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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
GTP Phosphohydrolases (2):
Recent article
GTP Phosphohydrolases
Molecular Plant (4)2 2011
Abstract
We report the ability of Toc90 to support the import of Toc159 client proteins. We show that the overexpression of Toc90 partially complements the albino knockout of Toc159 and restores photoautotrophic growth. Several lines of evidence including proteome profiling demonstrate the import and accumul...
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PMID: 21220583
PDF is available here.
PDF is available here.
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Molecular Cell (41)2 2011
Abstract
We addressed the significance of two mammalian outer membrane fusion DRPs using an in vitro mammalian mitochondrial fusion assay. We demonstrate that heterotypic MFN1-MFN2 trans complexes possess greater efficacy in fusion as compared to homotypic MFN1 or MFN2 complexes. In addition, we show that t...
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PMID: 21255726
PDF is available here.
PDF is available here.
EMBO Reports (11)11 2010
Abstract
We report that TpMs regulates the tethering between mitochondria and endoplasmic reticulum (ER) in a Mitofusin 2 (Mfn2)-dependent manner. Subcellular fractionation and immunostaining show that TpMs is present at the interface between mitochondria and ER. The expression of TpMs leads to mitochondrial...
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PMID: 20930847
PDF is available here.
PDF is available here.
EMBO Journal (29)18 2010
Abstract
We describe studies of dynamin PH domain mutations found in centronuclear myopathy (CNM) that increase dynamin's GTPase activity without altering phosphoinositide binding. CNM mutations in the PH domain C-terminal α-helix appear to cause conformational changes in dynamin that alter control of the G...
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PMID: 20700106
PDF is available here.
PDF is available here.
Abstract
We have recently found that Rem2 GTPase, highly expressed in human embryonic stem cells (hESC), maintains the cell cycle and controls proper differentiation towards ectoderm, suggesting a role in neuronal development. We describe here the use of the zebrafish (Danio rerio) model to determine the phy...
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PMID: 20729629
PDF is available here.
PDF is available here.
Abstract
In eukaryotes, eRF3 participates translation termination and belongs to the superfamily of GTPase. In this work, dissociation constants for E. octocarinatus eRF3 binding to nucleosides in presence and absence of eRF1a were determined using fluorescence spectra methods. Furthermore, the GTP hydrolyzi...
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PMID: 20890092
PDF is available here.
PDF is available here.
Abstract
MnmE, an evolutionarily conserved GTPase, is involved in modification of the uridine base (U34) at the wobble position of certain tRNAs. Previous crystal structures of MnmE suggest that it is a dimer with considerable conformational flexibility. To facilitate structural comparisons among MnmE protei...
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PMID: 20693664
PDF is available here.
PDF is available here.
Developmental Biology (344)1 2010
Abstract
We report here the physiological characterization of MAP4K3 mutant flies. Flies lacking MAP4K3 have reduced TORC1 activity detected by phosphorylation of S6K and 4EBP. Furthermore MAP4K3 mutants display phenotypes characteristic of low TORC1 activity and low nutrient availability, such as reduced gr...
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PMID: 20457147
PDF is available here.
PDF is available here.
Molecular Cell (39)2 2010
Abstract
We have carried out a comprehensive analysis of cytoplasmic maturation, ordering the known steps into a coherent pathway. Maturation is initiated by the ATPase Drg1. Downstream, assembly of the ribosome stalk is essential for the release of Tif6. The stalk recruits GTPases during translation. Becaus...
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PMID: 20670889
PDF is available here.
PDF is available here.
Cardiovascular Research (87)2 2010
Abstract
We will discuss the role of small GTPases for the maintenance of microvascular barrier functions under resting conditions as well as under conditions of increased permeability and their involvement in signalling pathways downstream of both barrier-stabilizing and inflammatory mediators. Rac1 and Cdc...
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PMID: 20299335
PDF is available here.
PDF is available here.
Abstract
We have described a series of small-molecule inhibitors of dynamin [myristyl trimethyl ammonium bromides (MiTMAB)] that competitively interfere with the ability of dynamin to bind phospholipids and prevent receptor-mediated endocytosis. We now report that dynII functions specifically during the absc...
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PMID: 20571068
PDF is available here.
PDF is available here.
Plant Physiology (153)3 2010
Abstract
We show that in Arabidopsis, the A-domain is not simply degraded but that it accumulates as a soluble, phosphorylated protein separated from Toc159. However, the physiological relevance of this process is unclear. The data show that the A-domain of Toc159 as well as those of its homologs Toc132 and...
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PMID: 20457805
PDF is available here.
PDF is available here.
Abstract
The actin cytoskeleton consists of multiple actin binding proteins (ABPs) that participate cooperatively in different cellular functions such as the maintenance of polarity and cell motility as well as the invasion of target cells and regulation of gene expression, among others. Due to the important...
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PMID: 20338197
PDF is available here.
PDF is available here.
Plant Journal (63)1 2010
Abstract
Thylakoid biogenesis is a crucial step for plant development involving the combined action of many cellular actors. CPSAR1 is shown here to be required for the normal organization of mature thylakoid stacks, and ultimately for embryo development. CPSAR1 is a chloroplast protein that...
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PMID: 20408996
PDF is available here.
PDF is available here.
Plant Journal (63)1 2010
Abstract
Thylakoid biogenesis is a crucial step for plant development involving the combined action of many cellular actors. CPSAR1 is shown here to be required for the normal organization of mature thylakoid stacks, and ultimately for embryo development. CPSAR1 is a chloroplast protein that...
|
PMID: 20408996
PDF is available here.
PDF is available here.
Plant Journal (63)1 2010
Abstract
Thylakoid biogenesis is a crucial step for plant development involving the combined action of many cellular actors. CPSAR1 is shown here to be required for the normal organization of mature thylakoid stacks, and ultimately for embryo development. CPSAR1 is a chloroplast protein that...
|
PMID: 20408996
PDF is available here.
PDF is available here.
Plant Journal (63)1 2010
Abstract
Thylakoid biogenesis is a crucial step for plant development involving the combined action of many cellular actors. CPSAR1 is shown here to be required for the normal organization of mature thylakoid stacks, and ultimately for embryo development. CPSAR1 is a chloroplast protein that...
|
PMID: 20408996
PDF is available here.
PDF is available here.
Plant Journal (63)1 2010
Abstract
Thylakoid biogenesis is a crucial step for plant development involving the combined action of many cellular actors. CPSAR1 is shown here to be required for the normal organization of mature thylakoid stacks, and ultimately for embryo development. CPSAR1 is a chloroplast protein that...
|
PMID: 20408996
PDF is available here.
PDF is available here.
Plant Journal (63)1 2010
Abstract
Thylakoid biogenesis is a crucial step for plant development involving the combined action of many cellular actors. CPSAR1 is shown here to be required for the normal organization of mature thylakoid stacks, and ultimately for embryo development. CPSAR1 is a chloroplast protein that...
|
PMID: 20408996
PDF is available here.
PDF is available here.
Plant Journal (63)1 2010
Abstract
Thylakoid biogenesis is a crucial step for plant development involving the combined action of many cellular actors. CPSAR1 is shown here to be required for the normal organization of mature thylakoid stacks, and ultimately for embryo development. CPSAR1 is a chloroplast protein that...
|
PMID: 20408996
PDF is available here.
PDF is available here.
Plant Journal (63)1 2010
Abstract
Thylakoid biogenesis is a crucial step for plant development involving the combined action of many cellular actors. CPSAR1 is shown here to be required for the normal organization of mature thylakoid stacks, and ultimately for embryo development. CPSAR1 is a chloroplast protein that...
|
PMID: 20408996
PDF is available here.
PDF is available here.
Plant Journal (63)1 2010
Abstract
Thylakoid biogenesis is a crucial step for plant development involving the combined action of many cellular actors. CPSAR1 is shown here to be required for the normal organization of mature thylakoid stacks, and ultimately for embryo development. CPSAR1 is a chloroplast protein that...
|
PMID: 20408996
PDF is available here.
PDF is available here.
Plant Journal (63)1 2010
Abstract
Thylakoid biogenesis is a crucial step for plant development involving the combined action of many cellular actors. CPSAR1 is shown here to be required for the normal organization of mature thylakoid stacks, and ultimately for embryo development. CPSAR1 is a chloroplast protein that...
|
PMID: 20408996
PDF is available here.
PDF is available here.
Plant Journal (63)1 2010
Abstract
Thylakoid biogenesis is a crucial step for plant development involving the combined action of many cellular actors. CPSAR1 is shown here to be required for the normal organization of mature thylakoid stacks, and ultimately for embryo development. CPSAR1 is a chloroplast protein that...
|
PMID: 20408996
PDF is available here.
PDF is available here.
Plant Journal (63)1 2010
Abstract
Thylakoid biogenesis is a crucial step for plant development involving the combined action of many cellular actors. CPSAR1 is shown here to be required for the normal organization of mature thylakoid stacks, and ultimately for embryo development. CPSAR1 is a chloroplast protein that...
|
PMID: 20408996
PDF is available here.
PDF is available here.
Plant Journal (63)1 2010
Abstract
Thylakoid biogenesis is a crucial step for plant development involving the combined action of many cellular actors. CPSAR1 is shown here to be required for the normal organization of mature thylakoid stacks, and ultimately for embryo development. CPSAR1 is a chloroplast protein that...
|
PMID: 20408996
PDF is available here.
PDF is available here.
Plant Journal (63)1 2010
Abstract
Thylakoid biogenesis is a crucial step for plant development involving the combined action of many cellular actors. CPSAR1 is shown here to be required for the normal organization of mature thylakoid stacks, and ultimately for embryo development. CPSAR1 is a chloroplast protein that...
|
PMID: 20408996
PDF is available here.
PDF is available here.
Plant Journal (63)1 2010
Abstract
Thylakoid biogenesis is a crucial step for plant development involving the combined action of many cellular actors. CPSAR1 is shown here to be required for the normal organization of mature thylakoid stacks, and ultimately for embryo development. CPSAR1 is a chloroplast protein that...
|
PMID: 20408996
PDF is available here.
PDF is available here.
Plant Journal (63)1 2010
Abstract
Thylakoid biogenesis is a crucial step for plant development involving the combined action of many cellular actors. CPSAR1 is shown here to be required for the normal organization of mature thylakoid stacks, and ultimately for embryo development. CPSAR1 is a chloroplast protein that...
|
PMID: 20408996
PDF is available here.
PDF is available here.
Plant Journal (63)1 2010
Abstract
Thylakoid biogenesis is a crucial step for plant development involving the combined action of many cellular actors. CPSAR1 is shown here to be required for the normal organization of mature thylakoid stacks, and ultimately for embryo development. CPSAR1 is a chloroplast protein that...
|
PMID: 20408996
PDF is available here.
PDF is available here.
Plant Journal (63)1 2010
Abstract
Thylakoid biogenesis is a crucial step for plant development involving the combined action of many cellular actors. CPSAR1 is shown here to be required for the normal organization of mature thylakoid stacks, and ultimately for embryo development. CPSAR1 is a chloroplast protein that...
|
PMID: 20408996
PDF is available here.
PDF is available here.
Plant Journal (63)1 2010
Abstract
Thylakoid biogenesis is a crucial step for plant development involving the combined action of many cellular actors. CPSAR1 is shown here to be required for the normal organization of mature thylakoid stacks, and ultimately for embryo development. CPSAR1 is a chloroplast protein that...
|
PMID: 20408996
PDF is available here.
PDF is available here.
Plant Journal (63)1 2010
Abstract
Thylakoid biogenesis is a crucial step for plant development involving the combined action of many cellular actors. CPSAR1 is shown here to be required for the normal organization of mature thylakoid stacks, and ultimately for embryo development. CPSAR1 is a chloroplast protein that...
|
PMID: 20408996
PDF is available here.
PDF is available here.
Plant Journal (63)1 2010
Abstract
Thylakoid biogenesis is a crucial step for plant development involving the combined action of many cellular actors. CPSAR1 is shown here to be required for the normal organization of mature thylakoid stacks, and ultimately for embryo development. CPSAR1 is a chloroplast protein that...
|
PMID: 20408996
PDF is available here.
PDF is available here.
Plant Journal (63)1 2010
Abstract
Thylakoid biogenesis is a crucial step for plant development involving the combined action of many cellular actors. CPSAR1 is shown here to be required for the normal organization of mature thylakoid stacks, and ultimately for embryo development. CPSAR1 is a chloroplast protein that...
|
PMID: 20408996
PDF is available here.
PDF is available here.
Plant Journal (63)1 2010
Abstract
Thylakoid biogenesis is a crucial step for plant development involving the combined action of many cellular actors. CPSAR1 is shown here to be required for the normal organization of mature thylakoid stacks, and ultimately for embryo development. CPSAR1 is a chloroplast protein that...
|
PMID: 20408996
PDF is available here.
PDF is available here.
Plant Journal (63)1 2010
Abstract
Thylakoid biogenesis is a crucial step for plant development involving the combined action of many cellular actors. CPSAR1 is shown here to be required for the normal organization of mature thylakoid stacks, and ultimately for embryo development. CPSAR1 is a chloroplast protein that...
|
PMID: 20408996
PDF is available here.
PDF is available here.
Plant Journal (63)1 2010
Abstract
Thylakoid biogenesis is a crucial step for plant development involving the combined action of many cellular actors. CPSAR1 is shown here to be required for the normal organization of mature thylakoid stacks, and ultimately for embryo development. CPSAR1 is a chloroplast protein that...
|
PMID: 20408996
PDF is available here.
PDF is available here.
Plant Journal (63)1 2010
Abstract
Thylakoid biogenesis is a crucial step for plant development involving the combined action of many cellular actors. CPSAR1 is shown here to be required for the normal organization of mature thylakoid stacks, and ultimately for embryo development. CPSAR1 is a chloroplast protein that...
|
PMID: 20408996
PDF is available here.
PDF is available here.
Plant Journal (63)1 2010
Abstract
Thylakoid biogenesis is a crucial step for plant development involving the combined action of many cellular actors. CPSAR1 is shown here to be required for the normal organization of mature thylakoid stacks, and ultimately for embryo development. CPSAR1 is a chloroplast protein that...
|
PMID: 20408996
PDF is available here.
PDF is available here.
Abstract
Our results show that increased expression of Mfn2 and mitochondrial fusion are important for mitochondrial function as well as cell survival during cold stress. These findings have important implications for understanding the mechanisms of mitochondrial fusion and fission in cold-stress-induced cel...
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PMID: 20580691
PDF is available here.
PDF is available here.
Abstract
We present here spectroscopic and kinetic studies of HydF that afford fundamental new insights into the mechanism of H-cluster assembly. Electron paramagnetic spectroscopy reveals that HydF binds both [4Fe-4S] and [2Fe-2S] clusters; however, when HydF is expressed in the presence of HydE and HydG (H...
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PMID: 20498089
PDF is available here.
PDF is available here.
Abstract
We observed that increasing mitochondrial calcium induced mitochondrial fragmentation, which correlated with the presence of Drp1 at the mitochondria in CGP treated cells. Under these conditions, we observed interactions between Drp1 and Fis1. The importance of Drp1 in fragmentation was confirmed by...
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PMID: 20428767
PDF is available here.
PDF is available here.
Abstract
We decided to analyze the possible implication of these microdomains in mitochondrial fission. We found that molecules involved in mitochondrial fission processes are associated with these domains. In particular, although hFis1 was constitutively included in mitochondrial raft-like domains, dynamin-...
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PMID: 20075943
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1803)6 2010
Abstract
Ribosome biogenesis is a fundamental process that provides cells with the molecular factories for cellular protein production. Accordingly, its misregulation lies at the heart of several hereditary diseases (e.g., Diamond-Blackfan anemia). The process of ribosome assembly comprises the processing an...
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PMID: 19879902
PDF is available here.
PDF is available here.
Abstract
We report that mutating its SWI-Thr to either Ala, Glu, Gln, or Asp results not only in diminished GTPase activity but also in spontaneous activation of the SWII domain. Upon close examination of existing alpha subunit crystals, we noted the oxygen of the backbone carbonyl of SWI-Thr and of the gamm...
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PMID: 20457940
PDF is available here.
PDF is available here.
Cancer Research (70)8 2010
Abstract
We have identified high levels of the DUB USP17 in several tumor-derived cell lines and primary lung, colon, esophagus, and cervix tumor biopsies. We also report that USP17 is tightly regulated during the cell cycle in all the cells examined, being abundantly evident in G(1) and absent in S phase. M...
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PMID: 20388806
PDF is available here.
PDF is available here.
Abstract
We show that growth factor erv1-like (Gfer) is involved in preserving mouse embryonic stem cell (ESC) mitochondrial morphology and function. Knockdown (KD) of Gfer in ESCs leads to decreased pluripotency marker expression, embryoid body (EB) formation, cell survival, and loss of mitochondrial functi...
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PMID: 20147447
PDF is available here.
PDF is available here.
Plant Journal (63)1 2010
Abstract
Thylakoid biogenesis is a crucial step for plant development involving the combined action of many cellular actors. CPSAR1 is shown here to be required for the normal organization of mature thylakoid stacks, and ultimately for embryo development. CPSAR1 is a chloroplast protein that...
|
PMID: 20408996
PDF is available here.
PDF is available here.
Abstract
We investigated SPG31 by analyzing the distribution, interactions, and functions of REEP1. We determined that REEP1 is structurally related to the DP1/Yop1p family of ER-shaping proteins and localizes to the ER in cultured rat cerebral cortical neurons, where it colocalizes with spastin and atlastin...
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PMID: 20200447
PDF is available here.
PDF is available here.
Abstract
We characterize kinetic mechanisms for the LRRK2-catalyzed phosphorylation of two peptide substrates: PLK-derived peptide (PLK-peptide) and LRRKtide. We found that LRRK2 follows a rapid equilibrium random mechanism for the phosphorylation of PLK-peptide with either ATP or PLK-peptide being the first...
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PMID: 20146535
PDF is available here.
PDF is available here.
Neurochemical Research (35)3 2010
Abstract
We reported that brain-derived growth factor (BDNF) protected neurons from phenylalanine-induced apoptosis and inhibition of Trk receptor by K252a or downregulation of TrkB abrogated the effect of BDNF. We further demonstrated that phenylalanine-induced RhoA activation and myosin light chain phospho...
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PMID: 19890711
PDF is available here.
PDF is available here.
Neurochemical Research (35)3 2010
Abstract
We reported that brain-derived growth factor (BDNF) protected neurons from phenylalanine-induced apoptosis and inhibition of Trk receptor by K252a or downregulation of TrkB abrogated the effect of BDNF. We further demonstrated that phenylalanine-induced RhoA activation and myosin light chain phospho...
|
PMID: 19890711
PDF is available here.
PDF is available here.
Neurochemical Research (35)3 2010
Abstract
We reported that brain-derived growth factor (BDNF) protected neurons from phenylalanine-induced apoptosis and inhibition of Trk receptor by K252a or downregulation of TrkB abrogated the effect of BDNF. We further demonstrated that phenylalanine-induced RhoA activation and myosin light chain phospho...
|
PMID: 19890711
PDF is available here.
PDF is available here.
Neurochemical Research (35)3 2010
Abstract
We reported that brain-derived growth factor (BDNF) protected neurons from phenylalanine-induced apoptosis and inhibition of Trk receptor by K252a or downregulation of TrkB abrogated the effect of BDNF. We further demonstrated that phenylalanine-induced RhoA activation and myosin light chain phospho...
|
PMID: 19890711
PDF is available here.
PDF is available here.
Neurochemical Research (35)3 2010
Abstract
We reported that brain-derived growth factor (BDNF) protected neurons from phenylalanine-induced apoptosis and inhibition of Trk receptor by K252a or downregulation of TrkB abrogated the effect of BDNF. We further demonstrated that phenylalanine-induced RhoA activation and myosin light chain phospho...
|
PMID: 19890711
PDF is available here.
PDF is available here.
Neurochemical Research (35)3 2010
Abstract
We reported that brain-derived growth factor (BDNF) protected neurons from phenylalanine-induced apoptosis and inhibition of Trk receptor by K252a or downregulation of TrkB abrogated the effect of BDNF. We further demonstrated that phenylalanine-induced RhoA activation and myosin light chain phospho...
|
PMID: 19890711
PDF is available here.
PDF is available here.
Neurochemical Research (35)3 2010
Abstract
We reported that brain-derived growth factor (BDNF) protected neurons from phenylalanine-induced apoptosis and inhibition of Trk receptor by K252a or downregulation of TrkB abrogated the effect of BDNF. We further demonstrated that phenylalanine-induced RhoA activation and myosin light chain phospho...
|
PMID: 19890711
PDF is available here.
PDF is available here.
Neurochemical Research (35)3 2010
Abstract
We reported that brain-derived growth factor (BDNF) protected neurons from phenylalanine-induced apoptosis and inhibition of Trk receptor by K252a or downregulation of TrkB abrogated the effect of BDNF. We further demonstrated that phenylalanine-induced RhoA activation and myosin light chain phospho...
|
PMID: 19890711
PDF is available here.
PDF is available here.
Neurochemical Research (35)3 2010
Abstract
We reported that brain-derived growth factor (BDNF) protected neurons from phenylalanine-induced apoptosis and inhibition of Trk receptor by K252a or downregulation of TrkB abrogated the effect of BDNF. We further demonstrated that phenylalanine-induced RhoA activation and myosin light chain phospho...
|
PMID: 19890711
PDF is available here.
PDF is available here.