Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Thioredoxin-Disulfide Reductase (2):
Recent article
Thioredoxin-Disulfide Reductase
Abstract
Gold(I) complexes such as auranofin have been used for decades to treat symptoms of rheumatoid arthritis and have also demonstrated a considerable potential as new anticancer drugs. The enzyme thioredoxin reductase (TrxR) is considered as the most relevant molecular target for these species. The her...
|
PMID: 21082862
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Parasitology Research (107)2 2010
Abstract
Thioredoxin reductase (TrxR) is an evolutionary diverse enzyme. In higher eukaryotes, TrxR contains a selenocysteine in the active site which confers high activity and a broad substrate range. The parasitic nematode Haemonchus contortus contains two TrxRs, a cytoplasmic enzyme HcTrxR1 with a selenoc...
|
PMID: 20495929
PDF is available here.
PDF is available here.
Phytochemistry (71)8-9 2010
Abstract
We describe the current knowledge on regulation of chlorophyll biosynthesis in plants by the chloroplast redox state with emphasis on the Mg-chelatase situated at the branch point between the heme and the chlorophyll pathway. We discuss the proposed role of the Mg-chelatase as a key regulator of the...
|
PMID: 20417532
PDF is available here.
PDF is available here.
Abstract
Thioredoxin (Trx) and thioredoxin reductase (TrxR) plus NADPH, comprising the thioredoxin system, has a large number of functions in DNA synthesis, defense against oxidative stress and apoptosis or redox signaling with reference to many diseases. All three isoenzymes of mammalian TrxR contain an ess...
|
PMID: 20494123
PDF is available here.
PDF is available here.
Abstract
A cDNA encoding putative thioredoxin reductase (TR) was identified from a medicinal mushroom, Taiwanofungus camphorata (T. camphorata). Alignment of the deduced amino acid sequence with TRs from other organisms showed high levels of identity (59-74%). A three-dimensional (3-D) homology structure was...
|
PMID: 20307095
PDF is available here.
PDF is available here.
British Journal of Nutrition (103)6 2010
Abstract
We assumed that fresh broccoli could be a superior cardioprotective agent compared to cooked broccoli. To test this, two groups of rats were fed with fresh (steamed) broccoli or cooked broccoli for 30 d, while a third group was given vehicle only for the same period of time. After 30 d, all the rats...
|
PMID: 19857366
PDF is available here.
PDF is available here.
Anticancer Research (30)3 2010
Thioredoxin and thioredoxin reductase expression in thyroid cancer depends on tumour aggressiveness.
Abstract
Thyroid cancer is the second most common malignancy following breast cancer in Arab females. Thioredoxin (TRX) is a small multi-functional redox protein with both intracellular and extracellular functions. The protein exists in either a reduced form (thioredoxin-SH2) or an oxidized form (thioredoxin...
|
PMID: 20392995
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Phytotherapy Research (24)3 2010
Abstract
These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that the addition of vitamin E helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
(c) 2009...
|
PMID: 19610042
PDF is available here.
PDF is available here.
Journal of Bacteriology (192)1 2010
Abstract
Thioredoxin reductase (encoded by trxB) protects Staphylococcus aureus against oxygen or disulfide stress and is indispensable for growth. Among the different sarA family mutants analyzed, transcription of trxB was markedly elevated in the sarA mutant under conditions of aerobic as well as microaero...
|
PMID: 19854896
PDF is available here.
PDF is available here.
Journal of Bacteriology (192)2 2010
Abstract
Our results show that D. radiodurans TrxR can utilize only NADPH for activity....
|
PMID: 19933368
PDF is available here.
PDF is available here.
Abstract
Malaria parasites adapt to the oxidative stress during their erythrocytic stages with the help of vital thioredoxin redox system and glutathione redox system. Glutathione reductase and thioredoxin reductase are important enzymes of these redox systems that help parasites to maintain an adequate intr...
|
PMID: 19967095
PDF is available here.
PDF is available here.
Bioscience Reports (29)5 2009
Abstract
We studied the complete selenoproteome in the mouse to uncover additional selenoprotein mRNAs that are highly regulated by Se status. Mice were fed on Se-deficient, Se-marginal and Se-adequate diets (0, 0.05 and 0.2 microg of Se/g respectively) for 35 days, and selenoprotein mRNA levels in liver and...
|
PMID: 19076066
PDF is available here.
PDF is available here.
Biochemistry (Washington) (48)38 2009
Abstract
Reporter gene transactivation by human p53 is inhibited in budding yeast lacking the TRR1 gene encoding thioredoxin reductase. To investigate the role of thioredoxin in controlling p53 activity, the level of reporter gene transactivation by p53 was determined in yeast lacking the TRX1 and TRX2 genes...
|
PMID: 19681600
PDF is available here.
PDF is available here.
Abstract
The model was stable during the simulation with the equilibrium root mean square deviation (RMSD) value of 1.2 A. Stereochemical evaluation revealed that 99.1% residues of the constructed model lie in the most favoured and allowed regions, thus, indicating a good quality model. CONCLUSION: Results o...
|
PMID: 19724080
PDF is available here.
PDF is available here.
Abstract
gamma-Glutamyl transpeptidase (gamma-GT) is a key enzyme in GSH metabolism that regulates intracellular GSH levels in response to extracellular GSH (GSH(o)). The objective of this study was to identify the role of gamma-GT in reversing pathogenic K(+) channel remodeling in the diseased heart. Chroni...
|
PMID: 19419996
PDF is available here.
PDF is available here.
Neurotoxicity Research (16)2 2009
Abstract
I inhibition as seen in males and the progressive dopaminergic cell loss in substantia nigra (SNpc) is significantly attenuated. Redox driven apoptotic signaling pathways regulated by thiol disulfide oxidoreductase(s) have been implicated in the neurodegeneration seen in PD. Oxidation of thioredoxin...
|
PMID: 19526288
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (284)28 2009
Abstract
We found that inactivation of EF-G (Slr1463) by H(2)O(2) was attributable to the oxidation of two specific cysteine residues and formation of a disulfide bond. Substitution of these cysteine residues by serine residues protected EF-G from inactivation by H(2)O(2) and allowed the EF-G to mediate tran...
|
PMID: 19447882
PDF is available here.
PDF is available here.
Nutrition and Cancer (61)3 2009
Abstract
We previously reported that the activity of the tumor suppressor PTEN is modulated by thioredoxin (Trx) in a RedOx-dependent manner. In this study, we demonstrated that the activity of Trx reductase (TR) is increased by sevenfold in the human prostate cancer cell line, DU-145, after 5 days of sodium...
|
PMID: 19373605
PDF is available here.
PDF is available here.
Molecular Pharmacology (76)1 2009
Abstract
The indolequinone ES936 {5-methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione} was previously developed in our lab as an antitumor agent against pancreatic cancer. The objective of this study was to identify indolequinones with improved potency against pancreatic cancer and to define th...
|
PMID: 19364812
PDF is available here.
PDF is available here.
Biochemistry (Washington) (48)26 2009
Abstract
We show that the Cys(2) mutant enzyme or the N-terminal reaction center alone can reduce Se-containing substrates selenocystine and selenite with only slightly less activity than the wild-type enzyme, in stark contrast to when Trx is used as the substrate when the enzyme suffers a 175-550-fold reduc...
|
PMID: 19366212
PDF is available here.
PDF is available here.
Molecular Plant (2)3 2009
Abstract
Thioredoxins (Trx) are ubiquitous proteins that participate in thiol disulfide reactions via two active site cysteine residues, allowing Trx to reduce disulfide bonds in target proteins. Recent progress in proteome analysis has resulted in identification of a wide range of potential...
|
PMID: 19825623
PDF is available here.
PDF is available here.
Abstract
The novel luminescent gold(I) complex [N-(N',N'-dimethylaminoethyl)-1,8-naphthalimide-4-sulfide](triethylphosphine)gold(I) was prepared and investigated for its primary biological properties. Cell culture experiments revealed strong antiproliferative effects and induction of apoptosi...
|
PMID: 19123857
PDF is available here.
PDF is available here.
Abstract
We report on spectroscopic and redox characterization of the [Fe4S4] center in Synechocystis sp. PCC 6803 H86Y ferredoxin:thoredoxin reductase in the accessible redox states of both the as purified and N-ethylmaleimide-modified forms, using the combination of UV-visible absorption and variable-tempe...
|
PMID: 19132843
PDF is available here.
PDF is available here.
Abstract
CTX at 800 mg/kg resulted in heart failure, in which cytoplasmic thioredoxin reductase (TrxR1) activity and non-protein free thiol (NPFT) level were suppressed by 90 and 62%, respectively. The combination of 350 mg/kg CTX and the glutathione synthesis inhibitor buthionine sulfoximine (BSO) also evok...
|
PMID: 19168513
PDF is available here.
PDF is available here.
Abstract
We evaluated the role of TrxR inhibition in the release of arachidonic acid (AA), cell toxicity, and intracellular signaling pathways in L929 mouse fibrosarcoma cells. Treatment with 1-chloro-2,4-dinitrobenzene (DNCB, an inhibitor of TrxR) under conditions involving limited inhibition of TrxR activi...
|
PMID: 19170071
PDF is available here.
PDF is available here.
Abstract
We have investigated the effects of some synthesized MF analogues on TrxR and HeLa cells. The studies of the mode of inhibition and the interactions of IG3, one of the most potent MF analogues, with TrxR showed MF compounds could be partly reduced by the C-terminal selenolthiol active site, and poss...
|
PMID: 18822278
PDF is available here.
PDF is available here.
Abstract
We show that trxB, a monocistronic operon under the control of NmlR, encodes a functional thioredoxin reductase. It is shown that neisserial TrxB has biochemical properties similar to those of its homologue from Escherichia coli. Analysis of a trxB mutant of N. gonorrhoeae showed that it was more se...
|
PMID: 19032106
PDF is available here.
PDF is available here.
Abstract
In HCT-116 cells, cisplatin (20 microM)-induced apoptosis was reduced by a calcium chelator from 9.9-fold induction (95% confidence interval [CI] = 8.1- to 11.7-fold to 3.1-fold induction) (95% CI = 2.0- to 4.2-fold) and by superoxide scavenging (from 9.3-fold, 95% CI = 8.8- to 9.8-fold, to 5.1-fold...
|
PMID: 19116379
PDF is available here.
PDF is available here.
Postepy biochemii (55)2 2009
Abstract
It is generally accepted that reactive oxygen species (ROS) act as signalling molecules and regulate various physiological processes, including proliferation, differentiation, apoptosis and migration. The initiation and proper functioning of several signalling pathways leading to the effective motil...
|
PMID: 19824470
PDF is available here.
PDF is available here.
Abstract
We hypothesized that the onium ions of sulfur or nitrogen mustards might produce carbon free radicals upon being reduced enzymatically, and that these radicals might constitute a metabolic activation. We set out to document radical production using an in vitro metabolic system and electron paramagne...
|
PMID: 18977373
PDF is available here.
PDF is available here.