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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Acid Anhydride Hydrolases (6):
Recent article
Acid Anhydride Hydrolases
Abstract
The RNA triphosphatase (RTPase) components of the mRNA capping apparatus are a bellwether of eukaryal taxonomy. Fungal and protozoal RTPases belong to the triphosphate tunnel metalloenzyme (TTM) family, exemplified by yeast Cet1. Several large DNA viruses encode metal-dependent RTPases unrelated to...
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PMID: 18400173
PDF is available here.
PDF is available here.
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Mutation Research (652)1 2008
Abstract
We have successfully cultured epithelial cells and fibroblasts isolated from non-neoplastic mucosa samples of 30 HNSCC patients and 56 controls. All cell cultures were exposed to bleomycin and chromosome instability was assessed by analysis of chromosome breakage in cells harvested after 2h of expos...
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PMID: 18243046
PDF is available here.
PDF is available here.
Cancer Science (99)3 2008
Abstract
We assessed the association between phosphorylated Chk2 (pChk2) and Fhit expression in oral squamous cell carcinoma. Loss of Fhit expression was an early event during oral carcinogenesis, whereas a decrease in the number of pChk2-positive cells was associated with tumor progression. Although tyrosin...
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PMID: 18167129
PDF is available here.
PDF is available here.
Neuroscience Letters (432)1 2008
Abstract
These results suggests that Ap(4)A signalling mediated by P2Y(1,12,13) receptors and enzymatically regulated by NPP1 activity may be particularly important in hypothalamus and add new support for neurotransmitter/neuromodulatory functions of diadenosine polyphosphates in brain....
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PMID: 18162317
PDF is available here.
PDF is available here.
Cancer Letters (259)2 2008
Abstract
We have measured the level of both these nucleotides in Fhit-positive HEK293 cells exposed to various apoptosis inducers. Cold shock, anti-Fas, cadmium ions and etoposide all increased the basal level of Ap4A of 0.500pmol/10(6)cells by about 50%. However, the corresponding increases in Ap3A from a b...
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PMID: 18006149
PDF is available here.
PDF is available here.
Journal of Molecular Biology (375)5 2008
Abstract
The crystal structure of the prototype exopolyphosphatase/guanosine pentaphosphate phosphohydrolase protein family member from Aquifex aeolicus in complex with the intracellular second messenger guanosine tetraphosphate was determined at 2.7-A resolution. The hydrolytic base is identified as E119. T...
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PMID: 18155044
PDF is available here.
PDF is available here.
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics (25)1 2008
Abstract
Hypermethylation of FHIT promoter was detected in 26 cases (48.1%). Association was not found between FHIT gene hypermethylation and sex, hematologic parameters and chromosomal abnormalities of MDS patients, but found between FHIT gene hypermethylation and age of the MDS cases. Although significant...
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PMID: 18247301
PDF is available here.
PDF is available here.
Nucleic Acids Research (36)2 2008
Abstract
We have used a combination of fluorescence spectroscopy, circular dichroism, denaturation studies and thermodynamic analyses to monitor the binding of magnesium ions to the cvRTPase. Using these techniques, the thermodynamic forces responsible for the interaction of metal ions with an RNA triphospha...
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PMID: 18039706
PDF is available here.
PDF is available here.
Abstract
We attempted to combine profiles of copy number and methylation patterns in four human cancer cell lines using BAC microarray-based approaches and we detected several clinically important genes which showed genetic and epigenetic relationships. Within the clones analyzed, many contained cancer-relat...
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PMID: 17997235
PDF is available here.
PDF is available here.
Abstract
We show that the E. coli protein RppH (formerly NudH/YgdP) is the RNA pyrophosphohydrolase that initiates mRNA decay by this 5'-end-dependent pathway. In vitro, RppH efficiently removes pyrophosphate from the 5' end of triphosphorylated RNA, irrespective of the identity of the 5'-terminal nucleotide...
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PMID: 18202662
PDF is available here.
PDF is available here.
Abstract
We have produced FHIT/FRA3B deletions closely resembling those in tumors by exposing human-mouse chromosome 3 somatic hybrid cells to aphidicolin-mediated replication stress. Clonal cell populations were analyzed for deletions by using PCR, array comparative genomic hybridization (aCGH), and FISH. T...
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PMID: 18162546
PDF is available here.
PDF is available here.
Acta Biochimica Polonica (55)1 2008
Abstract
We present efficient overexpression and detailed biochemical characteristics of the AtNUDX25 protein encoded by the At1g30110 gene. Aided by the determination of the binding constants of Mn(Ap(4)A) and Mg(Ap(4)A) complexes using isothermal titration calorimetry (ITC) we show that AtNUDX25 preferenti...
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PMID: 18345354
PDF is available here.
PDF is available here.
New Phytologist (178)1 2008
Abstract
We describe for the first time the ultrastructure and polyphosphate (poly P) distribution in rapidly frozen and freeze-substituted germ tubes of the AM fungus Gigaspora margarita. At the ultrastructural level, phosphorus distribution was analysed using energy-filtering transmission electron microsco...
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PMID: 18194149
PDF is available here.
PDF is available here.
Abstract
Immunohistochemical study results were as follows: 12 (40%) cases showed low FHIT expression and 18 (60%) showed high expression. There was no significant relationship between FHIT and age, gender or histological subtypes (p > 0.05). Ki-67 expression was 'low' in 13 (43.3%) cases and 'high' in 17 (5...
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PMID: 18038314
PDF is available here.
PDF is available here.
Cytogenetic and Genome Research (120)1-2 2008
Abstract
We have recently isolated the bovine gene, and the aim of this study was to test whether FHIT presents altered expression patterns in vesical tumors of cattle with CEH (chronic enzootic hematuria). CEH is a common syndrome affecting Mediterranean cattle: clastogenic, mutagenic and cancerogenic subst...
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PMID: 18467844
PDF is available here.
PDF is available here.
Cytotherapy (10)7 2008
Abstract
In vitro study showed that the population doubling times of MEC-1 and MEC-FHITc4 cells were 21.03 h and 26.86 h, respectively. FHIT gene transfer reduced the percentage of cells in cell cycle S phase (3.8%) and kept more cells in the G(1) phase (62.4%). Additionally, the clonal forming rates of MEC-...
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PMID: 18985481
PDF is available here.
PDF is available here.
Human Pathology (39)1 2008
Abstract
We used immunohistochemistry to investigate the expression of beta-catenin (CTNNB1), dickkopf, Xenopus, homolog of 3 (DKK3 gene), fibroblast growth factor receptor 3 (FGFR3), fragile histidine triad (FHIT), tumor protein p53 (TP53), mucin1 (MUC1), topoisomerase II alpha (TOP2A), and glutathione S-tr...
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PMID: 17949785
PDF is available here.
PDF is available here.
Oncology Reports (19)1 2008
Abstract
We examined endoscopically resected specimens of 30 adenomas, 30 carcinoma in adenomas (CIAs), and 18 early pure colorectal carcinomas without any adenoma component (EPCs, so called DN carcinoma) and compared the expression of Fhit, Mlh1, Msh2, P53 and cellular phenotype (HGM, MUC2 and CD10). Marked...
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PMID: 18097574
PDF is available here.
PDF is available here.
Abstract
Our findings showed that the FHITI VS8-17 T to A alteration identified in bronchoscopy specimens from patients with clinically suspected lung cancer is a polymorphism found in the Turkish population. We think that this polymorphism does not affect gene function because it is located in the intron po...
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PMID: 19267103
PDF is available here.
PDF is available here.
Anticancer Research (28)6A 2008
Abstract
The proportion of p53-positive cases increased progressively according to the severity of the pathology CD (7.7%), CM (26.1%), CE (522%) and ESCC (100%). However, p16 and Fhit did not show any statistically significant differences among the groups. CONCLUSION: p53 overexpression is involved in the i...
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PMID: 19189666
PDF is available here.
PDF is available here.
Acta Oncologica (47)8 2008
Abstract
Compared with the para-neoplastic and normal cholangiocytes, the expression of FHIT was obviously decreased (p=0.0001), whereas that of cyclin D1 was significantly increased (p=0.0001) in carcinoma cells. The expression of FHIT was found to be correlated with the histological grade (p=0.007) and the...
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PMID: 18618300
PDF is available here.
PDF is available here.
Analytical Biochemistry (372)1 2008
Abstract
We characterized the steady-state kinetics of Cet1p using both synthetic RNA oligos and nucleoside triphosphates. Nucleotide triphosphatase activity was measured in a scintillation proximity assay (SPA)-based high-throughput screen using [gamma-(33)P]biotin-11 GTP as substrate (GTP-SPA); the format...
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PMID: 17707331
PDF is available here.
PDF is available here.
Biochemistry (New York) (73)1 2008
Abstract
Content and chain lengths of inorganic polyphosphates (polyP) as well as exopolyphosphatase activities were compared in cytosol and mitochondria of the yeast Saccharomyces cerevisiae during growth on glucose or ethanol under phosphate surplus. PolyP metabolism in cytosol and mitochondria was substan...
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PMID: 18294131
PDF is available here.
PDF is available here.
Abstract
We report that Fhit associates with the lymphoid enhancer-binding factor 1/T cell factor/beta-catenin complex by directly binding to beta-catenin, a major player in the canonical Wnt pathway that is deregulated in numerous forms of human cancer. In binding to the beta-catenin C-terminal domain, Fhit...
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PMID: 18077326
PDF is available here.
PDF is available here.
Abstract
These results indicate that p16 and FHIT methylation may be one of the earliest events and an important mechanism for gene silencing in esophageal squamous cell carcinogenesis. This study may be helpful for screening the candidate molecular markers for early diagnosis of ESCC in high-risk area....
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PMID: 18365557
PDF is available here.
PDF is available here.