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Hydrolases (11):
Recent article
Hydrolases
Proteomics (11)12 2011
Abstract
We describe the benefits of heat treatment of neutrophils in reducing protein degradation for subsequent proteome analysis. Neutrophils isolated from four healthy volunteers were each divided into three aliquots and subjected to different preparation methods for 2-DE: (i) Heat treatment, (ii) resusp...
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PMID: 21598391
PDF is available here.
PDF is available here.
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Current protocols in protein science / editorial board, John E. Coligan ... [et al.] (Chapter 11) 2011
Abstract
Two enzymatic methods commonly used in N-terminal sequence analysis of blocked proteins are presented: one uses pyroglutamate aminopeptidase for N(α)-pyrrolidone carboxyl-proteins in solution or blotted onto a membrane, and the other uses acylaminoacyl-peptide hydrolase for N(α)-ac...
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PMID: 21400688
PDF is available here.
PDF is available here.
Abstract
We have shown that WalKR acts as the master controller of peptidoglycan metabolism, yet none of the identified regulon genes explain its requirement for cell viability. Transmission electron micrographs revealed cell wall thickening and aberrant division septa in the absence of WalKR, suggesting its...
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PMID: 21386961
PDF is available here.
PDF is available here.
Chemical Communications (46)38 2010
Abstract
We describe the development of a fluorescence polarization-Activity Based Protein Profiling (fluopol-ABPP) based high throughput screening assay that can be used to identify PAD-selective inhibitors. Using this assay, streptonigrin was identified as a potent, selective, and irreversible PAD4 inactiv...
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PMID: 20740228
PDF is available here.
PDF is available here.
Kidney International (78)10 2010
Abstract
Kidney International (78)10 2010
Abstract
FEMS Microbiology Letters (309)1 2010
Abstract
We have already identified the gene encoding 4THase (Af-tth) in this bacterium. The heterologous expression of Af-tth in Escherichia coli resulted in the formation of inclusion bodies of the protein in an inactive form. The recombinant protein (Af-Tth) was successfully activated after an in vitro re...
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PMID: 20546308
PDF is available here.
PDF is available here.
Abstract
Anti-CCP antibodies, in relation to HLA-DRB1*SE carriership, and PIP involvement are predictive for the development of RA from PR in the Japanese population....
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PMID: 20476860
PDF is available here.
PDF is available here.
Clinical Immunology (136)1 2010
Abstract
We investigated the role of natural killer (NK) cells and CD161, their primary C-type-lectin-like receptor in rheumatoid arthritis (RA). Samples were compared with healthy donors (HD), dermatomyositic (DM), polymyositic (PM), and osteoarthritic (OA) patients. RA, PM, and DM NK cell cytotoxicities si...
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PMID: 20359956
PDF is available here.
PDF is available here.
Current Microbiology (61)1 2010
Abstract
The marine bacterium Neptuniibacter sp. strain CAR-SF utilizes carbazole as its sole carbon and nitrogen sources. Two sets of clustered genes related to carbazole degradation, the upper and lower pathways, were obtained. The marine bacterium genes responsible for the upper carbazole degradation path...
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PMID: 20039169
PDF is available here.
PDF is available here.
Abstract
Monitoring and quantification of organohalide respiring bacteria is essential for optimization of on-site bioremediation of anoxic subsurface sites contaminated with chloroethenes. Molecular monitoring and model simulations were applied to determine degradation performance of an in situ dechlorinati...
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PMID: 20540543
PDF is available here.
PDF is available here.
Biochemistry (Washington) (49)23 2010
Abstract
We show here that Cl-amidine also exhibits a strong inhibitory effect against PADs 1 and 3, thus indicating its utility as a pan PAD inhibitor. Given the increasing number of diseases in which dysregulated PAD activity has been implicated, the development of PAD-selective inhibitors is of paramount...
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PMID: 20469888
PDF is available here.
PDF is available here.
Abstract
We have investigated and reviewed the signaling pathways which are affected by arginine deprivation and their consequences which lead to cell death. We have found that arginine deprivation inhibits mTOR signaling but leads to activation of MEK and ERK with no changes in BRAF. These changes most like...
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PMID: 20459375
PDF is available here.
PDF is available here.
Abstract
We have recently found that PAD4 serves as a p53 corepressor to regulate histone Arg methylation at the p53-target gene p21/WAF1/CIP1 promoter. However, it has not been tested whether histone Arg citrullination coordinates with other histone modifications to repress transcription. Here, we show that...
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PMID: 20190809
PDF is available here.
PDF is available here.
Abstract
Many filamentous fungi secrete considerable quantities of enzymes including protease, cellulase and xylanase, which are of major industrial importance. Over the past few decades, many of these fungal enzymes have been isolated and their relevant genes characterised. Solid-state fermentation (SSF), a...
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PMID: 20145973
PDF is available here.
PDF is available here.
Abstract
We discuss the historical background of anti-CCP as well as its diagnostic performance, usefulness for early diagnosis, prognostic capability, and pathogenesis of RA....
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PMID: 20560456
PDF is available here.
PDF is available here.
Abstract
A cis-epoxysuccinate hydrolase (CESH) from Bordetella sp. BK-52 was purified 51.4-fold with a yield of 27.1% using ammonium sulphate precipitation, ionic exchange, hydrophobic interaction, molecular sieve chromatograph and an additional anion exchange chromatography. The CESH was stable in a broad r...
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PMID: 20467235
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To optimize the conditions for enzymolysis of Icariin by snail hydrolase. METHOD: Take conversion rate as index, the effects of pH, temperature, reaction time, dosage of enzyme, concentration of Icariin and metal ion on hydrolysis were studied by single-factor designs and a L9 (3(4)) orth...
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PMID: 20575385
PDF is available here.
PDF is available here.
Innate Immunity (16)2 2010
Abstract
We demonstrated that Leptospira interrogans serovar Lai strain Lai had a similar ability to adhere to and enter primary and immortal (THP-1 and J774A.1) macrophages from human and mouse, but its intracellular fate in human macrophages differed markedly from that in mouse. The leptospires resided wit...
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PMID: 19587003
PDF is available here.
PDF is available here.
Innate Immunity (16)2 2010
Abstract
We demonstrated that Leptospira interrogans serovar Lai strain Lai had a similar ability to adhere to and enter primary and immortal (THP-1 and J774A.1) macrophages from human and mouse, but its intracellular fate in human macrophages differed markedly from that in mouse. The leptospires resided wit...
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PMID: 19587003
PDF is available here.
PDF is available here.
Innate Immunity (16)2 2010
Abstract
We demonstrated that Leptospira interrogans serovar Lai strain Lai had a similar ability to adhere to and enter primary and immortal (THP-1 and J774A.1) macrophages from human and mouse, but its intracellular fate in human macrophages differed markedly from that in mouse. The leptospires resided wit...
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PMID: 19587003
PDF is available here.
PDF is available here.
Abstract
The PADI4_94 genotype was not associated with RA in either the present cohort or the WTCCC cohort. Combined analysis of all the cases of RA (n=5591) and controls (n=13 638) gave an overall OR of 1.01 (95% CI 0.96 to 1.05, p=0.72). No association with anti-CCP antibodies and no interaction with eithe...
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PMID: 19470526
PDF is available here.
PDF is available here.
Abstract
The levels of the serum thyroid hormone (free T4 and free T3) are determined not only by thyroid hormone synthesis/secretion but also by their metabolism. Thyroid hormone metabolism is mediated by three selenoproteins, selenodeiodinase type 1, 2, and 3 (D1, D2, and D3), the expression and function o...
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PMID: 20408442
PDF is available here.
PDF is available here.
Cold Spring Harbor Protocols (2010)2 2010
Abstract
Biotechnology Letters (32)2 2010
Abstract
Immobilization of cis-epoxysuccinate hydrolase-containing E. coli for D(-)-tartaric acid production was screened by various methods. The highest recovery of activity was obtained by entrapment in kappa-carrageenan gel. 23.6 g biomass/l and 43.4 g kappa-carrageenan/l were the best imm...
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PMID: 19844664
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
Immobilization of cis-epoxysuccinate hydrolase-containing E. coli for D(-)-tartaric acid production was screened by various methods. The highest recovery of activity was obtained by entrapment in kappa-carrageenan gel. 23.6 g biomass/l and 43.4 g kappa-carrageenan/l were the best imm...
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PMID: 19844664
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
Immobilization of cis-epoxysuccinate hydrolase-containing E. coli for D(-)-tartaric acid production was screened by various methods. The highest recovery of activity was obtained by entrapment in kappa-carrageenan gel. 23.6 g biomass/l and 43.4 g kappa-carrageenan/l were the best imm...
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PMID: 19844664
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
Immobilization of cis-epoxysuccinate hydrolase-containing E. coli for D(-)-tartaric acid production was screened by various methods. The highest recovery of activity was obtained by entrapment in kappa-carrageenan gel. 23.6 g biomass/l and 43.4 g kappa-carrageenan/l were the best imm...
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PMID: 19844664
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
Immobilization of cis-epoxysuccinate hydrolase-containing E. coli for D(-)-tartaric acid production was screened by various methods. The highest recovery of activity was obtained by entrapment in kappa-carrageenan gel. 23.6 g biomass/l and 43.4 g kappa-carrageenan/l were the best imm...
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PMID: 19844664
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
Immobilization of cis-epoxysuccinate hydrolase-containing E. coli for D(-)-tartaric acid production was screened by various methods. The highest recovery of activity was obtained by entrapment in kappa-carrageenan gel. 23.6 g biomass/l and 43.4 g kappa-carrageenan/l were the best imm...
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PMID: 19844664
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
Immobilization of cis-epoxysuccinate hydrolase-containing E. coli for D(-)-tartaric acid production was screened by various methods. The highest recovery of activity was obtained by entrapment in kappa-carrageenan gel. 23.6 g biomass/l and 43.4 g kappa-carrageenan/l were the best imm...
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PMID: 19844664
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
Immobilization of cis-epoxysuccinate hydrolase-containing E. coli for D(-)-tartaric acid production was screened by various methods. The highest recovery of activity was obtained by entrapment in kappa-carrageenan gel. 23.6 g biomass/l and 43.4 g kappa-carrageenan/l were the best imm...
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PMID: 19844664
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
Immobilization of cis-epoxysuccinate hydrolase-containing E. coli for D(-)-tartaric acid production was screened by various methods. The highest recovery of activity was obtained by entrapment in kappa-carrageenan gel. 23.6 g biomass/l and 43.4 g kappa-carrageenan/l were the best imm...
|
PMID: 19844664
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
Immobilization of cis-epoxysuccinate hydrolase-containing E. coli for D(-)-tartaric acid production was screened by various methods. The highest recovery of activity was obtained by entrapment in kappa-carrageenan gel. 23.6 g biomass/l and 43.4 g kappa-carrageenan/l were the best imm...
|
PMID: 19844664
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
Immobilization of cis-epoxysuccinate hydrolase-containing E. coli for D(-)-tartaric acid production was screened by various methods. The highest recovery of activity was obtained by entrapment in kappa-carrageenan gel. 23.6 g biomass/l and 43.4 g kappa-carrageenan/l were the best imm...
|
PMID: 19844664
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
Immobilization of cis-epoxysuccinate hydrolase-containing E. coli for D(-)-tartaric acid production was screened by various methods. The highest recovery of activity was obtained by entrapment in kappa-carrageenan gel. 23.6 g biomass/l and 43.4 g kappa-carrageenan/l were the best imm...
|
PMID: 19844664
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
Immobilization of cis-epoxysuccinate hydrolase-containing E. coli for D(-)-tartaric acid production was screened by various methods. The highest recovery of activity was obtained by entrapment in kappa-carrageenan gel. 23.6 g biomass/l and 43.4 g kappa-carrageenan/l were the best imm...
|
PMID: 19844664
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
Immobilization of cis-epoxysuccinate hydrolase-containing E. coli for D(-)-tartaric acid production was screened by various methods. The highest recovery of activity was obtained by entrapment in kappa-carrageenan gel. 23.6 g biomass/l and 43.4 g kappa-carrageenan/l were the best imm...
|
PMID: 19844664
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
Immobilization of cis-epoxysuccinate hydrolase-containing E. coli for D(-)-tartaric acid production was screened by various methods. The highest recovery of activity was obtained by entrapment in kappa-carrageenan gel. 23.6 g biomass/l and 43.4 g kappa-carrageenan/l were the best imm...
|
PMID: 19844664
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
Immobilization of cis-epoxysuccinate hydrolase-containing E. coli for D(-)-tartaric acid production was screened by various methods. The highest recovery of activity was obtained by entrapment in kappa-carrageenan gel. 23.6 g biomass/l and 43.4 g kappa-carrageenan/l were the best imm...
|
PMID: 19844664
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
Immobilization of cis-epoxysuccinate hydrolase-containing E. coli for D(-)-tartaric acid production was screened by various methods. The highest recovery of activity was obtained by entrapment in kappa-carrageenan gel. 23.6 g biomass/l and 43.4 g kappa-carrageenan/l were the best imm...
|
PMID: 19844664
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
Immobilization of cis-epoxysuccinate hydrolase-containing E. coli for D(-)-tartaric acid production was screened by various methods. The highest recovery of activity was obtained by entrapment in kappa-carrageenan gel. 23.6 g biomass/l and 43.4 g kappa-carrageenan/l were the best imm...
|
PMID: 19844664
PDF is available here.
PDF is available here.
Journal of Bacteriology (192)3 2010
Abstract
Bacterial spores remain dormant and highly resistant to environmental stress until they germinate. Completion of germination requires the degradation of spore cortex peptidoglycan by germination-specific lytic enzymes (GSLEs). Bacillus anthracis has four GSLEs: CwlJ1, CwlJ2, SleB, and SleL. In this...
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PMID: 19966006
PDF is available here.
PDF is available here.
Abstract
The effect of pH value of cultivation medium on biosynthesis by bacteria of Bacillus genus of different types of hydrolases has been studied. The optimum pH medium values for each of the studied enzymes were chosen that allowed to increase the activity of produced xylanases and lypases--1.3-1.5 time...
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PMID: 21117290
PDF is available here.
PDF is available here.
Molecular Vision (16) 2010
Abstract
This is the first report demonstrating that like in POAG, NTG also possesses elevated levels of both PAD2 and protein-bound citrulline....
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PMID: 20806090
PDF is available here.
PDF is available here.
Abstract
We analyze the survival mechanisms used by the protozoan parasite Giardia lamblia during infection. In particular, we examine the multiple roles played by the enzyme arginine deiminase during colonization of the gut, also involving the parasite's mechanism of antigenic variation. Potential drug targ...
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PMID: 20953552
PDF is available here.
PDF is available here.
Abstract
The paper presents the characteristics of biological alternatives to antibiotics, that are bacteriophages, bacterial cell wall hydrolases and antimicrobial alternatives. Those substances are promising candidates that can successfully replace a lot of chemioterapeutics at the time of antibiotic-resis...
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PMID: 20976953
PDF is available here.
PDF is available here.
Abstract
Peptidylarginine deiminases (PADs) convert arginine within a peptide (peptidylarginine) into peptidylcitrulline. Citrullination by human PADs is important in normal physiology and inflammation. Porphyromonas gingivalis, a major pathogen in periodontitis, is the only prokaryote described to possess P...
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PMID: 20553633
PDF is available here.
PDF is available here.
Abstract
We investigated whether PADI4 polymorphisms contribute to anti-CCP-negative as well as -positive RA, whether they influence disease severity (erosive joint status), and whether they interact with two major risk factors for RA, Human Leukocyte Antigen-DRB1 (HLA-DRB1) shared epitope (SE) alleles and s...
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PMID: 20537173
PDF is available here.
PDF is available here.
Abstract
We present a clinical case of a female infant with multiple anomalies and distinctive facial features, with an exceptionally severe clinical course of Hirschsprung disease. The girl was also diagnosed with Mowat-Wilson syndrome, confirmed by molecular analysis as a heterozygous deletion of the ZEB2...
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PMID: 20145308
PDF is available here.
PDF is available here.
Abstract
We screened bacterioplankton genomic libraries for their ability to complement an Escherichia coli strain unable to use Pns as a P source. Using this approach we identified a phosphonatase pathway as well as a novel pair of genes that allowed utilization of 2-aminoethylphosphonate (2-AEPn) as the so...
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PMID: 19788654
PDF is available here.
PDF is available here.
Abstract
The current work extends the phenotypic and molecular characterization of the bacterial culture collection from the Rouge River to gain an understanding of the physiology of the strains and their potential for biotechnological applications. Phenotypic and molecular analyses were performed on six uni...
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PMID: 20662385
PDF is available here.
PDF is available here.
Casopis lekaru ceskych (149)9 2010
Abstract
Hereditary tyrosinemia type 1 (HT1) is a rare autosomal recessive inborn error of metabolism caused by deficiency of fumarylacetoacetate hydrolase. HT1 manifests with severe liver and kidney impairment and associates with an increased risk of liver cancer development. The aim of our study is to pres...
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PMID: 21117323
PDF is available here.
PDF is available here.
Journal of Andrology (31)2 2010
Abstract
We described the isolation of a detergent-stable complex from bovine sperm acrosome, termed the outer acrosomal membrane-associated matrix complex (OMC). This stable matrix assembly is associated with the luminal surface of the outer acrosomal membrane and exhibits specific binding activity for acro...
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PMID: 19478333
PDF is available here.
PDF is available here.
Journal of Andrology (31)2 2010
Abstract
We described the isolation of a detergent-stable complex from bovine sperm acrosome, termed the outer acrosomal membrane-associated matrix complex (OMC). This stable matrix assembly is associated with the luminal surface of the outer acrosomal membrane and exhibits specific binding activity for acro...
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PMID: 19478333
PDF is available here.
PDF is available here.
Journal of Andrology (31)2 2010
Abstract
We described the isolation of a detergent-stable complex from bovine sperm acrosome, termed the outer acrosomal membrane-associated matrix complex (OMC). This stable matrix assembly is associated with the luminal surface of the outer acrosomal membrane and exhibits specific binding activity for acro...
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PMID: 19478333
PDF is available here.
PDF is available here.
Journal of Andrology (31)2 2010
Abstract
We described the isolation of a detergent-stable complex from bovine sperm acrosome, termed the outer acrosomal membrane-associated matrix complex (OMC). This stable matrix assembly is associated with the luminal surface of the outer acrosomal membrane and exhibits specific binding activity for acro...
|
PMID: 19478333
PDF is available here.
PDF is available here.
Journal of Andrology (31)2 2010
Abstract
We described the isolation of a detergent-stable complex from bovine sperm acrosome, termed the outer acrosomal membrane-associated matrix complex (OMC). This stable matrix assembly is associated with the luminal surface of the outer acrosomal membrane and exhibits specific binding activity for acro...
|
PMID: 19478333
PDF is available here.
PDF is available here.
Journal of Andrology (31)2 2010
Abstract
We described the isolation of a detergent-stable complex from bovine sperm acrosome, termed the outer acrosomal membrane-associated matrix complex (OMC). This stable matrix assembly is associated with the luminal surface of the outer acrosomal membrane and exhibits specific binding activity for acro...
|
PMID: 19478333
PDF is available here.
PDF is available here.
Journal of Andrology (31)2 2010
Abstract
We described the isolation of a detergent-stable complex from bovine sperm acrosome, termed the outer acrosomal membrane-associated matrix complex (OMC). This stable matrix assembly is associated with the luminal surface of the outer acrosomal membrane and exhibits specific binding activity for acro...
|
PMID: 19478333
PDF is available here.
PDF is available here.