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Immunization (5):
Recent article
Immunization
Abstract
We compared the phenotype of constitutive CTMCs and induced MMCs in trachea and large airways in antigen-sensitized unchallenged and challenged mice to MCs in skin and helminthic-infected intestine. We found that in the trachea, unlike in skin and intestine, CTMCs and MMCs both express all six serin...
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PMID: 21825171
PDF is available here.
PDF is available here.
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Abstract
Among the exotoxins produced by Staphylococcus aureus and Streptococcus pyogenes, the superantigens (SAgs) are the most potent T-cell activators known to date. SAgs are implicated in several serious diseases including toxic shock syndrome (TSS), Kawasaki disease, and sepsis. However, the immunopathog...
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PMID: 21641398
PDF is available here.
PDF is available here.
Abstract
We cloned genes coding for human HMGB1 and its active components A box and B box by PCR and inserted the cloned genes into pET28a vectors for transformation of Escherichia coli BL21. The E. coli expressed proteins were then purified with a Ni(2+)-NTA column and the endotoxin content was removed. Rec...
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PMID: 21255697
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
Monoclonal antibodies (mabs) are powerful tools for the quantification, detection, and targeting of specific molecules. Allergen-specific mabs are important for the quantification of major allergens in allergen preparations used for allergen-specific immunotherapy and allergy diagnosis. Indeed, prog...
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PMID: 18612608
PDF is available here.
PDF is available here.
Journal of Immunotherapy (34)3 2011
Abstract
We investigated the effects of murine Trop2 (mTrop2) VLP immunization in a pancreatic cancer syngeneic murine model. VLPs incorporating mTrop2 were used to immunize C57BL/6 tumor-bearing mice. Immunization with mTrop2 VLPs led to a significant reduction in tumor growth accompanied by a broad activat...
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PMID: 21389873
PDF is available here.
PDF is available here.
Abstract
Our results indicate that the role of AMs in the context of airway inflammation should be re-examined....
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PMID: 21415590
PDF is available here.
PDF is available here.
Abstract
We discuss contact allergen presentation and the central role of antigen presenting cells during sensitization phase. There is an extremely complex interaction of different kinds of immune cells, such as antigen presenting cells, T, B, NK lymphocytes, keratinocytes (KCs), endothelium, mast cells (MC...
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PMID: 21489368
PDF is available here.
PDF is available here.
Abstract
We demonstrated the ability of esophageal epithelial cells to act as nonprofessional APCs in the presence of IFNγ. Esophageal epithelial cell antigen presentation may contribute to the pathophysiology of eosinophilic esophagitis....
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PMID: 21281807
PDF is available here.
PDF is available here.
Abstract
We show that an adenovirus type 5 (Ad5)-based human immunodeficiency virus type 1 vaccine can prime a durable antigen-specific CD8 T-cell response in the gut following intramuscular (IM) immunization in mice. The ability of Ad5 to prime gut-homing CD8 T cells in vivo was associated with Ad5-induced...
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PMID: 21289616
PDF is available here.
PDF is available here.
Scientific American (304)2 2011
Abstract
Abstract
An immunization information system (IIS) is a confidential, computerized, population-based system that collects and consolidates vaccination data from vaccine providers and provides tools for designing and sustaining effective immunization strategies at the provider and program levels. Among the cap...
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PMID: 21228762
PDF is available here.
PDF is available here.
Abstract
We designed and constructed two recombinant influenza vaccine candidates by fusing hemagglutinin 1 (HA1) fragment of A/Anhui/1/2005(H5N1) to either Fc of human IgG (HA1-Fc) or foldon plus Fc (HA1-Fdc), and evaluated their immune responses and cross-protection against divergent strains of H5N1 virus....
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PMID: 21304591
PDF is available here.
PDF is available here.
Abstract
To investigate the effect of Escherichia coli heat-labile enterotoxin (LT) B subunit (LTB) gene on canine parvovirus (CPV) VP2 gene vaccine.
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PMID: 21465794
PDF is available here.
PDF is available here.
Abstract
Studies of influenza virus evolution under controlled experimental conditions can provide a better understanding of the consequences of evolutionary processes with and without immunological pressure. Characterization of evolved strains assists in the development of predictive algorit...
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PMID: 21799726
PDF is available here.
PDF is available here.
Abstract
We focussed on tolerogenic IL-10-modulated DC (IL-10 DC) that are known to induce anergic regulatory T cells (iTregs)....
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PMID: 21818385
PDF is available here.
PDF is available here.
Abstract
We now show that CD4 blockade at the time of house dust mite sensitization induces antigen-specific tolerance in mice. Tolerance induction is robust enough to be effective in pre-sensitized animals, even in those where AHR was pre-established. Tolerant mice are protected from airways eosinophilia, T...
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PMID: 21818308
PDF is available here.
PDF is available here.
Abstract
In our earlier studies 34 kDa outer membrane protein (OMP) of Shigella flexneri 2a has been identified as an efficient immunostimulant.
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PMID: 21818362
PDF is available here.
PDF is available here.
Abstract
The data are consistent with a model whereby viral replication in response to SIV antigen stimulation limits the generation of SIV antigen-specific responses and suggests a potential mechanism for the early loss and poor HIV-specific CD4+ T cell response observed in HIV-infected individuals....
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PMID: 21752277
PDF is available here.
PDF is available here.
Abstract
The hypothesis that paracetamol might increase the risk of asthma and other allergic diseases have gained support from a range of independent studies. However, in studies based in developed countries, the possibility that paracetamol and asthma are associated through aspirin avoidance is difficult to...
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PMID: 21811632
PDF is available here.
PDF is available here.
Abstract
We compared the immunogenicity of a full-length VAR2CSA recombinant protein containing all six Duffy binding-like (DBL) domains to that of a three-domain construct (DBL4-6) in mice and rabbits. Animals immunized with either immunogen acquired antibodies reacting with several VAR2CSA individual domai...
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PMID: 21326877
PDF is available here.
PDF is available here.
Abstract
We could specifically neutralize IL-12 while leaving the IL-23 axis intact. Neutralization of IL-12 before M. tuberculosis challenge rendered C57BL/6 mice highly susceptible, resulting in 30-fold-higher CFU in spleen and lungs and accelerated mortality. In contrast, neutralization of IL-12 in BCG-va...
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PMID: 21084465
PDF is available here.
PDF is available here.
Abstract
We have previously shown that transgenic (tg) mice that have been created to overexpress bovine FcRn (bFcRn) demonstrate increased half-life of mouse IgG, significantly increased antigen-specific IgG in serum and augmented expansion of antigen-specific B cells and plasma cells after immunization. On...
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PMID: 21239891
PDF is available here.
PDF is available here.
Abstract
We have evaluated the immunostimulatory role of the highly-conserved outer membrane lipoprotein P6 from non-typeable Haemophilus influenzae (NTHI) to determine whether the presence of the lipid motif plays a critical role on its immunogenicity. We undertook a systematic analysis of the role that the...
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PMID: 21611194
PDF is available here.
PDF is available here.
Abstract
We identified the immunogenic T cell epitopes of AQP4 that are restricted to murine major histocompatibility complex (MHC) I-A(b). The N-terminal region of AQP4 was highly immunogenic. More precisely, the intracellular epitope AQP4(22-36) was detected as major immunogenic determinant. AQP4(82-108) (...
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PMID: 21264240
PDF is available here.
PDF is available here.
Abstract
A tissue culture method using MDCK cells grown under serum-free conditions was developed to produce an inactivated influenza subunit vaccine. The first clinical data suggest it to be equal to the conventional egg-derived influenza subunit vaccine. In a double-blind controlled trial, 2 groups (n = 57...
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PMID: 9240689
PDF is available here.
PDF is available here.
Abstract
The lesional skin of patients with atopic dermatitis has an increased number of type 2 helper T (TH2) cells in the dermis and is superficially colonized by Staphylococcus aureus. The purpose of this study was to determine the effects of peptidoglycan (PEG) from S aureus on TH2 cell induction in murin...
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PMID: 21905498
PDF is available here.
PDF is available here.
Abstract
Abstract
We have described the generation of quorum quenching monoclonal antibodies (mAbs) against acyl homoserine lactones (AHL) used by Pseudomonas aeruginosa as well as Staphylococcal autoinducing peptides (AIP). These mAbs suppressed QS signaling in bacteria and neutralized AHL-mediated cytotoxic effects...
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PMID: 21031321
PDF is available here.
PDF is available here.
Abstract
We have developed optimized methods that allow the rapid assembly of scFv libraries from chickens immunized with pools of immunogens. These methods allow the simplified generation of a single moderately sized library of single-chain Fv (scFv) and the subsequent isolation of diverse, high-affinity, a...
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PMID: 20978977
PDF is available here.
PDF is available here.
Abstract
In the present investigation hepatitis B surface antigen (HBsAg) encapsulated liposomes were developed and coupled with Ulex europaeus agglutinin 1 (UEA-1) to increase transmucosal uptake by M-cells of the Peyer's patches. The liposomes were characterized for shape, size, polydispersity and encapsul...
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PMID: 20843665
PDF is available here.
PDF is available here.
Abstract
This week Save the Children launches a campaign to make the millennium development goals on child health become a reality.
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PMID: 21329127
PDF is available here.
PDF is available here.
Abstract
Evaluation of immunobiological properties of recombinant atoxic forms of the Pseudomonas aeruginosa exotoxin. MATERIALS AND METHODS. 3 recombinant atoxic forms of the P. aeruginosa exotoxin A were produced and studied: aTox1, consisting only of exotoxin A domain 1; aTox1,2, consisting of domain 1 and...
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PMID: 21598613
PDF is available here.
PDF is available here.
Cancer Science (101)11 2010
Abstract
We constructed a DNA vaccine directed against FAP. This vaccine significantly suppressed primary tumor and pulmonary metastases primarily through CD8(+) T-cell-mediated killing in tumor-bearing mice. Most importantly, tumor-bearing mice vaccinated against FAP exhibited a 1.5-fold increase in lifespa...
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PMID: 20804499
PDF is available here.
PDF is available here.
NASN School Nurse (25)6 2010
Abstract
Abstract
Abstract
Component resolved diagnostics introduces new possibilities regarding diagnosis of allergic diseases and individualized, allergen-specific treatment. Furthermore, refinement of IgE-based testing may help elucidate the correlation or lack of correlation between allergenic sensitization and allergic d...
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PMID: 20628838
PDF is available here.
PDF is available here.
Clinical Immunology (136)3 2010
Abstract
We immunized 9 HIV-negative subjects and 29 HIV-infected patients with CD4>/=450 cells/microL and undetectable HIV RNA levels with 2 doses of diphtheria/tetanus toxoid (TT) and KLH, a presumed neoantigen. We quantified the response by lymphoproliferative assay, delayed-type hypersensitivity (DTH), a...
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PMID: 20472504
PDF is available here.
PDF is available here.
Abstract
We demonstrate that both gardiquimod and imiquimod promote the proliferation of murine splenocytes, stimulate the activation of splenic T, NK and natural killer T (NKT) cells, increase the cytolytic activity of splenocytes against B16 and MCA-38 tumor cell lines, and enhance the expression of costim...
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PMID: 20543857
PDF is available here.
PDF is available here.
Abstract
Veterinary Parasitology (172)1-2 2010
Abstract
These results suggested that C-Cp12-Cp21-DNA may provide an effective means of eliciting humoral and cellular responses and generating protective immunity against C. parvum infections in BALB/c mice.
(c) 2010 Elsevier B.V. All rights reserved....
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PMID: 20541869
PDF is available here.
PDF is available here.
Anticancer Research (30)9 2010
Abstract
These results suggest a potential use of this antibody generating method by phage display and indicate the potential of Fc-fusion proteins as therapeutic candidates....
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PMID: 20944114
PDF is available here.
PDF is available here.
Abstract
Vaccine benefit trends were seen for both primary end points, but they did not reach a prespecified significance level of P < or = 25. The estimated shifts in the time-averaged area under the curve and the ATI set point were 0.24 (P=.04, unadjusted) and 0.26 (P=.07, unadjusted) log(10) copies lower,...
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PMID: 20662716
PDF is available here.
PDF is available here.
Infection and Immunity (78)9 2010
Abstract
We have previously demonstrated the efficacy of recombinant chlamydial protease-like activity factor (rCPAF; a secreted chlamydial protein) in inducing antigen-specific CD4+ T cell/gamma interferon (IFN-gamma)-mediated but not antibody-mediated chlamydial clearance and reduction of upper genital tra...
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PMID: 20605976
PDF is available here.
PDF is available here.
Cell Host & Microbe (8)2 2010
Abstract
We developed a strategy to map the activation of key signaling networks in vivo and applied this approach to define and compare the earliest signaling events elicited by immunizing (vaccinia) and lethal (ectromelia) poxvirus infections in mice. Vaccinia induced rapid TLR2-dependent responses, leadin...
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PMID: 20709294
PDF is available here.
PDF is available here.
Cell Host & Microbe (8)2 2010
Abstract
We developed a strategy to map the activation of key signaling networks in vivo and applied this approach to define and compare the earliest signaling events elicited by immunizing (vaccinia) and lethal (ectromelia) poxvirus infections in mice. Vaccinia induced rapid TLR2-dependent responses, leadin...
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PMID: 20709294
PDF is available here.
PDF is available here.
Abstract
The Shiga-like toxins (Stx) are critical virulence factors for enterohemorrhagic Escherichia coli (EHEC), causing severe human illnesses of bloody diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome (HUS). A subunit of Stx, Stx1B protein, mediates the interaction between EHEC and the specif...
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PMID: 20715986
PDF is available here.
PDF is available here.
Abstract
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology (26)8 2010
Abstract
To investigate the immune responses and the protection induced by the transgenic Alfalfa (Medicago sativa) containing Eg95-EgA31 fusion gene of Echinococcus granulosus against Eg protoscoleces.
The leaf protein was extracted from the transgenic alfalfa by heat-coagulation method, its concentration w...
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PMID: 20619100
PDF is available here.
PDF is available here.
Parasitology Research (107)3 2010
Abstract
The immunogenicity of Eimeria acervulina cSZ-2 and chicken interferon gamma was observed against Eimeria tenella challenge. The chickens were randomly divided into six groups of 24 chicks each. Three groups of chickens were injected with DNA vaccines pVAX1-cSZ2, pVAX1-chIFN-gamma and pVAX1-cSZ2-chIF...
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PMID: 20574837
PDF is available here.
PDF is available here.
Abstract
We previously developed the human cell-line activation test (h-CLAT) in vitro skin sensitisation test, based on our reported finding that a 24-hour exposure of THP-1 cells (a human monocytic leukaemia cell line) to sensitisers is sufficient to induce the augmented expression of CD86 and CD54. The ai...
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PMID: 20822320
PDF is available here.
PDF is available here.
Abstract
We sought to determine whether hereditable furlessness resulting from a hypomorphic mutation in the Hairless gene would or would not also affect immune competence. By assessing humoral and cellular immunity of the SKH1 mouse line bearing the hypomorphic Hairless mutation, we determined that blood co...
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PMID: 20663932
PDF is available here.
PDF is available here.
Abstract
We sought to investigate novel approaches that would enable detection of vaccine specific IgA memory B cells. We demonstrate that stimulation of human peripheral blood mononuclear cells in vitro with immunostimulatory DNA in combination with B cell-activating factor (BAFF) and IL-15 promotes differe...
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PMID: 20547203
PDF is available here.
PDF is available here.
Journal of Immunology (185)2 2010
Abstract
We immunized wild-type and Apobec3-deficient C57BL/6 (B6) mice with (4-hydroxy-3-nitrophenyl) acetyl (NP) hapten and evaluated the binding affinity of the resultant NP-specific Abs. These studies revealed similar affinity maturation of NP-specific IgG1 Abs between wild-type and Apobec3-deficient mic...
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PMID: 20566830
PDF is available here.
PDF is available here.
Abstract
We characterized the levels of antibodies against protective antigen and found that over half of anthrax vaccinees had low serum levels of in vitro toxin neutralization capacity. Using solid-phase epitope mapping and confirmatory assays, we identified several neutralization-associated humoral epitop...
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PMID: 20533877
PDF is available here.
PDF is available here.
Abstract
These results demonstrate that the sequence of vaccination affects the expansion of cross-reactive CD8(+) T cells after heterologous chimeric flavivirus challenge....
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PMID: 20536361
PDF is available here.
PDF is available here.
British Journal of Cancer (103)2 2010
Abstract
Abstract
We formulated two model contact allergens (isoeugenol and dinitrochlorobenzene) in ethosomes and investigated the sensitization response using a modified local lymph node assay (LLNA). The results were compared with those for the same allergens in similar concentrations and vehicles without ethosome...
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PMID: 20574602
PDF is available here.
PDF is available here.
Abstract
We investigated the antitumor effect of adenovirus-mediated gene transfer of LIGHT, the tumor-necrosis factor (TNF) superfamily member also known as TNFSF14, in the murine A20 B-cell lymphoma. LIGHT gene modification resulted in upregulated expression of Fas and the accessory molecule--intercellular...
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PMID: 20418899
PDF is available here.
PDF is available here.
Abstract
We propose that the best strategy for management of highly sensitized patients awaiting heart transplantation is combining mechanical circulatory support as a bridge to a (-) VXM or XM together with adoption of a national prioritized sharing algorithm for highly sensitized patients....
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PMID: 20363155
PDF is available here.
PDF is available here.
Transplant Immunology (23)3 2010
Abstract
We have previously shown that allo-Ag-specific CD3 negative (-) cells as analyzed by cytokine flow cytometry (CFC) are elevated in many highly HLA-sensitized (HS) patients, but not most normal individuals. HS patients with high(+) CFC, especially to donor Ags, may be at high risk for AMR and may nee...
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PMID: 20472061
PDF is available here.
PDF is available here.