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Ileitis (1):
Recent article
Ileitis
Revue medicale suisse (6)269 2010
Abstract
The case of a immunocompromised HIV patient with fever and lymphadenopathy discussed in an anatomo-pathological round. This complex clinical case was used as an opportunity to discuss the broad differential diagnosis of fever in an immunocompromized individual with multiples lymphadenopathies. Clini...
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PMID: 21140959
PDF is available here.
PDF is available here.
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Abstract
Ileitis, or inflammation of the ileum, is often caused by Crohn's disease. However, ileitis may be caused by a wide variety of other diseases. These include infectious diseases, spondyloarthropathies, vasculitides, ischemia, neoplasms, medication-induced, eosinophilic enteritis, and others. The clin...
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PMID: 20532706
PDF is available here.
PDF is available here.
Abstract
Out of 334 patients, 39 (12%) were backwash ileitis-positive. Compared with backwash ileitis-negative patients, backwash ileitis-positive patients had a higher incidence of pancolitis (100% vs 74%; P = .0001), primary sclerosing cholangitis (15% vs 2%; P = .001) and high-level (>100 enzyme-linked im...
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PMID: 20551749
PDF is available here.
PDF is available here.
Abstract
In Spearman's correlation test the MRE score showed the strongest relationship with serum level of TNF-alpha type II receptor (r = 0.52, p < 0.001), correlating less significantly with IL-6 level (r = 0.37, p < 0.01) and CDAI (r = 0.40, p < 0.001). CONCLUSION: TNFalpha receptor type II shows better...
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PMID: 20642103
PDF is available here.
PDF is available here.
Abstract
Molecular and Cellular Biochemistry (336)1-2 2010
Abstract
We evaluated the role of the pro-inflammatory cytokine TNF-alpha on nitric oxide synthase (NOS) expression in indomethacin-induced jejunoileitis in rats. Jejunoileitis was induced in rats with subcutaneous injections of indomethacin (7.5 mg/kg) 24 h apart for two consecutive days, and animals were r...
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PMID: 19802525
PDF is available here.
PDF is available here.
Dermatology (220)3 2010
Abstract
Journal of Physiology and Pharmacology (60 Suppl 7) 2009
Abstract
Our results showed that the indomethacin-induced intestinal injury was remarkably improved in Bach1-deficient mice. Histological examination showed that the area of injured lesion was decreased in Bach1-deficient mice compared to wild-type mice. Administration of indomethacin induced expression of i...
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PMID: 20388958
PDF is available here.
PDF is available here.
Abstract
We examined its potential role in gut innate immune responses. Methods. In human intestinal xenografts grown in mice, we examined changes in the expression of MCH and its receptors following treatment with C. difficile toxin A, the causative agent of antibiotic-associated diarrhea in hospitalized pa...
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PMID: 18824554
PDF is available here.
PDF is available here.
Abstract
We describe a case of a 19-year-old male who developed CMV infection of the terminal ileum while receiving immunosuppression for lupus nephritis. This was a distinctly unusual site of infection which clinically mimicked Crohn's ileitis. We note that reports of terminal ileal CMV infection have been...
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PMID: 19750578
PDF is available here.
PDF is available here.
Ugeskrift for laeger (171)38 2009
Abstract
A 25-year-old woman was hospitalized repeatedly during a 5-year period due to abdominal pain, change in stool pattern, high CRP and leucocytosis. Ultrasound and small bowel examination showed oedema of terminal ileum, and morbus Crohn was initially suspected. A later ileocolonoscopy with biopsy and...
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PMID: 19758501
PDF is available here.
PDF is available here.
Abstract
We assessed the modulatory effects of SOM on both the short-term and long-term effects induced by the main mast cell mediators histamine (HIS) and 5-HT on spinal sensory neurons. Short-term incubation of dorsal root ganglion cultures with HIS and 5-HT induced neuronal CGRP-release and calcium-mediat...
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PMID: 19477916
PDF is available here.
PDF is available here.
Abstract
We characterized the protein expression profile (proteome) in primary intestinal epithelial cells (IEC) from iron-adequate and low-iron fed wild-type (WT) and TNFDeltaARE/WT mice. We performed all possible comparisons between the 4 groups according to genotype or diet. Histological analysis of iron-...
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PMID: 19422269
PDF is available here.
PDF is available here.
Abstract
Abstract
British Journal of Nutrition (101)7 2009
Abstract
A study was conducted in healthy elderly living independently in senior housing to assess the impact of a probiotic yoghurt supplement on small intestinal bacterial overgrowth. Twenty-three participants with positive and thirteen participants with negative hydrogen breath test were studied before an...
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PMID: 19353762
PDF is available here.
PDF is available here.
Abstract
We have evaluated carotenoids as markers of digestion and absorption. We compared fasting plasma carotenoids concentrations in 21 control subjects, 20 patients with Crohn's disease, and 18 patients with pancreatic cancer. Crohn's disease alters intestinal absorption while pancreatic cancer decreases...
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PMID: 20108210
PDF is available here.
PDF is available here.
Abstract
The aim of the present trial was to investigate the efficacy of Virbamix PE (Virbac SA, France) an appetite enhancer and feed flavouring material containing plant extracts of Origanum vulgaris and Allium sativum, added to the feed at one single dose in the control of proliferative enteropathy (PE) i...
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PMID: 19886265
PDF is available here.
PDF is available here.
BMC Physiology (9)1 2009
Abstract
Glutathione depletion aggravated ileal inflammation after infection as indicated by increased levels of mucosal myeloperoxidase and interleukin-1beta. Remarkably, intestinal permeability and Salmonella translocation were not increased. Cystine supplementation maintained glutathione in the intestinal...
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PMID: 19374741
PDF is available here.
PDF is available here.
Abstract
We report 2 patients with ulcerative colitis and severe BWI, with concomitant ileal bleeding and perforation. In both cases, staged operation without sacrificing the involved area of the terminal ileum led to ileal pouch-anal anastomosis, with a favorable postoperative outcome. Our cases suggest tha...
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PMID: 19159709
PDF is available here.
PDF is available here.
Cancer Research (68)24 2008
Abstract
We analyzed genome-wide DNA methylation in the mouse ileum during chronic inflammation, aging, and cancer. We found that inflammation leads to aberrant DNA methylation in PcG target genes, with 70% of the approximately 250 genes methylated in the inflamed tissue being PcG targets in embryonic stem c...
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PMID: 19074896
PDF is available here.
PDF is available here.
Gastroenterology (135)6 2008
Abstract
Our findings support an important role of CD44 expressed by CD4(+) and CD8(+) for development of ileitis mediated by TNF overproduction....
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PMID: 18854186
PDF is available here.
PDF is available here.
Abstract
Intestinal and extraintestinal complications of Crohn's disease are well documented. Changes in the connective tissue within the intestinal wall and surrounding tissue including mesenteric fat are characteristically seen in resected and autopsy specimens. A rare and unusually florid mesothelial reac...
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PMID: 18820098
PDF is available here.
PDF is available here.
Abstract
We provide photographs with the most characteristic features of AST and attempt to separate elephant ears (type 1) from less typical AST (type 2) in CD. Our study confirms previous reports that AST are more commonly found in association with CD as compared with UC and more so in the presence of dise...
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PMID: 18452201
PDF is available here.
PDF is available here.
Journal of Urology (180)3 2008
Abstract
European Journal of Pharmacology (589)1-3 2008
Abstract
These results suggest that the inflammatory response associated with cyclooxygenase-2 induction is involved in the opposite change in ileal tryptophan hydroxylase and monoamine oxidase activities in the delayed phase after single administration of cisplatin to rats....
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PMID: 18534574
PDF is available here.
PDF is available here.
Journal of Immunology (181)2 2008
Abstract
We investigated the role of TAK1 signaling in maintaining intestinal homeostasis by generating enterocyte-specific constitutive and inducible gene-deleted TAK1 mice. We found that enterocyte-specific constitutive TAK1-deleted mice spontaneously developed intestinal inflammation as observed by histol...
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PMID: 18606667
PDF is available here.
PDF is available here.
Abstract
Salvinorin A as well as the KOR agonist U-50488 reduced motility in croton oil treated mice. The inhibitory effect of both salvinorin A and U-50488 was counteracted by the KOR antagonist nor-binaltorphimine and by the cannabinoid CB1 receptor antagonist rimonabant. Rimonabant, however, did not cou...
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PMID: 18622408
PDF is available here.
PDF is available here.
Abstract
Abstract
In vivo, cannabidiol did not affect motility in control mice, but normalized croton oil-induced hypermotility. The inhibitory effect of cannabidiol was counteracted by the cannabinoid CB1 receptor antagonist rimonabant, but not by the cannabinoid CB2 receptor antagonist SR144528 (N-[-1S-endo-1,3,3-t...
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PMID: 18469842
PDF is available here.
PDF is available here.
Abstract
BGMP pretreatment (500 mg kg(-1) day(-1)) resulted in marked reduction of inflammatory injury, as assessed by lower extension of necrosis and damage score, myeloperoxidase, alkaline phosphatase, inducible nitric oxide synthase, interleukin 1beta, tumour necrosis factor and interleukin 17. These effe...
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PMID: 18536735
PDF is available here.
PDF is available here.
Abstract
A 19-year-old Japanese woman had melena 2 months after systemic lupus erythematosus was diagnosed. Colonoscopy showed diffuse ulceration with bleeding in the ileum, suggesting that the melena was due to ischemic enteritis associated with lupus enteritis. Because treatment with high doses of steroid,...
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PMID: 18924551
PDF is available here.
PDF is available here.
Abstract
Ten patients were enrolled and completed the study. Clinical remission was achieved in nine patients. At wireless capsule endoscopy and pouch endoscopy, a complete recovery of lesions was observed in eight patients. One patient presented four small lesions of the ileum at the 6 weeks of treatment an...
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PMID: 18298639
PDF is available here.
PDF is available here.
Regulatory Peptides (147)1-3 2008
Abstract
The mean serum I-FABP concentration /mL), whereas individuals with left-side colitis had a mean I-FABP concentration of 61.8+/-8.5 pg/mL. Significant serum I-FABP elevation was observed in UC patients with a severe form of the disease, in contrast to the serum I-FABP concentration in patients with t...
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PMID: 18201778
PDF is available here.
PDF is available here.
Abstract
We present a case of neonatal gastrointestinal tract (GIT) mucormycosis in a 2-day-old infant diagnosed following laparotomy and resection for presumptive NEC, together with a review of cases of GIT mucormycosis in newborn babies in the literature....
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PMID: 18437658
PDF is available here.
PDF is available here.
Abstract
Recent reports suggest increased incidence and severity of Clostridium difficile-associated diseases. These facts have raised the need for additional clarification of pathogenesis and for a search for new therapeutic strategies. This study evaluated the effects of the polysaccharide fucoidin, an L-s...
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PMID: 17805968
PDF is available here.
PDF is available here.
Abstract
Abstract
Coeliac disease is a malabsorption syndrome in which dietary gluten damages the small bowel mucosa. Gluten contains gliadin, the primary toxic component that is primarily found in wheat, barley and rye products. The initial diagnosis of coeliac disease is usually made by endoscopic biopsy of the jej...
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PMID: 17531415
PDF is available here.
PDF is available here.
Abstract
All nine ATG16L1 gene variants analyzed displayed highly significant associations with CD demonstrating a CD-protective effect for the minor allele. The strongest associations were found for rs2241879 and the coding SNP rs2241880 (T300A); P= 3.6 x 10(-6) and 3.7 x 10(-6), respectively (OR 0.74, 95%...
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PMID: 18162085
PDF is available here.
PDF is available here.
Abstract
Journal of Immunology (180)4 2008
Abstract
Journal of Immunology (180)4 2008
Abstract
We demonstrate dynamic changes in the expression and functional state of CD44 on CD8+ T cells. These cells coexpress CD44 and L-selectin, giving them a surface phenotype similar to that of central memory T cells. Yet functionally they exhibit the phenotype of effector T cells, because they produce I...
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PMID: 18250468
PDF is available here.
PDF is available here.
Abstract
Two hundred and twelve cases were identified. Corrected incidence for this decade was 66 x 10(6) per year (95% confidence interval: 58-76), showing a continuing rise compared to previous decades. The proportion with colonic disease at presentation continues to rise (43%) with a corresponding fall in...
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PMID: 18005244
PDF is available here.
PDF is available here.
Abstract
The presence of FEG is a good indicator for the diagnosis of Crohn's disease in adult patients with isolated chronic ileitis....
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PMID: 18648739
PDF is available here.
PDF is available here.
Abstract
The mean age at diagnosis was significantly lower in carriers of the CARD15 or IBD5 risk alleles. After correction for age and smoking, CARD15 mutations were strongly associated with both ileal disease (P=8.8 x 10(-6)) and stenotic disease (P=0.003), but the association with stenotic disease appeare...
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PMID: 18090989
PDF is available here.
PDF is available here.
Abstract
A 30-year-old lady presented with a 6-month history of recurrent partial intestinal obstruction associated with intermittent fever, anorexia and weight loss. Barium meal follow-through and colonoscopic evaluation suggested ulceration of the ileum and caecum with small bowel obstruction. Histology of...
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PMID: 18972773
PDF is available here.
PDF is available here.
Abstract
COX-2 immunoexpression is high in Crohn's disease, which suggest a possible role of the protein in the pathogenesis of the inflammation. The absence of epithelial dysplasia in all Crohn's disease samples was correlated with the lack of expression of p53....
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PMID: 19148357
PDF is available here.
PDF is available here.
Abstract
We evaluated indomethacin-induced enteropathy in rats, in relation to the expression of the inducible isoform of NO synthase (iNOS) using aminosalicylic acid (5-ASA), its isomer 4-ASA (10 or 50 mg/kg/day, po), and dexamethasone, an iNOS transcription inhibitor (3 mg/kg/day, sc). Enteropathy was indu...
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PMID: 17503181
PDF is available here.
PDF is available here.
Abstract
Ulcerative colitis patients with BI show impaired barrier function in the further course of the ileoanal pouch. Thus, BI has a long-term impact on epithelial barrier function....
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PMID: 18569988
PDF is available here.
PDF is available here.
Abstract
ASBT expression was comparably low both in gallstone (47% of controls, p = 0.0093) and Crohn's disease (42% of controls, p = 0.0008). In gallstone disease there was a non-significant trend towards elevated TNF-alpha and IL-1beta, but all cytokines were increased in active Crohn's disease. c-jun and...
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PMID: 18832832
PDF is available here.
PDF is available here.
Abstract
Our case is rarer in its involvement of the distal small bowel and presents unusually as intussusception. The disease if diagnosed in the initial stages responds well to medical treatment but if associated with complications or misdiagnosed, surgical modality is the treatment of choice. In our case,...
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PMID: 18081239
PDF is available here.
PDF is available here.
Abstract
We investigated whether the MAPK and AP-1 signaling pathway is involved in interleukin (IL)-8 expression and enteric inflammation in response to stimulation with toxin A. Toxin A activated MAPK and AP-1 composed of c-Jun/c-Fos heterodimers in primary intestinal epithelial cells and HT-29 cell lines....
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PMID: 17639289
PDF is available here.
PDF is available here.
Journal of Immunology (179)10 2007
Abstract
We examined the role of expression of RELMbeta in the initiation of ileal inflammation in SAMP1/Fc mice. RELMbeta was highly induced in the ilea of SAMP1/Fc mice beginning at age 5 wk, coincident with the histological appearance of inflammation. RELMbeta was found in ileal goblet cells and some inte...
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PMID: 17982092
PDF is available here.
PDF is available here.
Abstract
Macroscopic scores, morphological changes and increased tissue lipid peroxidation with a concomitant reduction in GSH of the ileitis or colitis groups were all reversed by treatment with ALA. ALA treatment was also effective in improving tissue MPO activity and CL values, which were elevated in untr...
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PMID: 17914960
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
We investigated the epithelial expression of major histocompatibility complex (MHC) I and MHC II and its interference with endocytic pathways, in vivo. During ileoscopy, ovalbumin (OVA) was sprayed onto ileal mucosa of CD patients (ileitis and remission) and controls. The epithelial traffic of OVA a...
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PMID: 17673546
PDF is available here.
PDF is available here.
Gastroenterology (133)4 2007
Abstract
Major targets for PKCepsilon include ion channels near the plasma membrane. PKCepsilon is likely to have a significant role in controlling the excitability of submucosal neurons and is probably an intermediate in causing hyperexcitability after inflammation....
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PMID: 17765238
PDF is available here.
PDF is available here.
Cell and Tissue Research (329)3 2007
Abstract
Our aim was to determine whether proliferation of EC cells contributed to the hyperplasia associated with intestinal inflammation. Ileitis was induced in guinea-pigs by intraluminal injection of 2,4,6-trinitrobenzene sulphonic acid (TNBS). A single pulse of 5-bromo-2'-deoxyuridine (BrdU) was injecte...
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PMID: 17508220
PDF is available here.
PDF is available here.
Journal of Immunology (179)5 2007
Abstract
We report a reduced expression in ileal CD of the Wnt-signaling pathway transcription factor Tcf-4, a known regulator of Paneth cell differentiation and alpha-defensin expression. Within specimens, the levels of Tcf-4 mRNA showed a high degree of correlation with both HD5 and HD6 mRNA. The levels of...
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PMID: 17709525
PDF is available here.
PDF is available here.