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Chromaffin System (5):
Recent article
Chromaffin System
Abstract
In C. auratus the adrenal chramaffin tissue is situated around the posterior cardinal veins, in the head kidney. Chromaffin tissue consists of two types of cells containing secretory granules, adrenaline and nor adrenaline cells. The cells produced catecholamine hormones. Adrenaline cell contains el...
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PMID: 18810974
PDF is available here.
PDF is available here.
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Abstract
Abstract
Initial PACAP-regulated transcriptomes of PACAP-treated cultured chromaffin cells, and the adrenal gland of wild-type versus PACAP-deficient mice, have been assembled using microarray analysis. These were compared to previously acquired PACAP-regulated transcriptome sets from PC12 cells and mouse ce...
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PMID: 17651866
PDF is available here.
PDF is available here.
Abstract
We visualized chromaffin cells of rat embryos at 13 to 17 days of gestation using anti-tyrosine hydroxylase (TH) antiserum, and created three-dimensional images from serial tissue sections. Between 13 and 15 days of gestation, TH-positive cells (chromaffin cells) migrated from a group of TH-positive...
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PMID: 15240937
PDF is available here.
PDF is available here.
Endocrinology (143)12 2002
Abstract
We describe the synthesis and pharmacological properties of [1-deamino-4-cyclohexylalanine] arginine vasopressin (d[Cha4]AVP). Binding experiments performed on various membrane preparations revealed that d[Cha(4)]AVP exhibits a nanomolar affinity for V1b receptors from various mammalian species (rat...
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PMID: 12446593
PDF is available here.
PDF is available here.
Development (129)20 2002
Abstract
We show now that MASH1 function is necessary for the development of the vast majority of chromaffin cells. Most adrenal medullary cells in Mash1(-/-) mice identified by Phox2b immunoreactivity, lack the catecholaminergic marker tyrosine hydroxylase. Mash1 mutant and wild-type mice have almost identi...
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PMID: 12361965
PDF is available here.
PDF is available here.
Abstract
This work presents the structure and ultrastructure of the interrenal gland and chromaffin cells, as well as the morphology of the head kidney of Brycon cephalus. The head kidney is composed of fused bilateral lobes located anterior to the swim bladder and ventrolateral to the spinal column. The par...
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PMID: 11820404
PDF is available here.
PDF is available here.
Abstract
It has been previously shown that the neuron-like chromaffin cells from the bovine adrenal medulla are heterogeneous. Among other differences, the cells also differed in secretory vesicles represented in their cytoplasm. The present study investigates the types of secretory vesicles in bovine chroma...
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PMID: 11254368
PDF is available here.
PDF is available here.
Acta Histochemica (103)1 2001
Abstract
These results suggest that in the dogfish the appearance of NPY-LI in the developing sympathoadrenal system is related to differentiation of chromaffin cells....
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PMID: 11252629
PDF is available here.
PDF is available here.
Endocrinology (141)12 2000
Abstract
The aim of the present study was to investigate the presence and localization of the main G protein alpha-subunits in the human fetal adrenal gland during the second trimester of gestation. Immunofluorescence studies conducted on sections from frozen glands obtained immediately after therapeutic abo...
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PMID: 11108240
PDF is available here.
PDF is available here.
Abstract
We found that antidromically identified adrenal sympathetic preganglionic neurons (SPNs) were excited by stimulation of the rostral ventrolateral medulla (RVLM) with either a short (mean: 29 ms) or a long (mean: 129 ms) latency. The latter group of adrenal SPNs were remarkably insensitive to barorec...
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PMID: 11049860
PDF is available here.
PDF is available here.
Journal of Experimental Biology (203)Pt 10 2000
Abstract
Experiments were performed on adult rainbow trout (Oncorhynchus mykiss) in vivo using chronically cannulated fish and in situ using a perfused posterior cardinal vein preparation (i) to characterise the desensitisation of chromaffin cell nicotinic receptors and (ii) to assess the ability of fish to...
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PMID: 10769221
PDF is available here.
PDF is available here.
Abstract
Abstract
The development of the adrenal gland in the lizard Calotes versicolor was studied histologically and histochemically from the day of oviposition (stage 27) to 60 days after hatching. At stage 27, the adrenocortical cells are found in association with the genital ridge (primordial gonad). The separat...
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PMID: 10620426
PDF is available here.
PDF is available here.
Abstract
Continuous incubation of bovine adrenal chromaffin cells with the nicotinic receptor agonist 1,1-dimethyl-4-phenylpiperazinium (DMPP) causes a twofold increase in the steady-state level of catalytically active tyrosine hydroxylase (TH) protein by 3-4 days. The present study examined the processes th...
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PMID: 10386968
PDF is available here.
PDF is available here.
Journal of Physiology (517 ( Pt 2)) 1999
Abstract
We report here the presence of VMAT1 in rat gastrin (G) cells and the relevance of VMAT1 function for the modulation of progastrin processing by biogenic and dietary amines. 2. In immunocytochemical studies VMAT1, but not VMAT2, was localized to subpopulations of G cells and enterochromaffin (EC) ce...
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PMID: 10332097
PDF is available here.
PDF is available here.
Cell and Tissue Research (295)1 1999
Abstract
Our results support the hypothesis that early sympathoblasts express a large repertoire of neuroactive substances and that the expression of these becomes restricted during further development as the sympathoblasts become principal neurons....
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PMID: 9931351
PDF is available here.
PDF is available here.
American Journal of Physiology -- Legacy Content (275)5 Pt 1 1998
Abstract
We used isotope dilution measurements of systemic and forearm NE spillover rates (SNESO and FNESO, respectively) to study the sympathochromaffin system during prolonged standing, hyperinsulinemic euglycemia, and hyperinsulinemic hypoglycemia in healthy humans. Prolonged standing led to decrements in...
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PMID: 9815008
PDF is available here.
PDF is available here.
Abstract
Molecular cloning of secretogranin II (SgII) in phylogenetically distant species has recently revealed the existence of a highly conserved 66-amino acid peptide flanked by preserved pairs of basic residues. This observation suggested that this peptide, named EM66, which had not been described to dat...
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PMID: 9709974
PDF is available here.
PDF is available here.
Abstract
We developed primary frog (Rana pipiens) adrenal co-cultures. In these co-cultures, chromaffin cells extend processes that project towards or onto adrenocortical cells, mimicking their organization in vivo and indicating a potential for interaction between the two cell types. Cell survival and diffe...
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PMID: 9700681
PDF is available here.
PDF is available here.
American Journal of Physiology -- Legacy Content (274)6 Pt 1 1998
Abstract
Toxin-gamma (Tgamma) from the Brazilian scorpion Tityus serrulatus venom caused a concentration- and time-dependent increase in the release of norepinephrine and epinephrine from bovine adrenal medullary chromaffin cells. Tgamma was approximately 200-fold more potent than veratridine judged from EC5...
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PMID: 9611141
PDF is available here.
PDF is available here.
Revista de Neurologia (26)154 1998
Abstract
We started by considering neurotrophic factors, especially NGF and its connection with DN disorders and its clinical applications, we made a summary of the main findings in this field to date....
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PMID: 9658489
PDF is available here.
PDF is available here.
Abstract
This study was carried out to characterize the set of voltage-dependent Ca2+ channel subtypes expressed by mouse adrenal chromaffin cells superfused with solutions containing low (2 mM) or high (10 mM) Ba2+ concentrations. Using 50-ms test pulses at 0 mV from a holding potential of -80 mV, averaged...
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PMID: 9560449
PDF is available here.
PDF is available here.
Abstract
These results suggest that, in porcine chromaffin cells, there is a omega-conotoxin GVIA-sensitive N-type Ca2+ channel that is under the inhibitory control of a G protein, which can be relieved by a conditioning pulse....
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PMID: 9518506
PDF is available here.
PDF is available here.
Abstract
We used stereological as well as spectrofluorimetric measurements, in 20-day-old fetuses and 1-, 3-, 5-, 7-, 9-, 11-, 13- and 14-day-old neonatal rats. Single Dx-treatment (1.5 mg/kg bw) of the dams led to a significant decrease in body and adrenal weight of their fetuses and neonatal offspring, and...
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PMID: 9624594
PDF is available here.
PDF is available here.
Analytical Biochemistry (257)2 1998
Abstract
Biological transport of moderately permeant compounds is obscured by diffusion of the compounds back across the membrane, so characterization of the transport of such compounds requires correction for permeability. A relatively simple method for determining kinetic parameters for moderately permeant...
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PMID: 9514783
PDF is available here.
PDF is available here.
Neuroendocrinology (67)3 1998
Abstract
We conclude that glutamate, through its four known glutamate receptors, can increase both basal and nicotine-evoked CA secretion in chromaffin cells by a process which involves membrane depolarization and an increase in intracellular calcium levels....
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PMID: 9630435
PDF is available here.
PDF is available here.
Abstract
We analyzed the role of apoptosis and infiltration of the adrenal medulla as features of this autoimmune process in parallel with the development of diabetes. Prediabetic and diabetic NOD mice aged 3 to 30 weeks were studied and compared with control mice. Apoptosis was assessed by in situ end-label...
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PMID: 10079028
PDF is available here.
PDF is available here.
Abstract
We have studied the contribution of proliferation and hypertrophy of glandular cells to the ontogenetic growth of adrenal chromaffin tissue using several methods (organometry, cytometry, cytophotometric quantitation of DNA in the nuclei, radioautographic analysis of 3H-thymidine incorporation, calcu...
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PMID: 9608958
PDF is available here.
PDF is available here.
Abstract
The role of protein tyrosine phosphorylation in the activation of the volume-sensitive Cl- current in bovine chromaffin cells was investigated by studying the effects of inhibitors of protein tyrosine kinases (PTKs) and phosphatases (PTPs). The whole-cell current was induced by intracellular guanosi...
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PMID: 9382946
PDF is available here.
PDF is available here.
Abstract
Our data show that extracellular ATP inhibits exocytosis via inhibition of ICa by activation of a pertussis-toxin-sensitive G-protein linked to P2Y receptors. Furthermore, our data strongly suggest that ATP activates another pathway, which is also G-protein dependent and accounts for the majority of...
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PMID: 9359901
PDF is available here.
PDF is available here.
Abstract
The characteristics of the binding sites for the Conus magus toxins omega-conotoxin MVIIC and omega-conotoxin MVIID, as well as their effects on K+-evoked 45Ca2+ entry and whole-cell Ba2+ currents (IBa), and K+-evoked catecholamine secretion have been studied in bovine adrenal chromaffin cells. Bind...
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PMID: 9359903
PDF is available here.
PDF is available here.
American Journal of Physiology -- Legacy Content (273)1 Pt 2 1997
Abstract
I [amino acid (AA) positions 1-7] and [Asn1, Val5]ANG I (AA 1-6), respectively. Pretreatment with either losartan (10(-5) M), PD-123319 (10(-5) M), or hexamethonium (10(-3) M) had no effect on [Asn1, Val5]ANG II-elicited catecholamine release. Pretreatment with captopril (10(-4) M) significantly red...
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PMID: 9249532
PDF is available here.
PDF is available here.
Abstract
(3 alpha,5 alpha)-3-Hydroxypregnan-20-ones and (3 alpha,5 alpha)-3-hydroxypregnane-11,20-diones bearing a 2 beta-morpholinyl substituent were synthesized, and the utility of these steroids as anesthetic agents was evaluated through determination of their potency and duration of hypnotic activity in...
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PMID: 9171876
PDF is available here.
PDF is available here.
Gastroenterology (112)5 1997
Abstract
The GATA-6 transcription factor is expressed in gastric endocrine cells and is a potential regulator of gastric differentiation and of genes involved in the response to feeding....
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PMID: 9136834
PDF is available here.
PDF is available here.
American Journal of Physiology -- Legacy Content (272)2 Pt 1 1997
Abstract
We investigated the contribution of different subtypes of voltage-dependent Ca2+ channels to changes in cytosolic free Ca2+ ([Ca2+]i) and secretion in noradrenergic and adrenergic bovine chromaffin cells. In single immunocytochemically identified chromaffin cells, [Ca2+]i increased transiently durin...
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PMID: 9124290
PDF is available here.
PDF is available here.
Endocrinology (138)2 1997
Abstract
Our results are as follows: 1) Both types of chromaffin cells contained and secreted comparable amounts of immunoreactive-CRH under basal conditions and after K(+)-induced depolarization, nicotine, and interleukin-1 beta; 2) the physicochemical characteristics of the immunoreactive-CRH in the cells...
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PMID: 9003004
PDF is available here.
PDF is available here.
Abstract
The SSTR2 is expressed by the mastomys' ECL cell and ECLoma. Receptor activation inhibits both ECL cell secretory and proliferative functions....
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PMID: 8957490
PDF is available here.
PDF is available here.
Endocrine Research (22)4 1996
Abstract
We previously developed co-cultures of frog (Rana pipiens) adrenal (interrenal) cells. Importantly, chromaffin cells in these co-cultures extend processes that project toward or onto adrenocortical cells, thereby providing the substrate for direct autonomic regulation of adrenocortical function and...
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PMID: 8969947
PDF is available here.
PDF is available here.
Abstract
This study was undertaken to reassess the set of voltage-dependent Ca2+ channel subtypes expressed by bovine adrenal chromaffin cells maintained in primary cultures. Previous views on the pharmacology of such channels had to be revised in the light of the novel data which arose from the use in this...
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PMID: 8781197
PDF is available here.
PDF is available here.
Abstract
We present evidence that alpha-LT induces exocytosis of catecholamines from rat adrenal chromaffin cells beginning as rapidly as 30 s after close application of the toxin. This release is largely dependent on adequate levels of extracellular Ca2+ ([Ca2+]o). Lowering [Ca2+]o from 2 mM to
PDF is available here.
PDF is available here.
Abstract
We demonstrate that high-pass filtering (200 Hz) of cyclic voltammograms recorded at 300 V/s decreases the background current and digitization noise at these microelectrodes, leading to an improved signal. Also, high-pass filtering discriminated against ascorbic acid, DOPAC, and acidic pH changes, t...
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PMID: 8797378
PDF is available here.
PDF is available here.
Abstract
An increase in extracellular Ca2+ concentration from 0.25 to 10 mM enhanced secretion of norepinephrine and epinephrine induced by a high extracellular K+ concentration (75 mM). The increment in extracellular Ca2+ concentration also increased the observed peak inward Ca2+ current in response to long...
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PMID: 8752112
PDF is available here.
PDF is available here.
Abstract
Our data suggest that PNMT expression is regulated differently in the two chromaffin cell subpopulations....
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PMID: 8752129
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1283)1 1996
Abstract
Trichosporin-B-VIa (TS-B-VIa) has a Pro14-kinked helical structure which is considered to be important for the formation of peptaibol-type ion-channels in lipid bilayer membranes. TS-B-VIa and its analog [Aib14]TS-B-VIa with Pro-->Aib substitution at position 14, resulting in a straight helical stru...
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PMID: 8765091
PDF is available here.
PDF is available here.
Abstract
The cortical F-actin cytoskeleton represents a negative control for secretion, and it must be locally disassembled to allow chromaffin vesicle exocytosis. Recombinant scinderin (a Ca(2+)-dependent F-actin-severing protein) potentiated Ca(2+)-evoked F-actin disassembly and exocytosis in permeabilized...
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PMID: 8780652
PDF is available here.
PDF is available here.
Abstract
We used antisera specific for the cytoplasmic sequence of APP to show that primary bovine chromaffin cells secrete a soluble APP, termed solAPPcyt, of an apparent molecular mass of 130 kDa. This APP was oversecreted from Chinese hamster ovary cells transfected with a full-length APP cDNA indicating...
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PMID: 8755600
PDF is available here.
PDF is available here.
Journal of Neuroscience (16)14 1996
Abstract
Our results suggest that during normal action potential activity only 10-20% of BK channels in each chromaffin cell see sufficient [Ca2+]i to be activated....
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PMID: 8699245
PDF is available here.
PDF is available here.
Abstract
We used cultured rat chromaffin cells to test the hypothesis that Ca2+ entry but not release from internal stores is utilized for exocytosis. Two protocols were used to identify internal versus external Ca2+ sources: (a) Ca2+ surrounding single cells was transiently displaced by applying agonist wit...
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PMID: 8666986
PDF is available here.
PDF is available here.
European Journal of Pharmacology (306)1-3 1996
Abstract
These results are compatible with ouabain causing elevation of [Ca2+]i in bovine chromaffin cells through a dual mechanism, i.e. cell depolarisation and slowing down of the Na(+)-Ca2+ exchanger of their plasmalemma. Through its binding to the Na+ site on the Na(+)-Ca2+ exchanger, Li+ ions generate p...
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PMID: 8813635
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1282)1 1996
Abstract
These results strongly suggest that the mechanism of Ca2+ influx by TS-B-VIa at the lower concentrations is distinct from the event of Ca2+ influx through receptor-operated or L-type voltage-sensitive Ca2+ channels in both excitable cells (the chrornaffin cells) and non-excitable cells (the C6 cells...
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PMID: 8679651
PDF is available here.
PDF is available here.
Abstract
We have used membrane capacitance measurements to assay Ca2+-triggered exocytosis in single bovine adrenal chromatin cells. Brief application of phorbol ester (PMA) enhances depolarization-evoked exocytosis severalfold while actually decreasing the Ca2+ current. Ca2+ metabolism is unchanged. Three d...
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PMID: 8663997
PDF is available here.
PDF is available here.
Abstract
We sought to determine if other Src family members were present in chromaffin cells, and if so, to examine them for subcellular localization and changes in activity following treatment with nicotinic agonists. To this end, antibodies for Fyn, Lck, Lyn, and Fgr were assembled and used in immunoprecip...
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PMID: 8776663
PDF is available here.
PDF is available here.
Gastroenterology (110)6 1996
Abstract
Calcium-signaling responses of gastric endocrine cells are distinctive. This allows individual cell types in a mixed population to be characterized and permits an analysis of the hormones and transmitters that act directly on a specific cell type....
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PMID: 8964409
PDF is available here.
PDF is available here.
Abstract
These results suggest that Fos and/or other components of AP-1 transcription factors, rather than CREB or other preexisting proteins, play a specific role in the induction of the proenkephalin gene in bovine chromaffin cells....
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PMID: 8632147
PDF is available here.
PDF is available here.
Journal of Neurosurgery (84)6 1996
Abstract
These results indicate the potential use of intrastriatal implantation of encapsulated hNGF-secreting cells for augmenting the survival of cografted chromaffin cells as well as promoting the functional recovery of hemiparkinsonian rats. These data indicate that this approach may have potential appli...
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PMID: 8847564
PDF is available here.
PDF is available here.
Abstract
These results suggest that voltage-gated Ca++ channels in porcine chromaffin cells are activated directly by persistent depolarization produced by Na+ entry through the nicotinic receptor channel under normal ionic conditions, and by Ca++ entry through the nicotinic receptor channel in the absence o...
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PMID: 8667180
PDF is available here.
PDF is available here.
Abstract
These results suggest that KN-62 inhibits catecholamine secretion and tyrosine hydroxylase activation due to mainly its ion channel blockade on the plasma membrane rather than the inhibition of CaM kinase II activity in the cells....
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PMID: 8632177
PDF is available here.
PDF is available here.
Abstract
We examine the effect of a series of deletion mutants of alpha-SNAP on exocytosis, and on the ability of alpha-SNAP to interact with NSF, to define essential domains involved in protein-protein interactions in exocytosis. Deletion of extreme N- or C-terminal regions of alpha-SNAP produced proteins u...
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PMID: 8744944
PDF is available here.
PDF is available here.
Abstract
The gastric enterochromaffin-like (ECL) cell secretes histamine in response to secretagogues (gastrin, acetylcholine) by calcium signaling-dependent exocytosis of intracellular vacuoles containing the hormone. ECL cells were isolated from rat fundic gastric mucosa by elutriation and density-gradient...
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PMID: 8967460
PDF is available here.
PDF is available here.