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Cytochromes (6):
Recent article
Cytochromes
Abstract
We determined that posttranslational modification and expression of amino-acid sequence variants change as a function of biofilm maturation. For Cytochrome₅₇₉ (Cyt₅₇₉), the most abundant cytochrome in the biofilms, late developmental-stage biofilms differed from early-stage biofilms in N...
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PMID: 20485387
PDF is available here.
PDF is available here.
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Abstract
These studies demonstrated that Danshen aqueous extract affected the metabolism of CYP1A2 substrates through competitive inhibition and altered their clearance....
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PMID: 20663043
PDF is available here.
PDF is available here.
Abstract
We have established chromosomal homologies between the Siberian roe deer and the dromedary (Camelus dromedarius) by cross-species chromosome painting with dromedary chromosome-specific painting probes. Dromedary chromosome paints detected 53 autosomal homologies in the genome of the Siberian roe dee...
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PMID: 20413959
PDF is available here.
PDF is available here.
Biophysical Chemistry (149)1-2 2010
Abstract
We summarize our efforts towards the understanding of heme biochemistry. We present: 1) results on ligand migration on globins coupled to the ligand binding event, 2) results on the localization of the spin density in compound I of cytochromes and peroxidases, 3) novel methodologies for mapping the...
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PMID: 20400222
PDF is available here.
PDF is available here.
Analyst (Cambridge UK) (135)5 2010
Abstract
The cytochrome distribution in hyphal tip cells of Schizophyllum commune was visualized using resonance Raman mapping and CARS microscopy. For comparison, resonance Raman mapping and CARS imaging of cytochrome was also performed during branch formation and in completely developed central hyphae. Cyt...
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PMID: 20419238
PDF is available here.
PDF is available here.
Geobiology (8)1 2010
Abstract
In an effort to improve the understanding of electron transfer mechanisms at the microbe-mineral interface, Shewanella oneidensis MR-1 mutants with in-frame deletions of outer-membrane cytochromes (OMCs), MtrC and OmcA, were characterized for the ability to reduce ferrihydrite (FH) u...
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PMID: 20002197
PDF is available here.
PDF is available here.
Geobiology (8)1 2010
Abstract
In an effort to improve the understanding of electron transfer mechanisms at the microbe-mineral interface, Shewanella oneidensis MR-1 mutants with in-frame deletions of outer-membrane cytochromes (OMCs), MtrC and OmcA, were characterized for the ability to reduce ferrihydrite (FH) u...
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PMID: 20002197
PDF is available here.
PDF is available here.
Geobiology (8)1 2010
Abstract
In an effort to improve the understanding of electron transfer mechanisms at the microbe-mineral interface, Shewanella oneidensis MR-1 mutants with in-frame deletions of outer-membrane cytochromes (OMCs), MtrC and OmcA, were characterized for the ability to reduce ferrihydrite (FH) u...
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PMID: 20002197
PDF is available here.
PDF is available here.
Geobiology (8)1 2010
Abstract
In an effort to improve the understanding of electron transfer mechanisms at the microbe-mineral interface, Shewanella oneidensis MR-1 mutants with in-frame deletions of outer-membrane cytochromes (OMCs), MtrC and OmcA, were characterized for the ability to reduce ferrihydrite (FH) u...
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PMID: 20002197
PDF is available here.
PDF is available here.
Geobiology (8)1 2010
Abstract
In an effort to improve the understanding of electron transfer mechanisms at the microbe-mineral interface, Shewanella oneidensis MR-1 mutants with in-frame deletions of outer-membrane cytochromes (OMCs), MtrC and OmcA, were characterized for the ability to reduce ferrihydrite (FH) u...
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PMID: 20002197
PDF is available here.
PDF is available here.
Abstract
We report that the toluidine blue O (TBO) effect on the arc mutants is light independent and observed only during aerobic growth conditions. Moreover, 16 suppressor mutants with restored growth were generated and analyzed. Thirteen of those possessed insertion elements upstream of the cydAB operon,...
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PMID: 19897650
PDF is available here.
PDF is available here.
Abstract
We demonstrate that the Mtr extracellular respiratory pathway is essential for the reduction of flavins and that decaheme cytochromes found on the outer surface of the cell (MtrC and OmcA) are required for the majority of this activity. Given the involvement of external flavins in the reduction of e...
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PMID: 19897659
PDF is available here.
PDF is available here.
Abstract
Altered expression of genes involved in metabolic and signaling pathways and functions of the organism occurs after perinatal exposure of rat offspring to BDE-47 at doses relevant for the general population....
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PMID: 20056577
PDF is available here.
PDF is available here.
Molecular and Cellular Biochemistry (331)1-2 2009
Abstract
Chronic exposure to elevated free fatty acids, in particular long chain saturated fatty acids, provokes endoplasmic reticulum (ER) stress and cell death in a number of cell types. The perturbations to the ER that instigate ER stress and activation of the unfolded protein in response to fatty acids i...
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PMID: 19444596
PDF is available here.
PDF is available here.
Current Biology (19)14 2009
Abstract
We describe the mechanism of the coaction of these photoreceptors in controlling both development and physiology. In seedlings grown under red light, a transient supplement with blue light induced persistent changes in the transcriptome and growth patterns. Blue light enhanced the expression of the...
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PMID: 19559617
PDF is available here.
PDF is available here.
Pharmacogenomics (10)5 2009
Abstract
The overall immunopathogenesis relevant to a large series of disorders caused by a drug or its associated hyperimmune condition is discussed based upon examining the genetics of severe drug-induced bullous skin problems (sporadic idiosyncratic adverse events including Stevens-Johnson syndrome and To...
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PMID: 19450129
PDF is available here.
PDF is available here.
Abstract
To study the enzyme kinetics of ligustilide metabolism and the effects of selective CYP450 inhibitors on the metabolism of ligustilide in liver microsomes of rat, a LC-MS method was established for quantitative analysis of ligustilide in liver microsomes incubation system with nitrendipine as intern...
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PMID: 19545058
PDF is available here.
PDF is available here.
Abstract
We compared cells grown on 2% glucose in the exponential phase and during chronological ageing and we found that many proteins undergo cysteine oxidation. The target proteins include enzymes involved in glucose metabolism. Both caloric restriction and growth on glycerol resulted in a decrease in the...
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PMID: 19205622
PDF is available here.
PDF is available here.
Abstract
We characterized the heme a3−NO complex formed in cytochrome ba3 from Thermus thermophilus and the product of its low-temperature illumination. We showed that the photolyzed NO group binds to CuB(I) to form an end-on NO−CuB or a side-on copper−nitrosyl complex, which is likely to represent the...
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PMID: 19187032
PDF is available here.
PDF is available here.
Biochemical Journal (417)2 2009
Abstract
We have developed a simple native-like surface-tethered membrane system to investigate the activity of cbo(3) (cytochrome bo(3)), a terminal oxidase in Escherichia coli. The tethered membranes consist of E. coli inner-membrane extracts mixed with additional E. coli lipids containing various amounts...
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PMID: 18821852
PDF is available here.
PDF is available here.
Abstract
The aim of the investigation was to study oxidative stress and hepatic monooxygenase function (HMF) in coronary heart disease (CHD) patients with multiple organ dysfunction (MOD) after myocardial revascularization. Twenty-seven CHD patients with signs of MOD and 38 patients with an uncomplicated pos...
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PMID: 19514442
PDF is available here.
PDF is available here.
Abstract
Journal of Biological Chemistry (283)42 2008
Abstract
To elucidate the mechanism of bifurcated oxidation of quinol in the cytochrome bc1 complex, Rhodobacter sphaeroides mutants, H198N and H111N, lacking heme bL and heme bH, respectively, were constructed and characterized. Purified mutant complexes have the same subunit composition as that of the wild...
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PMID: 18713733
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)41 2008
Abstract
Paracoccus pantotrophus cytochrome cd(1) is a nitrite reductase found in the periplasm of many denitrifying bacteria. It catalyzes the reduction of nitrite to nitric oxide during the denitrification part of the biological nitrogen cycle. Previous studies of early millisecond intermediates in the nit...
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PMID: 18669629
PDF is available here.
PDF is available here.
Biochemical Society Transactions (36)Pt 5 2008
Abstract
We observed that a fluorescently labelled terminal oxidase, the cytochrome bd complex, is heterogeneously distributed in the Escherichia coli plasma membrane. This observation forms the basis of a working hypothesis that patches of the E. coli plasma membrane ('respirazones') are dedicated to respir...
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PMID: 18793184
PDF is available here.
PDF is available here.
Biochemical Society Transactions (36)Pt 5 2008
Abstract
We propose that the decahaem cytochromes of the iron reductase system MtrA, MtrC and OmcA comprise pentahaem 'modules' similar to the electron donor protein, NrfB, from E. coli. To demonstrate this, we have isolated and characterized the N-terminal pentahaem module of MtrA by preparing a truncated f...
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PMID: 18793179
PDF is available here.
PDF is available here.
Aquatic Toxicology (89)3 2008
Abstract
The response of wild chubs (Leuciscus cephalus) to chemical pollution was assessed in a metal contaminated river (Cecina River, Italy) through a wide battery of biomarkers which included: Comet assay detecting DNA strand breaks; diffusion assay for apoptosis induction; micronucleus test assessing ch...
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PMID: 18691772
PDF is available here.
PDF is available here.
Abstract
The steady-state operation of photosynthetic reaction center from Rhodobacter sphaeroides was investigated by measuring the rate of cytochrome photo-oxidation under intensive continuous illumination (808 nm, 5 W cm(-2)). The native quinone UQ10 in Q(B) binding site of the reaction center was substit...
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PMID: 18368404
PDF is available here.
PDF is available here.
Abstract
We show that caspase-3 and caspase-7 exhibit differential activity toward multiple substrate proteins, including Bid, XIAP, gelsolin, caspase-6, and cochaperone p23. Caspase-3 was found to be generally more promiscuous than caspase-7 and appears to be the major executioner caspase during the demolit...
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PMID: 18723680
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1777)9 2008
Abstract
The redox properties of a periplasmic triheme cytochrome, PpcB from Geobacter sulfurreducens, were studied by NMR and visible spectroscopy. The structure of PpcB was determined by X-ray diffraction. PpcB is homologous to PpcA (77% sequence identity), which mediates cytoplasmic electron transfer to e...
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PMID: 18534185
PDF is available here.
PDF is available here.
Abstract
Most methanogenic archaea can reduce CO(2) with H(2) to methane, and it is generally assumed that the reactions and mechanisms of energy conservation that are involved are largely the same in all methanogens. However, this does not take into account the fact that methanogens with cytochromes have co...
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PMID: 18587410
PDF is available here.
PDF is available here.
Abstract
We have interrogated each of the multi-heme cytochromes (MtrA, STC, and solubilized versions of the membrane-bound proteins CymA, OmcA, and MtrC) under identical conditions for the first time. Each cytochrome reveals a broad envelope of voltammetric response, indicative of multiple redox cofactors t...
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PMID: 18575901
PDF is available here.
PDF is available here.
Physiologia Plantarum (133)4 2008
Abstract
We evaluate the consequence of tuber-specific expression of yeast invertase, on the pathways of carbohydrate oxidation, in potato (Solanum tuberosum L. cv. Desiree). We analysed the relative rates of glycolysis and the oxidative pentose phosphate pathway that these lines exhibited as well as the rel...
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PMID: 18494735
PDF is available here.
PDF is available here.
Journal of Bacteriology (190)15 2008
Abstract
MtrC and OmcA are cell surface-exposed lipoproteins important for reducing solid metal oxides. Deletions of type II secretion system (T2SS) genes reduced their extracellular release and their accessibility to the proteinase K treatment, demonstrating the direct involvement of T2SS in translocation o...
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PMID: 18502849
PDF is available here.
PDF is available here.
Biochemistry (Washington) (47)30 2008
Abstract
We compared wild-type and E107L mutant enzymes during single turnover using absorption and electrometric techniques with a microsecond time resolution. Both wild-type and E107L mutant cytochromes bd in the fully reduced state bind O 2 rapidly, but the formation of the oxoferryl species in the mutant...
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PMID: 18597483
PDF is available here.
PDF is available here.
Abstract
We show that at pH 6.0, a significant proportion of the enzyme undergoes turnover and releases NO. An early intermediate, which was previously overlooked, is also identified; enzyme immediately following product release is a candidate. However, even at pH 6.0 a considerable fraction of the enzyme re...
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PMID: 18471989
PDF is available here.
PDF is available here.
Abstract
We found that the Fe(II)-dependent reduction of Cyt(579) was thermodynamically favorable at a pH of >3, raising the possibility that Cyt(579) acts as an accessory protein for electron transfer. The results of transmission electron microscopy of immunogold-labeled biofilm indicated that Cyt(579) is l...
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PMID: 18469132
PDF is available here.
PDF is available here.
Abstract
We present a relatively simple, abstract, yet mechanistically realistic, in silico intestinal device (ISID). Its design enabled exploration of the mechanistic details of absorption for passively absorbed compounds that are also dual substrates of drug-metabolizing enzymes (cyp) and transporters (pgp...
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PMID: 18436618
PDF is available here.
PDF is available here.
Journal of Bacteriology (190)14 2008
Abstract
We have functionally produced the outer membrane cytochrome OmcA from Shewanella oneidensis in Escherichia coli. Substrate accessibility experiments indicate that OmcA is surface exposed in an E. coli B strain but not in a K-12 strain. We show that a functional type II secretion system is required f...
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PMID: 18487320
PDF is available here.
PDF is available here.
FEBS Letters (582)15 2008
Abstract
We identified gramicidin S as a potent inhibitor for cytochrome bd-type quinol oxidase from Escherichia coli. We found that gramicidin S inhibited the oxidase with IC(50) of 3.5 microM by decreasing V(max) and the affinity for substrates but showed the stimulatory effect at low concentrations. Our f...
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PMID: 18519036
PDF is available here.
PDF is available here.
Chemistry & Biology (15)6 2008
Abstract
We describe a general strategy for exploring the catalytic potentials of orphan monooxygenases based on direct infusion analysis by Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR/MS). Eight cytochromes P450 from Bacillus subtilis were recombinantly expressed in Escherichia coli...
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PMID: 18559267
PDF is available here.
PDF is available here.
Geobiology (6)3 2008
Abstract
Biochemistry (Washington) (47)20 2008
Abstract
We tentatively designate the PetJ2 group as c6C cytochromes and the other new group as c6B cytochromes. Possible functions of these cytochromes are discussed....
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PMID: 18439023
PDF is available here.
PDF is available here.
Extremophiles (12)3 2008
Abstract
Anaerobic enrichments with H2 as electron donor and thiosulfate/polysulfide as electron acceptor at pH 10 and 0.6 M total Na+ yielded two non sulfate-reducing representatives of reductive sulfur cycle from soda lake sediments. Strain AHT 1 was isolated with thiosulfate as the electron acceptor from...
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PMID: 18317684
PDF is available here.
PDF is available here.
Abstract
Early investigation of the electron paramagnetic resonance spectra of bis-histidine-coordinated membrane-bound ferriheme proteins led to the description of a spectral signal that had only one resolved feature. These became known as "highly anisotropic low-spin" or "large g(max)" ferriheme centers. E...
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PMID: 18418633
PDF is available here.
PDF is available here.
Journal of Bacteriology (190)9 2008
Abstract
Strains derived from HfrH carrying the arcA2 null mutation exhibit a higher respiratory rate, enhanced glucose consumption, and a more-reduced intracellular redox state than arcA deletion mutants of a different lineage. The phenotype of the arcA2 mutants was due to the presence of a creC constitutiv...
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PMID: 18326580
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)18 2008
Abstract
We have investigated the effect of a physiological electron donor to cytochrome cd(1), the copper protein pseudoazurin, on the mechanism of nitrite reduction by the enzyme. Our data clearly show that initially oxidized pseudoazurin causes rapid further turnover by the enzyme to give a final product...
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PMID: 18310770
PDF is available here.
PDF is available here.
Abstract
We recently demonstrated that the hepatic cytochrome P-450 (CYP) isoform 1A2 is downregulated in sepsis, which appears to play an important role in the inflammatory response and liver injury. However, the mechanism responsible for the decreased CYP1A2 remains unknown. Since the transcription factor...
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PMID: 18360687
PDF is available here.
PDF is available here.
Abstract
We analyzed the gene expression profile of wild-type D. vulgaris grown on cathodic hydrogen, generated at an iron electrode surface with an imposed negative potential of -1.1 V (cathodic protection conditions). The gene expression profile of cells grown on cathodic hydrogen was compared to that of c...
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PMID: 18310429
PDF is available here.
PDF is available here.
Abstract
Dietary conditioning of juvenile trout changed the acyl chain composition of mitochondrial phospholipids and the oxidative capacities of muscle mitochondria. Trout were fed three diets differing only in fatty acid (FA) composition. The highly unsaturated 22:6 n-3 (DHA) accounted for 0.4, 14, and 30%...
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PMID: 18210132
PDF is available here.
PDF is available here.
Abstract
I has been replaced by alanine [Zhang, J., Hellwig, P., Osborne, J. P., Huang, H. W., Moenne-Loccoz, P., Konstantinov, A. A., and Gennis, R. B. (2001) Biochemistry 40, 8548-8556]. The absorption bands of ferrous heme b595 are absent from the spectrum of the dithionite-reduced E445A form of cytochrom...
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PMID: 18205406
PDF is available here.
PDF is available here.
Abstract
Genetic risk factors for ticlopidine-induced hepatotoxicity were determined in 22 Japanese patients with ticlopidine-induced hepatotoxicity and 85 Japanese patients who tolerated ticlopidine therapy without experiencing adverse reactions. There was a significant correlation between ticlopidine-induc...
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PMID: 17339877
PDF is available here.
PDF is available here.
Plant Physiology (146)2 2008
Abstract
We identified the thermogenic cells and performed expression and functional analyses of these genes in this organism. Thermographic analysis combined with in situ hybridization revealed that the putative thermogenic cells surround the stamens in the florets of skunk cabbage and coexpress transcripts...
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PMID: 18162588
PDF is available here.
PDF is available here.
Abstract
We investigated the biological role of p40(phox) in differentiated PLB-985 neutrophils, and we show that depletion of endogenous p40(phox) using lentiviral short hairpin RNA reduces ROS production and impairs bacterial killing under conditions where p67(phox) levels remain constant. Biochemical stud...
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PMID: 18029359
PDF is available here.
PDF is available here.
Abstract
Abstract
To understand the nature and evolution of LUCA, or Last Universal Common Ancestor, the minimum genome of LUCA has been identified based on the genes common to the eight primitive Euryarchaea and Crenarchaea species Methanopyrus kandleri, Methanothermobacter thermautotrophicum, Methanococcus jannasch...
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PMID: 18508609
PDF is available here.
PDF is available here.
Abstract
Shewanella species are widespread in various environments. Here, the genome sequence of Shewanella piezotolerans WP3, a piezotolerant and psychrotolerant iron reducing bacterium from deep-sea sediment was determined with related functional analysis to study its environmental adaptation mechanisms. T...
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PMID: 18398463
PDF is available here.
PDF is available here.
Abstract
The total content of rat liver microsomal cytochrome P450 (CYP) significantly decreased after repeated i.p. administration of the antiviral agent tenofovir ((R)-9-[2-(phosphonomethoxy)propyl] adenine) and tenofovir disoproxil at a daily dose 25 mg/kg, although the content of liver microsomal protein...
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PMID: 17949244
PDF is available here.
PDF is available here.
Abstract
The in vitro metabolism of deoxypodophyllotoxin (DPT), a medicinal herbal product isolated from Anthriscus sylvestris (Apiaceae), was investigated in rats and human microsomes and human recombinant cDNA-expressed CYPs. The incubation of DPT with pooled human microsomes in the presence of NADPH gener...
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PMID: 18050240
PDF is available here.
PDF is available here.
Abstract
Using a small database of defined substrates in humans for cytochrome P450 mixed function oxidases, a series of descriptors and classification methods were evaluated with respect to how well they correctly classified substrates. The descriptors ranged from structural keys to topological to electroni...
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PMID: 18217216
PDF is available here.
PDF is available here.