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Recent article
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Abstract
We studied the effect of exercise training on islet and β-cell morphology and plasma insulin and glucose, following an intraperitoneal glucose tolerance test (IPGTT) in juvenile and adult male Wistar-Kyoto rats born small. Bilateral uterine vessel ligation performed on day 18 of pregnancy resulted...
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PMID: 21810930
PDF is available here.
PDF is available here.
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Abstract
Abstract
: To test the hypothesis that myometrial thickness predicts the success of external cephalic version.
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PMID: 21934456
PDF is available here.
PDF is available here.
Acta Biomaterialia (7)10 2011
Abstract
In this study, a two-part bone tissue engineering scaffold was investigated. The scaffold consists of a solid poly(propylene fumarate) (PPF) intramedullary rod for mechanical support surrounded by a porous PPF sleeve for osseointegration and delivery of poly(dl-lactic-co-glycolic aci...
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PMID: 21757034
PDF is available here.
PDF is available here.
Abstract
We concluded that the exposure of rats to GA(3) induced oxidative stress and histopathological changes in kidneys of suckling rats and their mothers during late pregnancy and early postnatal periods....
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PMID: 21305369
PDF is available here.
PDF is available here.
Abstract
We concluded that the exposure of rats to GA(3) induced oxidative stress and histopathological changes in kidneys of suckling rats and their mothers during late pregnancy and early postnatal periods....
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PMID: 21305369
PDF is available here.
PDF is available here.
Abstract
We concluded that the exposure of rats to GA(3) induced oxidative stress and histopathological changes in kidneys of suckling rats and their mothers during late pregnancy and early postnatal periods....
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PMID: 21305369
PDF is available here.
PDF is available here.
Abstract
We have previously found that 50% food restriction (FR) increases plasma IL-6, haptoglobin and both alanine transaminase (ALT) and alkaline phosphatase (AST) aminotransferases, indicating the existence of an inflammatory response. To study whether such FR influences the hypothalamic-pituitary-adrena...
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PMID: 21952442
PDF is available here.
PDF is available here.
Abstract
We measured hippocampal and amygdala volumes as well as stress hormone (glucocorticoid) levels in children exposed (n = 17) or not (n = 21) to maternal depressive symptomatology since birth. Results revealed no group difference in hippocampal volumes, but larger left and right amygdala volumes and i...
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PMID: 21844357
PDF is available here.
PDF is available here.
Abstract
I (IGF-1) levels are closely associated with cardiac performance although the role of IGF-1 in alcoholic cardiac dysfunction is unknown. This study was designed to evaluate the impact of severe liver IGF-1 deficiency (LID) on chronic alcohol-induced cardiomyocyte contractile and intracellular Ca(2+)...
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PMID: 20731752
PDF is available here.
PDF is available here.
Abstract
Structurally-functional myocardium parameters and their interconnection with erythropoietin and tumour necrosis factor-alpha levels in blood plasma of patients with heart failure were analysed. Prevalence of erythropoietin over tumour necrosis factor-alpha in blood had positive effec...
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PMID: 21961313
PDF is available here.
PDF is available here.
Abstract
We hypothesized that higher permeability scaffolds will enhance bone regeneration for a given cell seeding density. We manufactured poly-ɛ-caprolactone scaffolds, designed to have the same internal pore design and either a low permeability (0.688×10(-7)m(4)/N-s) or a high permeability (3.991×10(-...
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PMID: 21395465
PDF is available here.
PDF is available here.
Scientific American (305)1 2011
Abstract
Abstract
Our aim was to examine relations between physical capacity, nutritional status, systemic inflammation and disease severity in COPD. Method: Forty nine patients with moderate to severe COPD were included in the study. Spirometry was preformed. Physical capacity was determined by a progressive symp...
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PMID: 21679348
PDF is available here.
PDF is available here.
Abstract
We have previously demonstrated the possibility, by this technique, to extract information of the spatial and quantitative distribution of the islets of Langerhans in the intact mouse pancreas. In order to further increase the sensitivity of OPT imaging for this type of assessment, we have developed...
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PMID: 21633198
PDF is available here.
PDF is available here.
Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica / Associazione ricerche in urologia (83)2 2011
Abstract
With the advent of medical management and minimally techniques for benign prostate hypeplasia (BPH), invasive surgical procedures such open prostatectomy (OPSU) have become less common, although selected patients may still benefit from open prostatectomy. Aim of this study was to evaluate efficacy an...
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PMID: 21826881
PDF is available here.
PDF is available here.
Abstract
To evaluate the reproducibility of ImageJ software in analyzing the color of the optic disc.
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PMID: 21655042
PDF is available here.
PDF is available here.
Abstract
The prostate of the brushtail possum undergoes growth and regression during the year. The present study investigated the morphological changes and expression of androgen and oestrogen receptors during the breeding and non-breeding seasons. Prostate tissue was collected from adult possums at 2-monthly...
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PMID: 21635819
PDF is available here.
PDF is available here.
Abstract
We assessed olfactory bulb volume of MS patients with magnetic resonance imaging (MRI) and related it to the OF....
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PMID: 21743881
PDF is available here.
PDF is available here.
Abstract
The histopathology of type 1 diabetes is defined by a decreased β-cell mass in association with insulitis, a characteristic lymphocytic infiltration limited to the islets of Langerhans and prominent in early stage disease in children. A cytotoxic T-cell mediated destruction of insul...
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PMID: 21606672
PDF is available here.
PDF is available here.
Abstract
We demonstrate the potential for using virtual endocasts (VEs) to examine inter- and intraspecific variation in brain volume in members of the family Hyaenidae. Total endocranial volume (adjusted for body size) and anterior cerebrum volume (adjusted for endocranial volume) were greater in the spotte...
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PMID: 21599694
PDF is available here.
PDF is available here.
Abstract
We conducted a comparative survey of the visible gross morphology of the insular cortex and the claustrum in 26 mammalian species, representing most of the major mammalian radiations. We observed several features that are conserved in the mammals that we examined, including the absence of expansion...
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PMID: 21599698
PDF is available here.
PDF is available here.
Abstract
We use in vivo magnetic resonance imaging (MRI) and advanced image processing using surface rendering to visualize and characterize myeloarchitecture in a small nonhuman primate, the common marmoset (Callithrix jacchus). Through images made in four female adult marmosets, we produce a representative...
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PMID: 21599695
PDF is available here.
PDF is available here.
Abstract
We determined the association between statin use and prostate cancer in men who underwent prostate biopsy.
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PMID: 21571344
PDF is available here.
PDF is available here.
Abstract
We performed a genome-wide association study of this phenotype by analyzing a discovery cohort consisting of 3620 participants of the Study of Health in Pomerania (SHIP). Four genetic loci were associated with thyroid volume on a genome-wide level of significance. Of these, two independent loci are...
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PMID: 21565293
PDF is available here.
PDF is available here.
Abstract
We generated a mouse with near total abrogation of circulating IGF-I by disrupting the GH signaling mediator, Janus kinase (JAK)2, in hepatocytes. We then crossed these mice, termed JAK2L, to GH-deficient little mice (Lit). Compound mutant (Lit-JAK2L) and control (Lit-Con) mice were treated with equ...
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PMID: 21527499
PDF is available here.
PDF is available here.
Abstract
MAPK kinase (MEK)1 and MEK2 were deleted from Leydig cells by crossing Mek1(f/f);Mek2(-/-) and Cyp17iCre mice. Primary cultures of Leydig cell from mice of the appropriate genotype (Mek1(f/f);Mek2(-/-);iCre(+)) show decreased, but still detectable, MEK1 expression and decreased or absent ERK1/2 phosp...
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PMID: 21527500
PDF is available here.
PDF is available here.
Abstract
We present evidence for a function of amyloid precursor protein (APP) and Aβ in regulating osteoclast (OC) differentiation in vitro and in vivo. Tg2576 mice, which express the Swedish mutation of APP (APPswe) under the control of a prion promoter, exhibit biphasic effects on OC activation, with an...
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PMID: 21542009
PDF is available here.
PDF is available here.
Abstract
We report that the atypical Rac1 exchange factor Dock5 is necessary for osteoclast function both in vitro and in vivo. We discovered that establishment of the sealing zone and consequently osteoclast resorbing activity in vitro require Dock5. Mechanistically, our results suggest that osteoclasts lac...
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PMID: 21542010
PDF is available here.
PDF is available here.
Abstract
We present a model that emulates the expansion of the lateral ventricles seen in hydrocephalus. To quantify the ventricular volume, sensor prototypes were fabricated and tested with this experimental model. Fluid was injected and withdrawn cyclically in a controlled manner and volume measurements we...
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PMID: 20501343
PDF is available here.
PDF is available here.
Abstract
Background & objectives : The length of cervix predicts the risk of preterm delivery. The objective of this study was to assess cervical length in pregnancy by transvaginal ultrasonography for generating normative data for nulliparous women at no special risk of preterm labour. Methods : An observati...
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PMID: 21623033
PDF is available here.
PDF is available here.
Abstract
We evaluated factors predicting operative blood loss, such as prostate volume, body mass index (BMI), age, and preoperative PSA level. Group with smaller prostate volume and group with lower BMI showed significantly less blood loss compared to that of a higher group (p = 0.0009, p = 0.0014, respecti...
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PMID: 21846065
PDF is available here.
PDF is available here.
Abstract
Introduction. Loss of penile length after penile prosthesis implantation is one of the most common complaints. There is no recognized reliable technique to gain length once the device is placed. Aims. This noncontrolled pilot study was designed to evaluate the efficacy and safe...
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PMID: 21492409
PDF is available here.
PDF is available here.
Human Molecular Genetics (20)8 2011
Abstract
We generated transgenic mice expressing cDNA that encodes htt N118-82Q with the mouse prion promoter vector. In mice generated in this manner, we demonstrate robust inclusion pathology accompanied by early death and failure to gain weight. These phenotypes are the most robust abnormalities identifie...
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PMID: 21307087
PDF is available here.
PDF is available here.
Georgian medical news ()193 2011
Abstract
In literature a well codified definition of unilateral asymptomatic testis enlargement does not exist. Therefore in these cases the pediatrician or adolescentologist will have to make a clinical and diagnostic evaluation in order to exclude: a) an enlarged testis secondary to tumors,...
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PMID: 21617270
PDF is available here.
PDF is available here.
Abstract
Previous anatomic studies have established a reduction in hippocampal volume in schizophrenia, but few have investigated the progressive course of these changes and whether they are trait markers. In the present study, the authors examined hippocampal volumes in relation to age for patients with chil...
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PMID: 21245087
PDF is available here.
PDF is available here.
Abstract
We conclude that tooth width ratios vary between different racial groups, and therefore that these should be calculated specifically for each patient racial group....
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PMID: 21537638
PDF is available here.
PDF is available here.
Abstract
Preterm birth is the major cause of perinatal mortality and morbidity. During the last decade, it has become an important issue in public health policies of developing countries. Gestational diabetes mellitus and Pregnancy induced hypertension are two important high-risk factors for preterm birth. Th...
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PMID: 21522101
PDF is available here.
PDF is available here.
Medical Physics (38)4 2011
Abstract
Accurate anatomical characterization of the breast is useful in breast phantom development and computer modeling of breast imaging technologies. Capitalizing on the three-dimensional capabilities of dedicated breast CT (bCT), a number of parameters which describe breast shape and fibroglandular distr...
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PMID: 21626952
PDF is available here.
PDF is available here.
Abstract
To investigate the antidiabetic, antioxidant and hypolipidemic efficacy of Cynodon dactylon in diabetic rats.
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PMID: 21565691
PDF is available here.
PDF is available here.
Abstract
Abstract
The developmental taxonomic theory proposes that neurodevelopmental factors play a critical role in the etiology of early-onset conduct disorder, whereas adolescent-onset conduct disorder arises as a result of social mimicry of deviant peers. Recent studies have challenged this theory by demonstratin...
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PMID: 21454920
PDF is available here.
PDF is available here.
Abstract
Pretransplant obesity does not appear to be associated with poor posttransplant outcomes. Larger pretransplant muscle mass, reflected by higher pretransplant serum creatinine level, is associated with greater posttransplant graft and patient survival....
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PMID: 21415312
PDF is available here.
PDF is available here.
Abstract
We sought to determine the best blood fraction for multiplex evaluation of circulating biomarkers in post-menopausal women, and to explore body composition phenotype discrimination by biomarkers....
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PMID: 21361852
PDF is available here.
PDF is available here.
Abstract
We analyzed hearing function and morphological features of auditory ossicles in osteopetrotic mice, which lack osteoclasts because of the deficiency of either cytokine RANKL or transcription factor c-Fos. The auditory brainstem response showed that mice of both genotypes experienced hearing loss, an...
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PMID: 21356377
PDF is available here.
PDF is available here.
Abstract
To estimate whether, by using a new ultrasonographic technique (extended view; XTD view), young lean women with polycystic ovary syndrome (PCOS) have a more android fat distribution in comparison with normally menstruating women with ultrasonographic evidence of polycystic ovaries (PCO) and healthy c...
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PMID: 21401530
PDF is available here.
PDF is available here.
Abstract
We use the second approach, providing an extant comparative framework for hominid paleoneurological studies. We explore endocranial size and shape differences among great apes and humans, as well as between sexes. We virtually extracted 72 endocasts, sampling all extant great ape species and modern...
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PMID: 21365614
PDF is available here.
PDF is available here.
Abstract
We tested the translational hypothesis that blocking ligand binding to ActRIIB for 12 weeks would stimulate skeletal muscle growth and improve muscle function in the mdx mouse. ActRIIB was targeted using a novel inhibitor comprised of the extracellular portion of the ActRIIB fused to the Fc portion...
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PMID: 21356379
PDF is available here.
PDF is available here.
Abstract
We have used three different complementary approaches: i) diethylnitrosamine (DEN)-induced chemical hepatocarcinogenesis in COX-2 Tg mice, ii) DEN/phenobarbital treatment of human COX-2 Tg hepatocyte-like cells, and iii) COX-2 Tg hepatocyte-like cells implants in nude mice. The data suggest that PGs...
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PMID: 21356386
PDF is available here.
PDF is available here.
Abstract
I and II, the bodyweights of donors were the same as those of recipients; however, in group III the bodyweights of donors were 100-120 g less than those of the recipients. The duration needed for transplantation, the 7-day survival rates, and the technical complication rates were compared among thes...
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PMID: 21681683
PDF is available here.
PDF is available here.
Abstract
The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) was created to identify markers of disease progression in patients with autosomal dominant polycystic kidney disease (ADPKD).
Linear mixed models were utilized to model effects of basel...
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PMID: 21088290
PDF is available here.
PDF is available here.
Abstract
The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) was created to identify markers of disease progression in patients with autosomal dominant polycystic kidney disease (ADPKD).
Linear mixed models were utilized to model effects of basel...
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PMID: 21088290
PDF is available here.
PDF is available here.
Abstract
The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) was created to identify markers of disease progression in patients with autosomal dominant polycystic kidney disease (ADPKD).
Linear mixed models were utilized to model effects of basel...
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PMID: 21088290
PDF is available here.
PDF is available here.
Abstract
The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) was created to identify markers of disease progression in patients with autosomal dominant polycystic kidney disease (ADPKD).
Linear mixed models were utilized to model effects of basel...
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PMID: 21088290
PDF is available here.
PDF is available here.
Abstract
The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) was created to identify markers of disease progression in patients with autosomal dominant polycystic kidney disease (ADPKD).
Linear mixed models were utilized to model effects of basel...
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PMID: 21088290
PDF is available here.
PDF is available here.
Circulation (123)8 2011
Abstract
We divided the patients by type of aortic valve dysfunction-either aortic stenosis (AS) or pure aortic regurgitation (AR)-something not previously undertaken.
Of 122 patients with ascending aortic aneurysm (unassociated with aortitis or acute dissection), the aortic valve was congeni...
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PMID: 21321157
PDF is available here.
PDF is available here.
Abstract
We show, in a randomized controlled trial with 120 older adults, that aerobic exercise training increases the size of the anterior hippocampus, leading to improvements in spatial memory. Exercise training increased hippocampal volume by 2%, effectively reversing age-related loss in volume by 1 to 2...
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PMID: 21282661
PDF is available here.
PDF is available here.
Abstract
Thirty to forty percent of ruminant pregnancies are lost during the first third of gestation due to inadequate progesterone secretion. During the estrous cycle, luteinizing hormone (LH) regulates progesterone secretion by small luteal cells (SLC). Loss of luteal progesterone secretion during the estr...
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PMID: 21109016
PDF is available here.
PDF is available here.
Abstract
The objective of the study was to test whether ultrasound-measured fetal adrenal gland volume (AGV) and fetal zone enlargement (FZE) predicts preterm birth (PTB) better than cervical length (CL).
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PMID: 21292230
PDF is available here.
PDF is available here.