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Neural Crest (0)
Articles on Neural Crest
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Evolutionary functional analysis and molecular regulation of the ZEB transcription factors.
Cell Mol Life Sci 69(15):2527-41 (2012) PMID 22349261
We analyzed how the specific organization of the different domains and regulatory sites in ZEB1 and ZEB2 came into existence. On the basis of this analysis, a detailed overview is provided of the different cofactors and post-translational mechanisms that are associated with ZEB protein functionality... -
Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest.
Development 139(2):397-410 (2012) PMID 22186729
We show that cranial melanocytes arise from at least two different cellular sources: initially from nerve-associated Schwann cell precursors (SCPs) and later from a cellular source that is independent of nerves. Unlike the midbrain-hindbrain cluster from which melanoblasts arise independently of ner... -
Fishing the molecular bases of Treacher Collins syndrome.
PLoS One 7(1):e29574 (2012) PMID 22295061
We therefore assessed it as a model for studying TCS. We identified in silico the putative zebrafish TCOF1 ortholog and cloned the corresponding cDNA. The derived polypeptide shares the main structural domains found in mammals and amphibians. Tcof1 expression is restricted to the anterior-most regio... -
Autocrine endothelin-3/endothelin receptor B signaling maintains cellular and molecular properties of glioblastoma stem cells.
Mol Cancer Res 9(12):1668-85 (2011) PMID 22013079
We report that endothelin 3 (EDN3), an essential mitogen for NCC development and migration, is highly produced by GSCs. Serum-induced proliferative differentiation rapidly decreased EDN3 production and downregulated the expression of stemness-associated genes, and reciprocally, two glioblastoma mark... -
Enforced expression of the transcription factor HOXD3 under the control of the Wnt1 regulatory element modulates cell adhesion properties in...
J Anat 219(5):589-600 (2011) PMID 21929743
We previously found that overexpression of the homeobox gene HOXD3 alters expression levels of cell adhesion molecules in human cancer cell lines. Here, we have investigated whether HOXD3 expression is related to the cell adhesion processes during mouse development focusing on dorsal midline cells o... -
A phenotype-driven ENU mutagenesis screen identifies novel alleles with functional roles in early mouse craniofacial development.
Genesis 49(4):342-59 (2011) PMID 21305688
We performed a phenotype-driven ENU mutagenesis screen in mice with the aim of identifying novel alleles in an unbiased manner, that are critically required for early craniofacial development. Here we describe 10 new mutant lines, which exhibit phenotypes affecting frontonasal and pharyngeal arch pa... -
Influence and timing of arrival of murine neural crest on pancreatic beta cell development and maturation
Dev Biol 349(2):10 (2011) PMID 21081123 PMCID PMC3019241
We expand on that work to describe timing of neural crest arrival at the developing pancreatic bud and extend our knowledge of the non-cell autonomous role for neural crest derivatives in the process of beta cell maturation. We demonstrated that murine neural crest entered the pancreatic mesenchyme... -
Prospective identification and isolation of enteric nervous system progenitors using Sox2.
Stem Cells 29(1):128-40 (2011) PMID 21280162 PMCID PMC3059409
We now show that SOX2 is expressed in the ENS from embryonic to adult stages, and constitutes a novel marker of ENS progenitor cells and their glial cell derivatives. We also show that SOX2 expression overlaps significantly with SOX10, a well-established marker of ENS progenitors and enteric glial c... -
Differentiation of neural-crest-derived intermediate pluripotent progenitors into committed periodontal populations involves unique molecula...
Stem Cells Dev 20(1):39-52 (2011) PMID 20604680 PMCID PMC3128775
We have defined key factors involved in the differentiation of dental follicle (DF) intermediate progenitors into periodontal lineages, including alveolar bone (AB) osteoblasts, cementoblasts, and periodontal ligament (PDL) cells. When comparing differentially expressed genes, PDL cells most closely... -
Phenothiourea sensitizes zebrafish cranial neural crest and extraocular muscle development to changes in retinoic acid and IGF signaling.
PLoS One 6(8):e22991 (2011) PMID 21886774
We found that 0.003% PTU altered retinoic acid and insulin-like growth factor (IGF) regulation of neural crest and mesodermal components of craniofacial development. Reduction of retinoic acid synthesis by the pan-aldehyde dehydrogenase inhibitor diethylbenzaldehyde, only when combined with 0.003% P...
