Abstract
We also studied progression of fibrosis in relation to rs12979860 C/T genotypes over two years.
82% of the patients were on HAART (74% without detectable HI viremia) and 67% were haemophiliacs, respectively. HCV genotype 1 was present in 62%. Cross-sectional median liver stiffness wa...
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PMID: 21813376
PDF is available here.
Abstract
We increase our understanding of the biological mechanisms involved for each phenotypic and/or functionally distinct leukocyte subset, immunotherapeutic strategies can be developed to overcome the inherent barriers to the development of improved strategies for the treatment of liver disease and tumo...
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PMID: 21241810
PDF is available here.
Abstract
We increase our understanding of the biological mechanisms involved for each phenotypic and/or functionally distinct leukocyte subset, immunotherapeutic strategies can be developed to overcome the inherent barriers to the development of improved strategies for the treatment of liver disease and tumo...
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PMID: 21241810
PDF is available here.
Abstract
An alert system in a hospital information system (HIS) would be helpful for physicians to prescribe medication appropriately. In this study we developed an alert system that extracts target problems from the raw data and verifies whether contraindicated medication is prescribed.
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PMID: 21706868
PDF is available here.
Abstract
Recombinant factor VIIa (rFVIIa) is approved for treatment of bleeding in patients who have hemophilia with inhibitors but has been applied to a wide range of off-label indications.
To estimate patterns of off-label rFVIIa use in U.S. hospitals.
Retros...
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PMID: 21502649
PDF is available here.
Abstract
We provide an overview of the key causes, disease mechanisms of pathogenesis, and recommendations for treatment options including the evolving role of liver transplantation.
Copyright © 2011 Elsevier Ltd. All rights reserved....
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PMID: 21459211
PDF is available here.
Abstract
Unbalanced Th1/Th2 T-cell responses in the liver are a characteristic of hepatic inflammation and subsequent liver fibrosis. The recently discovered Th17 cells, a subtype of CD4(+) T-helper cells mainly producing IL-17 and IL-22, have initially been linked to host defense against inf...
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PMID: 21197451
PDF is available here.
Abstract
We studied the long-term survival of intrasplenically transplanted hepatocytes in an attempt to provide a safe and effective support to the diseased native liver.
A preliminary study was performed to identify the optimal number of hepatocytes to be transplanted into the spleen of rat...
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PMID: 21830411
PDF is available here.
Abstract
We hypothesized that early neuronal and delayed inducible nitric oxide synthase blockade attenuates multiple organ dysfunctions during sepsis.
Sheep were randomly allocated to sham-injured, nontreated animals (n = 6); injured (48 breaths of cotton smoke and instillation of Pseudomonas aeruginosa int...
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PMID: 21068663
PDF is available here.
Abstract
This study investigated the time course of heme oxygenase (HO)-1 expression and the role of endogenous HO-1 in hepatic ischemia and reperfusion (I/R). Rats were pretreated with hemin, an HO-1 inducer, and zinc protoporphyrin (ZnPP), an HO-1 inhibitor. Hepatic HO activity increased at...
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PMID: 20446775
PDF is available here.
Abstract
Disrupted l-methionine (Met) metabolism can lead to hepatic, neurological and cardiovascular dysfunction in humans. Aberrant methyl group flux likely contributes to the development of these pathologies, but when patients also become hypermethionemic, additional toxicological mechanisms may be releva...
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PMID: 20874374
PDF is available here.
Abstract
Inserting a transjugular intrahepatic portosystemic shunt by means of interventional radiology has become the procedure of choice for decompression of portal hypertension. The indications and criteria for patient selection have been expanded and refined accordingly.
To review our experience with TIP...
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PMID: 21243870
PDF is available here.
Abstract
Sarcoidosis is a multi-systemic inflammatory disease of unknown etiology, histologically characterized by the presence of non caseating granulomas. The diagnostic suspicion relies on clinical, epidemiological, biological and radiological elements. It is confirmed by an evocative histology and by the...
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PMID: 21140958
PDF is available here.
Abstract
Liver disease is the fifth commonest cause of death in the UK. Observational and case-controlled studies have suggested that coffee is beneficial in liver disease, but this evidence has yet to be evaluated or placed into the context of the natural history of liver disease. The aim of this study was...
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PMID: 20802342
PDF is available here.
Abstract
Hepatocyte injury is ubiquitous in clinical practice, and the mode of cell death associated with this injury is often apoptosis, especially by death receptors. Information from experimental systems demonstrates that hepatocyte apoptosis is sufficient to cause liver hepatic fibrogenesis. The mechanis...
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PMID: 20960379
PDF is available here.
Abstract
The field of hepatobiliary-pancreatic surgery involves performing hepatectomy, pancreatectomy, and hepatopancreatoduodenectomy, which are all very invasive procedures. Since bile and pancreatic juice are associated with the etiology of disease, appropriate management is necessary for patients with c...
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PMID: 21174712
PDF is available here.
Abstract
Liver transplantation has rapidly advanced from an experimental therapy to a mainstream treatment option for a wide range of acute and chronic liver diseases. Indications for liver transplant have evolved to include previously contraindicated conditions such as hepatocellular carcinoma and alcohol-r...
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PMID: 20960380
PDF is available here.
Abstract
We assessed the sustainability of early QOL benefits after LTX.
Patients who underwent LTX (n = 381) were followed for 12 years. We collected clinical information, survival data, and data on 5 QOL domains: physical distress (PHY), psychological distress (PSY), social/role function (SRF), personal fu...
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PMID: 20600035
PDF is available here.
Abstract
Two motivations for studying radiation risk are (1) to quantify the magnitude of risk as an aid to setting radiation protection standards and (2) to understand causality as an aid to assigning compensation for radiation exposed individuals whose disease or death may have been related to radiation ex...
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PMID: 20938230
PDF is available here.
Abstract
We examined the kinetics and molecular mechanisms of neutrophil recruitment to sites of focal hepatic necrosis in vivo. Adenosine triphosphate released from necrotic cells activated the Nlrp3 inflammasome to generate an inflammatory microenvironment that alerted circulating neutrophils to adhere wit...
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PMID: 20947763
PDF is available here.
Abstract
We conducted a "before and after study" on severe obstructive jaundice patients as a model of inhibition of the excessive process by bile duct decompression. Specimens of liver biopsies were taken before and after decompression of the bile duct and then stained by terminal deoxynucleotide transferas...
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PMID: 20943462
PDF is available here.
Abstract
Obesity is associated with a higher risk of developing non-alcoholic fatty liver disease (NAFLD) and contributes to the progression of liver diseases of distinct etiologies such as chronic hepatitis C virus (HCV) infection. The discovery that adipose tissue is submitted to a state of chronic inflamm...
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PMID: 20206411
PDF is available here.
Abstract
A 13-year-old, neutered male domestic cat presented with signs of weight loss, anemia, and hepatomegaly. Pathognomonic signs of porphyria were identified. Charcoal-like renal calculi and severe liver changes were observed, neither of which has been previously reported in association with feline porp...
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PMID: 21197209
PDF is available here.
Abstract
We discuss how to recognize NAFLD, including NASH, in our outpatient clinic....
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PMID: 21077292
PDF is available here.
Abstract
The increase in the life expectancy achieved following the introduction of more effective antiretroviral therapy (ART) in recent years now means that the HIV-infected population are for the first time being exposed to the age-related diseases that affect the general population. Nevertheless, the pre...
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PMID: 20929492
PDF is available here.
Abstract
Technosphere® [Bis-3,6(4-fumarylaminobutyl)-2,5-diketopiperazine (FDKP)] microparticles, the integral component of the Technosphere inhalation system, deliver drugs to the deep lung and have been used to administer insulin and glucagon-like peptide-1 via inhalation in clinical studi...
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PMID: 20920436
PDF is available here.
Abstract
We discuss recent findings pertaining to the aforementioned factors of liver IR, and we highlight areas with gaps in our knowledge, necessitating further research.
(c) 2010 AASLD....
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PMID: 20818739
PDF is available here.
Abstract
We report three additional cases of inflammatory pseudotumor of the liver diagnosed by liver biopsy. Two of these cases were treated successfully with antibiotics. The other case, who was resistant to medical treatment, had coexisting neuroendocrine neoplasms of the rectum and the lung. Since her ge...
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PMID: 20931439
PDF is available here.
Abstract
We identified the following as independent risk factors: elevated body mass index; elevated preoperative serum creatinine; and history of chronic obstructive pulmonary disease, liver disease, congestive heart failure, hypertension, and underlying heart disease. Renal impairment was significantly ass...
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PMID: 20570102
PDF is available here.
Abstract
We hypothesized that serum B12 concentration would become elevated in intestinal failure-associated liver disease and would reflect in disease severity.
We retrospectively evaluated 13 patients with short bowel syndrome (<200 cm residual small intestine) that included complete terminal ileum resecti...
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PMID: 20421811
PDF is available here.
Abstract
Despite the efficacy of combination antiretroviral therapy (ART), a large proportion of patients living with HIV/AIDS on ART does not achieve or maintain adequate virological suppression. Therapeutic drug monitoring (TDM) has been utilised to improve treatment outcomes of ART. AREAS COVERED IN THE R...
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PMID: 20350281
PDF is available here.
Abstract
We believe that this policy is not evidence-based. In this article, we will provide arguments against the traditional concept that patients with liver failure have a hemostasis-related bleeding tendency. Consequences of these new insights for hemostatic management will be discussed....
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PMID: 20400681
PDF is available here.
Abstract
Gram-positive bacteria such as Staphylococcus aureus have been a common cause of infection among liver transplant (LT) recipients in recent decades. The understanding of local epidemiology and its evolving trends with regard to pathogenic spectra and antibiotic susceptibility is beneficial to prophy...
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PMID: 20819529
PDF is available here.
Abstract
We analyzed how allogeneic skin transplant (Tx) affected the sequel of host's own liver damage induced by partial warm ischemia and reperfusion. Our data clearly showed that allo-Tx recipients had increased inflammatory response against IR insult in their native livers, as evidenced by significantly...
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PMID: 20659085
PDF is available here.
Abstract
We localized BCS1L in inner mitochondrial membranes. In patient liver, kidney, and heart BCS1L and Rieske protein levels, as well as the amount and activity of complex III, were decreased. Major histopathology was found in kidney and liver with cirrhosis and iron deposition, but of iron-related prot...
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PMID: 20580947
PDF is available here.
Abstract
We concluded that pediatric liver transplantation is gradually developing and would probably be a promising therapy for pediatric end-stage liver diseases in Mainland China....
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PMID: 20557474
PDF is available here.
Abstract
We here report successful diagnosis and treatment of two cases with right-sided diaphragmatic hernia developed after OLT both utilizing left-sided allografts. Combination of factors related to the surgical techniques and patient characteristics might explain the pathophysiology behind the diaphragma...
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PMID: 19344340
PDF is available here.
Abstract
Positive correlations were found between duration and longitudinal diameter (r = 0.66; P < .001), transverse diameter (r = 0.66; P < .001), distance of ablation beyond the electrode tip (r = 0.56; P < .001), and volume of lesions (r = 0.66; P < .001). Temperature was also positively correlated with...
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PMID: 20599156
PDF is available here.
Abstract
In spite of risk factors for osteoporosis in patients with digestive diseases, health-care practices by providers in regard to bone health recommendations warrant further improvement....
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PMID: 20127169
PDF is available here.
Abstract
Colorectal surgery in CLD patients is associated with significant morbidity and mortality. Furthermore, those who develop major complications have a significantly higher risk of death compared to non-CLD. These very high risks should be discussed at length with patients prior to undertaking major su...
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PMID: 20622652
PDF is available here.
Abstract
Liver regeneration has traditionally been investigated in mammalian models. Recent technological developments in mouse genetics have greatly enhanced the resolving power of these studies. In addition, the zebrafish system has emerged as a complementary genetic system to study liver regeneration. One...
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PMID: 20665380
PDF is available here.
Abstract
Nomenclature describing liver anatomy and liver resection has been standardized with the Brisbane 2000 terminology. When performing liver resection, blood loss should be minimized by using low central venous pressure (CVP) anesthesia and vascular occlusion as appropriate. There are many options for...
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PMID: 20637944
PDF is available here.
Abstract
Understanding the complexities of the liver has been a long-standing challenge to physicians and anatomists. Significant strides in the understanding of hepatic anatomy have facilitated major progress in liver-directed therapies--surgical interventions, such as transplantation, hepatic resection, he...
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PMID: 20637938
PDF is available here.
Abstract
Although minimally invasive hepatic resection surgery has shown decreased morbidity in select patients, conventional laparoscopic liver resection has inherent limitations with reduced freedom of movement within the abdominal cavity and 2-dimensional view of the operative field. Robotic liver surgery...
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PMID: 20637946
PDF is available here.