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Enzymes and Coenzymes (4)
Articles on Enzymes and Coenzymes
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Molybdoenzymes and molybdenum cofactor in plants.
J Exp Bot 53(375):1689-98 (2002) PMID 12147719
The transition element molybdenum (Mo) is essential for (nearly) all organisms and occurs in more than 40 enzymes catalysing diverse redox reactions, however, only four of them have been found in plants. (1) Nitrate reductase catalyses the key step in inorganic nitrogen assimilation,... -
High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): relevance to genetic disease...
Am J Clin Nutr 75(4):616-58 (2002) PMID 11916749
As many as one-third of mutations in a gene result in the corresponding enzyme having an increased Michaelis constant, or K(m), (decreased binding affinity) for a coenzyme, resulting in a lower rate of reaction. About 50 human genetic dis-eases due to defective enzymes can be remedied or ameliorated... -
Compressibility gives new insight into protein dynamics and enzyme function.
ACTA-BIOENERG 1595(1-2):382-6 (2002) PMID 11983410
These results demonstrate that a small alteration of local structure by ligand binding and mutation is dramatically magnified in the flexibility of protein molecule to affect the function. Compressibility gives new insight into protein dynamics and enzyme function from the aspect of atomic packing o... -
Use of transposon Tn5367 mutagenesis and a nitroimidazopyran-based selection system to demonstrate a requirement for fbiA and fbiB in coenzy...
J Bacteriol 183(24):7058-66 (2001) PMID 11717263
We have named fbiA and fbiB for F(420) biosynthesis. Homologues of fbiA were found in all seven microorganisms that have been fully sequenced and annotated and that are known to make F(420). fbiB homologues were found in all but one such organism. Complementation of the fbiA mutant with fbiAB and co... -
Small-molecule metabolism: an enzyme mosaic.
Trends Biotechnol 19(12):482-6 (2001) PMID 11711174
Escherichia coli has been a popular organism for studying metabolic pathways. In an attempt to find out more about how these pathways are constructed, the enzymes were analysed by defining their protein domains. Structural assignments and sequence comparisons were used to show that 213 domain famili... -
Generation of new enzymes via covalent modification of existing proteins.
Chem Rev 101(10):3081-111 (2001) PMID 11710063
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The development of mechanistic enzymology in the 20th century.
Nat Prod Rep 18(5):465-93 (2001) PMID 11699881
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Enzyme redesign.
Chem Rev 101(10):3027-46 (2001) PMID 11710061
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Complexation of Cu(2+) by HETPP and the pentapeptide Asp-Asp-Asn-Lys-Ile: a structural model of the active site of thiamin-dependent enzymes...
Inorg Chem 40(18):4588-96 (2001) PMID 11511203
We have studied the interactions of Cu(2+) ions with 2-(alpha-hydroxyethyl)thiamin pyrophosphate (HETPP), the pentapeptide Asp-Asp-Asn-Lys-Ile surrounding the thiamin pyrophosphate moiety in the transketolase enzyme, and the tertiary Cu(2+)-pentapeptide-HETPP system in aqueous solutions at various p... -
Local synthesis of nuclear-encoded mitochondrial proteins in the presynaptic nerve terminal.
J Neurosci Res 64(5):447-53 (2001) PMID 11391699
We have established previously that a heterogeneous population of mRNAs and biologically active polyribosomes exist in the giant axon and presynaptic nerve terminals of the photoreceptor neurons in squid. We report that these mRNA populations contain mRNAs for nuclear-encoded mitochondrial proteins...
