Soumyabrata Roy,
Shyamal Goswami,
Anamika Bose,
Kuntal Kanti Goswami,
Koustav Sarkar,
Krishnendu Chakraborty,
Tathagata Chakraborty,
Smarajit Pal,
Atanu Haldar,
Parthasarathi Basu,
Jaydip Biswas and
Rathindranath Baral
Abstract
We have verified its dendritic cell (DC) maturating ability from monocytes of cervical cancer stage IIIB (CaCx-IIIB) patients. First, we evaluated the status of monocytes from CaCx-IIIB and healthy women by conducting flow cytometric studies of various activation markers and a cytokine analysis by e...
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PMID: 21925117
PDF is available here.
Abstract
We report on a challenging case of percutaneous epicardial ablation of an epicardial accessory pathway located at right atrial appendage in a 28-year-old man with Wolff-Parkinson-White syndrome, who had a prior history of unsuccessful endocardial ablation. Percutaneous epicardial ablation may be a v...
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PMID: 21983769
PDF is available here.
Abstract
We assessed the associations between increased vancomycin MIC, agr group II locus, and vancomycin treatment failure in Methicillin-resistant Staphylococcus aureus (MRSA) bacteremias....
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PMID: 21817905
PDF is available here.
Abstract
Providing effective pain control is a critical part of dental treatment, yet achieving consistently reliable anesthesia in the mandible has proved elusive. The traditional inferior alveolar nerve block (IANB) has a high failure rate; for example, the failure rate in lateral incisors...
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PMID: 21881055
PDF is available here.
Abstract
We believe it represents clear guidance for the deployed clinician and recommend the use of selective non-operative management when appropriate....
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PMID: 21977714
PDF is available here.
Abstract
The objective of this study is to assess cost-effectiveness of different biologic strategies in patients with moderate-to-severe active RA after an insufficient response to anti-TNF agents within the context of the Italian healthcare system.
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PMID: 21813056
PDF is available here.
Abstract
Hepatitis C virus (HCV), a major cause of liver disease throughout the world, is difficult to treat with interferon (IFN) (and various formulations and combinations thereof) being the only approved molecule available. It has been investigated recently that proinflammatory chemokine i...
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PMID: 21554996
PDF is available here.
Abstract
Non-response, loss of response, or intolerance to anti-tumour necrosis factor alpha (anti-TNFα) therapy is well recognised in Crohn's disease (CD) patients. Data concerning outcomes following the use of a second anti-TNFα therapy, particularly in patients who do not respond to a fi...
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PMID: 21683302
PDF is available here.
Abstract
Laparoscopic revision antireflux surgery appears to be feasible and safe, but subject to somewhat greater risk of conversion, higher morbidity, longer hospital stay, and poorer outcomes than primary laparoscopic fundoplication.
Copyright © 2011 Elsevier Inc. All rights reserved....
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PMID: 21788005
PDF is available here.
Abstract
Ablation is more successful for patients with paroxysmal atrial fibrillation (AF1) than for those with persistent (AF2) or longstanding persistent AF (AF3). Many patients fail initial ablation and undergo repeat ablations. Little is known about repeat ablation procedure times, complications, and outc...
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PMID: 21742108
PDF is available here.
Abstract
We hypothesize that specific and unique risk factors exist for failed extubation in trauma patients. The purpose of this study was to identify the risk factors in trauma patients....
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PMID: 21818012
PDF is available here.
Abstract
We present an adult aortic coarctation patient who had undergone a Bentall operation and two unsuccessful stent implantations for recurrent aortic coarctation. The patient then got an extra-anatomic bypass for aortic coarctation and concomitant mitral valve commissurotomy through median sternotomy....
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PMID: 21780060
PDF is available here.
Abstract
The acutely failing Fontan circulation requires urgent management to decompress the systemic venous pressures and augment cardiac output. This may involve the use of extracorporeal membrane oxygenation support to preserve life. Catheter-based effective Fontan takedown is an alternative to surgery in...
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PMID: 21718874
PDF is available here.
Abstract
To identify patient characteristics influencing treatment outcomes of allograft corneal rejection.
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PMID: 21683335
PDF is available here.
Abstract
We report a full-term neonate with severe pulmonary hypertension unresponsive to the treatment with HFOV and iNO, later associated with prostacyclin, who rapidly improved after the addition of vecuronium, a neuromuscular blocker....
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PMID: 21654603
PDF is available here.
Abstract
Tegafur/uracil (UFT) is suitable for metronomic chemotherapy because of its underlying antiangiogenesis mechanism. This study aimed to assess the efficacy of adding daily oral UFT to gefitinib treatment in patients with pulmonary adenocarcinoma who had failed previous chemotherapy....
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PMID: 21415778
PDF is available here.
Abstract
We identified from a prospective database all such patients ≤ 60 years of age treated with reduction and internal fixation. The main outcome measures were union, failure of fixation, nonunion and the development of avascular necrosis. There were 122 patients in the study. Union occurred in 83 pati...
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PMID: 21586782
PDF is available here.
Abstract
We reviewed results of patients who underwent salvage ureteral reimplantation following failed dextranomer/hyaluronic acid injection....
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PMID: 21575977
PDF is available here.
Abstract
These data suggest that in the long term, DBS remains a safe and effective treatment for treatment-resistant depression. Additional trials with larger samples are needed to confirm these findings....
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PMID: 21285143
PDF is available here.
Samir R SR Shah,
Keyur K Patel,
Patrick P Marcellin,
Graham R GR Foster,
Michael M Manns,
Shyam S Kottilil,
Letha L Healey,
Erik E Pulkstenis,
G Mani GM Subramanian,
John G JG McHutchison,
Mark S MS Sulkowski,
Stefan S Zeuzem and
David R DR Nelson
Abstract
Steatosis was associated with significantly higher rates of relapse, irrespective of viral load, in patients infected with HCV genotype 3 who had an RVR. Further studies are needed to determine if longer treatment durations are effective in patients with an RVR and these risk factors....
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PMID: 21640198
PDF is available here.
Abstract
We believe this risk can be decreased by using a separate approach for preparation of the subtalar joint....
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PMID: 21733457
PDF is available here.
Chikako C Tokoro,
Masahiko M Inamori,
Tomoko T Koide,
Yusuke Y Sekino,
Hiroshi H Iida,
Yasunari Y Sakamoto,
Hiroki H Endo,
Kunihiro K Hosono,
Hirokazu H Takahashi,
Masato M Yoneda,
Hiroaki H Yasuzaki,
Masami M Ogawa,
Yasunobu Y Abe,
Kensuke K Kubota,
Satoru S Saito,
Ichiro I Kawana,
Atsushi A Nakajima,
Shin S Maeda,
Reikei R Matsuda and
Daisuke D Takahashi
Abstract
We compared the efficacy of eradication regimen (lansoprazole/amoxicillin/clarithromycin) in patients with H. pylori infection with or without H2RA pretreatment....
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PMID: 21525804
PDF is available here.
Abstract
To assess the safety and efficacy of 48 weeks of re-treatment with peginterferon α-2a (40 kD) plus ribavirin in previously treated hepatitis C virus (HCV) genotype 1 patients.
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PMID: 21502923
PDF is available here.
Abstract
Anorexia nervosa is a serious psychiatric illness associated with substantial morbidity and mortality. Weight-restored females with anorexia nervosa with limited diet variety, assessed by a diet variety score, have been reported to have poor outcomes. Using the same patient cohort, the objective of t...
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PMID: 21515121
PDF is available here.
Abstract
AP was not superior to placebo in reducing the number of weekly heartburn events over 4 weeks in the primary analysis of the entire study population. Exploratory subgroup analyses suggest that response to PPI treatment before the study was associated with a response to AP treatment.Am J Gastroenterol...
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PMID: 21519360
PDF is available here.
Abstract
Short-term data on the immunogenicity of monoclonal antibodies showed associations between the development of antidrug antibodies and diminished serum drug levels, and a diminished treatment response. Little is known about the clinical relevance of antidrug antibodies against these d...
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PMID: 21486979
PDF is available here.
Abstract
We report radiation therapy in a relapsed/resistant stage IB patient with mycosis fungoides treated with local radiation therapy for symptomatic progression unresponsive to bexarotene therapy. Total skin electron beam therapy has been employed in early stage and for limited skin failure MF, while th...
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PMID: 21489904
PDF is available here.
Abstract
Fibrinolytic therapy remains the reperfusion strategy of choice for many regions treating patients presenting with ST-segment elevation myocardial infarction (STEMI). However, limited data exist regarding the pattern of use of rescue percutaneous coronary intervention (PCI) in patients with STEMI who...
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PMID: 21473977
PDF is available here.
Abstract
The author attempts to understand the underpinnings of a ruminative depression that occurred in a patient after a troubled first analysis. Negative therapeutic reaction is often assumed to be the result of a patient's unconscious guilt or masochism and thus an intrapsychic phenomenon, but the author...
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PMID: 21627007
PDF is available here.
Abstract
Treatment with intravitreal bevacizumab may be effective, as measured by visual and anatomic criteria, in patients who are unresponsive to treatment with intravitreal ranibizumab....
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PMID: 21708088
PDF is available here.
Abstract
Antibiotic-based regimens are frequently used for the treatment of Helicobacter pylori infection. These regimens fail to eradicate H pylori in 15% to 40% of patients, primarily due to antimicrobial resistance and insufficient patient compliance. Effective prevention and eradication of H pylori by pas...
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PMID: 21523262
PDF is available here.
Abstract
To describe our own experience with pyogenic liver abscesses over the past 10 years and investigate the risk factors associated with failure of initial percutaneous therapy.
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PMID: 21472130
PDF is available here.
Abstract
We intend to appraise the latest evolution in treatment strategies in IBD and to suggest an evidence-based approach and risk stratification while coping with cases of non-responders or loss of response to biological therapies....
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PMID: 21427713
PDF is available here.
Abstract
To determine responses to tocilizumab between patients with rheumatoid arthritis (RA) who switched to anti-TNF agents and those who are biologics-naïve.
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PMID: 21418781
PDF is available here.
Abstract
We aimed to determine if use of 5-aminosalicylates (5-ASA) was associated with a reduced risk of colorectal cancer (CRC) in people with inflammatory bowel disease (IBD).
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PMID: 21407180
PDF is available here.
Abstract
Crohn's disease (CD) and ulcerative colitis (UC) are inflammatory disorders of the gastrointestinal tract of unknown etiology. Evidence for treatment of the condition with biological therapies exists, but no systematic review and meta-analysis has examined this issue in its entirety.
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PMID: 21407183
PDF is available here.
Abstract
We performed an updated systematic review of the literature to clarify the efficacy of immunosuppressive therapy at inducing remission and preventing relapse in ulcerative colitis (UC) and Crohn's disease (CD)....
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PMID: 21407186
PDF is available here.
Abstract
The objective of this study was to review loss of response and need for adalimumab dose intensification in adult and pediatric patients with Crohn's disease. Studies were identified through the electronic databases of MEDLINE and the annual meetings of Digestive Disease Week, of the United European G...
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PMID: 21407178
PDF is available here.
Abstract
The use of glucocorticosteroids to treat both Crohn's disease (CD) and ulcerative colitis (UC) is widespread, but no systematic review and meta-analysis has examined the issue of efficacy of these agents in its entirety.
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PMID: 21407179
PDF is available here.
Abstract
The efficacy of 5-aminosalicylic acids (5-ASAs) in ulcerative colitis (UC) has been studied previously in meta-analyses. However, several randomized controlled trials (RCTs) have been published recently, and no previous meta-analysis has studied the effect of 5-ASA dosage used.
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PMID: 21407188
PDF is available here.
Abstract
Treatment of metastatic castrate resistant prostate cancer (mCRPC) after progression on docetaxel chemotherapy is a challenging clinical scenario with limited availability of treatment options. Re-treatment with docetaxel, either as monotherapy or in combination with other cytotoxics...
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PMID: 21426298
PDF is available here.
Abstract
We evaluated the effect of a combination of fibrin sealant and topical gentamicin on a colonic anastomosis in a rat model.
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PMID: 21367375
PDF is available here.
Abstract
To assess safety and tolerability of enfuvirtide, an antiretroviral, in Thai patients with advanced HIV-1 disease who have received antiretroviral treatment and failed on regimens that contain at least one of each antiretroviral (ARV) classes (PIs, NRTIs, and NNRTIs), or who have intolerance to previ...
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PMID: 21560837
PDF is available here.
Abstract
Outcomes for 77 cataractous eyes were compared after each eye underwent no treatment, topical medical treatment only, or phacoemulsification with intraocular lens implantation. Median follow-up time for all dogs was 2.3 y. Failure occurred in all untreated eyes and the rate of failure was 65 and 255...
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PMID: 21629421
PDF is available here.
Abstract
The efficiencies of IFN-α based therapy in chronic genotype 1b HCV patients are still unsatisfied to date. The mechanisms underlining treatment failure remain unclear and controversial. To investigate HCV sequence evolution in unsuccessfully treated genotype 1b patients before, duri...
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PMID: 21147266
PDF is available here.
Abstract
Patients with type 2 diabetes should improve lifestyle habits combined with metformin as first pharmacological compound (in absence of contra-indications). In case of failure of metformin monotherapy (due to the progression of the disease secondary to B-cell exhaustion), another oral glucose-lowering...
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PMID: 21560435
PDF is available here.
Abstract
We report a 33-year-old female patient who had hemodialysis-associated pseudoporphyria which did not respond to treatment with oral N-acetylcysteine. She responded favorably to treatment with the anti-malarial drug, chloroquine. The case is being reported to highlight the difficulty in interpreting t...
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PMID: 21422632
PDF is available here.