Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Diacylglycerol Kinase (0):
Recent article
Diacylglycerol Kinase
Diabetologia (53)8 2010
Abstract
We aimed to evaluate the impact of these variants on insulin release and insulin sensitivity estimated from OGTTs.
Eleven variants in or near DGKB/TMEM195, ADCY5, MADD, ADRA2A, FADS1, CRY2, SLC2A2, GLIS3, PROX1, C2CD4B and IGF1 were genotyped in 6,784 middle-aged participants of the...
|
PMID: 20419449
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Diabetologia (53)8 2010
Abstract
We aimed to evaluate the impact of these variants on insulin release and insulin sensitivity estimated from OGTTs.
Eleven variants in or near DGKB/TMEM195, ADCY5, MADD, ADRA2A, FADS1, CRY2, SLC2A2, GLIS3, PROX1, C2CD4B and IGF1 were genotyped in 6,784 middle-aged participants of the...
|
PMID: 20419449
PDF is available here.
PDF is available here.
Diabetologia (53)8 2010
Abstract
We aimed to evaluate the impact of these variants on insulin release and insulin sensitivity estimated from OGTTs.
Eleven variants in or near DGKB/TMEM195, ADCY5, MADD, ADRA2A, FADS1, CRY2, SLC2A2, GLIS3, PROX1, C2CD4B and IGF1 were genotyped in 6,784 middle-aged participants of the...
|
PMID: 20419449
PDF is available here.
PDF is available here.
Diabetologia (53)8 2010
Abstract
We aimed to evaluate the impact of these variants on insulin release and insulin sensitivity estimated from OGTTs.
Eleven variants in or near DGKB/TMEM195, ADCY5, MADD, ADRA2A, FADS1, CRY2, SLC2A2, GLIS3, PROX1, C2CD4B and IGF1 were genotyped in 6,784 middle-aged participants of the...
|
PMID: 20419449
PDF is available here.
PDF is available here.
Diabetologia (53)8 2010
Abstract
We aimed to evaluate the impact of these variants on insulin release and insulin sensitivity estimated from OGTTs.
Eleven variants in or near DGKB/TMEM195, ADCY5, MADD, ADRA2A, FADS1, CRY2, SLC2A2, GLIS3, PROX1, C2CD4B and IGF1 were genotyped in 6,784 middle-aged participants of the...
|
PMID: 20419449
PDF is available here.
PDF is available here.
Diabetologia (53)8 2010
Abstract
We aimed to evaluate the impact of these variants on insulin release and insulin sensitivity estimated from OGTTs.
Eleven variants in or near DGKB/TMEM195, ADCY5, MADD, ADRA2A, FADS1, CRY2, SLC2A2, GLIS3, PROX1, C2CD4B and IGF1 were genotyped in 6,784 middle-aged participants of the...
|
PMID: 20419449
PDF is available here.
PDF is available here.
Diabetologia (53)8 2010
Abstract
We aimed to evaluate the impact of these variants on insulin release and insulin sensitivity estimated from OGTTs.
Eleven variants in or near DGKB/TMEM195, ADCY5, MADD, ADRA2A, FADS1, CRY2, SLC2A2, GLIS3, PROX1, C2CD4B and IGF1 were genotyped in 6,784 middle-aged participants of the...
|
PMID: 20419449
PDF is available here.
PDF is available here.
Diabetologia (53)8 2010
Abstract
We aimed to evaluate the impact of these variants on insulin release and insulin sensitivity estimated from OGTTs.
Eleven variants in or near DGKB/TMEM195, ADCY5, MADD, ADRA2A, FADS1, CRY2, SLC2A2, GLIS3, PROX1, C2CD4B and IGF1 were genotyped in 6,784 middle-aged participants of the...
|
PMID: 20419449
PDF is available here.
PDF is available here.
Diabetologia (53)8 2010
Abstract
We aimed to evaluate the impact of these variants on insulin release and insulin sensitivity estimated from OGTTs.
Eleven variants in or near DGKB/TMEM195, ADCY5, MADD, ADRA2A, FADS1, CRY2, SLC2A2, GLIS3, PROX1, C2CD4B and IGF1 were genotyped in 6,784 middle-aged participants of the...
|
PMID: 20419449
PDF is available here.
PDF is available here.
Diabetologia (53)8 2010
Abstract
We aimed to evaluate the impact of these variants on insulin release and insulin sensitivity estimated from OGTTs.
Eleven variants in or near DGKB/TMEM195, ADCY5, MADD, ADRA2A, FADS1, CRY2, SLC2A2, GLIS3, PROX1, C2CD4B and IGF1 were genotyped in 6,784 middle-aged participants of the...
|
PMID: 20419449
PDF is available here.
PDF is available here.
Diabetologia (53)8 2010
Abstract
We aimed to evaluate the impact of these variants on insulin release and insulin sensitivity estimated from OGTTs.
Eleven variants in or near DGKB/TMEM195, ADCY5, MADD, ADRA2A, FADS1, CRY2, SLC2A2, GLIS3, PROX1, C2CD4B and IGF1 were genotyped in 6,784 middle-aged participants of the...
|
PMID: 20419449
PDF is available here.
PDF is available here.
Diabetologia (53)8 2010
Abstract
We aimed to evaluate the impact of these variants on insulin release and insulin sensitivity estimated from OGTTs.
Eleven variants in or near DGKB/TMEM195, ADCY5, MADD, ADRA2A, FADS1, CRY2, SLC2A2, GLIS3, PROX1, C2CD4B and IGF1 were genotyped in 6,784 middle-aged participants of the...
|
PMID: 20419449
PDF is available here.
PDF is available here.
Diabetologia (53)8 2010
Abstract
We aimed to evaluate the impact of these variants on insulin release and insulin sensitivity estimated from OGTTs.
Eleven variants in or near DGKB/TMEM195, ADCY5, MADD, ADRA2A, FADS1, CRY2, SLC2A2, GLIS3, PROX1, C2CD4B and IGF1 were genotyped in 6,784 middle-aged participants of the...
|
PMID: 20419449
PDF is available here.
PDF is available here.
Diabetologia (53)8 2010
Abstract
We aimed to evaluate the impact of these variants on insulin release and insulin sensitivity estimated from OGTTs.
Eleven variants in or near DGKB/TMEM195, ADCY5, MADD, ADRA2A, FADS1, CRY2, SLC2A2, GLIS3, PROX1, C2CD4B and IGF1 were genotyped in 6,784 middle-aged participants of the...
|
PMID: 20419449
PDF is available here.
PDF is available here.
Diabetologia (53)8 2010
Abstract
We aimed to evaluate the impact of these variants on insulin release and insulin sensitivity estimated from OGTTs.
Eleven variants in or near DGKB/TMEM195, ADCY5, MADD, ADRA2A, FADS1, CRY2, SLC2A2, GLIS3, PROX1, C2CD4B and IGF1 were genotyped in 6,784 middle-aged participants of the...
|
PMID: 20419449
PDF is available here.
PDF is available here.
Diabetologia (53)8 2010
Abstract
We aimed to evaluate the impact of these variants on insulin release and insulin sensitivity estimated from OGTTs.
Eleven variants in or near DGKB/TMEM195, ADCY5, MADD, ADRA2A, FADS1, CRY2, SLC2A2, GLIS3, PROX1, C2CD4B and IGF1 were genotyped in 6,784 middle-aged participants of the...
|
PMID: 20419449
PDF is available here.
PDF is available here.
Diabetologia (53)8 2010
Abstract
We aimed to evaluate the impact of these variants on insulin release and insulin sensitivity estimated from OGTTs.
Eleven variants in or near DGKB/TMEM195, ADCY5, MADD, ADRA2A, FADS1, CRY2, SLC2A2, GLIS3, PROX1, C2CD4B and IGF1 were genotyped in 6,784 middle-aged participants of the...
|
PMID: 20419449
PDF is available here.
PDF is available here.
Diabetologia (53)8 2010
Abstract
We aimed to evaluate the impact of these variants on insulin release and insulin sensitivity estimated from OGTTs.
Eleven variants in or near DGKB/TMEM195, ADCY5, MADD, ADRA2A, FADS1, CRY2, SLC2A2, GLIS3, PROX1, C2CD4B and IGF1 were genotyped in 6,784 middle-aged participants of the...
|
PMID: 20419449
PDF is available here.
PDF is available here.
Diabetologia (53)8 2010
Abstract
We aimed to evaluate the impact of these variants on insulin release and insulin sensitivity estimated from OGTTs.
Eleven variants in or near DGKB/TMEM195, ADCY5, MADD, ADRA2A, FADS1, CRY2, SLC2A2, GLIS3, PROX1, C2CD4B and IGF1 were genotyped in 6,784 middle-aged participants of the...
|
PMID: 20419449
PDF is available here.
PDF is available here.
Diabetologia (53)8 2010
Abstract
We aimed to evaluate the impact of these variants on insulin release and insulin sensitivity estimated from OGTTs.
Eleven variants in or near DGKB/TMEM195, ADCY5, MADD, ADRA2A, FADS1, CRY2, SLC2A2, GLIS3, PROX1, C2CD4B and IGF1 were genotyped in 6,784 middle-aged participants of the...
|
PMID: 20419449
PDF is available here.
PDF is available here.
Diabetologia (53)8 2010
Abstract
We aimed to evaluate the impact of these variants on insulin release and insulin sensitivity estimated from OGTTs.
Eleven variants in or near DGKB/TMEM195, ADCY5, MADD, ADRA2A, FADS1, CRY2, SLC2A2, GLIS3, PROX1, C2CD4B and IGF1 were genotyped in 6,784 middle-aged participants of the...
|
PMID: 20419449
PDF is available here.
PDF is available here.
Diabetologia (53)8 2010
Abstract
We aimed to evaluate the impact of these variants on insulin release and insulin sensitivity estimated from OGTTs.
Eleven variants in or near DGKB/TMEM195, ADCY5, MADD, ADRA2A, FADS1, CRY2, SLC2A2, GLIS3, PROX1, C2CD4B and IGF1 were genotyped in 6,784 middle-aged participants of the...
|
PMID: 20419449
PDF is available here.
PDF is available here.
Diabetologia (53)8 2010
Abstract
We aimed to evaluate the impact of these variants on insulin release and insulin sensitivity estimated from OGTTs.
Eleven variants in or near DGKB/TMEM195, ADCY5, MADD, ADRA2A, FADS1, CRY2, SLC2A2, GLIS3, PROX1, C2CD4B and IGF1 were genotyped in 6,784 middle-aged participants of the...
|
PMID: 20419449
PDF is available here.
PDF is available here.
Abstract
We observed that after IP or A2aR activation, a decrease in DGK activity was associated with the onset of hepatocyte tolerance to hypoxia. CGS21680-induced stimulation of A2aR specifically inhibited DGK isoform theta by activating RhoA-GTPase. Consistently, both siRNA-mediated downregulation of DGK...
|
PMID: 20057501
PDF is available here.
PDF is available here.
Abstract
Cell Calcium (45)6 2009
Abstract
The Drosophila TRPC channels TRP and TRPL are the founding members of the TRP superfamily of ion channels, which are important components of calcium influx pathways in virtually all cells. The activation of these channels in the context of fly phototransduction is one of the few in v...
|
PMID: 19362736
PDF is available here.
PDF is available here.
Cell Calcium (45)6 2009
Abstract
The Drosophila TRPC channels TRP and TRPL are the founding members of the TRP superfamily of ion channels, which are important components of calcium influx pathways in virtually all cells. The activation of these channels in the context of fly phototransduction is one of the few in v...
|
PMID: 19362736
PDF is available here.
PDF is available here.
Cell Calcium (45)6 2009
Abstract
The Drosophila TRPC channels TRP and TRPL are the founding members of the TRP superfamily of ion channels, which are important components of calcium influx pathways in virtually all cells. The activation of these channels in the context of fly phototransduction is one of the few in v...
|
PMID: 19362736
PDF is available here.
PDF is available here.
Cell Calcium (45)6 2009
Abstract
The Drosophila TRPC channels TRP and TRPL are the founding members of the TRP superfamily of ion channels, which are important components of calcium influx pathways in virtually all cells. The activation of these channels in the context of fly phototransduction is one of the few in v...
|
PMID: 19362736
PDF is available here.
PDF is available here.
Cell Calcium (45)6 2009
Abstract
The Drosophila TRPC channels TRP and TRPL are the founding members of the TRP superfamily of ion channels, which are important components of calcium influx pathways in virtually all cells. The activation of these channels in the context of fly phototransduction is one of the few in v...
|
PMID: 19362736
PDF is available here.
PDF is available here.
Cell Calcium (45)6 2009
Abstract
The Drosophila TRPC channels TRP and TRPL are the founding members of the TRP superfamily of ion channels, which are important components of calcium influx pathways in virtually all cells. The activation of these channels in the context of fly phototransduction is one of the few in v...
|
PMID: 19362736
PDF is available here.
PDF is available here.
Cell Calcium (45)6 2009
Abstract
The Drosophila TRPC channels TRP and TRPL are the founding members of the TRP superfamily of ion channels, which are important components of calcium influx pathways in virtually all cells. The activation of these channels in the context of fly phototransduction is one of the few in v...
|
PMID: 19362736
PDF is available here.
PDF is available here.
Cell Calcium (45)6 2009
Abstract
The Drosophila TRPC channels TRP and TRPL are the founding members of the TRP superfamily of ion channels, which are important components of calcium influx pathways in virtually all cells. The activation of these channels in the context of fly phototransduction is one of the few in v...
|
PMID: 19362736
PDF is available here.
PDF is available here.
Cellular Signalling (21)5 2009
Abstract
We demonstrated that nuclear DGK-zeta downregulated the expression of cyclin D1 and increased the expression of TIS21/BTG2/PC3, a transcriptional regulator of cyclin D1 with a strong anti-proliferative function. Overexpression of TIS21/BTG2/PC3 blocked the cells in G1 phase of the cell cycle and dec...
|
PMID: 19709620
PDF is available here.
PDF is available here.
Abstract
Abstract
We show that DGKzeta is targeted to excitatory synapses through its direct interaction with the postsynaptic PDZ scaffold PSD-95. Overexpression of DGKzeta in cultured neurons increases the number of dendritic spines, which receive the majority of excitatory synaptic inputs, in a manner requiring it...
|
PMID: 19229292
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1791)4 2009
Abstract
We screened a yeast two-hybrid cDNA library from HepG2 cells using aa 896-1097 of DGKdelta as a bait. We identified aa 184-317 (WD40 repeats 5-7) of receptor for activated C kinase 1 (RACK1), which interacts with various important signaling molecules, as a novel binding partner of DGKdelta. Co-immun...
|
PMID: 19416640
PDF is available here.
PDF is available here.
Human Genetics (124)6 2009
Abstract
We have performed the first genomewide association study (GWAS) in familial PD. Genotyping was performed with the Illumina HumanCNV370Duo array in 857 familial PD cases and 867 controls. A logistic model was employed to test for association under additive and recessive modes of inheritance after adj...
|
PMID: 18985386
PDF is available here.
PDF is available here.
Abstract
We investigated the cellular expression and subcellular localization of DGKbeta in the striatum of rat brain. DGKbeta was expressed in medium spiny neurons constituting the striatonigral and striatopallidal pathways, whereas striatal interneurons were below the detection threshold. DGKbeta was distr...
|
PMID: 19087171
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)43 2008
Abstract
We found that ADP-induced phosphorylation of pleckstrin, the main platelet substrate for PKC, was completely inhibited not only by an antagonist of the G(q)-coupled P2Y1 receptor but also upon blockade of the G(i)-coupled P2Y12 receptor. The role of G(i) on PKC regulation required stimulation of pho...
|
PMID: 18755689
PDF is available here.
PDF is available here.
Abstract
We recently demonstrated that protein kinase D (PKD) exerts a protective function during oxidative stress-induced intestinal epithelial cell injury; however, the exact role of DAG kinase (DGK)zeta, an isoform expressed in intestine, during this process is unknown. We sought to determine the role of...
|
PMID: 18694729
PDF is available here.
PDF is available here.
Molecules and Cells (26)3 2008
Abstract
These results suggest that OsBIDK1 may play a role in disease resistance responses....
|
PMID: 18679055
PDF is available here.
PDF is available here.
Biochemistry (Washington) (47)36 2008
Abstract
Lipid species changes for SV40-transformed fibroblasts from wild-type or from diacylglycerol kinase-epsilon (DGKepsilon) or diacylglycerol kinase-alpha (DGKalpha) knockout mice were determined for glycerophospholipids, polyphosphatidylinositides (GPInsP n ) and diacylglycerol (DAG) using direct infu...
|
PMID: 18702510
PDF is available here.
PDF is available here.
Abstract
We report here that DGK alpha and zeta synergistically promote T cell maturation in the thymus. Absence of both DGKalpha and zeta (DGKalpha(-/-)zeta(-/-)) results in a severe decrease in the number of CD4(+)CD8(-) and CD4(-)CD8(+) single-positive thymocytes correlating with increased DAG-mediated si...
|
PMID: 18689679
PDF is available here.
PDF is available here.
Immunological Reviews (224) 2008
Abstract
Both diacylglycerol (DAG) and phosphatidic acid (PA) are important second messengers involved in signal transduction from many immune cell receptors and can be generated and metabolized through multiple mechanisms. Recent studies indicate that diacylglycerol kinases (DGKs), the enzymes that catalyze...
|
PMID: 18759932
PDF is available here.
PDF is available here.
Current Drug Targets (9)8 2008
Abstract
Diacylglycerol (DAG) kinase (DGK) modulates the balance between the two signaling lipids, DAG and phosphatidic acid (PA), by phosphorylating (consuming) DAG to yield PA. Ten mammalian DGK isozymes have been identified to date. In addition to two or three cysteine-rich C1 domains (protein kinase C-li...
|
PMID: 18691010
PDF is available here.
PDF is available here.
Current Drug Targets (9)8 2008
Abstract
Our understanding of the diacylglycerol signaling pathways provides great confidence in the utility of intervention in these pathways for treatment of cancer and other conditions. Multiple compounds directed at these signaling proteins, including compounds directed at the C1 domains, are currently i...
|
PMID: 18691011
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)29 2008
Abstract
The Saccharomyces cerevisiae DGK1 gene encodes a diacylglycerol kinase enzyme that catalyzes the formation of phosphatidate from diacylglycerol. Unlike the diacylglycerol kinases from bacteria, plants, and animals, the yeast enzyme utilizes CTP, instead of ATP, as the phosphate donor in the reaction...
|
PMID: 18458076
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)29 2008
Abstract
We have shown previously that the activity of the conserved phosphatidate phosphatase Pah1p/Smp2p regulates nuclear structure in yeast by controlling phospholipid synthesis and membrane biogenesis at the nuclear envelope. Two screens for novel regulators of phosphatidate led to the identification of...
|
PMID: 18458075
PDF is available here.
PDF is available here.
Journal of Molecular Biology (380)3 2008
Abstract
We find a significant effect of phosphatidylglycerol (PG) on the folding of a trimeric alpha helical membrane protein from Escherichia coli diacylglycerol kinase. Both the rate and the yield of folding are increased by increasing the amount of PG in lipid vesicles. Moreover, there is a direct correl...
|
PMID: 18565344
PDF is available here.
PDF is available here.
Abstract
We examined whether DGKepsilon prevents cardiac hypertrophy and progression to heart failure under chronic pressure overload. We generated transgenic mice with cardiac-specific overexpression of DGKepsilon (DGKepsilon-TG) using an alpha-myosin heavy chain promoter. There were no differences in cardi...
|
PMID: 18487437
PDF is available here.
PDF is available here.
Abstract
We report the structure of a DAG kinase, DgkB from Staphylococcus aureus, both as the free enzyme and in complex with ADP. The molecule is a tight homodimer, and each monomer comprises two domains with the catalytic center located within the interdomain cleft. Two distinctive features of DkgB are a...
|
PMID: 18611377
PDF is available here.
PDF is available here.
FEBS Letters (582)12 2008
Abstract
We show that two DGKs from cluster I in Arabidopsis thaliana possess amino-terminal hydrophobic segments that are sufficient to address them to endoplasmic reticulum membranes....
|
PMID: 18466768
PDF is available here.
PDF is available here.
Journal of Immunology (180)9 2008
Abstract
We show that DGKalpha is tyrosine phosphorylated, and identify tyrosine 335 (Y335), at the hinge between the atypical C1 domains and the catalytic region, as essential for membrane localization. Generation of an Ab that recognizes phosphorylated Y335 demonstrates Lck-dependent phosphorylation of end...
|
PMID: 18424699
PDF is available here.
PDF is available here.
Abstract
We describe the evaluation of three potential undecaprenol kinases as agents for the chemoenzymatic synthesis of polyprenyl phosphates. Target enzymes were expressed in crude cell envelope fractions and quantified via the use of luminescent lanthanide-binding tags (LBTs). The Streptococcus mutans di...
|
PMID: 18374576
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)18 2008
Abstract
We show that mutations in the Drosophila gene for G(q)alpha (dgq) significantly reduce both the amplitude of the field potentials recorded from the whole antenna in responses to odorants as well as the frequency of evoked responses of individual sensory neurons. This requirement for G(q)alpha is for...
|
PMID: 18448651
PDF is available here.
PDF is available here.
Abstract
Diacylglycerol kinase (DGK) metabolizes diacylglycerol (DG), a glycerolipid containing two acyl chains, to convert phosphatidic acid. DG is produced through phosphoinositide turnover within the membrane and is well known to act as a second messenger that modulates the activity of protein kinase C in...
|
PMID: 18323690
PDF is available here.
PDF is available here.
Abstract
Endothelin-1 (ET-1) is released in various cardiovascular disorders including congestive heart failure, and may modulate significantly the disease process by its potent action on vascular and cardiac muscle cell function and gene regulation. In adult mouse ventricular cardiomyocytes loaded with indo...
|
PMID: 18275971
PDF is available here.
PDF is available here.
Abstract
We show that DGK delta SAM forms a polymer and map the polymeric interface by a genetic selection for soluble mutants. A crystal structure reveals that DGKSAM forms helical polymers through a head-to-tail interaction similar to other SAM domain polymers. Disrupting polymerization by polymer interfac...
|
PMID: 18334213
PDF is available here.
PDF is available here.
Abstract
We identified reduced diacylglycerol kinase delta (DGKdelta) expression and DGK activity in skeletal muscle from type 2 diabetic patients. In diabetic animals, reduced DGKdelta protein and DGK kinase activity were restored upon correction of glycemia. DGKdelta haploinsufficiency increased diacylglyc...
|
PMID: 18267070
PDF is available here.
PDF is available here.