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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Microscopy, Atomic Force (0):
Recent article
Microscopy, Atomic Force
FEBS Journal (278)19 2011
Abstract
Through its capability to transiently pack and unpack our genome, chromatin is a key player in the regulation of gene expression. Single-molecule approaches have recently complemented conventional biochemical and biophysical techniques to decipher the complex mechanisms ruling chroma...
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PMID: 21810177
PDF is available here.
PDF is available here.
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Abstract
The present investigation concerns with the development and optimization of a bipolymeric delivery device for the treatment of colonic diseases. Prednisolone - a popular glucorticoid was used a model drug. The formulations were designed with an objective to deliver the drug to the large bowel with a...
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PMID: 21928719
PDF is available here.
PDF is available here.
Abstract
A sensitive enzymeless organophosphate pesticides (OPs) sensor is fabricated by using Au nanoparticles (AuNPs) decorated graphene nanosheets (GNs) modified glassy carbon electrode as solid phase extraction (SPE). Such a nanostructured composite film, combining the advantages of AuNPs...
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PMID: 21807193
PDF is available here.
PDF is available here.
Biomacromolecules (12)9 2011
Abstract
We propose substrate-independent modification for creating a protein-repellent surface based on dopamine-melanin anchoring layer used for subsequent binding of poly(ethylene oxide) (PEO) from melt. We verified that the dopamine-melanin layer can be formed on literally any substrate and could serve a...
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PMID: 21823677
PDF is available here.
PDF is available here.
Molecular BioSystems (7)9 2011
Abstract
We report a general pH-responsive, DNA-directed assay for the design of a reversible assembly of GO-GO and GO-AuNPs hybrid using human telomeric G-quadruplex and i-motif DNA....
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PMID: 21748191
PDF is available here.
PDF is available here.
Abstract
We have used single-molecule force spectroscopy in combination with molecular dynamics simulations to characterize the mechanics of the myomesin dimer comprising immunoglobulin domains My12-My13. We find that at forces of approximately 30 pN the α-helical linker reversibly elongates allowing the m...
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PMID: 21825161
PDF is available here.
PDF is available here.
Acta Biomaterialia (7)7 2011
Abstract
Ultrathin films (also called nanofilms) are two-dimensional (2-D) polymeric structures with potential application in biology, biotechnology, cosmetics and tissue engineering. Since they can be handled in liquid form with micropipettes or tweezers they have been proposed as flexible s...
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PMID: 21421086
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1810)9 2011
Abstract
Deposition of protein fibrillar aggregates called amyloids in the tissue, is the principal cause of several degenerative diseases. Here, we have shown the disaggregation potential of rottlerin towards hen egg white lysozyme (HEWL) fibrils formed under alkaline conditions (pH-12.2).
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PMID: 21723915
PDF is available here.
PDF is available here.
Abstract
We report the aggregation behavior of catanionic mixtures of the anionic surfactant sodium dodecyl sulfate (SDS) and the cationic surfactant cetyltrimethylammonium bromide (CTAB) in solution and at the air/water interface obtained by the Langmuir-Blodgett (LB) technique. We employed Fourier transfor...
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PMID: 21675762
PDF is available here.
PDF is available here.
Biomacromolecules (12)6 2011
Abstract
We demonstrate that PEMs constructed from CS as the polyanion display a low Young's modulus correlated with poorly supported cell adhesion and proliferation. When the CS was adsorbed onto a stiffer polypeptide PEM basis, the Young's modulus increased, and the cell response was significantly improved...
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PMID: 21491904
PDF is available here.
PDF is available here.
Abstract
Abstract
We report AFM results on the formation pathways of β-oligomers and nonfibrillar aggregates from wild-type full-length recombinant human prion protein (WT) and an insertion mutant (10OR) with five additional octapeptide repeats linked to familial CJD. Upon partial denaturing, seeds consisting of 3-4...
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PMID: 21534611
PDF is available here.
PDF is available here.
Abstract
We discuss, production, characterization and in-vivo evaluation of nevirapine nanosuspensions. Laser diffraction showed that the average particles size was 457 nm. Following single-dose administration, the plasma gamma concentration profiles showed fast release. Macrophage uptake studies confirmed e...
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PMID: 21699078
PDF is available here.
PDF is available here.
Abstract
To assess whether pastes containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and calcium sodium phosphosilicate (CSP) protect acid softened enamel against further erosive episodes.
Enamel slabs of bovine teeth with preformed erosion-like lesions wer...
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PMID: 21874937
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1807)9 2011
Abstract
Carotenoids play important roles in photosynthesis where they are involved in light-harvesting, in photo-protection and in the assembly and structural stability of light-harvesting and reaction centre complexes. In order to examine the effects of carotenoids on the oligomeric state o...
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PMID: 21651888
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
We have determined the value of the glass transition temperature (T_{g}) as well as the steepness index (m_{P}) at various T-P conditions....
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PMID: 21728535
PDF is available here.
PDF is available here.
Abstract
A major obstacle in creating viable tissue engineered constructs using electrospinning is the lack of complete cellularization and vascularization due to the limited porosity in these densely packed fibrous scaffolds. One potential approach to circumvent this issue is the use of vari...
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PMID: 21528921
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1807)9 2011
Abstract
The functional domain size for efficient excited singlet state quenching was studied in artificial aggregates of the main light-harvesting complex II (LHCIIb) from spinach and in native thylakoid membranes by picosecond time-resolved fluorescence kinetics and quantum yield measuremen...
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PMID: 21616053
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1807)9 2011
Abstract
In the model photosynthetic bacterium Rhodobacter sphaeroides domains of light-harvesting 2 (LH2) complexes surround and interconnect dimeric reaction centre-light-harvesting 1-PufX (RC-LH1-PufX) 'core' complexes, forming extensive networks for energy transfer and trapping. These com...
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PMID: 21663730
PDF is available here.
PDF is available here.
Abstract
Single-walled carbon nanotube (SWNT) and other carbon-based coatings are being considered as replacements for indium tin oxide (ITO). The problems of transparent conductors (TCs) coatings from SWNT and similar materials include poor mechanical properties, high roughness, low temperature resilience, a...
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PMID: 21524068
PDF is available here.
PDF is available here.
Abstract
The two-dimensional self-assembly of a terbium(III) double-decker phthalocyanine on highly oriented pyrolitic graphite (HOPG) was studied by atomic force microscopy (AFM), and it was shown that it forms highly regular rectangular two-dimensional nanocrystals on the surface, that are...
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PMID: 21486019
PDF is available here.
PDF is available here.
Abstract
Our results reveal also the existence of two regimes, suggesting the presence of multiple energy barriers in the energy landscape. From these dynamic force spectroscopy measurements, the kinetic off-rate constant is determined. An average unbinding force in the range of 50-300 pN is obtained, depend...
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PMID: 21488141
PDF is available here.
PDF is available here.
Abstract
A bio-nanofilm consisting of a tetrad nanomaterial (nanotubes, nanoparticles, DNA, polymer) was fabricated utilizing in situ reduction and noncovalent interactions and it displayed effective antibacterial activity and biocompatibility. This bio-nanofilm was composed of homogenous sil...
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PMID: 21336791
PDF is available here.
PDF is available here.
Abstract
Etching resorbable blasting media (RM) processed implants is a common engineering procedure, but the interplay between the resulting physicochemical properties and its effects on early bone healing have not been thoroughly addressed.
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PMID: 21448026
PDF is available here.
PDF is available here.
Abstract
Fogorvosi szemle (104)1 2011
Abstract
The effects of three different decontaminating solutions in clinical use for peri-implantitis therapy on the chemical structure and surface roughness of commercially pure (CP) Ti were investigated. A further aim was to survey the response of the biological environment to these changes, by examining t...
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PMID: 21789931
PDF is available here.
PDF is available here.
Abstract
We sought to determine whether the predictable, three-dimensional side-chain patterns generated by β-peptides could be used in combination with single-molecule force spectroscopy to quantify how changes in nanometer-scale chemical patterns affect intermolecular interactions. To this end, we synthes...
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PMID: 21361359
PDF is available here.
PDF is available here.
Abstract
We report the design and construction of a novel DNA cross tile, called the double-decker tile. Its arms are symmetric and have four double helices each. Using its sticky ends, large two-dimensional square lattices have been constructed which are on the order of tens of micrometers. Furthermore, it...
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PMID: 21355587
PDF is available here.
PDF is available here.
Abstract
We developed selective nanocoatings by combining trinitrotoluene (TNT) receptors bound to conjugated polydiacetylene (PDA) polymers with single-walled carbon nanotube field-effect transistors (SWNT-FET). Selective binding events between the TNT molecules and phage display derived TNT receptors were...
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PMID: 21361351
PDF is available here.
PDF is available here.
Abstract
Metallogels form from Cu(II) ions and tetratopic ligand rctt-1,2-bis(3-pyridyl)-3,4-bis(4-pyridyl)cyclobutane. The tetrapyridyl cyclobutane has been synthesized in the organic solid state. The gel forms with a variety of counteranions and gels water. The hydrogel is thixotropic and is composed of nan...
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PMID: 21341662
PDF is available here.
PDF is available here.
Abstract
An azobenzene-capped DNA hairpin coupled to an AFM is presented as an optically triggered single-molecule motor. The photoinduced trans to cis isomerization of azobenzene affects both the overall length of the molecule and the ability of the DNA bases to hybridize. Using a combination of molecular dy...
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PMID: 21341796
PDF is available here.
PDF is available here.
Abstract
Birch reduction of few-layer graphene samples gives rise to hydrogenated samples containing up to 5 wt % of hydrogen. Spectroscopic studies reveal the presence of sp(3) C-H bonds in the hydrogenated graphenes. They, however, decompose readily on heating to 500 °C or on irradiation with UV or lase...
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PMID: 21282617
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1814)8 2011
Abstract
The protein folding reaction carries great significance for cellular function and hence continues to be the research focus of a large interdisciplinary protein science community. Single-molecule methods are providing new and powerful tools for dissecting the mechanisms of this complex process by virt...
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PMID: 21303706
PDF is available here.
PDF is available here.
Biomedical Materials (6)1 2011
Abstract
Fabrication of polycaprolactone (PCL)-chitosan (CS) three-dimensional (3D) scaffolds using the novel technique of melt stretching and multilayer deposition was introduced. In brief, firstly, the PCL-CS monofilaments containing 0% (pure PCL), 10%, 20% and 30% CS by weight were fabrica...
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PMID: 21205996
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1808)4 2011
Abstract
By using Fourier transform infrared (FT-IR) spectroscopy in combination with differential scanning calorimetry (DSC) coupled with pressure perturbation calorimetry (PPC), ultrasound velocimetry, Laurdan fluorescence spectroscopy, fluorescence microscopy and atomic force microscopy (AFM), the temperat...
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PMID: 21262194
PDF is available here.
PDF is available here.
Abstract
Fusion between opposing cellular membranes is essential for numerous cellular activities such as protein maturation, neurotransmission, hormone secretion, and enzyme release. The universal molecular mechanism of membrane fusion involves Ca(2+), and the assembly of a specialized set of proteins presen...
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PMID: 21432012
PDF is available here.
PDF is available here.
Tsitologiia (53)5 2011
Abstract
Fluorescent tags are extensively used for the diagnostic, labeling and marking in vivo and in vitro systems. In this study, fluorescent nanoparticles with Er/Yb lightning center were tested on neutrophilic granulocytes. The main purpose was to idenfity possible toxic effect. The negative impact of fl...
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PMID: 21786688
PDF is available here.
PDF is available here.
Abstract
We hypothesized that biotinylation modifies the physical structure of nucleosomes, and that biotin-induced conformational changes contribute to gene silencing associated with histone biotinylation....
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PMID: 21298003
PDF is available here.
PDF is available here.
Abstract
We show the different structural changes in mycobacterial nucleoid at different points of growth in the presence of different concentrations of glucose in the medium. We also observe that in Mycobacterium smegmatis, two different Dps proteins (Dps1 and Dps2) promote two types of nucleoid organizatio...
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PMID: 21283627
PDF is available here.
PDF is available here.
Abstract
We examine the role of acidic extracellular pH in regulating activation of integrin α(v)β(3). Through computational molecular dynamics simulations, we find that acidic extracellular pH promotes opening of the α(v)β(3) headpiece, indicating that acidic pH can thereby facilitate integrin activatio...
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PMID: 21283814
PDF is available here.
PDF is available here.
Abstract
Aims and background. Cell membranes were shown to be sensitive to and affected by static magnetic fields (SMF). Methods. Cells were treated with four anticancer drugs followed by treatment with a combination of drugs and SMF. Individual cells were examined using atomic force microscopy (AFM). The dru...
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PMID: 21789021
PDF is available here.
PDF is available here.
Abstract
We present a detailed AFM study on multilayered dry lipid films prepared from aqueous vesicle suspensions. Different preparation techniques were applied in order to optimize the preparation of homogeneous lipid films of various film thicknesses. Suspensions of preformed DOPC/DPPC vesicles were adsor...
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PMID: 20832257
PDF is available here.
PDF is available here.
Abstract
We have previously shown that besides its interaction with anionic lipids, the cyt c is also able to cross neutral lipid membranes. In this work, with the help of AFM and punch-through experiments, we have measured the force required to penetrate the membrane in the fluid and in the gel phases with...
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PMID: 20832261
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)2 2011
Abstract
Intravenous iron preparations are key components in the management of anaemia of various etiologies. These iron-carbohydrate complexes permit safe systemic delivery of iron, whilst protecting from the potential toxic effects of over-saturation. This in turn permits efficient haematop...
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PMID: 21428246
PDF is available here.
PDF is available here.
Acta Biomaterialia (7)1 2011
Abstract
We have utilized atomic force microscopy to characterize the microelastic properties of decellularized cell-derived matrix from human pulmonary fibroblasts. This heterogeneous three-dimensional matrix had an average thickness of 5 ± 0.4 μm and a Young's modulus of 105 ± 14 Pa. Ascorbate treatment...
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PMID: 20656080
PDF is available here.
PDF is available here.
Acta Biomaterialia (7)1 2011
Abstract
A periodontal membrane with a graded structure allows tailoring of the layer properties to design a material system that will retain its physical, chemical and mechanical characteristics for a period long enough to optimize periodontal regeneration. In this work a novel functionally...
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PMID: 20801241
PDF is available here.
PDF is available here.
Acta Biomaterialia (7)1 2011
Abstract
Polymeric endoaortic paving (PEAP) is a process by which a polymer is endovascularly delivered and thermoformed to coat or "pave" the lumen of the aorta. This method may offer an improvement to conventional endoaortic therapy in allowing conformal graft application with reduced risk...
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PMID: 20832506
PDF is available here.
PDF is available here.
Abstract
We show that matrix degradation at the cell material interface depends on surface chemistry in MMP-dependent way.
This work provides a broad overview of matrix remodeling at the cell-material interface, establishing correlations between surface chemistry, FN adsorption, cell adhesion...
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PMID: 21573010
PDF is available here.
PDF is available here.
Abstract
We investigated the partitioning of semisynthetic fully functional lipidated K-Ras4B proteins into heterogeneous anionic model membranes and membranes composed of viral lipid extracts. Independent of GDP/GTP-loading, K-Ras4B is preferentially localized in liquid-disordered (l(d)) lipid domains and f...
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PMID: 21141956
PDF is available here.
PDF is available here.
Abstract
We report here a designer self-assembling peptide nanofiber scaffold developed specifically for nerve tissue engineering. We synthesized a peptide FGL-RADA containing FGL (EVYVVAENQQGKSKA), the motif of neural cell adhesion molecule (NCAM), and then attended to make a FGL nanofiber scaffold (FGL-NS)...
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PMID: 20878982
PDF is available here.
PDF is available here.
Abstract
A label-free immunosensor based on an aptamer-modified graphene field-effect transistor (G-FET) is demonstrated. Immunoglobulin E (IgE) aptamers with an approximate height of 3 nm were successfully immobilized on a graphene surface, as confirmed by atomic force microscopy. The aptamer-modified G-FET...
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PMID: 21128665
PDF is available here.
PDF is available here.
Abstract
Generation-4 polyamidoamine (PAMAM) dendrimers were surface-functionalized with azides or alkynes and conjugated to one DNA strand. DNA-controlled self-assembly of alternating azide and alkyne dendrimers on a DNA template enabled the coupling of the dendrimers by the azide-alkyne "click" reaction to...
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PMID: 21133363
PDF is available here.
PDF is available here.
Lab On a Chip (10)23 2010
Abstract
Mixed-scale nano- and microfluidic networks were fabricated in thermoplastics using simple and robust methods that did not require the use of sophisticated equipment to produce the nanostructures. High-precision micromilling (HPMM) and photolithography were used to generate mixed-scale molding tools...
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PMID: 20938506
PDF is available here.
PDF is available here.
Abstract
We use Langevin dynamics to investigate the role played by the recently discovered force-induced entropic energy barrier on the two-state hopping phenomena that has been observed in single RNA, DNA and protein molecules placed under a stretching force. Simple considerations about the free energy of...
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PMID: 21050839
PDF is available here.
PDF is available here.
Abstract
We propose that AM AFM in high humidity will be a useful technique for probing DNA topology without some of the drawbacks of imaging under bulk solution....
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PMID: 20927466
PDF is available here.
PDF is available here.
Acta Biomaterialia (6)12 2010
Abstract
We have used peptide motifs that have been selected to bind to gold, platinum, glass and titanium to modify surfaces with poly(ethylene glycol) anti-fouling polymer and the integrin-binding RGD sequence. The peptides have several advantages over conventional molecular immobilization techniques; they...
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PMID: 20601249
PDF is available here.
PDF is available here.
Abstract
Mono-dispersed SiO(2)-CaO bioactive glass nanospheres (BGNS) were prepared by a two step sol-gel method in the absence of surfactant. The size of BGNS ranged from 200 to 350 nm in diameter and exhibited a rough surface texture. In vitro biomineralization tests showed that BGNS could...
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PMID: 20725980
PDF is available here.
PDF is available here.
Lab On a Chip (10)22 2010
Abstract
We investigate the nanofluidic membrane performance using custom diffusion and gas testing apparatuses to quantify molecular release rate and process uniformity as well as mechanical strength using a gas based burst test. The kinetics of the constrained zero-order release is probed with molecules pr...
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PMID: 20697650
PDF is available here.
PDF is available here.