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All › Embryonic Structures

Embryonic Structures (24)

Articles on Embryonic Structures

  1. Nucleolar development and allocation of key nucleolar proteins require de novo transcription in bovine embryos.
    Olga Svarcova, Jozef Laurincik, ... Poul Maddox-Hyttel

    Mol Reprod Dev 74(11):1428-35 (2007) PMID 17410544

    I and fibrillarin are transcribed de novo whereas nucleolin and nucleophosmin are maternally inherited as demonstrated by alpha -amanitin inhibition. However, localization of these two proteins to the nucleolar compartments was negatively affected by the alpha-amanitin treatment. Consequently, funct...
  2. Birth of correctly genotyped calves after multiplex marker detection from bovine embryo microblade biopsies.
    Jaana J Peippo, Sirja S Viitala, ... Johanna J Vilkki

    Mol Reprod Dev 74(11):1373-8 (2007) PMID 17440940

    We report a method for multiplex genotyping of bovine embryo microblade biopsies. We have tested the reliability of the method and the viability of the embryos in vitro and in vivo. Two polymorphic gene markers (GHR F279Y and PRLR S18N) associated with milk production traits and one marker for sex d...
  3. Nucleolar development and allocation of key nucleolar proteins require de novo transcription in bovine embryos.
    Olga Svarcova, Jozef Laurincik, ... Poul Maddox-Hyttel

    Mol Reprod Dev 74(11):1428-35 (2007) PMID 17410544

    I and fibrillarin are transcribed de novo whereas nucleolin and nucleophosmin are maternally inherited as demonstrated by alpha -amanitin inhibition. However, localization of these two proteins to the nucleolar compartments was negatively affected by the alpha-amanitin treatment. Consequently, funct...
  4. Knockout mice lacking cPGES/p23, a constitutively expressed PGE"2 synthetic enzyme, are peri-natally lethal
    Yoshihito Y Nakatani, Yutaka Y Hokonohara, ... Ichiro I Kudo

    Biochem Biophys Res Commun 362(2):6 (2007) PMID 17719010

    We have revealed that Hsp90 regulated both cPGES/p23 and its client protein kinase CK2. In this study, in order to examine the role of cPGES/p23 in vivo, we generated mice deficient in cPGES/p23 by a targeted disruption of exons 2 and 3, containing Tyr9, which is essential for catalytic activity. He...
  5. Mechanisms of action of the congenital diaphragmatic hernia-inducing teratogen nitrofen.
    B Rhiannon BR Noble, Randal P RP Babiuk, ... John J JJ Greer

    Am J Physiol Lung Cell Mol Physiol 293(4):L1079-87 (2007) PMID 17704186

    We use in vitro cell assays in conjunction with whole animal rodent studies to test hypotheses regarding nitrofen's mechanism of action. The first component examined the interaction of nitrofen with various aspects of the retinoid signaling pathway including uptake proteins, binding proteins, recept...
  6. Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature.
    R Sathish RS Srinivasan, Miriam E ME Dillard, ... Guillermo G Oliver

    Genes Dev 21(19):2422-32 (2007) PMID 17908929 PMCID 1993873

    We performed Cre/loxP-based lineage-tracing studies using mouse strains expressing Cre recombinase under the control of the Tie2, Runx1, or Prox1 promoter elements. These studies, together with the analysis of Runx1-mutant embryos lacking definitive hematopoiesis, conclusively determined that from v...
  7. Eye-open at birth phenotype with reduced keratinocyte motility in LGR4 null mice
    Shigeki S Kato, Yasuaki Y Mohri, ... Katsuhiko K Nishimori

    FEBS Lett 581(24):6 (2007) PMID 17850793

    We observed a consistent eye-open at birth (EOB) phenotype in mouse pups homozygous for a leucine-rich repeat containing G-protein coupled receptor 4 (Lgr4) allele deleting the whole transmembrane domain coding region. An in vitro wound-healing scratch assay showed notably reduced keratinocyte motil...
  8. GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion.
    Sherry S Wanderling, Birgitte B BB Simen, ... Yair Y Argon

    Mol Biol Cell 18(10):3764-75 (2007) PMID 17634284 PMCID 1995707

    We show that it has essential functions in embryonic development. grp94-/- embryos die on day 7 of gestation, fail to develop mesoderm, primitive streak, or proamniotic cavity. grp94-/- ES cells grow in culture and are capable of differentiation into cells representing all three germ layers. However...
  9. Epidermal terminal differentiation depends on B lymphocyte-induced maturation protein-1.
    Erna E Magnúsdóttir, Sergey S Kalachikov, ... Kathryn K Calame

    Proc Natl Acad Sci U S A 104(38):14988-93 (2007) PMID 17846422 PMCID 1986600

    We identified the transcriptional repressor Blimp-1 (B lymphocyte-induced maturation protein-1) as an important regulator of keratinocyte transition from the granular to the cornified layer. More than 250 genes are misregulated in conditional knockout epidermis, including those encoding transcriptio...
  10. Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination.
    Roberta R Benetti, Susana S Gonzalo, ... María A MA Blasco

    J Cell Biol 178(6):925-36 (2007) PMID 17846168 PMCID 2064618

    We demonstrate that the Suv4-20h enzymes are responsible for this histone modification at telomeres. Cells deficient for Suv4-20h2 or for both Suv4-20h1 and Suv4-20h2 show decreased levels of H4K20me3 at telomeres and subtelomeres in the absence of changes in H3K9me3. These epigenetic alterations ar...
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