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Acid Anhydride Hydrolases (6):
Recent article
Acid Anhydride Hydrolases
Abstract
We reported previously that dynamic changes in DNA methylation occurred during MCA/DEN-induced rat lung carcinogenesis. Here, we used the same animal model to further study the evolution of methylation alterations in tumor suppressor genes (TSGs) DAPK1, FHIT, RASSF1A, and SOCS-3. We found that none...
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PMID: 20970405
PDF is available here.
PDF is available here.
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Abstract
We evaluated the expression of Fragile Histidine Triad (FHIT) in basal cell carcinoma (BCC). The FHIT locus was found to be altered in numerous types of cancer [6,7,18,20,22,25,26]. However, we found only one study dealing with FHIT expression in BCC [11]. In our study, we used immunohistochemical m...
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PMID: 20399571
PDF is available here.
PDF is available here.
Abstract
We present the solution structure of acylphosphatase from Bacillus subtilis (BsAcP), the first from a Gram-positive bacterium. We found that its active site is disordered, whereas it converted to an ordered state upon ligand binding. The structure of BsAcP is sensitive to pH and it has multiple conf...
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PMID: 20447399
PDF is available here.
PDF is available here.
Abstract
Following analysis of nine markers, a profile of two markers was derived (carbonic anhydrase 9 and major vault protein), the co-expression of which conferred a significantly poor probability of locoregional control. The prognostic effect of these biomarkers in combination was greater than their effe...
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PMID: 20388242
PDF is available here.
PDF is available here.
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology (18)5 2010
Abstract
Absent/reduced FHIT and WWOX expression is associated with poor prognosis....
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PMID: 20510001
PDF is available here.
PDF is available here.
Abstract
We investigated the association of the status of FHIT promoter methylation and FHIT protein expression with the clinicopathological progression of DTC, using PCR-based methylation assay and immunohistochemical technique. While no FHIT gene promoter methylation was observed in the matched non-cancero...
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PMID: 20606729
PDF is available here.
PDF is available here.
Journal of Physiology and Pharmacology (60 Suppl 4) 2009
Abstract
Higher level of FHIT mRNA was found in 86% of CRC (P<0.001) and 60% of adenomas (P=0.016). IHC showed comparable results to QPCR (P=0.003), revealing the strongest presence of FHIT protein in Dukes' C/D stages (P<0.001) and N1/N2 lymph nodes metastasis in CRC (P=0.04). FHIT gene expression and Dukes...
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PMID: 20083853
PDF is available here.
PDF is available here.
Journal of Physiology and Pharmacology (60 Suppl 4) 2009
Abstract
Significant FHIT gene overexpression was found in 78% of active UC but not in CD. IHC showed comparable results to QPCR. CONCLUSION: The local up-regulation of FHIT gene and protein expression in active UC may represent an adequate response against inflammatory challenge of epithelial cell homeostas...
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PMID: 20083852
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (89)33 2009
Abstract
The positive expression rates of cyclinB1, FHIT and Ki-67 in gastric carcinoma were 66.1% (222/336), 39.9% (134/336) and 58.3% (196/336) respectively. CyclinB1 and Ki-67 were all correlated with tumor size, differentiation degree, infiltrative depth, clinical stage, lymphatic invasion and distant me...
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PMID: 20095356
PDF is available here.
PDF is available here.
Cancer Investigation (27)7 2009
Abstract
Our results suggested CC might act as a preinvasive stage in the pathogenesis of GBC....
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PMID: 19452299
PDF is available here.
PDF is available here.
Biochemistry (Washington) (48)32 2009
Abstract
Novel inhibitors of lupin diadenosine 5',5'''-P(1),P(4)-tetraphosphate (Ap(4)A) hydrolase have been identified by in silico screening of a large virtual chemical library. Compounds were ranked on the basis of a consensus from six scoring functions. From the top 100 ranked compounds six were selected...
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PMID: 19603790
PDF is available here.
PDF is available here.
Abstract
After DNMT3b siRNA transfection, the expression of DNMT3b was inhibited in SMMC-7721 cells, and the expression of FHIT was significantly higher than that in the control group. There was no significant difference in methylation status between the DNMT3b siRNA transfected cells and control cells. CONC...
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PMID: 19502167
PDF is available here.
PDF is available here.
Abstract
We have used single nucleotide polymorphism microarray analysis to examine genome-wide allelic imbalance in 60 cSCCs using paired non-tumor samples. The most frequent recurrent aberrations were loss of heterozygosity at 3p and 9p, observed in 39 (65%) and 45 (75%) tumors, respectively. Microdeletion...
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PMID: 19131950
PDF is available here.
PDF is available here.
Abstract
Purpose: To study whether fragile histidine triad (Fhit) prevents IR-induced hypoxanthineguanine phosphoribosyltransferase (HPRT) mutation and whether Fhit plays any role in preventing HPRT mutation through low dose-induced adaptive response.
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PMID: 19401904
PDF is available here.
PDF is available here.
Anticancer Research (29)4 2009
Abstract
SSCP analysis showed a mobility shift in 2/20 patients with grade IV megaesophagus (CDKN2A exon 1 and FHIT exon 7) and in 1/10 patients without megaesophagus (TP53 exons 5 and 8). However, DNA sequencing indicated a silent mutation in exon 7 of the FHIT gene (GCT --> GCC) in codon 88 in only one cas...
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PMID: 19414370
PDF is available here.
PDF is available here.
Abstract
We present the results of studies using novel diadenosine polyphosphate analogs, with an oxymethylene group replacing one or two bridging oxygen(s) in the polyphosphate chain. These have been tested as potential substrates and/or inhibitors of the symmetrically acting Ap(4)A hydrolase [bis(5'-nucleo...
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PMID: 19210543
PDF is available here.
PDF is available here.
Abstract
We established 4 human CC cell lines (SCK, JCK1, Cho-CK, and Choi-CK). In the present study, we characterized a typical sarcomatoid phenotype of SCK, and classified the other cell lines according to tumor cell differentiation (a poorly differentiated JCK, a moderately differentiated Cho-CK, and a we...
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PMID: 19287191
PDF is available here.
PDF is available here.
Abstract
We sought to develop a fluorescence polarization (FP) -based assay for triphosphatases, compatible with miniaturization and fast readouts. For this purpose, we took advantage of the nucleoside triphosphatase activity of this class of enzyme to successfully adapt the Transcreener ADP assay based on t...
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PMID: 19275531
PDF is available here.
PDF is available here.
Abstract
The results from this investigation suggested that reduced expression levels of Fhit, Wwox, and nuclear AP2gamma have roles in the pathogenesis of basal-like differentiation in breast cancer. Alteration in the expression of fragile site genes occurs in most of these cancers and may contribute to def...
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PMID: 19130459
PDF is available here.
PDF is available here.
Abstract
Bladder cancer remains one of the most common and expensive cancers to treat worldwide. Numerous molecular markers are being investigated as possible ways to decrease health care costs, increase patient survival and prognosis, and increase sensitivity in screening tests. Several genetic markers have...
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PMID: 19320188
PDF is available here.
PDF is available here.
Mikrobiologiia (78)3 2009
Abstract
Abstract
Deletions in the fifth and the eighth exons of FHIT gene were detected using intragenic microsatellites D3s1540 and D3s1234 in the patients with esophageal cancer. Samples were provided from 17 males and 5 females, residents of province Hebei, China. Homozygotic deletions in the fifth or eighth exon...
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PMID: 20458975
PDF is available here.
PDF is available here.
Abstract
Fhit protein is known to play a role in the process of neoplastic transformation. It has been demonstrated that FHIT gene inactivation is manifested by a lack or very low concentration of Fhit protein in tissues collected from tumours in many organs, including head, neck, breast, lungs, stomach or l...
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PMID: 19419937
PDF is available here.
PDF is available here.
Future Oncology (4)6 2008
Abstract
Environmental agents induce intragenic alterations in the FRA3B/FHIT chromosome fragile site, resulting in fragile FHIT allele loss early in cancer development. Fhit knockout mice are predisposed to tumor development and Fhit gene therapy reduces tumor burden. Repair-deficient cancers are likely to...
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PMID: 19086848
PDF is available here.
PDF is available here.
Abstract
We evaluated twin 4-month-old monozygotic baby boys who presented with MLL-rearranged precursor-B acute lymphoblastic leukemia. Two different MLL/AF4 variants were found in both the twins, the first involving MLL intron 8 and AF4 intron 3 and the second stemming from translocations of MLL exon 10 an...
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PMID: 19131787
PDF is available here.
PDF is available here.
Abstract
Ultrastructural and cytochemical characteristics of mononuclear phagocyte cells in turtles are not well described in the literature, especially in Phrynops hilarii. Thus, the aim of this study was to evaluate these characteristics in the mononuclear phagocyte cells and their phagocytic activity "in...
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PMID: 18448345
PDF is available here.
PDF is available here.
Abstract
Our study demonstrates for the first time that microsatellite-stable FHIT-negative sebaceous gland carcinomas accumulate mutations that target central components of the HRR network. This observation will prompt investigations in synthetic lethality of BRCA-deficient sebaceous gland carcinomas by the...
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PMID: 18717684
PDF is available here.
PDF is available here.
Abstract
The present work evaluated polyphosphate (poly P) metabolism in nuclear and mitochondrial fractions during Rhipicephalus microplus embryogenesis. Nuclear poly P decreased and activity of exopolyphosphatase (PPX - polyphosphate-phosphohydrolases; EC 3.6.1.11) increased after embryo cellularization un...
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PMID: 18706514
PDF is available here.
PDF is available here.
Chinese Medical Journal (121)20 2008
Abstract
Compared with in situ and invasive cancer specimens, both normal and atypical hyperplasia specimens had greater rates of detectable mRNA (WWOX rate ratio = 2.95, 95% CI 1.24 - 7.08; FHIT rate ratio = 4.58, 95% CI 1.82 - 11.81) and Western blotting detectable protein (WWOX rate ratio = 4.12, 95% CI 1...
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PMID: 19080258
PDF is available here.
PDF is available here.
Leukemia Research (32)10 2008
Abstract
We examined the methylation status of FHIT in patients with MDS. Methylation-specific polymerase (MSP) chain reaction was performed to detect the aberrant promoter methylation of FHIT gene in 55 patients with MDS. The abnormal methylation of the FHIT gene was found in 26 of 55 (47.2%) MDS cases, but...
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PMID: 18367246
PDF is available here.
PDF is available here.
Abstract
We stably transfected two BACs containing FRA3B sequences and two nonCFS control BACs containing similar sequence content into HCT116 cells and isolated cell clones with BACs integrated at ectopic sites. Integrated BACs were present at just a few to several hundred contiguous copies. Cell clones con...
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PMID: 18615677
PDF is available here.
PDF is available here.
Abstract
Addition of a 5' cap to RNA polymerase II transcripts, the first step of pre-mRNA processing in eukaryotes from yeasts to mammals, is catalyzed by the sequential action of RNA triphosphatase, guanylyltransferase, and (guanine-N-7)methyltransferase. The effects of knockdown of these capping enzymes i...
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PMID: 18678651
PDF is available here.
PDF is available here.
Biochemistry (Washington) (47)36 2008
Abstract
We show for the first time that h-prune efficiently hydrolyzes short-chain polyphosphates (k cat of 3-40 s (-1)), including inorganic tripoly- and tetrapolyphosphates and nucleoside 5'-tetraphosphates. Long-chain inorganic polyphosphates (>or=25 phosphate residues) are converted more slowly, whereas...
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PMID: 18700747
PDF is available here.
PDF is available here.
FEBS Letters (582)20 2008
Abstract
We show here that Fhit proteins, in addition to their function as dinucleoside triphosphate hydrolases, act similarly to adenylylsulfatases and nucleoside phosphoramidases, liberating nucleoside 5'-monophosphates from such natural metabolites as adenosine 5'-phosphosulfate and adenosine 5'-phosphora...
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PMID: 18694747
PDF is available here.
PDF is available here.
DNA and Cell Biology (27)9 2008
Abstract
We combined both MSP and expression studies (RT-PCR and Northern blotting) in a reproducible manner. Statistical analysis illustrated that hypermethylation of FHIT gene ( p < 0.0001) and p16 gene ( p=0.04) may be used as a potential diagnostic marker to diagnose the early and locally advanced stages...
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PMID: 18593338
PDF is available here.
PDF is available here.
Abstract
We previously discovered that microphthalmia transcription factor (MITF) and upstream stimulatory factor 2 (USF2) each forms a complex with its inhibitor histidine triad nucleotide-binding 1 (Hint-1) and with lysyl-tRNA synthetase (LysRS). Moreover, we showed that the dinucleotide diadenosine tetrap...
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PMID: 18644867
PDF is available here.
PDF is available here.
Abstract
Aberrations of the tumor suppressor gene, the fragile histidine triad gene (FHIT), have been reported in a wide variety of human cancers including cervical carcinoma, oral squamous cell carcinoma (SCC) and oesophageal SCC. This study aimed to examine the integrity of the FHIT gene in cutaneous SCC....
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PMID: 18494825
PDF is available here.
PDF is available here.
Abstract
For reactions using thiamine diphosphate (ThDP)-dependent enzymes many empirically-derived kinetic models exist. However, there is a lack of mechanistic kinetic models. This is especially true for the synthesis of symmetric 2-hydroxy ketones from two identical aldehydes, with one substrate acting as...
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PMID: 18404768
PDF is available here.
PDF is available here.
Abstract
The enrichment of bronchial epithelial cells could improve the diagnostic value of sputum and the efficiency of genetic and cytologic analysis of lung cancer.
(c) 2008 American Cancer Society....
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PMID: 18484646
PDF is available here.
PDF is available here.
FHIT and p53 status and response to platinum-based treatment in advanced non-small cell lung cancer.
Abstract
We retrospectively selected 55 NSCLC patients treated with carboplatin/gemcitabine. Pre-treatment formalin fixed biopsies were analyzed for FHIT and p53 protein expression by immunohistochemistry and representative micro dissected tissue for TP53 mutations by DG-DGGE/sequencing. The FHIT-negative im...
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PMID: 18690840
PDF is available here.
PDF is available here.
Pathology International (58)8 2008
Abstract
Penile carcinoma is a rare disease, accordingly there are few studies on molecular changes, and these results also vary greatly. A total of 26 penile squamous cell carcinomas in Japanese men were studied with respect to HPV, p53 alterations, and methylation of gene promoter region. HPV-DNA was detec...
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PMID: 18705766
PDF is available here.
PDF is available here.
Bioorganic Chemistry (36)4 2008
Abstract
Antiviral alpha-P-borano substituted NTPs are promising chain terminators targeting HIV reverse transcriptase (RT). Activation of antiviral nucleoside diphosphates (NDPs) to NTPs may be carried out by pyruvate kinase (PK) and creatine kinase (CK). Herein, are presented the effects of nucleobase, rib...
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PMID: 18433830
PDF is available here.
PDF is available here.
Abstract
Common chromosome fragile sites occur at specific sequences within mammalian genomes that exhibit apparent single-stranded regions in mitotic chromosomes on exposure of cells to replication stress. Recent progress in the characterization of sequences, and more precise mapping of common fragile sites...
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PMID: 18393361
PDF is available here.
PDF is available here.
Cancer Letters (265)2 2008
Abstract
We examined 22 paired samples of clear cell renal carcinoma and non-malignant renal tissue for the methylation of the FHIT 5'CpG island by methylation-specific PCR. Hypermethylation of the FHIT 5'CpG island was detected in 54.5% (12/22) of clear cell renal carcinomas. Bisulfite sequencing of the FHI...
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PMID: 18378390
PDF is available here.
PDF is available here.
Journal of Molecular Biology (379)5 2008
Abstract
These results indicate that the presence of a disulfide bond in a protein is an important determinant of the folding rate and allows its contribution to be determined in quantitative terms....
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PMID: 18495159
PDF is available here.
PDF is available here.
Abstract
RT-PCR and Western blot analysis showed that the expression level of FHIT-mRNA and FHIT protein was higher in Hep3B cells after infection with pcDNA3.1 (+)/FHIT. The growth of Hep3B cells treated with pcDNA3.1 (+)/FHIT was significantly inhibited. The pcDNA3.1 (+)/FHIT-transfected Hep3B cells showed...
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PMID: 18595145
PDF is available here.
PDF is available here.
Abstract
Aberrant FHIT transcripts were detected in 11 of 48 surrounding non-tumor liver tissues and 27 of 48 HCC samples (22.9% vs 56.3%, P = 0.002). No point mutations were identified within the open reading frame region of FHIT. Loss of heterozygosity (LOH) of the FHIT locus was detected in 4 of 42 inform...
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PMID: 18567082
PDF is available here.
PDF is available here.
Abstract
We tested for gefitinib effectiveness in a broad panel of 12 newly established HNSCC cell lines, investigating its ability to reduce cell growth, to induce apoptosis and to modulate cell cycle and various EGFR pathway-related targets. Gefitinib IC50 values ranged between 0.064 and 33 microM, its cap...
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PMID: 18506376
PDF is available here.
PDF is available here.
Journal of Virology (82)11 2008
Abstract
The baculovirus Autographa californica nucleopolyhedrovirus encodes two proteins with RNA triphosphatase activity. Late expression factor LEF-4, which is an essential gene, is a component of the RNA polymerase and also encodes the RNA capping enzyme guanylyltransferase. PTP/BVP is also an RNA tripho...
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PMID: 18385232
PDF is available here.
PDF is available here.
Abstract
Our studies characterize the 3p deletion as long and terminal and identify no interstitial deletion in that chromosome. Fhit and pVHL protein expression loss appear to be independent, as they can be dissociated. Our data are supportive of a role for FHIT (in addition to VHL) in renal tumorigenesis....
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PMID: 18517280
PDF is available here.
PDF is available here.
EMBO Journal (27)10 2008
Abstract
We show that a non-native state populated transiently during folding of the acylphosphatase from Sulfolobus solfataricus is enzymatically active. The structural characterization of this partially folded state reveals that enzymatic activity is possible even if the catalytic site is structurally hete...
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PMID: 18451804
PDF is available here.
PDF is available here.
Cell Cycle (7)10 2008
Abstract
We summarize these findings with special emphasis on the histidine triad proteins Hint1 and Fhit and their repressive activity on the beta-catenin signaling function....
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PMID: 18596417
PDF is available here.
PDF is available here.
Cancer Research (68)10 2008
Fhit-deficient hematopoietic stem cells survive hydroquinone exposure carrying precancerous changes.
Abstract
We now find that Fhit-deficient hematopoietic cells, exposed to the genotoxin hydroquinone, are resistant to the suppression of stem cell in vitro colony formation observed with wild-type (Wt) hematopoietic cells. In vivo-transplanted, hydroquinone-exposed, Fhit-deficient bone marrow cells also esca...
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PMID: 18483248
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)20 2008
Abstract
We have used protein cross-linking and proteomics methods to characterize a Fhit protein complex involved in triggering Fhit-mediated apoptosis. The complex includes Hsp60 and Hsp10 that mediate Fhit stability and may affect import into mitochondria, where it interacts with ferredoxin reductase, res...
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PMID: 18319262
PDF is available here.
PDF is available here.
Alterations of FHIT and P53 genes in keratocystic odontogenic tumor, dentigerous and radicular cyst.
Abstract
FHIT protein expression was different among groups. Aberrant expression was the highest in KOT, then in RC and DC. p53 protein expression was different among groups. LOH in paraffin-embedded specimens was detected in 22.6% and 12.9% for FHIT and p53 respectively. Mutation of p53 gene at codon 237 wa...
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PMID: 18221322
PDF is available here.
PDF is available here.
Revista Medica de Chile (136)4 2008
Abstract
An abnormal methylation pattern was associated with morphological features in gastric and gallbladder cancer and with a tendency towards a lower survival in colon and gastric cancer....
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PMID: 18769787
PDF is available here.
PDF is available here.
Abstract
We use the acylphosphatase from Sulfolobus solfataricus to show that assembly of folded protein molecules into native-like aggregates is prevented by single-point mutations that introduce structural protections within one of the most flexible region of the protein, the peripheral edge beta-strand 4....
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PMID: 18335927
PDF is available here.
PDF is available here.
Oncology Reports (19)4 2008
Abstract
We investigated the relationship between the expression of the FHIT protein, other tumor suppressor gene products (p53 and p16), the cellular proliferation marker (Ki-67) and the survival time of patients with LSCC. In our study, there were significant differences (p<0.05) in the expression of FHIT...
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PMID: 18357366
PDF is available here.
PDF is available here.
Virchows Archiv (452)4 2008
Abstract
Methylation of normally unmethylated CpG-rich islands in or near the promoter region has been associated with transcriptional inactivation of tumor-suppressor and tumor-related genes in human cancers. However, so far, only a few studies have searched for DNA methylation in penile carcinoma (PC). On...
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PMID: 18299890
PDF is available here.
PDF is available here.
Abstract
We investigated the role of ataxia-telangiectasia mutated (ATM), the main transducer of DNA double-strand break (DSB) signal, in this regulation. We demonstrate that replication stress conditions, which induce fragile site expression, lead to DNA fragmentation and recruitment of phosphorylated ATM t...
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PMID: 17934520
PDF is available here.
PDF is available here.