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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Mesonephros (0):
Recent article
Mesonephros
Abstract
Sex determination in the American alligator depends on the incubation temperature experienced during a thermo-sensitive period (TSP), although sex determination can be 'reversed' by embryonic exposure to an estrogenic compound. Thus, temperature and estrogenic signals play essential roles during tem...
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PMID: 19940440
PDF is available here.
PDF is available here.
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Cells Tissues Organs (191)2 2010
Abstract
We examined adenovirus-mediated gene transfer to endothelial cells in primary cultures from developing and regressing quail mesonephros. Quail embryos with developing and regressing mesonephros were examined on day 6 (30HH) and day 11 (40HH) of incubation, respectively. The senescence markers, assoc...
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PMID: 19641291
PDF is available here.
PDF is available here.
Development (136)15 2009
Abstract
We tested whether AGM HSC induction is influenced by the surrounding dorsal and ventral tissues. Our explant culture results at early and late embryonic day 10 show that ventral tissues induce and increase AGM HSC activity, whereas dorsal tissues decrease it. Chimeric explant cultures with genetical...
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PMID: 19570846
PDF is available here.
PDF is available here.
Developmental Biology (325)1 2009
Abstract
We will highlight some of the classic morphological studies and discuss some of the more recent genetic models that have all served to contribute to our understanding of this system. Where published information is scarce we will provide potential hypotheses that warrant further investigation and may...
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PMID: 18992735
PDF is available here.
PDF is available here.
Abstract
We examine IL-1 and its possible role in regulating hematopoiesis in the midgestation mouse embryo. We show that IL-1, IL-1 receptors (IL-1Rs), and signaling mediators are expressed in the aorta-gonad-mesonephros (AGM) region during the time when HSCs emerge in this site. IL-1 signaling is functiona...
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PMID: 18805969
PDF is available here.
PDF is available here.
Abstract
We previously reported that Mind bomb-1 (Mib1) regulates Notch ligands in the Notch signal-sending cells (B. K. Koo, M. J. Yoon, K. J. Yoon, S. K. Im, Y. Y. Kim, C. H. Kim, P. G. Suh, Y. N. Jan, and Y. Y. Kong, PLoS ONE 2:e1221, 2007). Here, we show that intraembryonic hematopoietic progenitors were...
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PMID: 18505817
PDF is available here.
PDF is available here.
Developmental Biology (319)2 2008
Abstract
We have explored the mechanisms underlying regional specific differentiation of the kidney forming mesoderm. Previous studies have shown a requirement for Hox11 paralogs (Hoxa11, Hoxc11 and Hoxd11) in metanephric development. Mice lacking all Hox11 activity fail to form metanephric kidney structures...
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PMID: 18485340
PDF is available here.
PDF is available here.
Abstract
The spatial and temporal pattern of the appearance of the fibroblast growth factor proteins (FGF-8 and FGF-10), the bone morphogenetic proteins (BMP-2/4 subfamily and BMP-7) and the vascular endothelial growth factor protein (VEGF) was investigated in the human mesonephros and metanephros of the 5-9...
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PMID: 18437684
PDF is available here.
PDF is available here.
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology (16)3 2008
Abstract
To investigate the effects of microenvironment of aorta-gonad-mesonephros (AGM) on embryonic hematopoiesis, mesenchymal stem cell like stromal cells (MSC like stromal cells) derived from dorsal aorta (DA) in AGM region were separated and identified by their growth characteristics, related molecules...
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PMID: 18549634
PDF is available here.
PDF is available here.
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology (16)3 2008
Abstract
This study was purposed to isolate human embryonic AGM derived HSPCs and investigate the effect of AGM stromal cells on AGM-derived HSPCs. Immunohistochemical sections of human AGM tissue were investigated for CD34, Flk-1 and VEGF expression. Human AGM-derived single cells were isolated and seeded o...
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PMID: 18549633
PDF is available here.
PDF is available here.
Leukemia Research (32)5 2008
Abstract
We have shown that human acute myeloid leukemia (AML) cells differentiate upon injection into murine blastocysts. We here describe that human AML Kasumi-1 cells, cocultured with murine aorta-gonad-mesonephros (AGM) region-derived DAS104-4 stromal cells, decrease proliferation and colony formation ef...
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PMID: 17980910
PDF is available here.
PDF is available here.
Development (135)10 2008
Abstract
We have previously shown that zebrafish EMPs arise in the posterior blood island independently from hematopoietic stem cells (HSCs). In this report, we demonstrate that a fourth wave of hematopoietic precursors arises slightly later in the zebrafish aorta/gonad/mesonephros (AGM) equivalent. We have...
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PMID: 18417622
PDF is available here.
PDF is available here.
Cell Stem Cell (2)4 2008
Abstract
We identified NCSCs in the bone marrow (BM), dorsal root ganglia, and whisker pad and prospectively isolated them from adult transgenic mice encoding neural crest-specific P0-Cre/Floxed-EGFP and Wnt1-Cre/Floxed-EGFP. Cultured EGFP-positive cells formed neurosphere-like structures that expressed NCSC...
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PMID: 18397758
PDF is available here.
PDF is available here.
Abstract
We study the role of Rac1 in HSC/P migration during ontogeny and seeding of fetal liver. Using a triple-transgenic approach, we have deleted Rac1 in HSCs/Ps during very early embryonic development. Without Rac1, there was a decrease in circulating HSCs/Ps in the blood of embryonic day (E) 10.5 embry...
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PMID: 18083846
PDF is available here.
PDF is available here.
Cell and Tissue Research (331)3 2008
Abstract
The cloning of cDNA and an examination of the tissue distribution of Na(+)/H(+) exchanger 3 (NHE3) were carried out in the Japanese black salamander, Hynobius nigrescens. The cellular localization of Hynobius NHE3 was examined by in situ hybridization and immunohistochemistry during ontogeny in the...
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PMID: 18071752
PDF is available here.
PDF is available here.
Abstract
We reported that human aorta-gonad-mesonephros (AGM) resided with bona fide MSCs. They were highly proliferative as fibroblastoid population bearing uniform surface markers (CD45(-), CD34(-), CD105(+), CD73(+), CD29(+), and CD44(+)), expressed pluripotential molecules Oct-4 and Nanog, and clonally d...
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PMID: 18045971
PDF is available here.
PDF is available here.
Abstract
We recently demonstrated in zebrafish the developmental migration of emerging hematopoietic stem cells (HSCs) that is thought to occur in mammalian embryos, from the aorta-gonad-mesonephros (AGM) area to the successive hematopoietic organs. CD41 is the earliest known molecular marker of nascent HSCs...
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PMID: 17934068
PDF is available here.
PDF is available here.
Abstract
We demonstrate the micro-dissection procedure we commonly use and also show the results of a typical FACS plotfter isolating these rare populations, it is possible to perform a variety of functional assays including: colony assays and bone marrow transplants....
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PMID: 19066546
PDF is available here.
PDF is available here.
Sexual Development (2)3 2008
Abstract
We and others speculated that peritubular myoid (PTM) cells were among the migratory cells and were likely the cell type required for cord formation. However, because no unique marker was found for PTM cells, their positive identification during or after migration remained unclear. alpha-Smooth Musc...
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PMID: 18769072
PDF is available here.
PDF is available here.
Human Reproduction (23)1 2008
Abstract
Our study demonstrates that mature oocytes can be derived from purified fetal germ cells through an aggregation and transplantation procedure. It also suggests that the synchronized interactions between oogonia and gonadal somatic cells are important to ensure normal folliculogenesis....
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PMID: 18000170
PDF is available here.
PDF is available here.
Abstract
We examined two closely related AGM stromal clones that differentially support HSCs. Expression analyses identified three putative HSC regulatory factors, beta-NGF (a neurotrophic factor), MIP-1gamma (a C-C chemokine family member) and Bmp4 (a TGF-beta family member). We show here that these three f...
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PMID: 18087045
PDF is available here.
PDF is available here.
Abstract
The protein of Shh was highly expressed on AGM-derived stromal cells. The proliferation of hemangioblasts was promoted when co-cultured with AGM-derived stromal cells, and the effects of the latter could be blocked by antibody of Shh. The proliferation of hemangioblasts was strengthened further and...
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PMID: 18457268
PDF is available here.
PDF is available here.
Abstract
These results suggest that BMP4 regulates c-Kit expression and differentiation potential in CD34(+) AGM cells and supports a role for BMP signalling in the maintenance of multipotency during embryonic haematopoiesis, providing an insight into stem cell homeostasis within the mammalian haematopoietic...
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PMID: 17897310
PDF is available here.
PDF is available here.
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology (15)4 2007
Abstract
The objective of this study was to investigate the expression of BMP-4 in stromal cells in vitro derived from human aorta-gonad-mesonephros (AGM) region. Stromal cells derived from human AGM region (hAGM S1-S5) and fibroblasts derived from human fetal trunk (hFT) were cultured in vitro. RT-PCR was u...
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PMID: 17708801
PDF is available here.
PDF is available here.
Endocrinology (148)8 2007
Abstract
We crossed Sf1 heterozygous mutant mice with Dhh homozygous null mice to test the function of these two genes in vivo. All of the compound Sf1(+/-); Dhh(-/-) mutants failed to masculinize and were externally female. However, embryonic gonads contained anastomotic testis cords with Sertoli cells and...
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PMID: 17495005
PDF is available here.
PDF is available here.
Abstract
Abstract
During the recent decade the interests of specialists in experimental mammalian embryology were focused on studies of signal networks, regulatory programs, phenotype and behavior of embryonic and mesenchymal stem cells in culture, which triggered more active use of pluripotent stem cells in cell tec...
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PMID: 18256767
PDF is available here.
PDF is available here.
Stem Cells (25)6 2007
Abstract
We developed a unique three-step assay of high proliferative potential (HPP) precursors. The AGM region contained a kind of HPP precursor that displayed hematopoietic self-renewal capacity and was able to differentiate into functional endothelial cells in vitro (i.e., incorporating DiI-acetylated lo...
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PMID: 17332512
PDF is available here.
PDF is available here.
Abstract
We have used cDNA microarray analyses on Wt1 knockout mice to identify Wt1-dependent genes involved in sexual development. The gene most dramatically affected by Wt1 inactivation was Amhr2, encoding the anti-Müllerian hormone (Amh) receptor 2. Amhr2 is an essential factor for the regression of the...
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PMID: 17420277
PDF is available here.
PDF is available here.
Developmental Dynamics (236)5 2007
Abstract
The egg of the direct-developing frog, Eleutherodactylus coqui, has 20 x the volume as that of the model amphibian, Xenopus laevis. Increased egg size led to the origin of nutritional endoderm, a novel cell type that provides nutrition but does not differentiate into digestive tract tissues. As the...
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PMID: 17436277
PDF is available here.
PDF is available here.
Mechanisms of Development (124)4 2007
Abstract
We report Six1/Six4-deficient mice that we generated in order to elucidate the functions of Six4 in Six1-deficient kidney development. The Six1/Six4-deficient mice exhibited more severe kidney phenotypes than the Six1-deficient mice; kidney and ureter agenesis was observed in all the neonates examin...
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PMID: 17300925
PDF is available here.
PDF is available here.
Experimental Cell Research (313)5 2007
Abstract
We report on the characterization of hematopoietic cells that emerge in the AGM culture. Based on the expression profiles of CD45 and c-Kit, we defined three cell populations: CD45(low) c-Kit(+) cells that had the ability to form hematopoietic cell colonies in methylcellulose media and in co-culture...
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PMID: 17275811
PDF is available here.
PDF is available here.
Developmental Biology (302)1 2007
Abstract
We performed fate mapping experiments in ovo, labelling at indifferent stages the coelomic epithelium by electroporation with a lacZ reporter gene and the underlying nephrogenous (or mesonephric) mesenchyme with chemical dyes. After sex differentiation, LacZ-positive cells were exclusively outside t...
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PMID: 17026980
PDF is available here.
PDF is available here.
Abstract
The study of the development of the mesonephros in the camel (Camelus dromedarius) was carried out on 16 embryos ranging from 0.9 to 8.6 cm crown vertebral rump length (CVRL). At 0.9 cm CVRL, the mesonephros is represented by a narrow strip along the roof of the thoracolumbar part of the vertebral c...
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PMID: 17266670
PDF is available here.
PDF is available here.
Abstract
Growth of the remnant embryonic kidney (the mesonephros), as expressed by wet weight, was more rapid in the chick embryos with experimentally induced unilateral renal agenesis compared to controls. The difference was significant between embryonic days 8-12, when the doubled weights of remnant kidney...
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PMID: 17973596
PDF is available here.
PDF is available here.
Mechanisms of Development (124)1 2007
Abstract
We used an organ culture system to study the role of BMPs during primordial germ cell (PGC) migration. PGCs are the embryonic precursors of the sperm and eggs. BMPs induce formation of primordial germ cells within the proximal epiblast of embryonic day 7.5 (E7.5) mouse embryos. PGCs then migrate via...
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PMID: 17112707
PDF is available here.
PDF is available here.
Experimental Cell Research (313)1 2007
Abstract
We examined the role of HIPK2 in hematopoiesis in mouse embryo. HIPK2 transcripts were found in fetal hematopoietic tissues such as the mouse AGM region and fetal liver. In cultured AGM cells, HIPK2 protein was detected in adherent cells. Functional analyses of HIPK2 were carried out by introducing...
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PMID: 17064687
PDF is available here.
PDF is available here.
Experimental Cell Research (312)18 2006
Abstract
We investigated whether the in vitro differentiation of ES cells into haematopoietic progenitors could be enhanced by exposure to the aorta-gonadal-mesonephros (AGM) microenvironment that is involved in the generation of haematopoietic stem cells (HSC) during embryonic development. We established a...
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PMID: 16952354
PDF is available here.
PDF is available here.
Developmental Biology (299)1 2006
Abstract
We show that cells with mixed adrenal and Leydig cell properties are found dispersed in the insterstitium of the embryonic and adult mouse testis. They express the adrenal markers Cyp11b1 and Cyp21 and respond to ACTH. Consistent with these properties, we show that the embryonic testis produces the...
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PMID: 16949566
PDF is available here.
PDF is available here.
Experimental Hematology (34)11 2006
Abstract
It was demonstrated that multiple clones showed high efficiency in supporting maintenance and expansion of primitive murine and human hematopoietic progenitors. In addition, we demonstrated for the first time that AGM stromal cell lines are also potent inducers of hematopoietic differentiation of mu...
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PMID: 17046570
PDF is available here.
PDF is available here.
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology (14)5 2006
Abstract
This study was aimed to investigate the hematopoietic growth factors expressed in human aorta-gonad-mesonephros (AGM)-derived stromal cells in vitro in order to provide the basic data for elucidating the role of AGM -derived-stromal cells in embryo-hematopoiesis and its hematopoietic suppoitive effe...
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PMID: 17096906
PDF is available here.
PDF is available here.
Haematologica (91)9 2006
Abstract
Haematologica (91)9 2006
Abstract
These results confirm the existence of mesenchymal stem/progenitor cells in the AGM region and suggest that the AGM hematopoietic microenvironment is highly complex, containing stromal cells with various mesenchymal lineage potentials....
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PMID: 16956815
PDF is available here.
PDF is available here.
Abstract
We examined expression of Sfrp2 and Sfrp5 during development of the Müllerian duct in male (XY) and female (XX) mouse embryos. We show that expression of both Sfrp2 and Sfrp5 is dynamic and sexually dimorphic. In addition, the male-specific expression observed for both genes prior to the onset of r...
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PMID: 16700072
PDF is available here.
PDF is available here.
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology (14)4 2006
Abstract
To screen and separate the genes differentially expressed in human embryonic aorta-gonad-mesonephros (AGM)-derived stromal cells, a subtracted library was generated through the suppression subtractive hybridization using the cDNA of human embryonic AGM-derived stromal cells as target and human fetal...
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PMID: 16928309
PDF is available here.
PDF is available here.
Endocrinology (147)8 2006
Abstract
We propose that the Sprouty proteins are involved normally in mediating the sexually dimorphic signaling of FGF9 and controlling cell migration from the mesonephros during testis development....
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PMID: 16675530
PDF is available here.
PDF is available here.
Developmental Biology (295)2 2006
Abstract
We examined the role of activin A, a member of TGF-beta family, in bud formation using an in vitro WD culture system. When cultured with the surrounding mesonephros, WDs formed many ectopic buds in response to GDNF. While the activin signaling pathway is normally active along the non-budding WD (as...
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PMID: 16643884
PDF is available here.
PDF is available here.
Abstract
We showed that the expression levels of the mRNAs coding for all 4 isoforms of the WT1 proteins were down-regulated. Similarly, Wnt 4 expression was down-regulated in these cell lines. Silencing of Sry in the transformed cell lines using ribozymes or short hairpin RNAs (shRNAs) resulted in elevated...
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PMID: 16571910
PDF is available here.
PDF is available here.
Abstract
Human AGM stromal cells S1-S5 could support the maintenance and expansion of umbilical cord blood CD34+ cells in vitro. hAGMS3, S4 cell had better effects on maintaining HSC activity, which would provide model cells and basic data for researches on hematopoiesis mechanism and hematopoietic different...
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PMID: 17147229
PDF is available here.
PDF is available here.
Pediatric Nephrology (21)5 2006
Abstract
The expression pattern of mitotic Ki-67 and anti-apoptotic bcl-2 proteins, as well as apoptotic caspase-3 and p53 proteins, were investigated in the human mesonephros and metanephros of 5-9 week-old human conceptuses. Apoptotic cells were additionally detected using the terminal deoxynucleotidyl tra...
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PMID: 16568307
PDF is available here.
PDF is available here.
Abstract
We found that retinoic acid, produced by mesonephroi of both sexes, causes germ cells in the ovary to enter meiosis and initiate oogenesis. Meiosis is retarded in the fetal testis by the action of the retinoid-degrading enzyme CYP26B1, ultimately leading to spermatogenesis. In testes of Cyp26b1-knoc...
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PMID: 16574820
PDF is available here.
PDF is available here.
Pathology International (56)2 2006
Abstract
Female adnexal tumors of probable wolffian origin (FATWO) are rare neoplasms believed to originate from mesonephric (wolffian) remnants. Rarity and variable location of FATWO make the diagnosis difficult. Although most cases follow a benign clinical course, approximately 10% of them either recur or...
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PMID: 16445822
PDF is available here.
PDF is available here.
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology (14)1 2006
Abstract
The objective of this study was to explore the supportive effects of human aorta-gonad-mesonephros (AGM)-derived stromal cells on human umbilical cord blood long-term culture-initiating cells (LTC-IC). A co-culture system was established with human AGM stromal cells and umbilical cord blood CD34(+)...
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PMID: 16584600
PDF is available here.
PDF is available here.
Clinical Nephrology (65)2 2006
Abstract
Tsitologiia (48)1 2006
Abstract
By light microscopy, the morphofunctional state of mesonephros was studied for various sturgeons and bony fishes taken from natural waters. Different changes were recorded in structural-functional elements of nephrons of the mesonephros. The most frequent disturbances are hemorrhages in the intertub...
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PMID: 16568829
PDF is available here.
PDF is available here.
Abstract
Senescence-associated beta-galactosidase activity was found only in old mesonephros. Moreover, at 11 days of incubation glomerular capillaries showed discontinuities and were thinner and more tortuous than those observed at 6 days, characteristics also reported for the aging human kidney. CONCLUSION...
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PMID: 17028443
PDF is available here.
PDF is available here.
Abstract
We investigated these renal primordial cells and structures in mouse ES cell outgrowths and their transplants. Gene expression essential for early kidney development was examined by RT-PCR in embryoid body (EB) outgrowths and their transplants in adult mice. Histochemical detection of kidney primord...
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PMID: 16106040
PDF is available here.
PDF is available here.
Journal of Experimental Medicine (202)11 2005
Abstract
Our findings establish Endomucin as a novel cell-surface marker for LTR-HSCs throughout development and provide a powerful tool in understanding HSC ontogeny....
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PMID: 16314436
PDF is available here.
PDF is available here.
Chinese Medical Journal (118)23 2005
Abstract
AGM-derived stromal cells in comparison with the BM-derived stromal cells could not only support the expansion of HSCs but also maintain the self-renewal and multi-lineage differentiation more effectively. They are promising in HSC transplantation....
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PMID: 16336834
PDF is available here.
PDF is available here.
British Poultry Science (46)6 2005
Abstract
1. Chick embryos in ovo were treated with a teratogenic dose of 1,2-dibromoethane (DBE) on embryonic day (ED) 3. On ED 6 and 10, histological sections of whole embryos were prepared for confocal microscopy. In parallel, mesonephroi of 10-d-old embryos were dissected for in situ staining with acridin...
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PMID: 16428107
PDF is available here.
PDF is available here.