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Thioredoxin-Disulfide Reductase (2):
Recent article
Thioredoxin-Disulfide Reductase
Nutrition and Cancer (61)2 2009
Abstract
We examined the hypothesis that nontoxic concentrations of selenium induce apoptosis and growth inhibition selectively in prostate cancer cells but not in benign prostate cells. Nontumorigenic BPH-1 prostate epithelial cells, androgen-sensitive LNCaP, and androgen-independent PC-3 prostate cancer ce...
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PMID: 19235042
PDF is available here.
PDF is available here.
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Mikrobiologiia (78)3 2009
Abstract
Abstract
We discuss the importance of vitagenes in the cellular stress response and analyse, from a pharmacological point of view, the potential use of dietary antioxidants in the treatment of neurodegenerative disorders in humans....
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PMID: 19273073
PDF is available here.
PDF is available here.
Abstract
We studied the impact of selenium compounds on the green chlorococcal alga Scenedesmus quadricauda. Both the dose and chemical forms of Se were critical factors in the cellular response. Se toxicity increased in cultures grown under sulfur deficient conditions. We selected three strains of Scenedesm...
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PMID: 19445666
PDF is available here.
PDF is available here.
Plant Journal (57)1 2009
Abstract
We describe the pattern of localization of NADPH thioredoxin reductase (NTR) in developing and germinating wheat seeds using an immunocytochemical analysis. The presence of NTR in transfer cells, vascular tissue, developing embryo and root meristematic cells, agrees with the localization of thioredo...
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PMID: 18786001
PDF is available here.
PDF is available here.
FEMS Microbiology Letters (289)2 2008
Abstract
OxyR regulates the expression of a peroxiredoxin (AhpC) and two catalases (KatA and KatB), which play roles in peroxide protection, at the transcription level in Pseudomonas putida KT2442. Proteome analysis indicated significantly increased amounts of the enzymes AhpC, KatA, KatB, and a peroxiredoxi...
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PMID: 19054104
PDF is available here.
PDF is available here.
Archives of Toxicology (82)12 2008
Abstract
These results show that oral administration of K2Cr2O7 to decrease in the activities of BBM enzymes, increase in oxidative stress and alters the activities of anti-oxidant enzymes in rat intestine....
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PMID: 18488194
PDF is available here.
PDF is available here.
Oncology Reports (20)6 2008
Abstract
We report on a non-toxic inhibitor, green tea. TrxR1 was found to be inhibited by green tea extracts (Gte) with an IC50 value of 256 microg/ml. Catechins, the major components of Gte, showed various inhibitory effects, in which (-)-epigallocatechin-3-gallate (EGCG) exhibited a stronger inhibition th...
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PMID: 19020731
PDF is available here.
PDF is available here.
Journal of Nutrition (138)12 2008
Abstract
We therefore conclude that redox-regulated proteins, such as PTP1B, represent important interfaces between dietary antioxidants such as Se and the regulation of metabolic processes....
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PMID: 19022953
PDF is available here.
PDF is available here.
Abstract
We included into the analysis antioxidant enzymes (AOEs) and related proteins, such as, manganese superoxide dismutase (MnSOD), gammaglutamylcysteine synthetase catalytic and regulatory subunits (GLCL-C and GLCL-R), thioredoxin (Trx) and thioredoxin reductase (TrxR). Their expression was studied in...
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PMID: 18682894
PDF is available here.
PDF is available here.
Abstract
Thioredoxin (Trx) is a ubiquitous protein disulfide reductase involved in a wide range of cellular redox processes. A large number of putative target proteins have been identified using proteomics approaches, but insight into target specificity at the molecular level is lacking since the reactivity...
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PMID: 19367707
PDF is available here.
PDF is available here.
Abstract
A series of ruthenium(II)-arene (RAPTA) compounds were evaluated for their ability to inhibit thioredoxin reductase (either cytosolic or mitochondrial) and cathepsin B, two possible targets for anticancer metallodrugs. In general, inhibition of the thioredoxin reductases was lower than that of cathe...
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PMID: 18834187
PDF is available here.
PDF is available here.
Biochemical Pharmacology (76)9 2008
Abstract
We assessed the redox state of the peroxiredoxins (Prxs) in Jurkat T-lymphoma cells treated with auranofin, and found that mitochondrial Prx3 was considerably more sensitive to oxidation than the cytosolic Prx1 and 2, indicating selective mitochondrial stress. Prx3 oxidation was detected at apoptoti...
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PMID: 18789312
PDF is available here.
PDF is available here.
Cancer Research (68)20 2008
Abstract
We examined the redox effect on SW480 and HT-29 colon cancer cells of four anticancer compounds, arsenic trioxide, phosphoaspirin, phosphosulindac, and nitric oxide-donating aspirin (NO-ASA). All compounds inhibited the growth of both cell lines (IC(50), 10-90 micromol/L) and induced RONS detected b...
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PMID: 18922898
PDF is available here.
PDF is available here.
Oral Oncology (44)10 2008
Abstract
The aim of this study was to evaluate the anti-cancer effect of a novel organoselenium compound BBSKE (1,2-[bis(1,2-Benzisoselenazolone-3(2H)-ketone)]ethane, BBSKE, PCT: CN02/00412) on cell growth and apoptosis, focusing on the protein activity of Thioredoxin Reductase (TrxR) and Caspase-3, in oral...
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PMID: 18282784
PDF is available here.
PDF is available here.
Abstract
The recruitment and differentiation of circulating stem/progenitor cells (SPCs) in subcutaneous Matrigel in mice was assessed. There were over one million CD34(+) SPCs per Matrigel plug 18 h after Matrigel implantation, and including a polymer to elevate the lactate concentration increased the numbe...
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PMID: 18710947
PDF is available here.
PDF is available here.
Biochemistry (Washington) (47)37 2008
Abstract
We present the cloning and biochemical characterization of a putative TrxR (Ta0984) and a putative Trx (Ta0866) from Thermoplasma acidophilum. Our data identify Ta0866 as a Trx through its capacity to reduce insulin and be reduced by Escherichia coli TrxR in a NADPH-dependent manner. Our data also e...
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PMID: 18717593
PDF is available here.
PDF is available here.
Biochemistry (Washington) (47)37 2008
Abstract
Thioredoxin reductases (TrxRs) are flavin-containing dithioloxidoreductases that couple reduction equivalents from the soluble NAD(P)H pool to the soluble protein thioredoxin (Trx). Previous crystallographic studies of the Escherichia coli enzyme ( ecTrxR) have shown that low molecular weight TrxRs...
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PMID: 18717594
PDF is available here.
PDF is available here.
Plant Physiology (148)1 2008
Abstract
Thioredoxins (Trxs) constitute a family of small proteins in plants. This family has been extensively characterized in Arabidopsis (Arabidopsis thaliana), which contains six different Trx types: f, m, x, and y in chloroplasts, o in mitochondria, and h mainly in cytosol. A detailed study of this fami...
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PMID: 18614707
PDF is available here.
PDF is available here.
Abstract
In GPxs, the redox-active Se or S, is at hydrogen bonding distance from Gln and Trp residues that contribute to catalysis. From sequence homology of >400 sequences and modeling of the DmGPx as a paradigm, Asn136 emerged as a fourth essential component of the active site. Mutational substitution of A...
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PMID: 18500926
PDF is available here.
PDF is available here.
Abstract
Series of curcumin derivatives were synthesized; the inhibitory activities on thioredoxin reductase (TrxR) of all analogues were evaluated by DTNB assay in vitro. It is found that most of the analogues can inhibit TrxR in the low micromolar range; Structure-activity relationship analysis reveals tha...
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PMID: 18678491
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)34 2008
Abstract
We propose thus a four-step disulfide cascade mechanism involving the transient glutathionylation of Cys(4) to convert this atypical thioredoxin h back to its active reduced form....
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PMID: 18552403
PDF is available here.
PDF is available here.
Abstract
We report the crystal structure (at 2.2 A resolution) of TGR from Schistosoma mansoni (SmTGR), deleted in the last two residues. The structure reveals the peculiar architecture of this chimeric enzyme: the small Glutaredoxin (Grx) domain at the N-terminus is joined to the large thioredoxin reductase...
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PMID: 18300227
PDF is available here.
PDF is available here.
FEBS Letters (582)18 2008
Abstract
We show that the Arabidopsis ntrc mutant is perturbed in chlorophyll biosynthesis and accumulate intermediates preceding protochlorophyllide formation. A specific involvement of NTRC during biosynthesis of protochlorophyllide is indicated from in vitro aerobic cyclase assays in which the conversion...
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PMID: 18625226
PDF is available here.
PDF is available here.
Molecular Microbiology (69)3 2008
Abstract
The Spx protein of Bacillus subtilis interacts with RNA polymerase (RNAP) to activate transcription initiation in response to thiol-oxidative stress. Protein-DNA cross-linking analysis of reactions containing RNAP, Spx and trxA (thioredoxin) or trxB (thioredoxin reductase) promoter DNA was undertake...
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PMID: 18687074
PDF is available here.
PDF is available here.