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Wolffian Ducts (0):
Recent article
Wolffian Ducts
Abstract
We find that this exclusion results from earlier Ret-dependent cell rearrangements in the caudal Wolffian duct, which generate a specialized epithelial domain that later emerges as the tip of the primary ureteric bud. By juxtaposing cells with elevated or reduced RET activity, we find that Wolffian...
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PMID: 19686681
PDF is available here.
PDF is available here.
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Abstract
In the metanephric kidney (metanephros), the renal tubule was selectively positive for HNF-1beta. HNF-1beta expression was detected in mesonephric (wolffian) duct derivatives, including the efferent duct or epididymis, in fetuses at the 12th, 21st and 22nd gestational weeks, but not detected in the...
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PMID: 19320191
PDF is available here.
PDF is available here.
Experimental Animals (58)1 2009
Abstract
At 0.8 cm of crown-rump length (CRL) in sexually undifferentiated cat fetuses, the Wolffian duct is already observable on the ventro-lateral side of the mesonephros. At 1.2 cm CRL, the anlage of the Müllerian duct growing caudally in close parallel with the Wolffian duct was first observed. At 2....
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PMID: 19151510
PDF is available here.
PDF is available here.
Abstract
We discuss epithelial-mesenchymal interactions in the processes of Wolffian duct and fetal testis cord development using the mouse as a model organism and propose inhibin beta A as a conserved mesenchyme-derived regulator in these two male-specific tubular structures.
Copyright 2008 Wiley-Liss, Inc....
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PMID: 18979542
PDF is available here.
PDF is available here.
Developmental Biology (325)1 2009
Abstract
We will highlight some of the classic morphological studies and discuss some of the more recent genetic models that have all served to contribute to our understanding of this system. Where published information is scarce we will provide potential hypotheses that warrant further investigation and may...
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PMID: 18992735
PDF is available here.
PDF is available here.
Journal of Pediatric Surgery (43)12 2008
Abstract
Congenital abnormalities of the genital or urinary tract are not uncommon and often occur together. This article discusses a unique case in which a functioning mesonephric remnant was found.
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PMID: 19040958
PDF is available here.
PDF is available here.
Abstract
Gartner's duct cysts associated with renal dysgenesis are rare malformations and represent a diagnostic challenge. We report on one such case in which final diagnosis was achieved by laparoscopy and discuss the possible role of minimally invasive surgery in the management of this condition.
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PMID: 18631919
PDF is available here.
PDF is available here.
Abstract
A 30-year-old man with azoospermia underwent an examination for infertility. He had a history of right orchiopexy due to cryptorchism. Radiological examinations showed an absence of the left kidney and the left seminal vesicle. A testicular biopsy revealed normal spermatogenesis in the left testis,...
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PMID: 18516928
PDF is available here.
PDF is available here.
Endocrine Journal (55)1 2008
Abstract
The research described in this review suggests a novel and important role for activin A in the developmental and repair processes of the kidney (Table 1). The results obtained in these studies indicate that activin A is a negative regulator of kidney development and plays an essential part in kidney...
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PMID: 17827789
PDF is available here.
PDF is available here.
Developmental Biology (314)1 2008
Abstract
We show that Hoxb7-Cre mediated removal of beta-catenin from the mouse Wolffian duct epithelium leads to the premature expression of gene products normally associated with the differentiated kidney collecting duct system including the water channel protein, Aquaporin-3 and the tight junction protein...
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PMID: 18177851
PDF is available here.
PDF is available here.
Frontiers in Bioscience (13)13 2008
Abstract
The discovery of tissue stem cells has launched the current boom in the field of regenerative research, which is tremendously exciting and holds enormous therapeutic potential. Despite such optimism, recent findings have tempered the potential for medical practice. Anatomically complicated organs, s...
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PMID: 17981756
PDF is available here.
PDF is available here.
Abstract
Forty cases of benign vaginal cysts were retrieved. There were 12 cases of mullerian cysts (30.0%), 11 cases of Bartholin's duct cysts (27.5%), ten cases of epidermal inclusion cysts (25.0%), five cases of Gartner's duct cysts (12.5%), one endometrioid cyst (2.5%) and one unclassified cyst (2.5%). P...
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PMID: 18390079
PDF is available here.
PDF is available here.
Abstract
A 5 year-old, intact female Yorkshire terrier was referred for dysuria and dyschezia. The radiographic and ultrasound examination showed a round shaped mass caudal to the urinary bladder that contained anechoic fluid within the thin walls. During surgery, the cyst was noted to be attached to the out...
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PMID: 17993759
PDF is available here.
PDF is available here.
Abstract
Abstract
We report an 81-year-old woman presenting with a 6-month history of postmenopausal bleeding. A pelvic transvaginal ultrasound scan demonstrated a midline, highly vascular, predominantly solid pelvic mass, approximately 14 cm, posterior to the uterus. CA-125 was moderately raised. She underwent total...
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PMID: 17885487
PDF is available here.
PDF is available here.
Abstract
A 56-year-old woman presented with gradually increasing lower abdominal lump since 1 year. She was subjected to laparotomy and a solid and cystic mass was removed from right broad ligament with pan-hysterectomy. Mass on histopathological examination was proved to be tumor of Wolffian origin. This is...
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PMID: 18306563
PDF is available here.
PDF is available here.
Cytopathology (18)4 2007
Abstract
Abstract
In this study the development of the bovine Fallopian tube was investigated using light microscopic methods. Formation and differentiation of the Müllerian duct were studied in mesonephroi of 16 embryos and fetuses with a crown-rump lengths (CRL) of 0.9-8.4 cm. The funnel field, the rostral beginni...
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PMID: 17617105
PDF is available here.
PDF is available here.
Abstract
We identified inhibin beta A (or Inhba) as a regional paracrine factor in mouse mesonephroi that controls coiling of the epithelium in the anterior Wolffian duct, the future epididymis. Inhba was expressed specifically in the mesenchyme of the anterior Wolffian duct at embryonic day 12.5 before the...
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PMID: 17592132
PDF is available here.
PDF is available here.
Endocrinology (148)7 2007
Abstract
Androgens are thought to separately regulate stabilization and differentiation of the Wolffian duct (WD), but the time windows for these effects are unclear. To address this, fetal rats were exposed to flutamide within either an early window (EW) [embryonic day 15.5 (E15.5) to E17.5], when the WD de...
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PMID: 17431008
PDF is available here.
PDF is available here.
Developmental Biology (306)2 2007
Abstract
We demonstrate that the Wolffian duct does not contribute cells to the Müllerian duct. Experimental embryological manipulations and molecular studies show that precursor cells at the caudal tip of the Müllerian duct proliferate to deposit a cord of cells along the length of the urogenital ridge. F...
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PMID: 17467685
PDF is available here.
PDF is available here.
Clinical Endocrinology (66)6 2007
Abstract
We thoroughly analysed internal genitalia at surgery and by histological examination. No signs of Wolffian duct (WD) development were present in any of the patients. Western blotting of proteins from gonadal and genital skin fibroblasts was performed with AR antibodies directed against different AR...
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PMID: 17408421
PDF is available here.
PDF is available here.
Developmental Biology (302)2 2007
Abstract
We report the results from lineage-tracing experiments in chicken and mouse embryos aimed to provide information of the dynamics of Mullerian duct formation. We show that all Mullerian duct components derive from the coelomic epithelium in both species. Our data support a model of a Mullerian epithe...
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PMID: 17070514
PDF is available here.
PDF is available here.
Abstract
Genetic and in-vitro evidence is beginning to provide a limited sense of the network topology in stages of kidney development. Intriguing data from other fields suggest how, with the aid of large-scale gene expression studies, these stages might be represented as dynamic attractor states. It is also...
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PMID: 17143064
PDF is available here.
PDF is available here.
Abstract
We present two patients with Gartner's duct cyst managed with simple marsupialization and successful long-term follow up.
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PMID: 17120138
PDF is available here.
PDF is available here.
Hormone Research (67)3 2007
Abstract
Wolffian ducts (WDs) are the embryonic structures that form the male internal genitalia. These ducts develop in both the male and female embryo. However, in the female they subsequently regress, whereas in the male they are stabilised by testosterone. The WDs then develop into separate but contiguou...
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PMID: 17077643
PDF is available here.
PDF is available here.
Urologia Internationalis (79)4 2007
Abstract
We report the case of a 13-year-old male patient with beta-thalassemic trait who presented for a colic pain. An ultrasound of the abdomen revealed absence of the right kidney with a complex hypoechogenic pelvic mass causing mild pressure on the posterior bladder wall. Urography showed hypertrophy of...
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PMID: 18025859
PDF is available here.
PDF is available here.
Abstract
Most often observed localization of the malformations of mesonephronic canal is bilateral at 54.81%. The testicular specimens proved preserved testicular architecture and spermatogenesis, and the epididymal slides showed dilatation of the epididymal tubules, which were overfilled with a lot of sperm...
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PMID: 18044318
PDF is available here.
PDF is available here.
Endocrinology (147)10 2006
Abstract
Androgens play a vital role in Wolffian duct (WD) development, but the mechanisms that underlie this are unknown. The present study used in utero exposure of pregnant rats to the androgen receptor antagonist flutamide (50 or 100 mg/kg) to explore possible mechanisms. Pregnant rats were treated from...
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PMID: 16809447
PDF is available here.
PDF is available here.
Journal of Urology (176)4 Pt 2 2006
Abstract
To our knowledge this is the first report of differential gene expression patterns in the developing mouse wolffian duct. Our results diverge from expression patterns reported in the kidney. This information will enable future comparisons between WT and transgenic mice with an abnormal phenotype....
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PMID: 16945627
PDF is available here.
PDF is available here.
Abstract
The establishment of the male internal reproductive system involves two crucial events: the formation of the testis and the maintenance and differentiation of the Wolffian duct. Testis formation, particularly the specification of Sertoli cell and Leydig cell lineages, is controlled strictly by genet...
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PMID: 16822678
PDF is available here.
PDF is available here.
Abstract
The embryogenesis and management of congenital urogenital anomalies that are associated with ureteric ectopia and the persistence of Gartner's duct are discussed. Ureteric ectopia with Gartner's duct cyst is caused by the failure of separation of the ureteric bud from the mesonephric duct, which lea...
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PMID: 16890546
PDF is available here.
PDF is available here.
Endocrinology (147)8 2006
Abstract
We propose that the Sprouty proteins are involved normally in mediating the sexually dimorphic signaling of FGF9 and controlling cell migration from the mesonephros during testis development....
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PMID: 16675530
PDF is available here.
PDF is available here.
Developmental Biology (295)2 2006
Abstract
We examined the role of activin A, a member of TGF-beta family, in bud formation using an in vitro WD culture system. When cultured with the surrounding mesonephros, WDs formed many ectopic buds in response to GDNF. While the activin signaling pathway is normally active along the non-budding WD (as...
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PMID: 16643884
PDF is available here.
PDF is available here.
Molecular Endocrinology (20)7 2006
Abstract
We investigate the role of Msx2 in normal vaginal development and in FRT response to DES. During vaginal development, Msx2 is required for Tgfbeta2 and Tgfbeta3 expression and for proper vaginal epithelial differentiation. Moreover, Msx2 is involved in caudal Wolffian duct regression by promoting ap...
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PMID: 16513791
PDF is available here.
PDF is available here.
Abstract
Human Reproduction (21)6 2006
Abstract
The Müller ducts converge until they fuse into one tube, but caudally they diverge and finally they fuse with the 'urogenital sinus bulbs' that are actually the distal portion of the Wolffian ducts according to the immunohistochemical marking with GZ1 and GZ2. The Müllerian tubercle is observed be...
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PMID: 16476676
PDF is available here.
PDF is available here.
Endocrinology (147)5 2006
Abstract
We conclude that dihydrotestosterone, largely formed in the tissue by the oxidation of androstanediol derived from the testes and also the 5alpha-reduction of testosterone, is responsible for Wolffian duct virilization in this species....
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PMID: 16469812
PDF is available here.
PDF is available here.
Development (133)1 2006
Abstract
We identified Gata3, a transcription factor gene associated with hypoparathyroidism, deafness and renal anomaly (HDR) syndrome. Gata3 is already expressed in the pronephric anlage, together with Pax2 and Pax8, suggesting that it may be a direct Pax2/8 target gene. Inactivation of Gata3 by insertion...
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PMID: 16319112
PDF is available here.
PDF is available here.
Hormone Research (65)4 2006
Abstract
Transcripts from 76 known genes were regulated, including modulators of insulin-like growth factor and transforming growth factor-beta signalling. By controlling these modulators, androgens may indirectly affect growth factor signalling pathways important in epithelial-mesenchymal interactions and o...
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PMID: 16567946
PDF is available here.
PDF is available here.
Journal of Andrology (27)1 2006
Abstract
This study aims to characterize the epididymis-like intratesticular structures (ELITSs), a rare lesion found in elderly men. ELITSs were identified in 6 patients from a review of 1442 autopsies and 271 surgical specimens of adult men. Bilateral lesions were seen in 5 cases. The lesion was located in...
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PMID: 16400082
PDF is available here.
PDF is available here.
Abstract
We report a case of the youngest patient affected by FATWO in October 2002. At laparotomy the left adnexa were deformed by a well-capsulated mass, totally removed and sent to the pathologist with a specimen of peritoneal fluid and of the omentum. The histological examination showed a prevalent tubul...
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PMID: 16800270
PDF is available here.
PDF is available here.
Abstract
Endocrinology (146)9 2005
Abstract
We demonstrate here that testosterone is produced by the ovary of Wnt-4-deficient female embryos and is also detected in the embryonic plasma. Consistent with this, the expression of several genes encoding enzymes in the pathway leading to the synthesis of testosterone in the mouse is induced in the...
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PMID: 15932923
PDF is available here.
PDF is available here.
Developmental Cell (9)2 2005
Abstract
We show that Wnt9b is expressed in the inductive epithelia and is essential for the development of mesonephric and metanephric tubules and caudal extension of the Müllerian duct. Wnt9b is required for the earliest inductive response in metanephric mesenchyme. Further, Wnt9b-expressing cells can fun...
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PMID: 16054034
PDF is available here.
PDF is available here.
Developmental Cell (9)2 2005
Abstract
We show that Wnt9b is expressed in the inductive epithelia and is essential for the development of mesonephric and metanephric tubules and caudal extension of the Müllerian duct. Wnt9b is required for the earliest inductive response in metanephric mesenchyme. Further, Wnt9b-expressing cells can fun...
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PMID: 16054034
PDF is available here.
PDF is available here.
Toxicological Sciences (86)1 2005
Abstract
Di(n-butyl) phthalate (DBP) is a common plasticizer and solvent that disrupts androgen-dependent male reproductive development in rats. In utero exposure to 500 mg/kg/day DBP on gestation days (GD) 12 to 21 decreases androgen biosynthetic enzymes, resulting in decreased fetal testicular testosterone...
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PMID: 15829613
PDF is available here.
PDF is available here.
Anatomy and Embryology (209)6 2005
Abstract
The mesonephrogenic cord disintegrates into approximately 35-40 provesicular cell masses which are in close contact with the mesonephric (Wolffian) duct (WD) on their lateral side. Here, the epithelium of the WD is columnar and shares a common basal lamina with the provesicular cell masses. This in...
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PMID: 15915348
PDF is available here.
PDF is available here.
Mechanisms of Development (122)6 2005
Abstract
We utilized both in vitro and in vivo models to study the possible regulatory relationship of Ret and Notch pathways. Urogenital blocks were exposed to exogenous GDNF, which promotes supernumerary ureteric budding from the Wolffian duct. GDNF-induced ectopic buds expressed Jag1, which suggests that...
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PMID: 15905075
PDF is available here.
PDF is available here.
Histopathology (46)6 2005
Abstract
Abstract
This study was undertaken to investigate effects of the prototypical dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on steroid-dependent development of the wolffian ducts of an amphibian, the tiger salamander (Ambystoma tigrinum). Larvae with immature gonads and undeveloped mullerian ducts were...
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PMID: 15707598
PDF is available here.
PDF is available here.
Developmental Cell (8)2 2005
Abstract
We report that loss of the receptor tyrosine kinase (RTK) antagonist, Sprouty1 (Spry1), causes defects in kidney development in mice. Spry1(-/-) embryos have supernumerary ureteric buds, resulting in the development of multiple ureters and multiplex kidneys. These defects are due to increased sensit...
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PMID: 15691764
PDF is available here.
PDF is available here.
Developmental Cell (8)2 2005
Abstract
We report that loss of the receptor tyrosine kinase (RTK) antagonist, Sprouty1 (Spry1), causes defects in kidney development in mice. Spry1(-/-) embryos have supernumerary ureteric buds, resulting in the development of multiple ureters and multiplex kidneys. These defects are due to increased sensit...
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PMID: 15691764
PDF is available here.
PDF is available here.
Journal de Radiologie (86)2 Pt 1 2005
Abstract
We report a case of a 30 month old baby presenting with recurrent urinary tract infection and Gartner's duct cyst communicating with the vagina and bladder with associated complete vaginal diaphragm. The diagnosis of Gartner's duct cyst was suggested by pelvic ultrasonography and MR imaging. Vaginal...
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PMID: 15798628
PDF is available here.
PDF is available here.
Der Urologe (44)2 2005
Abstract
We describe a case of testicular duplication presenting as torsion of the supernumerary distal testis in a 14-year-old boy. Clinical examination showed an unclear mass above the left testis; intraoperatively, the supernumerary testis was linked to the regular testis by a common epididymis and shared...
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PMID: 15602649
PDF is available here.
PDF is available here.
Abstract
We report the case of a 56-year-old male who presented with a swelling in the perineum thought to be a haematoma as the result of a complication of a laparoscopic inguinal hernia repair. It recurred after incision and two attempts at drainage and was then completely excised. Histology revealed the l...
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PMID: 16303731
PDF is available here.
PDF is available here.
Aktuelle Urologie (35)6 2004
Abstract
This case report demonstrates an abscess formation as complication of a previously asymptomatic rudimentary genital structure, which was associated with further abnormalities, such as left testicular agenesia, perineoscrotal hypospadias and transverse testicular ectopia....
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PMID: 15526231
PDF is available here.
PDF is available here.
Abstract
We hypothesize that mutant receptors with residual activity in vitro respond to high local testosterone concentrations in vivo, thereby stimulating WD development. The classification of androgen insensitivity in such patients should be considered severe rather than complete....
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PMID: 15531547
PDF is available here.
PDF is available here.
Abstract
Gynecologic Oncology (95)2 2004
Abstract
BACKGROUND: Female adnexal tumors of probable wolffian origin (FATWO) represent a rare gynecologic tumor and display in the majority of cases a benign behavior. CASE: A 27-year-old woman underwent a laparotomy for a left adnexal mass. Pathologic examination showed a FATWO. Three years later, 1 month...
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PMID: 15491766
PDF is available here.
PDF is available here.