Abstract
Most UC patients have no upper gastrointestinal inflammation in biopsies, and most of the inflammations they have are not unique. The most common upper gastrointestinal inflammatory pattern in patients with UC is focal gastritis, followed by gastric basal mixed inflammation and superficial plasmacyt...
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PMID: 20962621
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Abstract
We focus on the most common and well-described drug-related clinico-pathological conditions of the gastrointestinal tract using an organ and lesion based approach....
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PMID: 20939398
PDF is available here.
Abstract
Eosinophilic esophagitis (EE) is a motility disorder of the esophagus that typically presents with dysphagia. The objective of the present study was to explore patient characteristics, clinical and endoscopic features, and response to treatment of patients with EE. Patients were selected retrospecti...
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PMID: 21152459
PDF is available here.
Abstract
We describe a case of severe MSF complicated by acute renal failure and associated with herpetic oesophagitis. Acyclovir therapy resulted in remission of oesophageal symptoms within 48 h....
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PMID: 20508004
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Abstract
We have used the comet assay to assess DNA damage in individuals with various disorders of the upper gastrointestinal (GI) tract in a cohort of patients from South India. After thorough clinical, endoscopic, and histopathological evaluation, patients were categorized into cancers, precancers, inflam...
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PMID: 20632893
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Abstract
In total, 37 patients fulfilled diagnostic criteria for EOE. The mean duration of symptoms before the diagnosis was 4 years (range 4 months-30 years) and 14 patients (38%) remained undiagnosed until the time of study. Reasons for diagnostic failure and delay included: delayed request for endoscopy i...
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PMID: 20453656
PDF is available here.
Abstract
Pediatric eosinophilic esophagitis is an inflammatory condition associated with marked eosinophil accumulation in the mucosal tissues of the esophagus. Eosinophils are major proinflammatory cells thought to make a major contribution to allergic diseases that affect the upper and lower airways, skin...
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PMID: 20636000
PDF is available here.
Abstract
We describe 3 new cases of HE in otherwise healthy patients seen in our hospital within the last 5 years. We performed a comprehensive review of the previously reported cases of HE in immunocompetent adults and adolescents in the English and Spanish literature. We analyzed the clinical features, tre...
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PMID: 20616659
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Abstract
We have identified local mastocytosis and mast cell degranulation in the esophagi of patients with EE; identified an esophageal mast cell-associated transcriptome that is significantly divergent from the eosinophil-associated transcriptome, with carboxypeptidase A3 mRNA levels serving as the best ma...
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PMID: 20538331
PDF is available here.
Abstract
Eosinophils are multifunctional leukocytes that increase in various tissues in patients with a variety of disorders. Locally, they can be involved in the initiation and propagation of diverse inflammatory responses. In this review the clinical association of eosinophils with diseases of the skin, lu...
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PMID: 20392477
PDF is available here.
Abstract
All 10 patients had long-segment but variable-length narrowing of the thoracic esophagus (mean length, 15.4 cm) with tapered margins. The mean diameter at the aortic arch, carina, and one vertebral body above the gastroesophageal junction was 13.9, 14.3, and 15.1 mm, respectively, for patients with...
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PMID: 20505062
PDF is available here.
Abstract
In this study, 3 polymorphisms of IGF genes were associated with EAC or its precursors. These polymorphisms may be markers of disease risk; independent validation of our findings is required. These results suggest the IGF pathway is involved in EAC development.
Copyright 2010 AGA Institute. Publishe...
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PMID: 20403354
PDF is available here.
Abstract
IL-15 mediates in the pathogenesis of EoE. IL-15 activates CD4(+) T cells to produce cytokines that act on eosinophils.
Copyright 2010 AGA Institute. Published by Elsevier Inc. All rights reserved....
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PMID: 20381491
PDF is available here.
Abstract
Most, but not all, patients with EE are highly atopic individuals with frequent allergic sensitivities. Thus, serum IgE measurement of low-titer IgE antibody may be useful in identifying relevant food sensitivities and in distinguishing subgroups of patients with EE, making a more directed approach...
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PMID: 20568382
PDF is available here.
Abstract
Eosinophilic esophagitis (EoE) is a chronic, eosinophil-predominant inflammatory condition that can affect esophageal mucosa at any age. Distinguished from gastroesophageal reflux disease in the mid 1990's, it has seemed to be increasingly prevalent, and is usually a manifestation of food allergy. T...
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PMID: 20485252
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Abstract
Our systematic review does not reveal an inordinate frequency of esophageal perforation from dilation in patients with EoE, and it is not clear that dilation is any more hazardous for patients with EoE than for patients with other causes of esophageal stricture. Although esophageal dilation must be...
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PMID: 20238250
PDF is available here.
Abstract
Significant esophageal morbidity associated with EA extends into adulthood. Surgical complications, increasing age, and impaired esophageal motility predict development of epithelial metaplasia after repair of EA....
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PMID: 20485152
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Abstract
CONTEXT: Although the healthy esophageal mucosa contains no eosinophils, eosinophilic infiltration is observed in 2 major clinicopathologic settings: gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EE). The prevalence of EE is increasing in many countries, and this increase seem...
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PMID: 20524860
PDF is available here.
Abstract
Our aim was to study esophageal motility patterns in children with GERD, taking into account the presence of anatomical abnormalities and neurological impairment, the effect of age on esophageal motility in GERD, and the relation between esophageal manometry and GERD severity parameters (acid exposu...
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PMID: 20400913
PDF is available here.
Abstract
The maximum tolerated dose was determined to be 74 Gy/37 fractions (2.0 Gy per fraction) using three-dimensional conformal radiation therapy with concurrent paclitaxel and carboplatin therapy. This dose level in the Phase II portion has been well tolerated, with low rates of acute and late lung toxi...
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PMID: 20457350
PDF is available here.
Abstract
Dexlansoprazole provides another treatment option for the management of EE and symptoms of heartburn. Considering that the cost of dexlansoprazole is not favorable, further studies evaluating potential advantages over other agents are necessary to define the role of dexlansoprazole in the treatment...
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PMID: 20371754
PDF is available here.
Abstract
p53 overexpression and the Ki-67 (MIB-1) index were correlated with histologic findings of inflammation in the esophageal mucosa, particularly in the moderate and severe forms of chronic esophagitis....
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PMID: 20414055
PDF is available here.
Abstract
Sixty-three patients underwent endoscopy. Eighteen had dysphagia related to an esophageal stricture needing dilation and were subsequently excluded from the analysis. Forty-five patients (26 girls) with a median age of 7.3 years (range 0.4 to 17.9 years) were evaluated. Twenty-six patients (58%) wer...
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PMID: 20485706
PDF is available here.
Abstract
These preliminary data suggest that LECIN is feasible and can be safely performed with very low morbidity in children. Further studies with larger series and follow-up are expected.
Copyright (c) 2010 Elsevier Inc. All rights reserved....
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PMID: 20438954
PDF is available here.
Abstract
We emphasize discussion of challenges in his behavioral management and present a collaborative approach to behavioral management....
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PMID: 20453578
PDF is available here.
Abstract
Eosinophilic esophagitis (EoE) is a chronic clinicopathological entity characterized by large numbers of intraepithelial eosinophils infiltrating the esophageal mucosa, which is not caused by gastroesophageal reflux. This disease has become widely recognized over the past few years and new methods h...
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PMID: 20350261
PDF is available here.
Abstract
Forty-five consecutive patients were identified. All patients were found to have evidence of oesophagitis, with 28 having oesophageal erosions and two Barrett's oesophagitis. CONCLUSION: Flexible oesophagogastroscopy is a useful test in patients with upper aerodigestive tract squamous cell carcinoma...
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PMID: 19930785
PDF is available here.
Tomoyuki Akiyama,
Masahiko Inamori,
Keiko Akimoto,
Hiroshi Iida,
Hiroki Endo,
Kunihiro Hosono,
Tamon Ikeda,
Yasunari Sakamoto,
Koji Fujita,
Masato Yoneda,
Tomoko Koide,
Hirokazu Takahashi,
Chikako Tokoro,
Ayumu Goto,
Yasunobu Abe,
Noritoshi Kobayashi,
Kensuke Kubota,
Satoru Saito,
Akihiko Moriya,
Yasushi Rino,
Toshio Imada and
Atsushi Nakajima
Abstract
Distal gastrectomy is not a risk factor for the development of EE and BE. This lack of a positive association between distal gastrectomy and EE and BE may suggest that pancreatic-biliary reflux with a limited amount of acid is not sufficient to damage the esophageal mucosa....
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PMID: 20085437
PDF is available here.
Abstract
Esophageal dilation can be performed in eosinophilic esophagitis with low rates of tears, chest pain, and hospitalization. No perforations were found in our database. The effectiveness of dilation was best when a larger esophageal caliber was achieved, but patients undergoing more procedures was ass...
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PMID: 20170913
PDF is available here.
Abstract
Seventeen female and three male patients were included, with a mean age of 37.6 +/- 12.6 years. All patients reduced their body weight, from an initial BMI of 38.3 kg/m(2) to 28.2 kg/m(2) 6 months after surgery. No postoperative complications were observed in these patients. Preoperative mean LESP w...
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PMID: 20013071
PDF is available here.
Abstract
Patients with eosinophilic oesophagitis are hypersensitive to acid perfused in the oesophagus, and pathophysiologic findings are likely confined to the peripheral tissue. Reflux from physiological acid may play a role in the symptoms of eosinophilic oesophagitis....
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PMID: 20001646
PDF is available here.
Abstract
Chronic gastritis in H. pylori-negative subjects is more common than previously appreciated. These results highlight the need for better characterization of gastric mucosal histology in these gastrointestinal disorders....
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PMID: 19687753
PDF is available here.
Tomoyuki T Akiyama,
Masahiko M Inamori,
Hiroshi H Iida,
Hiroki H Endo,
Kunihiro K Hosono,
Yasunari Y Sakamoto,
Koji K Fujita,
Masato M Yoneda,
Hirokazu H Takahashi,
Tomoko T Koide,
Chikako C Tokoro,
Ayumu A Goto,
Yasunobu Y Abe,
Takeshi T Shimamura,
Noritoshi N Kobayashi,
Kensuke K Kubota,
Satoru S Saito and
Atsushi A Nakajima
Abstract
Barrett's epithelium was diagnosed in 374 cases (43%). Most of these were diagnosed as short-segment Barrett's epithelium. The prevalence of erosive esophagitis was significantly higher in subjects with flame-like than lotus-like Barrett's epithelium, and in those with a C extent of > or = 2 cm than...
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PMID: 20101776
PDF is available here.
Abstract
This 68-year-old man with a 2-year history of Crohn's esophagitis developed acute bilateral visual loss during his third infliximab infusion. His clinical features and laboratory tests were characteristic for a bilateral anterior optic neuropathy. Only three cases of possible infliximab-associated a...
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PMID: 19916016
PDF is available here.
Abstract
Marked tissue deposition of extracellular EDN is present in the esophagus of EoE patients. Tissue eosinophil counts may underestimate how extensively eosinophils are involved, particularly in individuals with marked eosinophil degranulation. Evaluation of EDN staining in esophageal biopsy specimens...
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PMID: 19888203
PDF is available here.
Abstract
A 52-year-old woman with a 6-year history of systemic lupus erythematosus (SLE) developed acute abdominal pain, nausea, vomiting, and diarrhea accompanied by hypocomplementemia. Herpes simplex virus (HSV) esophagitis and lupus enteritis were diagnosed on the basis of the results of endoscopic and hi...
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PMID: 19802650
PDF is available here.
Abstract
Both patients were expediently diagnosed, investigated and managed. CONCLUSION: A diagnosis of eosinophilic oesophagitis must be considered in patients presenting with food bolus impaction. Early involvement of a paediatric gastroenterology team in the diagnosis is recommended in children presenting...
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PMID: 19640326
PDF is available here.
Abstract
We present a recent literature review of the common features between atopic diseases (i.e., asthma, allergic rhinitis and atopic dermatitis) and EE. All of the disorders have allergen triggers and evidence of a possible Th2 inflammation at the site of disease. Murine models have also shown similar f...
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PMID: 20161677
PDF is available here.
Abstract
Acute corrosive poisonings cause severe chemical injuries of the upper gastrointestinal tract, the most common location being the esophagus and the stomach. There are different opinions concerning the question of taking food and liquids by mouth immediately after caustic ingestion. This prospective...
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PMID: 21218746
PDF is available here.
Abstract
The paper describes a case of multiple cerebral arterial aneurysms in a patient with prior subarachnoidal hemorrhage, who developed postoperative acute upper gastrointestinal tract (GIT) lesion manifesting itself as bleeding and requiring multiple endoscopic treatment procedures and eventually a dir...
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PMID: 20919547
PDF is available here.
Abstract
Allergy evaluation has a high yield in adult eosinophilic esophagitis as 81% of referred patients had one or more allergens identified and 50% had one or more skin tests positive to foods. Allergy evaluation should be considered in adult patients with eosinophilic esophagitis....
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PMID: 19564792
PDF is available here.
Abstract
Food allergies, defined as an immune response to food proteins, affect as many as 8% of young children and 2% of adults in westernized countries, and their prevalence appears to be rising like all allergic diseases. In addition to well-recognized urticaria and anaphylaxis triggered by IgE antibody-m...
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PMID: 19847094
PDF is available here.
Abstract
We report three cases of cheilitis potentially attributable to GOR. CASE REPORT: Three female patients consulted for cheilitis present for several months. Screening for an infectious cause was negative, as was allergological investigation using skin tests. However, questioning revealed nocturnal bre...
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PMID: 20004314
PDF is available here.
Abstract
We present two cases that had remission of their esophageal problems after differing bariatric operations....
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PMID: 19756886
PDF is available here.
Abstract
Acute esophageal necrosis (AEN), necrotizing esophagitis or "black esophagus", is a rare condition with less than 100 reported cases in the world literature. The condition arises due to necrosis of the esophageal mucosa leading to macroscopically black tissue. The condition is associated with a rela...
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PMID: 19887059
PDF is available here.
Abstract
A 13-year-old male intact Golden Retriever was presented for chronic regurgitation and vomitus. The only clinical abnormality was halitosis, a neurological examination was normal. Thoracic radiography revealed a moderately distended, air-filled esophagus and a presumptive diagnosis of idiopathic meg...
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PMID: 19780011
PDF is available here.
Abstract
Endoscopic findings of an 18-year old man with intermittent dysphagia showed widespread white exudations of the oesophagus. First misinterpreted as oesophageal candidiasis the mucosal biopsies revealed the histological features of a severe eosinophilic oesophagitis. Under treatment with topical ster...
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PMID: 19711290
PDF is available here.
Abstract
Patients with FH demonstrated the most SAREs that reached the proximal esophagus. EE patients demonstrated the lowest nadir pH during an SARE and NERD patients the most acid reflux events before an SARE, as compared with the other heartburn groups....
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PMID: 18797407
PDF is available here.
Abstract
It is imperative that ENT specialists recognize patients with eosinophilic esophagitis....
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PMID: 19504557
PDF is available here.