21844386
PDF is available here.
PDF is available here.
Biomacromolecules (12)9 2011
Abstract
We propose substrate-independent modification for creating a protein-repellent surface based on dopamine-melanin anchoring layer used for subsequent binding of poly(ethylene oxide) (PEO) from melt. We verified that the dopamine-melanin layer can be formed on literally any substrate and could serve a...
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PMID: 21823677
PDF is available here.
PDF is available here.
Abstract
Healthy epithelial cells, in vivo, have the ability to synthesize gold nanoparticles when aqueous tetrachloroauric acid is made to react with human skin. Neither a reducing agent nor a protecting chemical is needed for this bio-synthesis method. The first indication of gold nanoparticle formation is...
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PMID: 21817787
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1812)9 2011
Abstract
We examined the expression of the receptor for advanced glycation end products (RAGE) and its downstream target gene, monocyte chemoattractant protein-1 (MCP-1) using real-time PCR. In in vitro studies, exposure to high glucose or AGE induced oxidative stress and activation of the AGE/RAGE system in...
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PMID: 21651980
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1808)10 2011
Abstract
We created specific STx1B- and STx2B-deficient mutants of E. coli O157:H7. Surprisingly, STxA subunit was absent in the OMVs and periplasm of the STxB-deficient mutants. In parallel, the A subunit of heat-labile toxin (LT) of enterotoxigenic E. coli (ETEC) was absent in the periplasm of the LT-B-def...
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PMID: 21762677
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1808)10 2011
Abstract
The interaction of the extra-membranous domain of tetrameric inwardly rectifying Kir2.1 ion channels (Kir2.1NC(4)) with the membrane associated guanylate kinase protein PSD-95 has been studied using Transmission Electron Microscopy in negative stain. Three types of complexes were observed in electron...
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PMID: 21756874
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1808)10 2011
Abstract
We studied the potential of monoolein (MO) as helper lipid for cellular transfection. Lipoplexes composed of pDNA and dioctadecyldimethylammonium bromide (DODAB)/1-monooleoyl-rac-glycerol (MO) at different molar ratios (4:1, 2:1 and 1:1) and at different cationic lipid/DNA ratios were investigated....
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PMID: 21787746
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1813)9 2011
Abstract
We briefly summarize the principles of nucleocytoplasmic transport, and then describe the diverse strategies used by viruses to deliver their genomes into the host nucleus. Some of the emerging mechanisms include: (1) nuclear entry during mitosis, when the nuclear envelope is disassembled, (2) viral...
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PMID: 21167871
PDF is available here.
PDF is available here.
Abstract
We focus on the planarian excretory system, which consists of internal protonephridial tubules. We find that these assemble into complex branching patterns with a stereotyped succession of cell types along their length. Organ regeneration is likely to originate from a precursor structure arising in...
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PMID: 21828097
PDF is available here.
PDF is available here.
Abstract
Therapy of cancer, including basallike breast tumors, that targets the epidermal growth factor receptor (EGFR) would greatly benefit from noninvasive methods that can quantitatively monitor receptor status and treatment response.
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PMID: 21849406
PDF is available here.
PDF is available here.
Abstract
The Gracilaria (G.) sp are widely used in the traditional medicine in Malaysia. The methanol extract of Gracilaria changii B.M. Xia & I.A. Abbott (Gracilariaciae) was evaluated for antiyeast activity against Candida albicans (Berkhout).
The antiyeast activities were s...
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PMID: 22013724
PDF is available here.
PDF is available here.
Abstract
Electrospun fabrics for use in, for example, tissue engineering, wound dressings, textiles, filters and membranes have attracted a lot of attention due to their morphological nanoscale architectures which enhance their physical properties. A thorough detailed internal morphological s...
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PMID: 21842086
PDF is available here.
PDF is available here.
Abstract
We visually distinguished two sequential steps of secretagogue-stimulated exocytosis: fusion of individual secretory granules (Weibel-Palade bodies [WPBs]) and subsequent expulsion of von Willebrand factor (VWF) content. Based on our observations, we conclude that for fusion, WPBs are released from...
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PMID: 21844207
PDF is available here.
PDF is available here.
Abstract
Epitaxial films of In(2)O(3) have been grown on Y-stabilised ZrO(2)(111) substrates by molecular beam epitaxy over a range of thicknesses between 35 and 420 nm. The thinnest films are strained, but display a 'cross-hatch' morphology associated with a network of misfit dislocations which allow partial...
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PMID: 21813945
PDF is available here.
PDF is available here.
Developmental Cell (21)2 2011
Abstract
We show that selective autophagy downregulates Ty1 transposition by eliminating Ty1 VLPs from the cytoplasm under nutrient-limited conditions. Ty1 VLPs are targeted to autophagosomes by an interaction with Atg19. We propose that selective autophagy safeguards genome integrity against excessive inser...
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PMID: 21839922
PDF is available here.
PDF is available here.
Acta Biomaterialia (7)8 2011
Abstract
We investigated the microstructures, Young's moduli, and tensile properties of metastable Ti-30Zr-(Cr, Mo) alloys subjected to solution treatment (ST) and cold rolling (CR). All the alloys comprise a β phase and small athermal ω phase, and they exhibit low Young's moduli after ST. During CR, defor...
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PMID: 21569873
PDF is available here.
PDF is available here.
Proteomics (11)16 2011
Abstract
Pseudomonas aeruginosa, an opportunistic human bacterial pathogen, constitutively secretes outer membrane vesicles (OMVs) into the extracellular milieu. Although recent progress has revealed that OMVs are essential for pathogenesis of P. aeruginosa, their proteins have not been compr...
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PMID: 21751344
PDF is available here.
PDF is available here.
Abstract
Despite their great diversities, 2D-shaped macrocycles that can serve as the organogelators have been surprisingly rare; two planar macrocyclic fluoropentamers designed by us were highly able to gelate organic solvents, largely derived from their strong tendency to form 1D stacked fi...
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PMID: 21744782
PDF is available here.
PDF is available here.
Abstract
Fibrillar aggregates of beta-amyloid peptide (Abeta) are major constituents of the senile plaques found in the brains of patients suffering from Alzheimer's disease (AD). Previous studies have shown that spontaneous isomerization or racemization of aspartyl residues in Abeta peptides...
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PMID: 21812329
PDF is available here.
PDF is available here.
Abstract
Myofibroblast transdifferentiation plays a crucial role in the development and progression of renal tubulointerstitial fibrosis. However, the significance of α-smooth muscle actin (α-SMA) expression, which is the major morphological characteristic of myofibroblasts, remains to be d...
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PMID: 21630215
PDF is available here.
PDF is available here.
Abstract
Myofibroblast transdifferentiation plays a crucial role in the development and progression of renal tubulointerstitial fibrosis. However, the significance of α-smooth muscle actin (α-SMA) expression, which is the major morphological characteristic of myofibroblasts, remains to be d...
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PMID: 21630215
PDF is available here.
PDF is available here.
Abstract
Myofibroblast transdifferentiation plays a crucial role in the development and progression of renal tubulointerstitial fibrosis. However, the significance of α-smooth muscle actin (α-SMA) expression, which is the major morphological characteristic of myofibroblasts, remains to be d...
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PMID: 21630215
PDF is available here.
PDF is available here.
Cytoskeleton (68)7 2011
Abstract
We tested the hypothesis that PP2A is localized to the axoneme by a specialized, highly conserved 55-kDa B-type subunit identified in the Chlamydomonas flagellar proteome. The B-subunit gene is defective in the motility mutant pf4. Consistent with our hypothesis, both the B- and C- subunits of PP2A...
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PMID: 21692192
PDF is available here.
PDF is available here.
Abstract
Allyl-PEG capped inorganic NPs, including magnetic iron oxide (IONPs), fluorescent CdSe/ZnS quantum dots (QDs), metallic gold (AuNPs of 5 and 10 nm) both individually and in combination were covalently attached to pH-responsive Poly(2-vinylpyridine-co-divinylbenzene) nanogels via a f...
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PMID: 21692456
PDF is available here.
PDF is available here.
Abstract
These results further the understanding of the conductance blockades caused by nucleic acids in solid-state nanopores, relevant for future applications, such as the direct determination of RNA secondary structure.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim....
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PMID: 21638785
PDF is available here.
PDF is available here.
Abstract
These results indicated that solvent emulsification evaporation is a simple, easy, available and effective method for preparing SYR-SLN....
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PMID: 21699077
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1807)9 2011
Abstract
Carotenoids play important roles in photosynthesis where they are involved in light-harvesting, in photo-protection and in the assembly and structural stability of light-harvesting and reaction centre complexes. In order to examine the effects of carotenoids on the oligomeric state o...
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PMID: 21651888
PDF is available here.
PDF is available here.
Biomedical Materials (6)3 2011
Abstract
A key step during the synthesis of collagen constructs is the incubation of monomeric collagen in phosphate buffer saline (PBS) to promote fibrillogenesis in the collagen network. Optimal PBS-treatment conditions for monomeric collagen solutions to induce gelation are well establishe...
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PMID: 21540522
PDF is available here.
PDF is available here.
Abstract
To evaluate the therapeutic efficiency of tissue-engineered human corneal endothelia (TE-HCEs) on rabbit primary corneal endotheliopathy (PCEP), TE-HCEs reconstructed with monoclonal human corneal endothelial cells (mcHCECs) and modified denuded amniotic membranes (mdAMs) were transp...
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PMID: 21634043
PDF is available here.
PDF is available here.
Transplantation (91)9 2011
Abstract
We investigated in vivo the effects of sirolimus on nephrin, podocin, CD2ap, and actin protein expression. Slit diaphragm (SD)-associated protein expressions were evaluated in T0 and T2 biopsies. The same analysis was performed in cultured human podocytes treated with different doses of sirolimus (5...
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PMID: 21364499
PDF is available here.
PDF is available here.
Transplantation (91)9 2011
Abstract
We investigated in vivo the effects of sirolimus on nephrin, podocin, CD2ap, and actin protein expression. Slit diaphragm (SD)-associated protein expressions were evaluated in T0 and T2 biopsies. The same analysis was performed in cultured human podocytes treated with different doses of sirolimus (5...
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PMID: 21364499
PDF is available here.
PDF is available here.
Abstract
These results suggest that the topical application of SERS nanoparticles in the mouse colon appears to minimize their systemic distribution, thus avoiding potential toxicity and supporting the clinical translation of Raman spectroscopy as an endoscopic imaging tool.
Copyright © 2011...
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PMID: 21608124
PDF is available here.
PDF is available here.
Abstract
Abstract
Multispiked gold nanoparticles are required in large quantities for many fundamental studies and applications like (bio)sensing, but their preparation in high yield by the bottom-up chemical synthetic method is challenging. A water-based, non-'seed-mediated', straightforward method f...
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PMID: 21630442
PDF is available here.
PDF is available here.
Abstract
We report a facile chemical synthesis of well-defined gold nanocrosses through anisotropic growth along both ⟨110⟩ and ⟨001⟩, whereas gold nanorods grow only along either ⟨110⟩ or ⟨001⟩. The multiple branching was achieved by breaking the face-centered-cubic lattice symmetry of gold t...
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PMID: 21563806
PDF is available here.
PDF is available here.
Abstract
Melittin liposomes surface modified with poloxamer 188 were developed, and the effect of poloxamer 188 was investigated with regard to anti-cancer effect and vascular stimulation. Melittin liposomes surface modified with poloxamer 188 at different concentrations (0%, 2%, and 5%) were prepared using t...
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PMID: 21699070
PDF is available here.
PDF is available here.
Abstract
We performed an agglutination assay. Agglutination in DL treated H. pylori suspension suggested selectivity of DL towards the PE surface receptor of H. pylori. Monotherapy is generally not recommended for treatment of a H. pylori infection due to the danger of development of resistance and unaccepta...
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PMID: 21699071
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1807)9 2011
Abstract
In the model photosynthetic bacterium Rhodobacter sphaeroides domains of light-harvesting 2 (LH2) complexes surround and interconnect dimeric reaction centre-light-harvesting 1-PufX (RC-LH1-PufX) 'core' complexes, forming extensive networks for energy transfer and trapping. These com...
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PMID: 21663730
PDF is available here.
PDF is available here.
Abstract
A bottom-up strategy has been developed to construct a multiple electron transfer system composed of organic/inorganic ternary composites (porphyrin, zinc oxide nanoparticles, reduced graphene oxide) on a semiconducting electrode without impairing the respective donor-acceptor components. The hierarc...
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PMID: 21520962
PDF is available here.
PDF is available here.
Abstract
Transplant glomerulopathy (TxG) can show secondary focal and segmental glomerulosclerosis (FSGS). FSGS in native kidneys is caused by podocytopenia. This study examines podocytopenia and the role of decreased paracrine Met activation on podocytes by decreased glomerular hepatocyte growth factor (HGF)...
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PMID: 21514418
PDF is available here.
PDF is available here.
Abstract
To explore gambogenic acid (GNA)-induced apoptosis and underlying mechanism in vivo. A549 nude mice xenografts were used as in vivo model to study anticancer effect of GNA by observing tumor growth curve and weight of the tumor. Ultrastructure of A549 cells treated by GNA was observed by TE. Expressi...
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PMID: 21842653
PDF is available here.
PDF is available here.
Abstract
We propose a tissue engineering approach concerning the fabrication of an electrospun cardiac graft functionalized with G-CSF, in order to provide the correct signalling sequence to orientate myoblast differentiation and exert important systemic and local effects, positively modulating the infarctio...
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PMID: 20518852
PDF is available here.
PDF is available here.
Abstract
Amyloid fibril diseases are characterized by the abnormal production of aggregated proteins and are associated with many types of neuro- and physically degenerative diseases. X-ray diffraction techniques, solid-state magic-angle spinning NMR spectroscopy, circular dichroism (CD) spectroscopy, and tra...
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PMID: 21524071
PDF is available here.
PDF is available here.
Abstract
We introduced wild-type DNM2 (WT-DNM2) or R465W DNM2 (RW-DNM2), the most common ADCNM mutation, into adult wild-type mouse skeletal muscle by intramuscular adeno-associated virus injections. We detected altered localization of RW-DNM2 in mouse muscle. Several ADCNM features were present in RW-DNM2 m...
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PMID: 21514436
PDF is available here.
PDF is available here.
Abstract
We show how mesenchyme-derived single stem cell populations can be induced to transdifferentiate in vitro in a structure similar to a dental bud. The presence of stem cells in the adipose tissue has been previously reported. We incubated primary cultures of human adipose tissue-derived stem cells in...
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PMID: 21514442
PDF is available here.
PDF is available here.
Abstract
Both the immune system and the epidermis likely have an important role in the pathogenesis of atopic dermatitis (AD). The objective of the present study was to develop a human skin equivalent model exhibiting morphologic and molecular characteristics of AD in a controlled manner. Skin equivalents gen...
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PMID: 21514424
PDF is available here.
PDF is available here.
Abstract
We report here that the presence of FLG mutations in Caucasians predicts dose-dependent alterations in epidermal permeability barrier function. Although FLG is an intracellular protein, the barrier abnormality occurred solely via a paracellular route in affected stratum corneum. Abnormal barrier fun...
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PMID: 21514438
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of a weekly application of retinal ischemia pulses (ischemic conditioning) on retinal damage induced by experimental diabetes. Diabetes was induced by an intraperitoneal injection of streptozotocin. Retinal ischemia was induced by increasing intraocular pressure to 120 mmH...
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PMID: 21514439
PDF is available here.
PDF is available here.
Abstract
Studies of familial Alzheimer's disease suggest that misfolding and aggregation of amyloid-β (Aβ) peptides initiate the pathogenesis. The Arctic mutation of Aβ precursor protein (APP) results in AD, and Arctic Aβ is more prone to form Aβ protofibrils and extracellular deposits. Herein is demonst...
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PMID: 21514441
PDF is available here.
PDF is available here.
Abstract
Homotypic cell fusion occurs in several cell types including macrophages in the formation of foreign body giant cells. Previously, monocyte chemoattractant protein-1 (MCP-1) was demonstrated to be required for foreign body giant cell formation in the foreign body response. The present study investiga...
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PMID: 21514443
PDF is available here.
PDF is available here.
Abstract
Our results showed that this sPLA(2) induced a marked increase in LB numbers in macrophages, induced the recruitment of ADRP in macrophages, and up-regulated ADRP expression. Ultrastructural analysis showed the presence of weakly and strongly osmiophilic LBs in sPLA(2)-stimulated cells. Enlargement...
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PMID: 21478270
PDF is available here.
PDF is available here.
Abstract
The main objective of present research study was to evaluate the potential of lipid nanoparticles for active delivery of an antiretroviral drug to lymphatic tissues. Stavudine entrapped drug loaded solid lipid nanoparticles (SLNs) were prepared and characterized for a variety of phys...
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PMID: 21612153
PDF is available here.
PDF is available here.
Abstract
Sanguinarine liposomes were prepared by a remote loading method using three different ammonium salts. A series of studies, including in vitro release, in vitro and in vivo anti-tumor effects and pharmacokinetics in rats, were conducted. The three liposomes showed pH-sensitive release...
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PMID: 21612152
PDF is available here.
PDF is available here.
Tropical biomedicine (28)1 2011
Abstract
Swietenia mahogani crude methanolic (SMCM) seed extract was investigated for the antifungal activity against Candida albicans which has not been evaluated previously. The antifungal activity was evaluated against C. albicans via disk diffusion, minimum inhibition concentration (MIC), scanning electro...
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PMID: 21602779
PDF is available here.
PDF is available here.
Abstract
We evaluated muscle changes in vivo after blocking the mitochondrial complex II of the respiratory chain by using 3-nitropropionic acid (3-NP). This neurotoxin has been used as a pharmacological tool in animal models to address some of the metabolic modifications that might underlie central neurodeg...
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PMID: 20734097
PDF is available here.
PDF is available here.
Abstract
We examine reversible switching of the morphology of these micelles through a phosphorylation-dephosphorylation cycle and study peptide-sequence directed changes in morphology in response to proteolysis. Furthermore, the exceptional uniformity of these polymer-peptide particles makes them amenable t...
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PMID: 21462979
PDF is available here.
PDF is available here.