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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Neural Tube (0):
Recent article
Neural Tube
Abstract
We demonstrate that Tbx6-dependent regulation of Sox2 determines the fate of axial stem cells. In wild-type embryos, enhancer N1 of the neural primordial gene Sox2 is activated in the caudal lateral epiblast, and the cells staying in the superficial layer sustain N1 activity and activate Sox2 expres...
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PMID: 21331042
PDF is available here.
PDF is available here.
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Abstract
We identify Plxdc2 as a novel regulator of these processes, using in ovo electroporation and in vitro cultures of mammalian cells. Plxdc2 is a type I transmembrane protein with some homology to nidogen and to plexins. It is expressed in a highly discrete and dynamic pattern in the developing nervous...
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PMID: 21283688
PDF is available here.
PDF is available here.
Abstract
Oligodendrocytes and astrocytes are macroglial cells of the vertebrate central nervous system. These cells have diverse roles in the maintenance of neurological function. In the embryo, the genetic mechanisms that underlie the specification of macroglial precursors in vivo appear strikingly similar...
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PMID: 21068830
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)45 2010
Abstract
We report novel functions of B56ε in regulating apoptosis. We provide evidence that B56ε has both anti- and pro-apoptotic functions. B56ε suppresses p53-independent apoptosis during neural development, but triggers p53-dependent apoptosis. Mechanistically, B56ε regulates the p53-dependent apopto...
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PMID: 20807766
PDF is available here.
PDF is available here.
Neurological Research (32)6 2010
Abstract
We examined miRNA expression profiles of murine embryonic stem cells (ESC), NSC induced from ESC and isolated from E8.5 mouse neural tube (E8.5-NSC) using microarray technique. It was found that a total of 40 miRNAs had similar expression level in all the three cells [false discovery rate (FDR)=0, f...
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PMID: 19660235
PDF is available here.
PDF is available here.
Development (137)14 2010
Abstract
We show that neural tube closure in Xenopus depends on orthologs of two proteins: MID1, which is responsible for Opitz G/BBB syndrome in humans, and its paralog MID2. Depletion of the Xenopus MIDs (xMIDs) by morpholino-mediated knockdown disrupted epithelial morphology in the neural plate, leading t...
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PMID: 20534674
PDF is available here.
PDF is available here.
Abstract
We have identified the adherens junction molecule neural alpha-catenin (alphaN-catenin) as a Snail2 target gene whose repression is critical for chick neural crest cell migration. Knock-down and overexpression of alphaN-catenin enhances and inhibits neural crest cell migration, respectively. Further...
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PMID: 20542025
PDF is available here.
PDF is available here.
Developmental Cell (18)5 2010
Abstract
We identify a phosphatase- and Erk-dependent role for Shp2 in neural crest specification and migration. We also identify an unexpected phosphatase- and Erk-independent function, mediated through its SH2 domains, which is evolutionarily conserved and prevents p53-mediated apoptosis in the brain and n...
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PMID: 20493809
PDF is available here.
PDF is available here.
Acta Neurochirurgica (152)5 2010
Abstract
Turkish Neurosurgery (20)2 2010
Abstract
While the groups Aand B showed no neural tube defects, totally eight defective embryos were detected in the groups C and D (three in group C and five in group D. CONCLUSION: Our results suggested that meloxicam, a nonselective COX inhibitor, caused neural tube closure defects when injected at suprat...
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PMID: 20401837
PDF is available here.
PDF is available here.
Development (137)6 2010
Abstract
We have observed LIN28 expression in the developing mouse neural tube, colocalizing with SOX2, suggesting a role in neural development. To better understand its normal developmental function, we investigated LIN28 activity during neurogliogenesis in vitro, where the succession of neuronal to glial c...
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PMID: 20179095
PDF is available here.
PDF is available here.
RHAMM mRNA expression in proliferating and migrating cells of the developing central nervous system.
Abstract
We reported a detailed gene expression analysis of RHAMM during Xenopus laevis development comparing its mRNA distribution with that of the hyaluronan synthases and CD44 genes, in order to provide a first insight into the possible role of RHAMM during vertebrate embryogenesis. Our findings point out...
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PMID: 20044037
PDF is available here.
PDF is available here.
Abstract
We document the entire procedure for transplanting human stem cells into the developing central nervous system of the chicken embryo. The procedure starts with incubation of fertilized eggs until embryos of the desired age have developed. The eggshell is then opened, and the embryo contrasted by inj...
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PMID: 20644515
PDF is available here.
PDF is available here.
Abstract
In neural crest cell development, the expression of the cell adhesion proteins cadherin-7 and cadherin-11 commences after delamination of the neural crest cells from the neuroepithelium. The canonical Wnt signaling pathway is known to drive this delamination step and is a candidate for inducing expr...
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PMID: 20523111
PDF is available here.
PDF is available here.
Nature Cell Biology (12)1 2010
Abstract
We identified Sec24b, a cargo-sorting member of the core complex of the endoplasmic reticulum (ER)-to-Golgi transport vesicle COPII, as critical for neural tube closure. Sec24bY613 mutant mice exhibit craniorachischisis, deficiencies in convergent extension and other PCP-related phenotypes. Vangl2,...
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PMID: 19966784
PDF is available here.
PDF is available here.
Abstract
Employment of enhancer elements to drive expression of reporter genes in neurons is a widely used paradigm for tracking axonal projection. For tracking axonal projection of spinal interneurons in vertebrates, germ line-targeted reporter genes yield bilaterally symmetric labeling. Therefore, it is ha...
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PMID: 20440258
PDF is available here.
PDF is available here.
Development (136)15 2009
Abstract
We show here that HAI2 is a potent regulator of protease-guided cellular responses, including motogenic activity and transepithelial resistance of epithelial monolayers. Furthermore, we show that inhibition of the transmembrane serine protease matriptase (encoded by St14) is an essential function of...
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PMID: 19592578
PDF is available here.
PDF is available here.
Journal of Cell Science (122)Pt 14 2009
Abstract
We used in vivo four-dimensional confocal microscopy to explore the role of Cdc42 in governing cell division in the developing neural epithelium of Xenopus laevis. We find that Cdc42 is crucial for stable positioning of the metaphase spindle in these cells, but was not required for spindle positioni...
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PMID: 19549689
PDF is available here.
PDF is available here.
Turkish Neurosurgery (19)3 2009
Abstract
Embryos of the cotinine (regular dose), vehicle and control groups were normal, but embryos subjected to higher cotinine concentrations were malformed at the cranial part of the thoracic neural tube. CONCLUSION: Association of cotinine with neural tube defects was demonstrated in the present study....
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PMID: 19621285
PDF is available here.
PDF is available here.
Prenatal Diagnosis (29)4 2009
Abstract
We describe the process of neural tube formation, discuss the cellular mechanisms involved and highlight recent findings that provide links between molecular signaling pathways and morphogenetic tissue movements....
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PMID: 19206138
PDF is available here.
PDF is available here.
Birth Defects Research (85)4 2009
Abstract
This review provides a brief description of folate use and folic acid metabolism in relation to neural tube defect (NTD) risk. First, a meta-analysis of reduction in NTD recurrence and occurrence risk with periconceptional folic acid supplementation is presented. Second, an overview of the complex f...
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PMID: 19301298
PDF is available here.
PDF is available here.
Neuroreport (20)5 2009
Abstract
Androgen effects, mediated by the androgen receptor, regulate important cellular processes such as growth, proliferation, and differentiation. The presence of androgen receptor has been described in structures of the central nervous system, mainly in advanced fetuses, newborns, and adult animals. Th...
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PMID: 19262415
PDF is available here.
PDF is available here.
Abstract
We report the expression pattern of Frizzled10 in mouse CNS from embryonic stages to adulthood. Frizzled10 is expressed strongly at embryonic days E8.5 and E9.5 in the neural tube and tail bud. At E10.5, Frizzled10 is expressed in the forebrain vesicle, the fourth ventricle and the dorsal spinal cor...
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PMID: 19056517
PDF is available here.
PDF is available here.
Abstract
We recently showed that DEspR-haploinsufficiency resulted in increased neuronal autophagy and spongiform changes in the adult brain especially the hippocampus, cerebral cortex and basal ganglia, causing cognitive performance deficits. This model demonstrates a causal link between increased autophagy...
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PMID: 19139631
PDF is available here.
PDF is available here.
Abstract
Mutations in each of the transcriptional co-activator genes - CBP, p300, Cited2, Cart1 and Carm1 - result in neural tube defects in mice. The present study thus furnishes a complete and comparative temporal and spatial expression map of CBP/p300 and associated transcriptional co-activators, Cited2, C...
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PMID: 19598128
PDF is available here.
PDF is available here.
Abstract
This historical review of gliogenesis begins with Schwann's introduction of the cell doctrine in 1839. Subsequent microscopic studies revealed the cellular structure of many organs and tissues, but the CNS was thought to be different. In 1864, Virchow created the concept that nerve cells are held to...
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PMID: 19230601
PDF is available here.
PDF is available here.
Abstract
We describe xenotransplantation of mouse embryonic stem cell-derived motor neurons into the developing chick neural tube as an alternative for testing the ability of in vitro generated neurons to survive, integrate, extend axons, and form appropriate synaptic contacts with functionally relevant targ...
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PMID: 19089356
PDF is available here.
PDF is available here.
Abstract
We show that somites are required for the up-regulation of Hoxb4 in the neural tube at the level of somites 1 to 5, the anterior-most domain of expression. However, each somite immediately adjacent to the neural tube is not sufficient at each level; planar signaling is additionally required particul...
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PMID: 19243620
PDF is available here.
PDF is available here.
Abstract
We define a gene regulatory network for Hoxa2, responsible for temporal and spatial expression in hindbrain development. Hoxa2 plays an important role in regulating the regional identity of rhombomere 2 (r2) and is the only Hox gene expressed in this segment. In this study, we found that a Hoxa2 cis...
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PMID: 19104046
PDF is available here.
PDF is available here.
Cell Cycle (7)24 2008
Abstract
We generated Mlin41 mouse mutants to ascertain a functional role for Mlin41. Strong loss of function Mlin41 gene-trap mutants demonstrated a striking neural tube closure defect during development, and embryonic lethality. Like C. elegans lin-41, Mlin41 also appears to be regulated by the let-7 and m...
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PMID: 19098426
PDF is available here.
PDF is available here.
Abstract
We have analyzed the differential gene expression profiling in the cranial neural tube of embryos from diabetic and control mice by using the oligonucleotide microarray. Expression patterns of genes and proteins that are differentially expressed in the cranial neural tube were further examined by th...
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PMID: 18655203
PDF is available here.
PDF is available here.
Human Molecular Genetics (17)23 2008
Abstract
We studied zebrafish embryos after depletion of NPHP5 and NPHP6. Knockdown of zebrafish zNPHP5 and zNPHP6 produced similar phenotypes, and synergistic effects were observed after the combined knockdown of zNPHP5 and zNPHP6. The N-terminal domain of nephrocystin-6-bound nephrocystin-5, and mapping st...
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PMID: 18723859
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)48 2008
Abstract
We use morpholino knock-down technology to demonstrate that Repulsive Guidance Molecule (RGMa)-Neogenin interactions are essential for effective neural fold elevation during Xenopus neurulation and that loss of these molecules results in disrupted neural tube closure. We demonstrate that Neogenin an...
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PMID: 19036958
PDF is available here.
PDF is available here.
Abstract
We show that during early chick myogenesis WNT11 has an essential role in the oriented elongation of the myocytes. We find that the neural tube, known to drive WNT11 expression in the medial border of somites, is necessary and sufficient to orient myocyte elongation. We then show that the specific i...
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PMID: 18987628
PDF is available here.
PDF is available here.
Developmental Dynamics (237)11 2008
Abstract
We report the generation of a Hoxa11eGFP targeted knock-in allele in mice in which eGFP replaces the first coding exon of Hoxa11 as an in-frame fusion. This allele closely recapitulates the reported mRNA expression patterns for Hoxa11. Hoxa11eGFP can be visualized in the tail, neural tube, limbs, ki...
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PMID: 18942146
PDF is available here.
PDF is available here.
Abstract
We generated mice deficient in Sall2 and, contrary to previous reports, 11% of our Sall2-deficient mice showed background-specific neural tube defects, suggesting that Sall2 has a role in neurogenesis. To investigate whether Sall4 may compensate for the absence of Sall2, we generated compound Sall2...
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PMID: 18818376
PDF is available here.
PDF is available here.
Abstract
We show that the serine/threonine kinase death-associated protein kinase (DAPK) is involved in the signal transduction of neogenin. Neogenin interacts with DAPK and reduces DAPK autophosphorylation on Ser308 in vitro. Neogenin-induced cell death is abolished in the presence of RGM or by blocking DAP...
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PMID: 18583991
PDF is available here.
PDF is available here.
Birth Defects Research (82)10 2008
Abstract
On this basis, it is possible that Grhl3 has a direct regulatory function in cell proliferation in the hindgut endoderm. Identification of the transcriptional targets of Grhl3 will serve not only to further our understanding of the mechanisms of mammalian neural tube closure, but also to identify po...
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PMID: 18683893
PDF is available here.
PDF is available here.
Abstract
We show that netrin-1 is not only an attractive cue for developing commissural axons but also promotes their survival. In primary neuronal culture, in mice or in chick embryos, netrin-1 inhibits the proapoptotic activity of DCC in developing commissural neurons. Thus, adequate commissural neurons na...
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PMID: 18796601
PDF is available here.
PDF is available here.
Developmental Biology (321)2 2008
Abstract
We show that inhibition of C2C12 muscle cell differentiation by FGFs, which interferes with the activity of MRFs, suppressed the expression of miR-1, miR-206 and miR-133. To further investigate the role of myogenic regulators (MRFs), Myf5, MyoD, Myogenin and MRF4 in the regulation of muscle specific...
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PMID: 18619954
PDF is available here.
PDF is available here.
Developmental Biology (321)2 2008
Abstract
We show an early onset of NP25 expression in the chick embryo neural tube. NP25 represents, together with NeuroM, one of the earliest markers for postmitotic neurons. To elucidate its function in the developing nervous system, NP25 was overexpressed in E5 and E9 sensory neurons, E7 sympathetic neuro...
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PMID: 18652818
PDF is available here.
PDF is available here.
Developmental Biology (321)1 2008
Abstract
We show that although inhibition of Galpha(i) protein activity appears to significantly reduce Hh pathway activity in Ptc(-/-) mouse embryonic fibroblasts and the NIH3T3-based Shh-light cells, it fails to derepress Shh- or a Smo-agonist-induced inhibition of Gli3 protein processing, a known in vivo...
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PMID: 18590719
PDF is available here.
PDF is available here.
Developmental Biology (321)1 2008
Abstract
We focus on the role of FK506-binding protein 8 (FKBP8) in controlling neural cell identity through its antagonism of the Shh pathway. Our data indicate that disruption of FKBP8 function activates the Shh signaling pathway cell-autonomously at a step that is independent of the transmembrane protein...
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PMID: 18590716
PDF is available here.
PDF is available here.
Abstract
This study showed evidence that paving of the distal optic nerve microenvironment with proteolytically active MMPs and providing stem-cell-derived growth factors is a suitable method for facilitating regenerative repair of the optic nerve. Understanding the molecular mechanisms of this repair has fu...
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PMID: 18408190
PDF is available here.
PDF is available here.
Developmental Biology (320)1 2008
Abstract
We report that Twist1(-/-) mice exhibit OFTs that contain amorphic cellular nodules within their OFT endocardial cushions. The nodular mesenchyme expresses the related bHLH factors Hand1 and Hand2, but reduced levels of the normal cushion marker Periostin. Lineage mapping confirms that nodule cells...
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PMID: 18539270
PDF is available here.
PDF is available here.
Journal of Cell Science (121)Pt 15 2008
Abstract
We used deletion constructs of Nagie oko in functional rescue experiments to define domains essential for cell polarity, maintenance of epithelial integrity and cardiac morphogenesis. Inability of Nagie oko to interact with Crumbs proteins upon deletion of the PDZ domain recreates all aspects of the...
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PMID: 18628301
PDF is available here.
PDF is available here.
Development (135)15 2008
Abstract
We discuss recent advances in our understanding of these events and highlight unresolved questions....
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PMID: 18621990
PDF is available here.
PDF is available here.
Abstract
We focus on the contribution of functional genomics in elucidating the role of apoptosis and autophagy genes in neurodevelopment. On the basis of compared phenotypical analysis, here we discuss the relative importance of a tuned control of both apoptosome-mediated cell death and basal autophagy for...
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PMID: 18451869
PDF is available here.
PDF is available here.
Abstract
We describe a novel rabbit antibody raised against the c-terminal portion of the mouse Ptf1a protein and report immunodetection, for the first time, as early as embryonic day (e) 8.5-e8.75 in the dorsal and ventral buds of the mouse pancreas as well as in the neural tube at e10.0. Detailed confocal...
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PMID: 18347078
PDF is available here.
PDF is available here.
Abstract
We found marked apical accumulation of Rho in developing chick embryos undergoing folding of the neural plate during neural tube formation, with similar accumulation of activated myosin II. The timing of accumulation and biochemical activation of both Rho and myosin II was coincident with the dynami...
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PMID: 18337466
PDF is available here.
PDF is available here.
Development (135)10 2008
Abstract
We report that the capacity of Notch to maintain neural cells in an undifferentiated state requires the activity of SoxB1 proteins, whereas the mechanism by which SoxB1 block neurogenesis is independent of Notch signaling. A common feature of Notch signaling and SoxB1 proteins is their ability to in...
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PMID: 18417619
PDF is available here.
PDF is available here.
Development (135)9 2008
Abstract
We reduced the number of NCC by ablating the neural tube adjacent to somites 3-6 to produce aganglionic gut. We then back-transplanted various somite lengths of quail neural tube into the ablated region to determine the 'tipping point', whereby sufficient progenitors were available for complete ENS...
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PMID: 18385256
PDF is available here.
PDF is available here.
Development (135)10 2008
Abstract
We investigate the role of PDGF signaling in ophthalmic trigeminal placode induction. By in situ hybridization, PDGF receptor beta is expressed in the cranial ectoderm at the time of trigeminal placode formation, with the ligand PDGFD expressed in the midbrain neural folds. Blocking PDGF signaling i...
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PMID: 18417621
PDF is available here.
PDF is available here.
Developmental Biology (316)2 2008
Abstract
We found that in the absence of functional Pax3, as in Splotch embryos, the neural crest cells undergo premature neurogenesis, as evidenced by increased Brn3a positive staining in neural tube explants, in comparison with wild-type. Premature neurogenesis in the absence of functional Pax3 may be due...
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PMID: 18308300
PDF is available here.
PDF is available here.
Circulation Research (102)7 2008
Abstract
We have identified cysteine-rich intestinal protein 2 (crip2), a gene encoding for a LIM domain-containing protein, as a novel marker for cardiac NCCs in zebrafish. We observed a dynamic expression pattern for crip2, with expression being detected in the premigratory NCCs in rhombomere 6 (r6), migra...
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PMID: 18292601
PDF is available here.
PDF is available here.
Developmental Dynamics (237)4 2008
Abstract
We report here the creation of a Gcn5(flox(neo)) allele, which is only partially functional and gives rise to a hypomorphic phenotype. Mice homozygous for this allele had an increased risk of cranial neural tube closure defects (NTDs) and exencephaly. These defects were found at an even greater pene...
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PMID: 18330926
PDF is available here.
PDF is available here.
Abstract
To address the role of PKC isoforms in hyperglycemia-induced apoptosis and malformations in the embryos of diabetic pregnancies, expression of PKCalpha, beta1, beta 2, gamma, delta, epsilon, and zeta was examined in the neural tube of rat embryos and showed to overlap with the regions of increased a...
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PMID: 18497343
PDF is available here.
PDF is available here.
Abstract
We have analyzed NEDD9 mRNA expression in the mouse and identified new relevant expression sites. In addition, we have characterized NEDD9 protein expression pattern for the first time in mammals. At E9.5-E10.5, high levels of Nedd9 and the neurogenic transcription factor neurogenin-2 (Ngn2) were fo...
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PMID: 18282814
PDF is available here.
PDF is available here.
Developmental Biology (315)2 2008
Abstract
We show that Notch signaling promotes Xenopus radial glia formation and that the Notch activation is sufficient for radial glia formation prior to neural tube closure. Moreover, we have identified Oct-1 (POU2f1), a POU transcription factor, as a downstream target of Notch signaling by microarray bas...
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PMID: 18241856
PDF is available here.
PDF is available here.