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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Liver (1):
Recent article
Liver
Abstract
We have developed a size-controllable spheroidal hepatosphere and heterosphere model by mono-culturing of primary hepatocytes and by co-culturing primary hepatocytes and hepatic stellate cells (HSCs). We demonstrated that uniform-sized heterospheres, which self-aggregated from primary hepatocytes an...
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PMID: 21813175
PDF is available here.
PDF is available here.
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Journal Of Cellular Physiology (226)11 2011
Abstract
We have shown recently that epimorphin (EPM), a protein exclusively expressed on the surface of hepatic stellate cells and myofibroblasts of the liver, induces bile duct formation of hepatic stem-like cells (WB-F344 cells) in a putative biophysical way. Therefore, the aim of this study was to presen...
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PMID: 21935930
PDF is available here.
PDF is available here.
Abstract
New England Journal of Medicine (365)14 2011
Abstract
Journal of Surgical Research (170)2 2011
Abstract
We induced POLF by combining extended left hepatectomy and ischemia of the small liver remnant of 150 min duration. Subsequently, the remnant liver parenchyma was reperfused and the animals were closely monitored for 24 h.
Twelve Landrace pigs (weight 25-30 kg) were randomly assigned...
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PMID: 21816413
PDF is available here.
PDF is available here.
New England Journal of Medicine (365)12 2011
Abstract
New England Journal of Medicine (365)12 2011
Abstract
A total of 432 patients underwent randomization to receive one of four doses of BIBF 1120 (50 mg once a day, 50 mg twice a day, 100 mg twice a day, or 150 mg twice a day) or placebo. In the group receiving 150 mg of BIBF 1120 twice a day, FVC declined by 0.06 liters per year, as compared with 0.19 l...
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PMID: 21992121
PDF is available here.
PDF is available here.
Proteomics (11)17 2011
Sample preparation method for isolation of single-cell types from mouse liver for proteomic studies.
Abstract
We described could simultaneously isolate population of hepatocytes (HCs), hepatic stellate cells (HSCs), Kupffer cells (KCs) and liver sinusoidal endothelial cells (LSECs) by a combination of collagenase-based density gradient centrifugation and magnetic activated cell sorting with high purity and...
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PMID: 21751380
PDF is available here.
PDF is available here.
Abstract
We characterized the pharmacokinetics of fentanyl in 15 patients (American Society of Anesthesiologists Physical Status Classification 2 or 3) undergoing living-donor liver transplantation (LDLT). Fentanyl was continuously infused at the rate of 200-400 µg/h throughout the operation. The time cour...
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PMID: 21814196
PDF is available here.
PDF is available here.
Critical Care Medicine (39)9 2011
Abstract
We have recently shown that MFG-E8 treatment attenuates organ injury, inflammatory responses, and survival after sepsis through the enhancement of phagocytosis of apoptotic cells. The purpose of this study was to determine whether administration of MFG-E8 attenuates renal ischemia-reperfusion injury...
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PMID: 21666453
PDF is available here.
PDF is available here.
Critical Care Medicine (39)9 2011
Abstract
We have recently shown that MFG-E8 treatment attenuates organ injury, inflammatory responses, and survival after sepsis through the enhancement of phagocytosis of apoptotic cells. The purpose of this study was to determine whether administration of MFG-E8 attenuates renal ischemia-reperfusion injury...
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PMID: 21666453
PDF is available here.
PDF is available here.
Journal of Chromatography B (879)24 2011
Abstract
We investigated and compared the profiles of metabolites in nude mice with alcohol-induced liver injury or bearing a HCC xenograft (HCCX). Alcohol-induced liver injury was achieved by daily administration of grain liquor, and HCC xenografts were generated by subcutaneous inoculation of HepG2 cells i...
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PMID: 21763219
PDF is available here.
PDF is available here.
Abstract
We aimed at investigating (i) whether a daily dose of 300 mg resveratrol/kg body weight in healthy male Wistar rats for a period of 8 wk affects the selected parameters of glucose and lipid metabolism and (ii) whether the resulting plasma concentrations of resveratrol metabolites were effective...
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PMID: 21732533
PDF is available here.
PDF is available here.
Abstract
I (IGF-1) levels are closely associated with cardiac performance although the role of IGF-1 in alcoholic cardiac dysfunction is unknown. This study was designed to evaluate the impact of severe liver IGF-1 deficiency (LID) on chronic alcohol-induced cardiomyocyte contractile and intracellular Ca(2+)...
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PMID: 20731752
PDF is available here.
PDF is available here.
Proteomics (11)16 2011
Abstract
We have used 2-DE coupled with MS to identify proteins differentially expressed in the livers of juvenile gilthead sea bream (Sparus aurata) grown under fish-farm conditions and fed with a 100 mg/kg MA-enriched diet (MA(100)). After the comparison of the protein profiles from MA(100) fed fish and...
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PMID: 21751345
PDF is available here.
PDF is available here.
Abstract
The aim of the present study is to examine the effects of dietary saturated fatty acids on liver adiponectin receptor 1 (AdipoR1) and adiponectin receptor 2 (AdipoR2) in ethanol-administered animals and in ethanol-exposed cultured hepatic cells, and to explore the underlying molecula...
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PMID: 21194380
PDF is available here.
PDF is available here.
Abstract
The pathological changes present in channel catfish Ictalurus punctatus spontaneously infected by Streptococcus iniae are described. The most consistent gross findings were marked petechial hemorrhages of the skin and congestion of internal organs, particularly the liver, spleen and...
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PMID: 21932531
PDF is available here.
PDF is available here.
Abstract
The pathological changes present in channel catfish Ictalurus punctatus spontaneously infected by Streptococcus iniae are described. The most consistent gross findings were marked petechial hemorrhages of the skin and congestion of internal organs, particularly the liver, spleen and...
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PMID: 21932531
PDF is available here.
PDF is available here.
Abstract
The pathological changes present in channel catfish Ictalurus punctatus spontaneously infected by Streptococcus iniae are described. The most consistent gross findings were marked petechial hemorrhages of the skin and congestion of internal organs, particularly the liver, spleen and...
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PMID: 21932531
PDF is available here.
PDF is available here.
Abstract
We show that hepatic glycogen accumulates H(2) after oral administration of H(2)-water, explaining why consumption of even a small amount of H(2) over a short span time efficiently improves various disease models. This finding was supported by an in vitro experiment in which glycogen solution mainta...
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PMID: 21293445
PDF is available here.
PDF is available here.
Abstract
Atherosclerotic vascular disease, diabetes mellitus (DM) and dementia are major global health problems. Both endogenous and exogenous factors activate genes functioning in biological processes. This review article focuses on gene-activation mechanisms that regress atherosclerosis, el...
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PMID: 21568932
PDF is available here.
PDF is available here.
Abstract
We evaluated time-courses of glucose, insulin, C-peptide, and the incretin glucagon like peptide-1 (GLP-1) following an oral glucose load. Insulin-sensitivity was measured by a hyperinsulinemic-isoglycemic-clamp-test; glucose-turnover was determined using D-[6,6-(2)H(2)] glucose. Examinations were p...
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PMID: 21494227
PDF is available here.
PDF is available here.
Abstract
We assessed hepatovenous pressure gradient (HVPG), liver stiffness (transient elastography), and interleukin (IL)-28B polymorphisms (rs12979860) in 90 cirrhotic patients with HCV infection (82% genotype 1 or 4) before antiviral therapy with pegylated interferon and ribavirin. Efficacy and safety wer...
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PMID: 21397726
PDF is available here.
PDF is available here.
Abstract
We examined the impact of CR on a model of inflammation-associated pancreatitis and pancreatic dysplasia, with a focus on the mechanistic contribution of systemic IGF-1. Administration of a 30% CR diet for 14 weeks decreased serum IGF-1 levels and hindered pancreatic ductal lesion formation and dysp...
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PMID: 21593196
PDF is available here.
PDF is available here.
Abstract
Thirty subjects participated in the hepatic impairment study (normal hepatic function, n = 8; mild hepatic impairment [Child-Pugh class A], n = 8; moderate hepatic impairment [Child-Pugh class B], n = 8; severe hepatic impairment [Child-Pugh class C], n = 6). Thirty-three subjects we...
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PMID: 21651314
PDF is available here.
PDF is available here.
Cell Metabolism (13)6 2011
Abstract
Sirtuins have emerged in recent years as critical regulators of metabolism, influencing numerous facets of energy and nutrient homeostasis. Here, we review recent advances on the role of this fascinating family of mammalian proteins and their well-orchestrated function in modulating...
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PMID: 21641544
PDF is available here.
PDF is available here.
Abstract
We investigated the anti-inflammatory effect of genistein on non-alcoholic steatohepatitis (NASH) rats induced by high fat diet (HFD), and explored its potential mechanisms. Rats were fed with normal chow diet or HFD for 12 weeks with or without low (4 mg/kg/day body weight) or high (8 mg/kg/day bod...
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PMID: 21320636
PDF is available here.
PDF is available here.
Liver Transplantation (17)6 2011
Abstract
We used sequential high-abundance protein depletion and isobaric tag for relative and absolute quantitation liquid chromatography-tandem mass spectrometry to characterize the serum proteome in serum samples of patients with or without ACR. Seven of the 41 proteins identified as differentially abunda...
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PMID: 21618694
PDF is available here.
PDF is available here.
Abstract
Civilian liver trauma is generally sustained by blunt injury, with management strategies increasingly focusing on selective non-operative strategies and endovascular intervention. Military liver trauma is more often ballistic in nature and almost always requiring operative interventi...
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PMID: 21805762
PDF is available here.
PDF is available here.
Cancer Cell (19)5 2011
Abstract
We report a tumor-suppressor function of Shp2. Hepatocyte-specific deletion of Shp2 promotes inflammatory signaling through the Stat3 pathway and hepatic inflammation/necrosis, resulting in regenerative hyperplasia and development of tumors in aged mice. Furthermore, Shp2 ablation dramatically enhan...
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PMID: 21575863
PDF is available here.
PDF is available here.
Abstract
We have employed two-dimensional electrophoresis to detect and quantitate gene expression effects of candidate chemoprevention compounds in the livers of treated rats. Oltipraz, an inducer of several phase II enzymes, affected a series of at least 26 proteins, most of which were slightly decreased b...
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PMID: 8538186
PDF is available here.
PDF is available here.
Abstract
A comparative study of proteome maps from control and Cd-exposed rat liver was performed using a new technology of two-dimensional liquid chromatography separation method (PF-2D system, Beckman Coulter). Rats were fed for one month 0 or 100 μg Cd g(-1). The between-replicate and bet...
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PMID: 21093054
PDF is available here.
PDF is available here.
Abstract
It has been shown that elevated levels of alanine and aspartate aminotransferases (ALT and AST) are associated with insulin resistance and type 2 diabetes mellitus; however, the pattern of this association in diabetic patients with negative or mild steatosis is not well understood. T...
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PMID: 21091060
PDF is available here.
PDF is available here.
Abstract
We discuss specificities of SIRT1 effects in the liver versus pancreatic β-cells, ultimately converging towards metabolic homeostasis at the organism level....
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PMID: 21483037
PDF is available here.
PDF is available here.
Abstract
We have developed a directed differentiation protocol to obtain insulin-producing cells from ESCs. The ESCs are first induced towards a homogeneous monolayer of definitive endoderm-like cells by co-culture with primary hepatocytes. Pancreatic commitment is induced by plating the ESC-derived endoderm...
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PMID: 20717889
PDF is available here.
PDF is available here.
Abstract
To test whether obese children with non-alcoholic fatty liver disease have impaired vascular function compared with obese children with normal liver fat content.
Obese children (n = 28, 16 males, mean age 10.9 ± 0.7 years, body mass index [BMI] 31.9 ± 4.5 kg/m(2)) w...
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PMID: 20950125
PDF is available here.
PDF is available here.
Abstract
We have recently shown that allogeneic intrabone marrow-bone marrow transplantation + adult thymus transplantation (TT) is effective for hosts with malignant tumors. However, since thymic and hematopoietic cell functions differ with age, the most effective age for such intervention needed to be...
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PMID: 20672991
PDF is available here.
PDF is available here.
Abstract
We examined the semiserial histology of 20 human embryos and fetuses (crown-rump length 11-40 mm). We started observations of the canal at the stage through which the lung bud extends far caudally along the dorsal body wall to the level of the future adrenal, and the phrenic nerve has already reache...
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PMID: 21370493
PDF is available here.
PDF is available here.
Molecular BioSystems (7)4 2011
Abstract
We characterised metabolic imbalance in Watanabe heritable hyperlipidaemic rabbits as a model of hypercholesterolaemia. Using a mass spectrometry-based system, we measured a total of 335 metabolites in plasma and tissues (liver, aorta, cardiac muscle, and brain) from WHHL and healthy control rabbits...
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PMID: 21258713
PDF is available here.
PDF is available here.
Molecular BioSystems (7)4 2011
Abstract
We characterised metabolic imbalance in Watanabe heritable hyperlipidaemic rabbits as a model of hypercholesterolaemia. Using a mass spectrometry-based system, we measured a total of 335 metabolites in plasma and tissues (liver, aorta, cardiac muscle, and brain) from WHHL and healthy control rabbits...
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PMID: 21258713
PDF is available here.
PDF is available here.
Abstract
The Lancet (377)9772 2011
Abstract
We provide an overview of the key causes, disease mechanisms of pathogenesis, and recommendations for treatment options including the evolving role of liver transplantation.
Copyright © 2011 Elsevier Ltd. All rights reserved....
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PMID: 21459211
PDF is available here.
PDF is available here.
Parasitology (138)5 2011
Abstract
Our results show, for the first time, that maintenance under laboratory conditions can not abolish the deleterious effect of L. intestinalis on gametogenesis in roach, and indicate a specific inhibition of host reproduction by endocrine disruption....
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PMID: 21092374
PDF is available here.
PDF is available here.
Abstract
We previously reported that the intravenous administration of unmodified silica particles with a diameter of 70 nm (SP70) caused hepatic injury. Here, we examined the acute hepatic toxicity of SP70 modified with amino group (SP70-N) or carboxyl group (SP70-C). When administered intravenously into mi...
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PMID: 21612155
PDF is available here.
PDF is available here.
Abstract
Abstract
We used a metabolomics approach to generate unbiased small-molecule metabolic profiles in plasma that predict risk for CVD. Three metabolites of the dietary lipid phosphatidylcholine--choline, trimethylamine N-oxide (TMAO) and betaine--were identified and then shown to predict risk for CVD in an ind...
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PMID: 21475195
PDF is available here.
PDF is available here.
Annals of Surgery (253)4 2011
Abstract
We recently reported that platelets accumulate in the liver immediately after extended hepatectomy and promote residual liver regeneration. Liver regeneration depends on the number of accumulated platelets in the sinusoids.
Male Sprague-Dawley rats underwent 70% hepatectomy and were...
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PMID: 21475016
PDF is available here.
PDF is available here.
Abstract
We examined the structure and function relationship among various alk(en)yl sulfides on the expression of the pi class of glutathione S-transferase (GSTP) in rat Clone 9 cells, and what mechanism is involved. Cells were treated with 300 μM dipropyl sulfide (DPS), dipropyl disulfide (DPDS), propyl m...
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PMID: 21381664
PDF is available here.
PDF is available here.
Abstract
We report several proteins and peptides that exhibit heightened degradation sensitivity, for instance superoxide dismutase in liver, and peptidyl-prolyl cis-trans isomerase and insulin C-peptides in pancreas. Tissue sampling based on snap freezing produces a greater amount of degradation products an...
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PMID: 20110281
PDF is available here.
PDF is available here.
Abstract
We examined the relationship of maternal insulin resistance (IR), a metabolically important consequence of increased adiposity, to adverse consequences of obesity for fetal development. We used mice heterozygous for a null allele of the insulin receptor (Insr) to study the contributions of maternal...
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PMID: 20948526
PDF is available here.
PDF is available here.
Abstract
We analyzed longitudinal clinical data for patients with hemoglobin H disease arising from the deletion of three of four α-globin genes (HbH) and from hemoglobin H Constant Spring (HCS), caused by the deletion of two α-globin genes and the Constant Spring mutation.
We identified 86...
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PMID: 21345100
PDF is available here.
PDF is available here.
Liver Transplantation (17)2 2011
Abstract
We investigated ER stress signaling and blockade in the mediation of CIR injury in severely steatotic rodent allografts. Steatotic allografts from genetically leptin-resistant rodents had increased ER stress responses and increased markers of hepatocellular injury after liver transplantation into st...
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PMID: 21280192
PDF is available here.
PDF is available here.
Abstract
Aging is associated with various metabolic disorders that may have their origin in the liver, including non-alcoholic fatty liver disease, obesity, type 2 diabetes mellitus, and atherosclerosis. Although well-characterized in models of caloric restriction, relatively little is known...
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PMID: 21386135
PDF is available here.
PDF is available here.
Abstract
The goal of this study is to develop a focal zone sharpening strategy that produces more precise lesions for pulsed cavitational ultrasound therapy, or histotripsy. Precise and well-confined lesions were produced by locally suppressing cavitation in the periphery of the treatment foc...
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PMID: 21342816
PDF is available here.
PDF is available here.
Abstract
The clinical applicability of high-intensity focused ultrasound (HIFU) for noninvasive therapy is today hampered by the lack of robust and real-time monitoring of tissue damage during treatment. The goal of this study is to show that the estimation of local tissue elasticity from she...
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PMID: 21342822
PDF is available here.
PDF is available here.
Abstract
We sought to determine in biopsies from lean and obese aging rhesus monkeys the nature of defects in insulin activation and, further, the potential for mitigation of such defects by an in vivo insulin sensitizer, rosiglitazone, and a thiazolidinedione activator of the peroxisome proliferator-activat...
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PMID: 20518698
PDF is available here.
PDF is available here.
Abstract
We evaluate the effects of BP-4 in eleuthero-embryos and in the liver, testis and brain of adult male fish on the transcriptional level by focusing on target genes involved in hormonal pathways to provide a more complete toxicological profile of this important UV-absorber. Eleuthero-embryos and male...
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PMID: 20937294
PDF is available here.
PDF is available here.
Abstract
We treated male CD-1 mice, New Zealand white rabbits and cynomolgus monkeys with MeOH (2.0 g/kg ip) and 6h later assessed oxidative damage to DNA, measured as 8-oxo-2'-deoxyguanosine (8-oxodG) by HPLC with electrochemical detection. We found no MeOH-dependent increases in 8-oxodG in lung, liver or k...
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PMID: 20950637
PDF is available here.
PDF is available here.
Abstract
We present Mayday SeaSight, an extension that allows to integrate data from different platforms such as deep sequencing and microarrays. It offers methods for computing expression values from mapped reads and raw microarray data, background correction and normalization and linking microarray probes...
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PMID: 21305015
PDF is available here.
PDF is available here.
Abstract
We employed SILAM (Stable Isotope Labeling in Mammals) combined with mass spectrometry to quantify the proteome between mammalian tissues. Using (15)N labeled rat tissue, we quantified 3742 phosphorylated peptides in nuclear extracts from liver and brain tissue. Analysis of the phosphorylation sites...
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PMID: 21283754
PDF is available here.
PDF is available here.