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Immunoenzyme Techniques (2):
Recent article
Immunoenzyme Techniques
Developmental Cell (21)4 2011
Abstract
We use a combination of in vivo quantitative proteomics and analyses of cyclin E knockout mice to demonstrate that in terminally differentiated neurons cyclin E forms complexes with Cdk5 and controls synapse function by restraining Cdk5 activity. Ablation of cyclin E led to a decreased number of s...
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PMID: 21944720
PDF is available here.
PDF is available here.
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Developmental Cell (21)4 2011
Abstract
We generated and characterized Atxn1L(-/-) and Atxn1(-/-); Atxn1L(-/-) mice. Atxn1L(-/-) mice have hydrocephalus, omphalocele, and lung alveolarization defects. These phenotypes are more penetrant and severe in Atxn1(-/-); Atxn1L(-/-) mice, suggesting that ATXN1 and ATXN1L are functionally redundan...
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PMID: 22014525
PDF is available here.
PDF is available here.
Abstract
We tested 10 diagnostic assays, including 1 commercial real-time polymerase chain reaction (qPCR) test for the laboratory detection of toxigenic C difficile on 1,000 stool samples. Sensitive culture for toxigenic C difficile using 2 types of media with broth enrichment defined the reference standard...
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PMID: 21846912
PDF is available here.
PDF is available here.
Saudi medical journal (32)9 2011
Abstract
To determine age-specific prostate-specific antigen (PSA) reference values in a community-based sample of Sudanese men, aged 40-90 years.
This study was conducted in the Central Laboratory Services, Soba University Hospital, Khartoum, Sudan from January 2008 to May 20...
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PMID: 21894356
PDF is available here.
PDF is available here.
Abstract
Evaluation of anti-pertussis antibodies in pertussis patients at different stages after the onset of the disease.
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PMID: 21809645
PDF is available here.
PDF is available here.
Clinical and Experimental Rheumatology (29)1 Suppl 64 2011
Abstract
Abstract
We show that [(3)H]-resveratrol enters colon cancer cells (SW480, SW620, HT29) and leukemia U937 cells through a monensin (5-20 μmol/L) -sensitive process that suggests clathrin-independent endocytosis. Uptake of the molecule can be prevented by methyl-β-cyclodextrin (2-12 mg/mL), nystatin (12 ng/...
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PMID: 21467134
PDF is available here.
PDF is available here.
Abstract
We found 35 brains with deposits of 3 proteins (tau, β-amyloid, and α-synuclein). In these two series of brains, the high incidence of deposition of multiple proteins in neurodegenerative disorders is shown. Our results are in agreement with previous findings showing that tau, β-amyloid, and α-s...
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PMID: 21618706
PDF is available here.
PDF is available here.
Abstract
We examined the impact of CR on a model of inflammation-associated pancreatitis and pancreatic dysplasia, with a focus on the mechanistic contribution of systemic IGF-1. Administration of a 30% CR diet for 14 weeks decreased serum IGF-1 levels and hindered pancreatic ductal lesion formation and dysp...
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PMID: 21593196
PDF is available here.
PDF is available here.
Abstract
We then investigated its glomerular expression by IHC and found that the Jund promoter is mainly active in Jund(-/-) podocytes. Furthermore, cultured glomeruli from Jund(-/-) mice showed relatively increased expression of vascular endothelial growth factor A (Vegfa), Cxcr4, and Cxcl12, well-known HI...
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PMID: 21640331
PDF is available here.
PDF is available here.
Abstract
We hypothesized that dual antagonism of these chemokines might have additive protective effects on the progression of diabetic nephropathy. We used chemokine antagonists based on structured l-enantiomeric RNA (so-called Spiegelmers) ie, the CCL2-specific mNOX-E36 and the CXCL12-specific NOX-A12. Mal...
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PMID: 21703397
PDF is available here.
PDF is available here.
Abstract
MOC-31 alone was found to be highly sensitive for distinguishing reactive mesothelial cells/mesothelioma from metastatic adenocarcinoma in effusion specimens. Interpreting membranous MOC-31 staining as positive can help prevent confusion between reactive mesothelial cells/mesothelioma and metastatic...
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PMID: 21732548
PDF is available here.
PDF is available here.
Abstract
We show that Ly6C/G(+) (Gr-1(+)) cells, including neutrophils and inflammatory monocytes, accumulate in the splenic red pulp during infection. Cell depletion using monoclonal antibody against either Ly6C/G(+) (Gr-1; RB6) or Ly6G(+) (1A8) cells increased parasite burden. In contrast, depletion of Ly6...
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PMID: 21703391
PDF is available here.
PDF is available here.
Abstract
We hypothesized that immune gene-related signatures would predict the presence of unique histological features of lymphoid cell infiltrates in colorectal carcinoma (CRC) that correlate with clinical parameters. Metagene analysis with gene chip technology was performed on 326 CRCs, which were then sor...
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PMID: 21703392
PDF is available here.
PDF is available here.
Abstract
We studied the effects of the LXRα,β-agonist GW3965 on acute and chronic organ damage in the F344-LEW rat kidney transplantation model. In addition, to gain LXR isoform and cell-specific insights BALB/c kidneys were transplanted into mice with macrophage overexpression of LXRα (mLXRα-tg) and eva...
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PMID: 21703396
PDF is available here.
PDF is available here.
Abstract
We hypothesized that overexpression of RelB in the airways of mice would dampen acute smoke-induced pulmonary inflammation. Mice received a recombinant adenovirus encoding RelB by intranasal aspiration to induce transient RelB overexpression in the lungs and were subsequently exposed to mainstream c...
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PMID: 21703398
PDF is available here.
PDF is available here.
Abstract
We used in situ methods, such as (fluorescent) IHC staining, three-dimensional reconstruction, and laser microdissection, followed by mRNA expression analysis. We generated compartment-specific expression patterns in the lungs of 25 patients (11 with PAH associated with systemic shunts, 6 with idiop...
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PMID: 21703400
PDF is available here.
PDF is available here.
Abstract
CD45(+) and collagen I-positive (Col(+)) fibrocytes are implicated in fibrogenesis in skin, lungs, and kidneys. Fibrocyte migration in response to liver injury was investigated using bone marrow (BM) from chimeric mice expressing luciferase (Col-Luc→wt) or green fluorescent protein (Col-GFP→wt) u...
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PMID: 21703401
PDF is available here.
PDF is available here.
Abstract
We examined pathological manifestations in models of macrophage- or neutrophil-depleted mice challenged with sublethal doses of influenza A virus H1N1 strain PR8. Infected mice depleted of macrophages displayed excessive neutrophilic infiltration, alveolar damage, and increased viral load, later pro...
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PMID: 21703402
PDF is available here.
PDF is available here.
Abstract
We have developed a murine model of chronic disease by challenging C57BL/6 mice intranasally with a low dose of B. pseudomallei and monitoring them up to 100 days postinfection. Bacterial burdens were heterogeneous in different animals at all time points, consistent with the spectrum of clinical sev...
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PMID: 21703409
PDF is available here.
PDF is available here.
Abstract
We conclude the following: i) overexpression of ΔNp63 contributes to salivary tumorigenesis, ii) ΔNp63 plays a dominant negative effect on the TA isoform in the modulation of cell migration and invasion, and iii) the ΔN isoform plays an oncogenic role and may represent an attractive target for th...
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PMID: 21703418
PDF is available here.
PDF is available here.
Abstract
Expression of E-cadherin is used to monitor the epithelial phenotype, and its loss is suggestive of epithelial-mesenchymal transition (EMT). EMT triggers tumor metastasis. Exit from EMT is marked by increased E-cadherin expression and is considered necessary for tumor growth at sites...
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PMID: 21703419
PDF is available here.
PDF is available here.
Abstract
We recently identified that MSH2, a key DNA mismatch repair (MMR) protein integral to the suppression of tumorigenesis, is an NPM-ALK-interacting protein. In this study, we found in vitro evidence that enforced expression of NPM-ALK in HEK293 cells suppressed MMR function. Correlating with these fin...
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PMID: 21703420
PDF is available here.
PDF is available here.
Abstract
We characterize the transformed phenotypes resulting from deletion of the Pten and TP53 tumor suppressors in prostate epithelium. Using the PB-Cre4(+)Pten(fl/fl)TP53(fl/fl) model of prostate cancer, we describe the histological and metastatic properties of primary tumors, transplanted primary tumor...
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PMID: 21703421
PDF is available here.
PDF is available here.
Abstract
Tissue dendritic cells (DCs) may influence the progression of renal cell carcinoma (RCC) by regulating the functional capacity of antitumor effector cells. DCs and their interaction with T cells were analyzed in human RCC and control kidney tissues. The frequency of CD209(+) DCs in RCCs was found to...
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PMID: 21703422
PDF is available here.
PDF is available here.
Abstract
We propose that iPLA(2) is a potential effective and novel target for EOC. We tested this concept and found that bromoenol lactone (BEL), a selective inhibitor of iPLA(2), significantly inhibited EOC metastatic tumor growth in mouse xenograft models using human SKOV3 and HEY ovarian cancer cells. Mo...
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PMID: 21703423
PDF is available here.
PDF is available here.
Abstract
Malignant astrocytomas, the most common primary brain tumors, are predominantly fatal. Improved treatments will require a better understanding of the biological features of high-grade astrocytomas. To better understand the role of neuronal PAS 3 (NPAS3) in diseases in human beings, it was investigate...
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PMID: 21703424
PDF is available here.
PDF is available here.
Abstract
We have developed tools for IHC of RREB1 protein isoform-specific amplification of RREB1 mRNA and selective knockdown of RREB1 isoforms and use these to provide new information by characterizing RREB1 expression in bladder and prostate cancer cell lines and human tissue samples. Previously described...
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PMID: 21703425
PDF is available here.
PDF is available here.
Abstract
We established a three-dimensional (3D) human cell culture system that recapitulates the tumor heterogeneity observed in vivo. Human colon tumor cells were grown as multicellular spheroids and subsequently co-cultured with normal fibroblasts or CAFs in collagen I gels. This in vitro model system clo...
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PMID: 21703426
PDF is available here.
PDF is available here.
Abstract
We investigated the contribution of the four PAR family members to motility of lung carcinomas and primary tumor samples from patients. We found that of the four PARs, only PAR1 expression was highly increased in the lung cancer cell lines. Primary lung cancer cells isolated from patient lung tumors...
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PMID: 21703428
PDF is available here.
PDF is available here.
Abstract
We performed gene expression analysis and found that the level of P-cadherin was higher in tissue from liver metastases of colon cancer than in the corresponding primary colon cancer tissues. IHC analysis also showed that P-cadherin expression was significantly higher in liver metastases than in pai...
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PMID: 21703417
PDF is available here.
PDF is available here.
Abstract
We performed a global proteomic profiling to identify the downstream functional proteins of HBx, thereby detecting the mechanisms of action of HBx on virion replication.
HBx in the HepG2.2.15 cell line was knocked down by the transfection of small interfering RNA (siRNA). The replica...
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PMID: 21669574
PDF is available here.
PDF is available here.
Abstract
We characterized lesions in the respiratory tract and central nervous system (CNS) of ferrets (n = 8) inoculated intranasally with influenza virus A/Indonesia/5/2005 (H5N1). By 7 days after inoculation, only 3 of 8 ferrets had a mild or moderate bronchointerstitial pneumonia. In contrast, all 8 ferr...
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PMID: 21640972
PDF is available here.
PDF is available here.
Abstract
IL-33 and its soluble receptor and cell-associated receptor (ST2L) are all increased in clinical and experimental asthma. The present study addressed the hypothesis that ST2L impairs the therapeutic effects of CpG in a fungal model of asthma. C57BL/6 mice were sensitized to Aspergillus fumigatus and...
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PMID: 21640974
PDF is available here.
PDF is available here.
Abstract
We describe a spontaneous mouse model of intestinal inflammation with fibrosis and the profibrotic role of arginase I. The Src homology 2 domain-containing inositol polyphosphate 5'-phosphatase-deficient (SHIP(-/-)) mice developed spontaneous discontinuous intestinal inflammation restricted to the d...
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PMID: 21640975
PDF is available here.
PDF is available here.
Abstract
We hypothesized that selective stimulation of VEGFR2 could be beneficial in this setting. However, VEGFR2 activation may be deleterious in the presence of nitric oxide deficiency. We systematically overexpressed a mutant form of VEGF-A binding only VEGFR2 (Flk-sel) using an adeno-associated virus-1...
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PMID: 21640973
PDF is available here.
PDF is available here.
Abstract
We carried out this study to determine the antioxidant activities of ferritin, glutathione peroxidase (GPx), glutathione S-transferase (GST) and catalase, and glutathione (GSH). These enzymes had their greatest activity among 4 day old virgin female mosquitoes. Using a single blood feed model, group...
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PMID: 21706932
PDF is available here.
PDF is available here.
Abstract
Our results indicate that MS methods are superior to immunochemical methods in detecting gluten proteins in wines and that adverse reactions against gluten treated wines cannot be excluded....
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PMID: 21375303
PDF is available here.
PDF is available here.
Abstract
We investigated the clinical significance of excision repair cross-complementation group 1 (ERCC1), breast cancer susceptibility 1 (BRCA1), and class III β-tubulin (TUBB3) expression in thymic epithelial tumors.
Fifty-six patients with thymic epithelial tumors were included in this...
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PMID: 21289518
PDF is available here.
PDF is available here.
Abstract
We analyzed the B-cell response in a rat model of long-term cardiac allograft tolerance induced by a short-term immunosuppression. We observed that tolerated allografts are infiltrated by numerous B cells organized in germinal centers that are strongly regulated in their IgG alloantibody response. M...
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PMID: 21114655
PDF is available here.
PDF is available here.
Abstract
We explored the feasibility (user friendliness) and test characteristics (sensitivity and specificity) of a new prototype device to detect Chlamydia in adolescent women by using small numbers of subjects and rapid communication with the manufacturer. We compared cervical POC test results to the gold...
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PMID: 20934941
PDF is available here.
PDF is available here.
Abstract
Our recent studies have shown that stem-cell transplantation marginally improves myocardial oxygenation in the infarct tissue leading to improvement in cardiac function. The aim of the present study was to determine the effect of hyperbaric oxygen (HBO) treatment on myocardial oxygenation and recove...
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PMID: 21445785
PDF is available here.
PDF is available here.
Abstract
While the pathologic events associated with multiple sclerosis (MS), diffuse axonal injury, cognitive damage, and white matter plaques, have been known for some time, the etiology of MS is still unknown and therapeutic efforts are somewhat disappointing. This may be due to a lack of fundamental knowl...
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PMID: 21445784
PDF is available here.
PDF is available here.
Abstract
We subsequently re-evaluated the expression of TKTL-1 in six different cancer cell lines (HeLa, MCF-7, A549, HT-1080, M21 and TF-1). Using RT-PCR and consecutive sequence analysis, we show that transketolase (TKT), not TKTL-1, is the dominant isoform of transketolases in the cell lines analyzed. Our...
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PMID: 21445778
PDF is available here.
PDF is available here.
Abstract
We find 18 different biallelic mutations in the gene encoding glutamine-fructose-6-phosphate transaminase 1 (GFPT1) in 13 unrelated families with an autosomal recessive CMS. Consistent with these data, downregulation of the GFPT1 ortholog gfpt1 in zebrafish embryos altered muscle fiber morphology an...
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PMID: 21310273
PDF is available here.
PDF is available here.
Abstract
To evaluate the role of the follicular helper T (T(FH)) cell markers, CD10, BCL6, programmed death-1 (PD-1) and CXCL13, in the differential diagnosis of nodal peripheral T cell lymphomas (PTCLs) and to determine whether PTCL subtypes other than angioimmunoblastic T cell lymphoma (AITL) express T(FH)...
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PMID: 21330314
PDF is available here.
PDF is available here.
Abstract
To assess the presence of transforming growth factor-β (TGFβ) pathway markers in the epithelium of keratoconus patient corneas.
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PMID: 21310385
PDF is available here.
PDF is available here.
Proteomics (11)3 2011
Abstract
Ovarian teratoma is a dermoid cyst in the ovary that contains mature tissues such as hair, teeth, bone, thyroid, etc. To understand the molecular mechanisms of ovarian teratoma growth, a comparative proteomic analysis was undertaken using mesenchymal stem cell-like cells (MSCLCs) iso...
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PMID: 21268265
PDF is available here.
PDF is available here.
Abstract
We show that mutations in prickle genes are associated with seizures in humans, mice, and flies. We identified human epilepsy patients with heterozygous mutations in either PRICKLE1 or PRICKLE2. In overexpression assays in zebrafish, prickle mutations resulted in aberrant prickle function. A seizure...
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PMID: 21276947
PDF is available here.
PDF is available here.
Abstract
We demonstrated that a fully differentiated tissue developed on a ventricular septal occluder that had been implanted due to infarct-related septum rupture. We suggested that this tissue originated from circulating stem cells. The aim of the present study was to evaluate this hypothesis and to inves...
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PMID: 19941631
PDF is available here.
PDF is available here.
Abstract
We previously reported that the mitogen-activated protein kinase (MAPK) pathway plays an important role in aPL-induced TF expression on monocytes. In this study, we identified plasma gelsolin as a protein associated with β(2) GPI by using immunoaffinity chromatography and mass spectrometric analysi...
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PMID: 19840195
PDF is available here.
PDF is available here.
Terapevticheskii arkhiv (83)2 2011
Abstract
To determine the role of immune response with production of auto- and heterologous antibodies (Ab) in development of the pathological process and in structural changes in colon mucosa (CM) in diverticulosis (Dv).
Of 219 Dv patients, 39 were newly diagnosed with x-ray-...
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PMID: 21516846
PDF is available here.
PDF is available here.
Terapevticheskii arkhiv (83)2 2011
Abstract
To estimate serum and urine IL-6 levels and to study its role in diagnosis of nephritis activity in patients with cryoglobulinemic glomerulonephritis (CGN) associated with chronic hepatitis C (CHC).
Enzyme immunoassay was used to assay IL-6 in blood serum of 124 patie...
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PMID: 21516850
PDF is available here.
PDF is available here.
Public Health Reports (126)1 2011
Abstract
We evaluated four key attributes of NYC's HIV incidence surveillance system-simplicity, data quality, timeliness, and acceptability--using CDC's guidelines for surveillance system evaluation. The evaluation revealed that the system could potentially provide HIV incidence estimates stratified by boro...
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PMID: 21337929
PDF is available here.
PDF is available here.
Abstract
We found that the tumor suppressor microRNA, let-7 was significantly downregulated in a proportion of primary HCC tissues (12 of 33, 36.4%) and HCC cell lines. In line with this finding, we have engineered a chimeric Ad5/11 fiber oncolytic adenovirus, SG7011(let7T), by introducing eight copies of le...
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PMID: 21814544
PDF is available here.
PDF is available here.
Abstract
Our aims were: i) to experimentally prove the presumptive association of Congestive Heart Failure (CHF) and Isolated Atrial Amyloidosis (IAA); ii) to characterize ANP aggregation, thereby elucidating IAA implication in the CHF pathogenesis....
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PMID: 21814559
PDF is available here.
PDF is available here.
Abstract
We investigated whether the Wnt/β-catenin pathway might regulate TTF-1 expression in a human PTC model and examined the molecular mechanisms underlying this regulation. Immunofluorescence analysis, real time RT-PCR and Western blot studies revealed that TTF-1 as well as the major Wnt pathway compon...
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PMID: 21814573
PDF is available here.
PDF is available here.
Abstract
We performed genome-wide mRNA expression analysis on 6 non-malignant prostate samples and 24 prostate carcinomas with (n = 16) and without (n = 8) TMPRSS2-ERG fusion as determined by FISH. The top-most differentially expressed genes and their associations with ERG over-expression were techni...
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PMID: 21814574
PDF is available here.
PDF is available here.
Abstract
We investigate the role of NF-κB inhibitor IκBα in atherosclerosis. Myeloid-specific deletion of IκBα results in larger and more advanced lesions in LDL-R-deficient mice without affecting the compositional phenotype of the plaques or systemic inflammatory markers in the plasma. We show that Iκ...
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PMID: 21814576
PDF is available here.
PDF is available here.
Abstract
We investigated whether the collagen chaperone HSP47 could be functionally correlated with APP. We found that HSP47 accumulates in amyloid deposits of two different mouse models and of some AD patients, is capable to physically interact with APP and can be relocalized by APP overexpression. Notably,...
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PMID: 21829458
PDF is available here.
PDF is available here.