Abstract
We conducted a serosurvey there in 2005. A total of 4686 subjects were enrolled and vaccination history and blood samples collected. HBV infective markers were determined by radioimmunoassay. The results were compared with the data of 1985. Our results show that the overall HBsAg prevalence was 7·5...
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PMID: 21156099
PDF is available here.
Abstract
We hypothesized that testosterone regulates components of prostate tight junctions which serve as a barrier to inflammation, thus providing a connection between age- and treatment-associated testosterone declines and prostatic pathology. We examined the expression and distribution of tight junction...
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PMID: 21761342
PDF is available here.
Abstract
We compared the skeletal phenotype of wild-type (ERα(+/+)) and ERα knock out (ERα(-/-)) mice with that of mice in which the only ERα present had a knock-in mutation abolishing ERE binding (non-classical ERα knock-in [NERKI], ERα(-/NERKI)). All three groups were in the same genetic background (...
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PMID: 21458604
PDF is available here.
Abstract
These results suggest that both absolute sex steroid hormone levels and the rates at which the levels change may be important in the development of urologic conditions in aging men....
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PMID: 21367876
PDF is available here.
Abstract
Plasma concentration of progesterone and 17beta-estradiol of black-rumped agouti (Dasyprocta prymnolopha) during the estrous cycle. The agouti is a game animal that have been raised in captivity for conservation and sustainability purposes. However, the management of wild animals in an intensive bree...
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PMID: 21513191
PDF is available here.
Abstract
To investigate plasma ghrelin, gastrin and growth hormone secretagogue receptor (GHS-R) expression in advanced gastric cancer (GC) before and after resection.
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PMID: 21274374
PDF is available here.
Abstract
We conducted this pilot study to evaluate the effect of rimonabant on body weight and composition of adults with PWS.
This was a double blind placebo controlled study. Body weight, total fat mass, fasting ghrelin, leptin, IGF1 and insulin like growth factor binding protein (IGFBP-3)...
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PMID: 20965292
PDF is available here.
Abstract
The local secretion of hGH by tumour explants - presenting a positive immunohistochemical reaction (IHCR) to the product of P53 gene - was twice as high as those with no IHCR to product of P53 gene; the opposite was noted in the case of IGF-I, IGFBP-2 and IGFBP-3 secretion. In both cases, the level...
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PMID: 21670726
PDF is available here.
Abstract
I Disorders diagnosis of psychotic disorder (67 immigrants, 66 Norwegians). The reference sample consisted of 1,046 subjects (177 immigrants, 869 Norwegians). Serum levels of vitamin D were measured by radioimmunoassay, and results were presented as 25-hydroxyvitamin D levels.
Over 80% (n = 55) of i...
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PMID: 20441728
PDF is available here.
Abstract
We propose to analyze whether human AM combined with human AMBP-1 provides benefit in a model of THI in the rat.
Male adult rats were subjected to trauma hemorrhage by resection of ∼50% of total liver tissues and allowed bleeding for 15 minutes. Immediately thereafter, human AM (48 μg/kg birth we...
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PMID: 21057332
PDF is available here.
Abstract
To examine whether implantation of islet preparation-derived proliferating islet cells (PIC) could ameliorate diabetes in rats.
PIC were expanded from rat islet preparation by supplementation of basic fibroblast growth factor (bFGF) and implanted into rats with strept...
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PMID: 20953209
PDF is available here.
Abstract
We examined the association of hyperuricemia with centrally adjudicated incident HF in Cardiovascular Health Study participants with and without hyperinsulinemia. Of the 5,411 participants ≥65 years of age without baseline HF, 1,491 (28%) had hyperuricemia (serum UA ≥6 mg/dl for women and ≥7 m...
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PMID: 20920653
PDF is available here.
Abstract
Over half (55%) of pregnant women with abnormalities suggestive of autoimmune thyroiditis and/or hypothyroidism would be missed if only those with high-risk criteria were examined. A more extensive screening of thyroid autoimmunity and dysfunction seems warranted....
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PMID: 20682632
PDF is available here.
Abstract
We hypothesized that dopaminergic neurotransmission would be enhanced after Roux-en-Y-Gastric Bypass (RYGB) and Vertical Sleeve Gastrectomy (VSG) surgery and that these changes would influence eating behaviors and contribute to the positive outcomes from bariatric surgery.
Five females with obesity...
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PMID: 20362560
PDF is available here.
Zbigniew Czernicki,
Alexander Baethmann,
Umeo Ito,
Yoichi Katayama,
Toshihiko Kuroiwa,
David Mendelow,
Stanisław Hendryk,
Zenon Czuba,
Halina Jędrzejewska-Szypułka,
Piotr Bażowski,
Hanna Doleżych and
Wojciech Król
Abstract
Our results show that acute and prolonged focal cerebral ischemia and reperfusion induce statistically significant increases in the oxidative activity of PMNs. The concentration of proinflammatory mediators (IL-1beta, TNFalpha) as well as ET-1 is also increased, indicating the important role of immu...
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PMID: 19812916
PDF is available here.
Abstract
We therefore investigated whether plasma levels of renin and aldosterone differ between suicide attempters, non-suicidal depressive patients and healthy controls. Furthermore, we analyzed the relation of renin and aldosterone to psychiatric symptoms in the patients. Suicidal patients with MDD, adjus...
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PMID: 20797799
PDF is available here.
Abstract
We conclude that low IGFBP1 and elevated waist measurement predict diabetes development and that IGFBP1 production is suppressed by a novel factor(s) in women developing diabetes. Increasing levels of IGFBP1 during the emergence of diabetes in men and women suggest the emergence of hepatic insulin r...
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PMID: 20508082
PDF is available here.
Abstract
We compared CCK-like immunoreactivity (CCK-LI) in plasma from 25 subjects in the late luteal phase (LLP) and the follicular phase (FP) and found that there was no difference during the menstrual cycle (n=25, R(2)=89.60%, p=n.s.). In the follicular phase no significant difference was found between CC...
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PMID: 20457200
PDF is available here.
Abstract
Blunted GH response to stimulation occurring in the face of reduced IGF-I feedback inhibition with tamoxifen indicates that GH secretion was suppressed by estrogen receptor antagonism. Because circulating estradiol was unaffected, these data indicate a significant role of local estrogen in the centr...
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PMID: 20444909
PDF is available here.
Abstract
Our study suggests that PC2 expression and Akt phosphorylation are related at the molecular level, resulting in a change in cell cycle and an increase in pituitary adenoma size. An elevation of plasma alphaMSH could conjecture the activation of the phosphatidylinositol 3/Akt cascade in PC2-positive...
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PMID: 20501680
PDF is available here.
Abstract
We and others have previously reported that thyrotropin-releasing hormone (TRH, pGlu-His-Pro-NH(2)) and TRH-like peptides (pGlu-X-Pro-NH(2), where "X" can be any amino acid residue) have neuroprotective, antidepressant, anti-epileptic, analeptic, anti-ataxic, and anorectic properties. For this reaso...
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PMID: 20546704
PDF is available here.
Fernando Santos,
M Llanos Moreno,
Arlete Neto,
Gema Ariceta,
Julia Vara,
Angel Alonso,
Alberto Bueno,
Alberto Caldas Afonso,
António Jorge Correia,
Rafael Muley,
Vicente Barrios,
Carlos Gómez and
Jesús Argente
Abstract
Our aim was to evaluate the growth-promoting effect of growth hormone (GH) treatment in infants with chronic renal failure (CRF) and persistent growth retardation despite adequate nutritional and metabolic management.
The study design included randomized, parallel groups in an open,...
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PMID: 20522533
PDF is available here.
Abstract
We require a thorough understanding of how common single nucleotide polymorphisms (SNPs) influence serum concentrations of 25-hydroxyvitamin D (25OHD). We undertook a systematic review of the literature in order to identify studies that examined 25OHD concentrations, and common SNPs. We found nine s...
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PMID: 20363324
PDF is available here.
Thomas M O'Dorisio,
Siegfried R Krutzik,
Eugene A Woltering,
Erika Lindholm,
Saju Joseph,
Abby E Gandolfi,
Yi-Zarn Wang,
J Phillip Boudreaux,
Aaron I Vinik,
Vay Liang W Go,
James R Howe,
Thor Halfdanarson,
M Sue O'Dorisio and
Gregg Mamikunian
Abstract
This highly specific, sensitive pancreastatin assay can detect small changes in liver tumor progression and is up to 100-fold more sensitive and specific than CgA assays in the United States....
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PMID: 20124939
PDF is available here.
Abstract
We explored the actions of TH in the deacetylase activating domain mutant (DADm) mouse, whose NCoR-HDAC3 interaction is genetically disrupted. Several TH-activated genes were derepressed in the liver of euthyroid and hypothyroid DADm mice, consistent with the corepressor paradigm and a critical role...
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PMID: 20427468
PDF is available here.
Takuo Hirose,
Kazuhito Totsune,
Nobuyoshi Mori,
Takefumi Mori,
Ryo Morimoto,
Hirohito Metoki,
Kei Asayama,
Masahiro Kikuya,
Takayoshi Ohkubo,
Masahiro Kohzuki,
Kazuhiro Takahashi and
Yutaka Imai
Abstract
We examined the expression of AM2/IMD in the kidneys of rats with hypertension or chronic renal impairment using quantitative RT-PCR, radioimmunoassay, and immunohistochemistry. Kidneys of 8-wk-old male spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats were dissected into inner medul...
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PMID: 20462970
PDF is available here.
Abstract
We tested the hypothesis that in POTS women during orthostasis, activation of the renin-angiotensin-aldosterone system is greater, leading to better compensated hemodynamics in the midluteal phase (MLP) than in the early follicular phase of the menstrual cycle. Ten POTS women and 11 healthy women (c...
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PMID: 20479333
PDF is available here.
Abstract
We investigated the role of kisspeptin in the control of hypothalamic DA and pituitary PRL secretion in adult rats. Intracerebroventricular kisspeptin-10 (Kp-10) elicited PRL release in a dose-dependent manner in estradiol (E2)-treated ovariectomized rats (OVX+E2), whereas no effect was found in oil...
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PMID: 20410200
PDF is available here.
Abstract
We hypothesize that PVAT undergoes adaptative mechanisms during initial steps of diet-induced obesity (DIO) which contribute to preserve vascular function. Four-week-old male C57BL/6J mice were assigned either to a control [low-fat (LF); 10% kcal from fat] or to a high-fat diet (HF; 45% kcal from fa...
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PMID: 20410199
PDF is available here.
Abstract
In ruminants, prostaglandin F2alpha (PGF(2alpha)) is the uterine luteolytic hormone. During luteolysis, PGF(2alpha) is synthesized and released from the endometrium in a pulsatile pattern. The unique structure of the vascular utero-ovarian plexus (UOP) allows transport of luteolytic PGF(2alpha) puls...
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PMID: 20410207
PDF is available here.
Abstract
The unique cis-triene structure of vitamin D and related metabolites makes it susceptible to oxidation, ultraviolet (UV) light-induced conformational changes, heat-induced conformational changes, and attacks by free radicals. Vitamin D(2) is much less bioactive than vitamin D(3) in humans. Metabolic...
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PMID: 20511051
PDF is available here.
Abstract
Though melatonin and melatonin receptor agonists are in clinical use and under development for treating insomnia, the role of endogenous melatonin in the regulation of the sleep-wake cycle remains uncertain. Some clinical case reports suggest that reduced nocturnal melatonin secretion is linked to sl...
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PMID: 20550025
PDF is available here.
Abstract
These findings mimic experimental animal findings and provide the first direct human evidence that increased cortisol in utero is associated with impaired cognitive development, and that its impact is dependent on the quality of the mother-infant relationship.
Copyright 2010 Society of Biological Ps...
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PMID: 20188350
PDF is available here.
Abstract
We use crossing the ArKO mice with APP23 transgenic mice, a mouse model of AD, to produce APP23/Ar(+/-) mice to study the estrogen-independent effect of testosterone on AD. We found a significant reduction in brain plaque formation, improved cognitive function and increase NEP activity in male APP23...
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PMID: 20505099
PDF is available here.
Abstract
Hepcidin-25 was detected in all biological fluids tested. The mean +/- SD hepcidin-25 in serum was 15.68 +/- 15.7 ng/mL, bile 7.37 +/- 7.4 ng/mL, saliva 3.4 +/- 2.8 ng/mL, exudative fluid 65.64 +/- 96.82 ng/mL and transudative fluid 14.1 +/- 17.8 ng/mL. CONCLUSION: We provide clear evidence that hep...
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PMID: 20440853
PDF is available here.
Abstract
We employed isotope-dilution liquid chromatography (LC) tandem-mass spectrometry (MS/MS) for the measurement of both 25-OH vitamin D3 and 25-OH vitamin D2 in human serum. Hexadeuterium labelled 25-OH vitamin D3 internal standard (IS) was added to calibrators (prepared in phosphate-buffered saline wi...
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PMID: 20381436
PDF is available here.
Abstract
There was no significant difference in RBP4 levels according to the presence of metabolic syndrome, although adiponectin and HMW adiponectin were significantly lower in metabolic syndrome. Correlation analysis of log RBP4 with IR and metabolic indices revealed that there was no significant correlati...
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PMID: 20376890
PDF is available here.
Abstract
While healthy controls had low TK serum levels (median 2.5 U/l, 95th percentile 8.8 U/l), they were significantly higher in patients with lung cancer (median 4.2 U/l, p=0.014) and also in patients with benign lung diseases (median 5.7 U/l; p=0.002). Patients with lung cancer and benign lung diseases...
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PMID: 20592392
PDF is available here.
Abstract
The score for the primary and related symptoms of the menstruation was increased significantly among patients treated with the WJJ. The differences on the FSH, PRL, and E2 levels of patients were significant before and after the treatment with WJJ. Comparing the WJJ group and the placebo group, the...
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PMID: 20051257
PDF is available here.
Abstract
The National Institute on Drug Abuse (NIDA) and the Office of National Drug Control Policy (ONDCP) reported a 1.5-fold increase in the delta-9-tetrahydrocannabinol (THC) content of street cannabis seizures from 1997 to 2001 versus 2002 to 2006. This study was conducted to compare the changes, over t...
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PMID: 20074884
PDF is available here.
Abstract
The first TM EQA results of 2008 showed that the pass percentage of all participating laboratories ranged from 87.3% (CA125) to 95.5% (beta-2-microglobulin). And the second batch ranged from 83.5% (HCG) to 94.0% (beta-2-microglobulin). The coefficient variances (CVs) of intra-group values determined...
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PMID: 20646652
PDF is available here.
Abstract
We often observe change of weight in thyroid disease. It is emphasized that changes in hormones such as peptide levels are in close relationship with regulation of body mass: ghrelin increases appetite and in effect increases body mass, but obestatin decreases appetite and weight. The aim of the stu...
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PMID: 20583539
PDF is available here.
Abstract
There may be a positive relationship between severity of IR and peak GH in obese girls....
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PMID: 20583540
PDF is available here.
Abstract
In this review, some light is thrown on various labeled immunoassays that depend on antigen-antibody (Ag-Ab) reactions, including immunofluorescence, radioimmunoassay, and enzyme immunoassay (EIA or ELISA). Their definitions, principles, and applications are described, then they are discussed chrono...
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PMID: 20383411
PDF is available here.
Abstract
We used a mouse developmental vitamin D (DVD) deficiency model. Female C57Bl/6J mice were fed a vitamin D-free diet for 6 weeks prior to conception and during gestation. At birth, dams and their offspring were fed a normal vitamin D-containing diet. The adult offspring underwent a learning test base...
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PMID: 20079764
PDF is available here.
Abstract
The serum levels of alanine transaminase and aspartate transaminase were increased in the model group compared with the control group (P < 0.01), and they were decreased in the three treatment groups compared with the model group. The serum levels of total protein and albumin were decreased in the m...
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PMID: 20333785
PDF is available here.
Abstract
Migraine is a high prevalence disorder which affects a significant proportion of the general population, especially women during their central and more productive time of the life, thus causing severe disability. The genetic basis of the disease is unknown and the mechanism is poorly understood. The...
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PMID: 20336417
PDF is available here.
Abstract
The new Hamilton diluter increased the accuracy of the neopterin test procedure. Results are now identical with those of RIA and ELISA when run in a semi-automated manner. Differences in pipetting performance of standards and samples are considered as one possible explanation for the earlier discrep...
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PMID: 20020818
PDF is available here.
Abstract
We investigated the endogenous expression of IGF-1, and two related binding proteins (IGF-binding proteins, IGFBP-2 and BP-3) in serum and cerebrospinal fluid (CSF) of 54 sporadic ALS (sALS) patients. Twenty-five healthy individuals and 25 with other neurological diseases (OND) were used as controls...
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PMID: 19845745
PDF is available here.
Abstract
Selected physiological parameters were monitored over a 4-year period in the Barrow Island euro, Macropus robustus isabellinus, in Western Australia in a study of this species' homeostatic capabilities in an extremely arid habitat where individuals are exposed to high environmental temperatures and...
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PMID: 20178800
PDF is available here.
Abstract
The nucleic acid barcode dot method does not require special equipment or complex procedures, but its detection limit is 2-3 orders of magnitude lower than ELISA....
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PMID: 20001442
PDF is available here.
Abstract
6MWT and neurohumoral markers (mainly BNP, but also NA and TNFalpha) are good predictors of the degree of LV remodelling, showing an independent correlation with the level of LV dilatation/dysfunction in chronic severe MR.These assessments may supplement standard echocardiography in LV decompensatio...
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PMID: 20306889
PDF is available here.
Abstract
C(2) or AUC sparse sampling methods are widely recommended for therapeutic monitoring of cyclosporin A (CsA). One additional reason for promoting the C(2) sampling time in place of commonly used C(0) is that the C(2) level may actually provide more accurate measurement of parent drug concentration b...
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PMID: 20137760
PDF is available here.
E Struwe,
G Berzl,
R Schild,
H Blessing,
L Drexel,
B Hauck,
A Tzschoppe,
M Weidinger,
M Sachs,
C Scheler,
E Schleussner and
J Dötsch
Abstract
Besides foetal or maternal disorders, placental dysfunction is a major cause of intrauterine growth restriction (IUGR). Although numerous macro- and histopathological changes have been described, little is known about the precise aetiology and the contribution of foetal/placental gen...
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PMID: 19548955
PDF is available here.
E Struwe,
G Berzl,
R Schild,
H Blessing,
L Drexel,
B Hauck,
A Tzschoppe,
M Weidinger,
M Sachs,
C Scheler,
E Schleussner and
J Dötsch
Abstract
Besides foetal or maternal disorders, placental dysfunction is a major cause of intrauterine growth restriction (IUGR). Although numerous macro- and histopathological changes have been described, little is known about the precise aetiology and the contribution of foetal/placental gen...
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PMID: 19548955
PDF is available here.
E Struwe,
G Berzl,
R Schild,
H Blessing,
L Drexel,
B Hauck,
A Tzschoppe,
M Weidinger,
M Sachs,
C Scheler,
E Schleussner and
J Dötsch
Abstract
Besides foetal or maternal disorders, placental dysfunction is a major cause of intrauterine growth restriction (IUGR). Although numerous macro- and histopathological changes have been described, little is known about the precise aetiology and the contribution of foetal/placental gen...
|
PMID: 19548955
PDF is available here.
E Struwe,
G Berzl,
R Schild,
H Blessing,
L Drexel,
B Hauck,
A Tzschoppe,
M Weidinger,
M Sachs,
C Scheler,
E Schleussner and
J Dötsch
Abstract
Besides foetal or maternal disorders, placental dysfunction is a major cause of intrauterine growth restriction (IUGR). Although numerous macro- and histopathological changes have been described, little is known about the precise aetiology and the contribution of foetal/placental gen...
|
PMID: 19548955
PDF is available here.
E Struwe,
G Berzl,
R Schild,
H Blessing,
L Drexel,
B Hauck,
A Tzschoppe,
M Weidinger,
M Sachs,
C Scheler,
E Schleussner and
J Dötsch
Abstract
Besides foetal or maternal disorders, placental dysfunction is a major cause of intrauterine growth restriction (IUGR). Although numerous macro- and histopathological changes have been described, little is known about the precise aetiology and the contribution of foetal/placental gen...
|
PMID: 19548955
PDF is available here.