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Inflammatory Bowel Diseases (2):
Recent article
Inflammatory Bowel Diseases
Cytotherapy (13)9 2011
Abstract
We studied the combined effect of MSC and IBD drugs in in vitro functionality assays.
The effects of azathioprine, methotrexate, 6-mercaptopurine and anti-tumor necrosis factor (TNF)-α on MSC phenotype, survival, differentiation capacity and immunosuppressive capacity were studied....
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PMID: 21846292
PDF is available here.
PDF is available here.
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Abstract
This paper in the series from the World Congress of Gastroenterology addresses the safety and immunogenicity of biological therapy. The safety profile in randomized controlled studies of all biological agents in Crohn's disease (CD) and ulcerative colitis has been generally favorable...
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PMID: 21844919
PDF is available here.
PDF is available here.
Abstract
This paper in the series from the World Congress of Gastroenterology addresses the safety and immunogenicity of biological therapy. The safety profile in randomized controlled studies of all biological agents in Crohn's disease (CD) and ulcerative colitis has been generally favorable...
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PMID: 21844919
PDF is available here.
PDF is available here.
Abstract
We sought to assess important skill sets used by our fellows but not formally observed or measured: handoffs, telephone management, and note writing. We designed an Observed Standardized Clinical Examination (OSCE) form and provided the faculty with checklists to rate fellows' performance on specifi...
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PMID: 21811269
PDF is available here.
PDF is available here.
Abstract
We conducted a population-based study in Ireland to address it.
We used the National Cancer Registry to collect data on all patients diagnosed with CRC in Ireland from 1994 to 2005 (n = 22,335) and identified those who also had IBD (n = 170). The clinical characteristics, treatment,...
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PMID: 21565283
PDF is available here.
PDF is available here.
Abstract
Abstract
We found that MNV infection can accelerate bacteria-induced inflammatory bowel disease (IBD) progression in Mdr1a(-/-) mice. The studies presented here examined whether MNV infection also affects the phenotype of a bacterially driven mouse model of inflammation-associated colon cancer in genetically...
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PMID: 21819691
PDF is available here.
PDF is available here.
Abstract
We emphasize the major role of the Th17/IL-23 axis in dictating the perpetuation of intestinal inflammation, augmented by a failure of physiological control by regulatory T-cells. In conclusion, there is a central genesis of the defects underlying IBD, which therefore, in our opinion, is best accomm...
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PMID: 21651357
PDF is available here.
PDF is available here.
Abstract
Patients with inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease, are at increased risk of developing colon cancer, confirming that chronic inflammation predisposes to development of tumors. Moreover, it appears that colon cancers that do not develop as a com...
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PMID: 21247378
PDF is available here.
PDF is available here.
Abstract
Abstract
Anemia is an important complication of inflammatory bowel disease (IBD). Recent data suggest that hepcidin is a major mediator of anemia with a central role in iron homeostasis and metabolism. The aim of this study was to evaluate the serum levels of hepcidin and its prohormone, proh...
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PMID: 21285884
PDF is available here.
PDF is available here.
Abstract
We presently lack a thorough knowledge of the cell type(s) involved in its induction and maintenance in the inflamed intestinal mucosa. This study aimed to determine whether platelet (PLT) adhesion to inflamed intestinal endothelial cells of human origin may favour angiogenesis. Unstimulated or thro...
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PMID: 20158572
PDF is available here.
PDF is available here.
Mucosal Immunology (4)2 2011
Abstract
We generated transgenic mice that constitutively express TL1A in T cells or dendritic cells. These mice spontaneously develop IL-13-dependent inflammatory small bowel pathology that strikingly resembles the intestinal response to nematode infections. These changes were dependent on the presence of a...
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PMID: 20980995
PDF is available here.
PDF is available here.
Mucosal Immunology (4)2 2011
Abstract
We have recently shown that in IBD, there is a defective synthesis of the counter-regulatory cytokine, interleukin (IL)-25. In this study we investigated factors that control IL-25 production in the gut. IBD patients produced less IL-25 when compared with normal controls. Stimulation of normal intes...
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PMID: 20944558
PDF is available here.
PDF is available here.
Abstract
The pathogenesis of inflammatory bowel disease (IBD) is complex and involves both innate and adaptive immune responses. This article addresses, in a selective and speculative fashion, the topic of how the various components of the intestinal innate immune system can be manipulated fo...
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PMID: 21309670
PDF is available here.
PDF is available here.
Abstract
Interleukin-25 (IL-25) plays a key role in the initiation and expansion of T helper (Th) 2 cell-mediated immune responses, thereby contributing to allergic diseases and host defense against helminthic parasites. More recent studies have however shown that IL-25 can also control the f...
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PMID: 21189120
PDF is available here.
PDF is available here.
Abstract
The management of IBD remains a challenge, with the main issue being to combine therapeutic efficiency with minimal side effects and optimal quality of life. Efforts towards achieving this objective continued in 2010—we discuss some of the most relevant publications and their poten...
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PMID: 21293506
PDF is available here.
PDF is available here.
Abstract
We have shown that CD26 interacts with structures with essential cellular functions in T cell responses. We will review emerging data that suggest CD26 may be an appropriate therapeutic target for the treatment of selected immune disorders....
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PMID: 21404914
PDF is available here.
PDF is available here.
Abstract
Significant concern exists regarding the effect of proctectomy on sexual function in patients with IBD. Little is known about gender-specific differences.
This study aimed to examine sexual function and quality of life in men and women with IBD before and after proctectomy.
This is a prospective coh...
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PMID: 21160316
PDF is available here.
PDF is available here.
Abstract
We generated two transgenic (Tg) murine models with constitutive Tl1a expression in either lymphoid or myeloid cells. Compared to wildtype (WT) mice, constitutive expression of Tl1a in either lymphoid or myeloid cells showed mild patchy inflammation in the small intestine, which was more prominent i...
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PMID: 21264313
PDF is available here.
PDF is available here.
Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology ()2 2011
Abstract
Acta Physiologica (201)1 2011
Abstract
The gastrointestinal (GI) tract is fundamental for the intake of fluid and electrolytes and accommodates a large proportion of bodily hemodynamics and host defence systems. Despite that the renin-angiotensin system (RAS) is a prominent regulatory system for fluid and electrolyte home...
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PMID: 20626369
PDF is available here.
PDF is available here.
Abstract
eight boys with IBD, median age 14.8 years, had pubertal induction using either monthly injections of 50 mg Sustanon or daily 2.5/5 mg Andropatch. Seven boys showed an advance of pubertal status. Six boys had a greater than 50% increase in HV; median HV at T0 was 1.6 cm/year (0, 5) compared with 6.9...
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PMID: 20664179
PDF is available here.
PDF is available here.
Abstract
We evaluated the risk and benefits of therapy with tumor necrosis factor (TNF) inhibitors in these patients.
We collected data from patients with IBD treated with infliximab (n = 2475) and adalimumab (n = 604) from 2000 to 2009 at 16 tertiary centers. Ninety-five patients (3%) were m...
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PMID: 20951835
PDF is available here.
PDF is available here.
Abstract
We investigated the medications, duration of therapy, and ages of patients associated with HSTCL.
We collected and analyzed data on the association between HSTCL, and anti-TNF and thiopurine therapies in patients with IBD from published reports and the MedWatch reporting system of th...
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PMID: 20888436
PDF is available here.
PDF is available here.
Abstract
Patients with inflammatory bowel disease are at high risk for surgical site infections. Preoperative factors including weight loss, smoking, emergent surgery and an ASA score >2 are strong predictors of surgical site infections. Operative time and wound class are important intraoperative predictors....
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PMID: 20940595
PDF is available here.
PDF is available here.
Abstract
to evaluate the frequency of sleep problems and daytime tiredness among adolescents with inflammatory bowel disease (IBD) in comparison with their healthy peers.
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PMID: 21102990
PDF is available here.
PDF is available here.
Autoimmunity (43)7 2010
Abstract
There is a need for methods to improve the diagnosis, patient staging and evaluation of therapeutic response in patients with autoimmune conditions to improve patient care. Inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) are two inflammatory diseases characterized by involvement of in...
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PMID: 20388060
PDF is available here.
PDF is available here.
Autoimmunity (43)7 2010
Abstract
The inflammatory bowel diseases ulcerative colitis and Crohn's disease (CD) are heterogeneous syndromes representing the outcome of the colliding influences of shared and distinct genetic risk factors, environmental or lifestyle modifiers and immune effector mechanisms. Identification of specific ge...
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PMID: 20388058
PDF is available here.
PDF is available here.
Abstract
We review recent findings on the role of the innate immune system and microbial symbionts in the development of IBD.
Both the inflammatory and immune responses may be characterized according to modules of initiators, triggers, mediators and effectors. Use of this framework may guide our understandin...
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PMID: 20871398
PDF is available here.
PDF is available here.
Abstract
The intestinal epithelium serves as a highly dynamic immunologic frontier - exhibiting both innate and adaptive immune features. This review focuses on recent advances and novel insights into key intrinsic processes of the intestinal epithelium to closely monitor its intracellular and extracellular...
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PMID: 20664345
PDF is available here.
PDF is available here.
Abstract
To review recent findings dealing with the involvement of mucosal immunoglobulin A (IgA) in the gut barrier function and various gastrointestinal diseases. New information will be discussed in the context of previous knowledge in this field.
The epithelial barrier function seems to be central in man...
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PMID: 20693891
PDF is available here.
PDF is available here.
Abstract
We review recent developments elucidating distinct phenotypic adaptations in intestinal macrophages that determine their functional role in a microbe-rich environment. The involvement of intestinal macrophages in the pathogenesis of inflammatory bowel disease is also discussed.
Intestinal macrophage...
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PMID: 20717022
PDF is available here.
PDF is available here.
Abstract
Sophoridine (SRI), one of the quinolizidine alkaloids, is a new anticancer drug with noticeable antitumor action and lower toxicity. To our knowledge, there is no report about its effect on colitis. Repeated colitis was induced by administration of four cycles of 4% DSS. The severity of colitis was...
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PMID: 21061213
PDF is available here.
PDF is available here.
Hospital practice (1995) (38)4 2010
Abstract
A new era in medical science has dawned with the realization of the critical role of the "forgotten organ," the enteric flora, in health and disease. Central to this beneficial interaction between the flora and humans is the manner in which the bacteria contained within the gut "talk" to the immune...
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PMID: 21068536
PDF is available here.
PDF is available here.
Abstract
We explore the history of reported cases of hepatosplenic T-cell lymphoma in relation to the possible existence of a causal relationship between infliximab use and HSTCL. The treatments for HSTCL will be briefly addressed.
A comprehensive literature search using multiple databases wa...
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PMID: 21122554
PDF is available here.
PDF is available here.
Abstract
We have generated a cell-permeable Foxp3 protein by fusion with the unique human HHph-1-PTD (protein transduction domain), examined its regulatory function in T cells, and characterized its therapeutic effect in autoimmune and allergic disease models. HHph-1-Foxp3 was rapidly and effectively transdu...
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PMID: 20937878
PDF is available here.
PDF is available here.
Abstract
Clostridium difficile (C. difficile) infection (CDI) is the leading identifiable cause of antibiotic-associated diarrhea. While there is an alarming trend of increasing incidence and severity of CDI in the United States and Europe, superimposed CDI in patients with inflammatory bowel disease (IBD) h...
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PMID: 20954275
PDF is available here.
PDF is available here.
Abstract
Intestinal microbiota is essential for gut homeostasis. Specifically, the microorganisms inhabiting the gut lumen interact with the intestinal immune system, supply key nutrients for the major components of the gut wall, and modulate energy metabolism. Host-microbiome interactions ca...
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PMID: 20865476
PDF is available here.
PDF is available here.
Abstract
The article summarizes the current knowledge on the pathogenesis, clinical aspects and treatment of bone problems in the major inflammatory bowel diseases (Crohn's disease and ulcerative colitis) and celiac disease. It presents the physiological relationship between intestine and bone as well as the...
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PMID: 20599670
PDF is available here.
PDF is available here.
Clinica Chimica Acta (411)19-20 2010
Abstract
pANCA and ASCA are useful in confirming the diagnosis of IBD and differentiating between UC and CD in an IBD cohort in central China.
Copyright 2010 Elsevier B.V. All rights reserved....
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PMID: 20570669
PDF is available here.
PDF is available here.
Tijdschrift voor diergeneeskunde (135)19 2010
Abstract
Adverse reactions to food or dietary hypersensitivity are frequently seen problems in companion animal medicine and may be difficult to differentiate from inflammatory bowel disease (IBD). Dietary hypersensitivity can be divided into two subgroups: immunological and nonimmunological problems. Non-im...
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PMID: 21073096
PDF is available here.
PDF is available here.
Recenti progressi in medicina (101)10 2010
Abstract
Inflammatory Bowel Diseases (IBD) affect mainly younger people. Biologic therapies are safe and effective in inducing and maintain remission in that patients. We reviewed herein the current knowledge about the safety and the effectiveness of biologic therapies in managing pregnant IBD patients.
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PMID: 21137576
PDF is available here.
PDF is available here.
Saudi medical journal (31)10 2010
Abstract
Saudi medical journal (31)10 2010
Abstract
Abstract
Spontaneous development of intestinal inflammation in many different kinds of genetically engineered mice as well as the presence of numerous susceptibility genes in humans suggests that inflammatory bowel disease (IBD) is mediated by more complicated mechanisms than previously predicted. The human...
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PMID: 20860919
PDF is available here.
PDF is available here.
Abstract
We analyzed 115 patients: 32 with ulcerative colitis (UC), 44 with Crohn's disease (CD), 9 with hemorrhagia from the lower part of the digestive tract, but without inflammatory bowel disease and 30 from the control group. In all patients were measured the concentration of calprotectin in the sample...
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PMID: 21207640
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
We review the current understanding of the regulatory role of the nervous system in the maintenance of barrier function in healthy state, or during pathological conditions of, for instance, stress-induced colitis, surgical trauma or inflammation. We will discuss the clinical potential for advances i...
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PMID: 20932148
PDF is available here.
PDF is available here.
Abstract
We diagnosed 15 patients (15/482, 3.1%) with HBV or HCV. Of these, 11 were HBV (11/482, 2.3%) and 4 were HCV (4/482, 0.8%). Nine of eleven HBV patients received antiviral therapy (8 lamivudine, 1 IFNa). Five lamivudine patients were switched to tenofovir and in another one adefovir dipivoxil were ad...
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PMID: 21122543
PDF is available here.
PDF is available here.
Abstract
The first ECCO pathogenesis workshop focused on anti-TNF therapy failures in inflammatory bowel diseases (IBDs). The overall objective was to better understand and explore primary non response and loss of response to anti-TNF agents in IBD. The outcome of this workshop is presented i...
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PMID: 21122530
PDF is available here.
PDF is available here.
Abstract
The thiopurines azathioprine and 6-mercaptopurine have been used in the treatment of Crohn's disease and ulcerative colitis for over 40 years. Randomized controlled trials have supported their use in the treatment of active disease, as well as for the maintenance of disease remission...
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PMID: 20932143
PDF is available here.
PDF is available here.
Abstract
We studied 44 unrelated patients with IBD and 75 subjects with no history of IBD as controls. Using pyrosequencing technology, we identified gene polymorphisms in IL-10, TNF-A, ILB-31, and TLR4. H. pylori status was determined by serology. Individuals homozygous for IL10-592 A or IL10-1082 A genotyp...
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PMID: 20518842
PDF is available here.
PDF is available here.
Abstract
The present retrospective study describes the diagnostic workup and collected findings in 7 horses with chronic inflammatory bowel disease over the years 2000-2006. The diagnosis could be confirmed histologically with biopsies taken during laparoscopy or laparotomy or during post mortem examination....
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PMID: 20814860
PDF is available here.
PDF is available here.
Abstract
The Crohn's and Colitis Foundation of Canada (CCFC) hosted a research symposium in April 2009. The current article presents short synopses of the presentations given at that symposium. Invitees included CCFC-funded clinician-scientists and researchers, research administrators and international leade...
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PMID: 21152461
PDF is available here.
PDF is available here.
Abstract
Abstract
Inflammatory bowel diseases are characterized by chronic intestinal inflammation at different sites. Data from animal models as well as human patients including gene-association studies suggest that different components of the innate barrier function are primarily defective. These re...
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PMID: 20828289
PDF is available here.
PDF is available here.
Abstract
We aimed to prospectively assess the safety and tolerance of infliximab infusion in patients with IBD in a specialized unit adhering to strict standard operation procedures including switch to accelerated 1h infusions.
A prospective audit of a referral center IBD infusion unit was pe...
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PMID: 21122522
PDF is available here.
PDF is available here.
Abstract
Systemic amyloidosis is a rare but life-threatening complication of inflammatory bowel disease (IBD), most cases being reported among Crohn's disease (CD) patients. The only two available retrospective studies showed a prevalence ranging from 0.9% to 3% among CD patients....
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PMID: 21122515
PDF is available here.
PDF is available here.