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Enzyme-Linked Immunosorbent Assay (0):
Recent article
Enzyme-Linked Immunosorbent Assay
Abstract
We previously demonstrated that LPA-primed astrocytes induce neuronal commitment of cerebral cortical progenitors (Spohr et al. 2008). In the present study, we analyzed neurite outgrowth induced by LPA-treated astrocytes and the molecular mechanism underlying this event. LPA-primed astrocytes incre...
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PMID: 21834854
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PDF is available here.
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Abstract
We have measured blood concentrations of kynurenines and inflammatory markers in 28 patients undergoing coronary arterial graft surgery and, for comparison, 28 patients undergoing non-bypass thoracic surgery. A battery of cognitive tests was completed before and after the operations. The results sho...
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PMID: 21819405
PDF is available here.
PDF is available here.
Abstract
These results suggest the potential defined antigens for development of an accurate diagnostic test for schistosomiasis....
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PMID: 21976571
PDF is available here.
PDF is available here.
Abstract
Abstract. A dengue vaccine effective against all four serotypes is urgently needed. However, safety and immunogenicity could be affected by prior exposure to flaviviruses. This open, controlled, phase IIa study was conducted in 35 healthy adults who had received monovalent, live attenuated Vero cell-...
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PMID: 21976579
PDF is available here.
PDF is available here.
Abstract
Abstract. From September 2005 to March 2007, 238 individuals being vaccinated for the first time with the yellow fever (YF) -17DD vaccine were enrolled in a cohort established in Recife, Brazil. A prospective study indicated that, after immunization, anti-YF immunoglobulin M (IgM) an...
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PMID: 21976581
PDF is available here.
PDF is available here.
Abstract
We hypothesize that UCHL1 would be an effective serum biomarker for brain injury as tested in canine models of hypothermic circulatory arrest (HCA) and cardiopulmonary bypass (CPB)....
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PMID: 21924148
PDF is available here.
PDF is available here.
Abstract
Gene expression profiles of paired hepatocellular carcinoma (HCC) and adjacent noncancerous liver tissue samples revealed preferential expression of midkine in HCC. This finding suggested the clinical usefulness of midkine measurement in serum for monitoring HCC treatment response, recurrence, and pr...
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PMID: 21917682
PDF is available here.
PDF is available here.
Abstract
Biliary atresia (BA) is an idiopathic progressive inflammation and fibrosclerosis of the extra and intrahepatic bile ducts.
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PMID: 21922857
PDF is available here.
PDF is available here.
Abstract
We compared plasma protein profiles of four mouse models of lung cancer with profiles of models of pancreatic, ovarian, colon, prostate, and breast cancer and two models of inflammation. A protein signature for Titf1/Nkx2-1, a known lineage-survival oncogene in lung cancer, was found in plasmas of m...
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PMID: 21907921
PDF is available here.
PDF is available here.
Abstract
We aimed to clarify the underlying mechanisms of this cross talk. We found significantly higher titers of Ag-specific secretory IgA Ab in the vaginal wash after mucosal vaccination by both the intranasal (i.n.) and the intravaginal routes but not by the s.c. route. Interestingly, Ag-specific IgA Ab-...
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PMID: 21832166
PDF is available here.
PDF is available here.
Abstract
We present a mouse model in which a polyclonal sheep anti-mouse podocyte Ab caused subepithelial immune complex formation. Mice developed a nephrotic syndrome with severe edema, proteinuria, hypoalbuminemia, and elevated cholesterol and triglycerides. Development of proteinuria was biphasic: an init...
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PMID: 21844386
PDF is available here.
PDF is available here.
Abstract
We performed in-depth studies of the effects of the TLR9-associated ligands, oligodeoxynucleotides (ODNs), on highly purified T lymphocytes. Both CpG and non-CpG ODNs directly costimulate mouse and human CD4(+) T cells, resulting in activation marker upregulation, cytokine secretion, elevated TCR ph...
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PMID: 21844387
PDF is available here.
PDF is available here.
Abstract
We hypothesized that recombinant activated protein C would also suppress SLE and lupus nephritis. To test this concept, autoimmune female MRL-Fas(lpr) mice were injected with either vehicle or recombinant human activated protein C from week 14-18 of age. Activated protein C treatment significantly s...
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PMID: 21849682
PDF is available here.
PDF is available here.
Abstract
We demonstrate heightened susceptibility to thioglycollate-induced peritonitis in CD93(-/-) mice. CD93(-/-) mice showed a 1.6-1.8-fold increase in leukocyte infiltration during thioglycollate-induced peritonitis between 3 and 24 h that returned to wild type levels by 96 h. Impaired vascular integrit...
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PMID: 21849679
PDF is available here.
PDF is available here.
Abstract
We tracked fluorescent and radiolabeled LPS from a s.c. inoculation site to its draining lymph nodes (DLN), blood, and liver. Although we found FITC-labeled LPS in DLN within minutes of injection, drainage of radiolabeled LPS continued for 6 wk. Within the DLN, most of the LPS was found in the subca...
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PMID: 21849675
PDF is available here.
PDF is available here.
Abstract
We confirm previous results that efficient removal of apoptotic cells (efferocytosis) is bolstered in the presence of wild-type mouse serum, through the C3 deposition on the apoptotic cell surface. In contrast, sera from three mouse models of SLE, Mer(KD), MRL(lpr), and New Zealand Black/WF1 did not...
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PMID: 21813769
PDF is available here.
PDF is available here.
Abstract
We show that in both RAW264.7 macrophage cells and primary bone marrow-derived macrophages, the production of IFN-β and IL-6, but not TNF, in response to cyclic-di-AMP and cyclic-di-GMP requires MPYS (also known as STING, MITA, and TMEM173). Furthermore, expression of MPYS was required for IFN resp...
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PMID: 21813776
PDF is available here.
PDF is available here.
Abstract
Journal of Immunotherapy (34)7 2011
Abstract
We established several CD4 T-cell clones by in vitro stimulation of peripheral blood mononuclear cells from a healthy donor by a peptide pool of 28 to 30 amino acid long peptides spanning the entire Melan-A/MART-1 protein. These CD4 T-cell clones recognized a peptide that is embedded within Melan-A/...
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PMID: 21760531
PDF is available here.
PDF is available here.
Abstract
To evaluate the effect of human amniotic fluid (HAF) on retinal pigmented epithelial cells growth and trans-differentiation into retinal neurons, retinal pigmented epithelium (RPE) cells were isolated from neonatal human cadaver eye globes and cultured in Dulbecco's modified Eagle's...
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PMID: 21142973
PDF is available here.
PDF is available here.
Avian Diseases (55)3 2011
Abstract
Two different wild duck species common in Chile and neighboring countries, Chiloe wigeon (Anas sibilatrix) and cinnamon teal (Anas cyanoptera), were intranasally inoculated with 10(6) mean embryo infective dose (EID50) of the H7N3 low pathogenicity (LP) avian influenza virus (AIV) (A...
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PMID: 22017047
PDF is available here.
PDF is available here.
Abstract
We performed biochemical characterization and quantification of TDP-43 in homogenates from parietal neocortex of subjects with aclinical diagnosis of no cognitive impairment (NCI, n = 12), mild cognitive impairment (MCI, n = 12), or AD (n = 12). Immunoblots revealed increased detergent-insoluble TDP...
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PMID: 21865887
PDF is available here.
PDF is available here.
Abstract
We measured select markers of coagulation activation prothrombin fragments 1 and 2 (PF1 + 2), thrombin-antithrombin complexes and plasma von Willebrand Factor antigen in 21 patients undergoing hepatic resection. The impact of hepatic resection on coagulation and fibrinolysis was studied with thrombo...
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PMID: 21970128
PDF is available here.
PDF is available here.
Abstract
Matrix metalloproteinase (MMP) 9 is a gelatinase associated with tissue remodeling. It is thought to play a part in the pathogenesis of allergy. Increased levels of MMP-9 have been shown to increase in the acute allergic response in the nose, lungs, and skin. Exposure to passive tobacco smoke is asso...
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PMID: 21819758
PDF is available here.
PDF is available here.
Abstract
The biopolymer matrigel loaded with cytokine can be used for the recruitment in vivo of specific cell populations and as a vector for the preparation of cell cultures. Data demonstrate that the injection of the matrigel biopolymer supplemented with interleukin-8 (IL-8) in the leech H...
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PMID: 21400659
PDF is available here.
PDF is available here.
Abstract
To evaluate tear levels of neuromediators in patients with dry eye disease and to identify statistical correlations with the clinical findings.
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PMID: 21825181
PDF is available here.
PDF is available here.
Abstract
Study Type - Aetiology (case series). Level of Evidence: 4. What's known on the subject? and What does the study add? Oxidative stress seems to be one of the biochemical causes of defective sperm function. Paraoxonases are antioxidant enzymes that degrade lipid peroxides. There is a paucity of data o...
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PMID: 21091978
PDF is available here.
PDF is available here.
Abstract
To determine the aqueous humour levels of vascular endothelial growth factor (VEGF) and erythropoietin (EPO) in eyes with diabetic macular oedema before and after intravitreal EPO injection.
Prospective interventional case series.
Eleven eyes of 11 pat...
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PMID: 21819507
PDF is available here.
PDF is available here.
Abstract
We studied the seasonal dynamics of Bordetella bronchiseptica in a free-living rabbit population over 5 years and discuss the possible mechanisms of infection. This bacterium has been isolated in livestock and wildlife where it causes respiratory infections that rapidly spread between individuals an...
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PMID: 20943004
PDF is available here.
PDF is available here.
Abstract
Structurally-functional myocardium parameters and their interconnection with erythropoietin and tumour necrosis factor-alpha levels in blood plasma of patients with heart failure were analysed. Prevalence of erythropoietin over tumour necrosis factor-alpha in blood had positive effec...
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PMID: 21961313
PDF is available here.
PDF is available here.
Abstract
We have investigated the evolution of myocardial leptin expression following myocardial infarction (MI) and evaluated the consequences of specific cardiac leptin inhibition on subsequent LV dysfunction. Anaesthetized rats were subjected to temporary coronary occlusion. An antisense oligodesoxynucleo...
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PMID: 20731748
PDF is available here.
PDF is available here.
Hormones and Cancer (2)4 2011
Abstract
We previously demonstrated that H2 relaxin (RLN2) facilitates castrate-resistant (CR) growth of prostate cancer (CaP) cells through PI3K/Akt/β-catenin-mediated activation of the androgen receptor (AR) pathway. As inhibition of this pathway caused only ~50% reduction in CR growth, the goal of the cu...
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PMID: 21789713
PDF is available here.
PDF is available here.
Abstract
The Quantitative Assay Database (QuAD), http://proteome.moffitt.org/QUAD/, facilitates widespread implementation of quantitative mass spectrometry in cancer biology and clinical research through sharing of methods and reagents for monitoring protein expression and modification....
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PMID: 21656910
PDF is available here.
PDF is available here.
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology (27)8 2011
Abstract
To study whether rSj26-Sj32 fusion protein can be used for diagnosis of chronic schistosomiasis japonicum.
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PMID: 21806877
PDF is available here.
PDF is available here.
Abstract
Beta-arrestin 2 has been shown to participate in the pathogenesis of asthma by inducing Th2 cell migration to the lungs. Whether beta-arrestin 2 regulates cytokine production of CD4+ T cells is still unknown. The aim of the present study was to investigate the effect of beta-arrestin...
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PMID: 21870426
PDF is available here.
PDF is available here.
Journal of Neuroscience (31)31 2011
Abstract
We examine the effect of endotoxin-induced inflammation on Ox neuron biology and LMA in rats. Our results demonstrate a vital role for diminished Ox signaling in mediating inflammation-induced lethargy. This work defines a specific population of inflammation-sensitive, arousal-associated Ox neurons...
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PMID: 21813697
PDF is available here.
PDF is available here.
Abstract
Human toxocariasis is a worldwide parasitic disease. Children are more frequently infected because of the closer contact with contaminated soil and relatively frequent geophagia. Toxocariasis in children has variable modes of presentation but clinical diagnosis is difficult. Various...
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PMID: 21980766
PDF is available here.
PDF is available here.
Clinical Nephrology (76)2 2011
Abstract
Hepcidin was inversely associated with eGFR and linearly associated with ferritin (p...
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PMID: 21762639
PDF is available here.
PDF is available here.
Clinical Nephrology (76)2 2011
Abstract
Urinary IL-6 and TGF-β levels at diagnosis were significantly higher in patients with IgA nephropathy compared to healthy subjects. TGF-β levels, were significantly higher in patients with proteinuria > 1 g/24 h and/or severe mesangial proliferation. Although a significant reduction of proteinuria...
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PMID: 21762647
PDF is available here.
PDF is available here.
Clinical Nephrology (76)2 2011
Abstract
Urinary AGT levels correlated positively with proteinuria, urinary TGF-beta1 levels and diastolic blood pressure, but negatively with the estimated glomerular filtration rate (GFR). Urinary AGT concentrations were increased in patients with severe glomerulosclerosis, tubular atrophy and interstitial...
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PMID: 21762643
PDF is available here.
PDF is available here.
Abstract
To investigate the possible influence of tumour necrosis factor-alpha (TNF), TNF receptor I (TNFRI) and TNF receptor II (TNFRII) gene polymorphisms on anti-TNF treatment responsiveness, stratified by autoantibody status.
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PMID: 21813066
PDF is available here.
PDF is available here.
Abstract
We aimed to determine the effect of using alternate LP reconstitution acids on physiologic parameters, blood loss, coagulation, oxidative DNA damage, and proinflammatory cytokines in a polytrauma and hemorrhagic shock model....
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PMID: 21818011
PDF is available here.
PDF is available here.
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders (28)1 2011
Abstract
We analysed the association between these lung-specific biomarkers and skin involvement, anti-Scl-70 antibody titres and an index of disease activity.
Serum SP-D, KL-6 and anti-Scl-70 concentrations were determined by ELISA in 25 SSc patients. Disease activity and lung function param...
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PMID: 21796888
PDF is available here.
PDF is available here.
Abstract
We present the results from the first two rounds of the program.
The program is open for laboratories using commercially available kits for Aβ, T-tau, or P-tau. CSF samples (aliquots of pooled CSF) are sent for analysis several times a year from the Clinical Neurochemistry Laborator...
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PMID: 21784349
PDF is available here.
PDF is available here.
Abstract
We screened Calycolpus moritzianus (O. Berg) Burret leaves extracts by a competitive ELISA-based assay. MeOH and CHCl3 extracts and several their fractions demonstrated to be able to prevent VEGF or PlGF interaction with Flt-1, with an inhibition about 50% at concentration of 100 microg/mL. Phytoche...
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PMID: 21834229
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1812)7 2011
Abstract
We analyzed an osteoblast primary culture derived from the cervical vertebrae of a mandibuloacral dysplasia type A patient bearing the homozygous R527H LMNA mutation. Mandibuloacral dysplasia type A osteoblasts showed nuclear abnormalities typical of laminopathic cells, but they proliferated in cult...
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PMID: 21419220
PDF is available here.
PDF is available here.
Abstract
We used in situ methods, such as (fluorescent) IHC staining, three-dimensional reconstruction, and laser microdissection, followed by mRNA expression analysis. We generated compartment-specific expression patterns in the lungs of 25 patients (11 with PAH associated with systemic shunts, 6 with idiop...
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PMID: 21703400
PDF is available here.
PDF is available here.
Abstract
We used three distinct animal models to investigate the hypothesis that increases in the levels of serum enzymes can be the result of decreases in KCs in the apparent absence of hepatic or skeletal muscle injury. Specifically, neutralizing M-CSF activity via a novel human monoclonal antibody reduced...
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PMID: 21703406
PDF is available here.
PDF is available here.
Abstract
We used the agonist AP214 to test MC-dependent anti-inflammatory effects. In zymosan peritonitis, treatment of mice with AP214 (400 to 800 μg/kg) inhibited cell infiltration, an effect retained in MC receptor type 1, or MC(1), mutant mice but lost in MC(3) null mice. In vitro, cytokine release from...
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PMID: 21703408
PDF is available here.
PDF is available here.
Abstract
We developed a guinea pig infection model for acute and chronic Chagas disease. Seventy-two guinea pigs were inoculated intradermally with 10(4) trypomastigotes of T. cruzi strain Y (experimental group); 18 guinea pigs were used as control group. Eight animals from the experimental group and two fro...
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PMID: 21703410
PDF is available here.
PDF is available here.
Abstract
We examined the role of Bmp6 in retinal iron regulation and in AMD pathogenesis. Bmp6 was detected in the retinal pigment epithelium (RPE), a major site of pathology in AMD. In cultured RPE cells, Bmp6 was down-regulated by oxidative stress and up-regulated by iron. Intraocular Bmp6 protein injectio...
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PMID: 21703414
PDF is available here.
PDF is available here.
Abstract
We established a three-dimensional (3D) human cell culture system that recapitulates the tumor heterogeneity observed in vivo. Human colon tumor cells were grown as multicellular spheroids and subsequently co-cultured with normal fibroblasts or CAFs in collagen I gels. This in vitro model system clo...
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PMID: 21703426
PDF is available here.
PDF is available here.
Abstract
We report that IMT504, the prototype of a major class of immunostimulatory ODNs, is a potent adjuvant of the influenza vaccine in young adult and elderly rats. Flu vaccines that use virosomes or whole viral particles as antigens were combined with IMT504 and injected in rats. Young adult and elderly...
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PMID: 21793787
PDF is available here.
PDF is available here.
Abstract
Elevation of IL-17 and IFN-γ may be an important dysregulation of cellular immunity in pediatric patients with chronic ITP. The disease activity is associated with reduced production of TGF-β1. Pediatr Blood Cancer © 2011 Wiley-Liss, Inc.
Copyright © 2011 Wiley-Liss, Inc....
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PMID: 21721104
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of TRAIL on OPG release. Unexpectedly, recombinant TRAIL decreased the spontaneous OPG release in all cell types examined. Moreover, TRAIL decreased OPG release also in stromal cells co-cultured with lymphoma cells and counteracted the OPG induction by TN-alpha in HUVEC an...
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PMID: 21660951
PDF is available here.
PDF is available here.
Abstract
362 nonredundant proteins were identified, 113 of which were expressed differentially between preeclampsia and normal pregnant group and 31 differential proteins among three groups. These differential proteins were associated with biological processes of blood coagulation, cell adhesion and differen...
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PMID: 21538910
PDF is available here.
PDF is available here.
Abstract
Abstract. Plasmodium vivax remains an important cause of morbidity outside Africa, and no effective vaccine is available against this parasite. The P. vivax Duffy binding protein (PvDBP) is essential during merozoite invasion into erythrocytes, and it is a target for protective immun...
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PMID: 21633032
PDF is available here.
PDF is available here.
Abstract
Our results showed that 76% and 93% of these patients had elevated IgM and IgG against r47b, respectively, and 98% and 100% had elevated IgM and IgG against r56s, respectively. The kinetics of antibody responses against r47b and r56s can be grouped into three patterns. In the first type of response,...
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PMID: 21508168
PDF is available here.
PDF is available here.
New England Journal of Medicine (364)22 2011
Abstract
We searched for antibodies against bovine serum albumin and circulating bovine serum albumin by means of enzyme-linked immunosorbent assay and Western blotting in serum specimens obtained from 50 patients with membranous nephropathy and 172 controls. The properties of immunopurified circulating bovi...
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PMID: 21631322
PDF is available here.
PDF is available here.
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology / edited by the Gaetano Conte Academy for the study of striated muscle diseases (30)1 2011
Abstract
Muscle degeneration in Duchenne muscular dystrophy (DMD) is exacerbated by increased oxidative stress and the endogenous inflammatory response, with a key role played by nuclear factor kappa-B (NF-kappaB) and other related factors such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-6. Howe...
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PMID: 21842588
PDF is available here.
PDF is available here.