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Microspheres (0):
Recent article
Microspheres
Abstract
Hereditary hemorrhagic telangiectasia (HHT) is a rare systemic fibrovascular dysplasia also known as Rendu-Osler-Weber disease. Epistaxis is often the first and foremost symptom of the disease and recurrent epistaxis is the main complaint.
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PMID: 21816895
PDF is available here.
PDF is available here.
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Abstract
We report on the use of 3,4,9,10-perylenetetracarboxylic diimide microfibers (PDIMs) as an effective fluorescent sensing platform for DNA detection for the first time. This sensing system exhibits a detection limit as low as 15 nmol L(-1) and has a high selectivity down to single-base mismatch. The...
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PMID: 21819867
PDF is available here.
PDF is available here.
Abstract
Proteomics (11)16 2011
Abstract
We investigated the ability of this platform to discriminate between the "sputome" of patients with asthma and chronic obstructive pulmonary disease, and between these groups and those of healthy control subjects. Six m/z peaks emerged as potential diagnostic peptidic patterns able to differentiate...
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PMID: 21751363
PDF is available here.
PDF is available here.
Abstract
We investigated the delivery of vascular endothelial growth factor (VEGF) and the effect on in vitro cultured human umbilical vein endothelial cells (HUVECs), in an attempt to provide experimental basis for promoting the vascularization of tissue-engineered bone grafts. A mechanical stimulator was d...
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PMID: 21341993
PDF is available here.
PDF is available here.
Abstract
We designed a strategy to improve the efficiency of cell adhesion using hydrophobic cell culture environment to enhance cells adhering to a scaffold. Cells have lower affinity to the surface of polydimethylsiloxane (PDMS) than tissue culture polystyrene (TCPS) plates. When cells were cultured with g...
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PMID: 21504053
PDF is available here.
PDF is available here.
Abstract
Nonunion is a common complication in open fractures and other severe bone injuries. Recombinant human bone morphogenetic protein-2 (rhBMP-2) delivered on a collagen sponge enhances healing of fractures. However, the burst release of rhBMP-2 necessitates supra-physiological doses of r...
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PMID: 21338268
PDF is available here.
PDF is available here.
Abstract
Abstract
Our present findings, coupled with earlier work with the three-dimensional small intestinal INT407 model, demonstrate the utility of 3-D cell culture methods to develop infectivity assays for enteric viruses that do not readily infect mammalian cell cultures....
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PMID: 21942189
PDF is available here.
PDF is available here.
Abstract
We used the selective PDGF-B-blocking oligonucleotide aptamer AX102 to determine whether disruption of pericyte-endothelial crosstalk alters vascular leakiness or remodeling in the airways of mice under four different conditions: i) baseline, ii) acute inflammation induced by bradykinin, iii) sustai...
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PMID: 21550017
PDF is available here.
PDF is available here.
Abstract
The ultimate goal of quantitative ultrasound (QUS) imaging methods based on backscatter coefficient (BSC) estimates is to obtain system-independent structural information about samples. In the current study, three BSC estimation methods were compared and evaluated using the same backscattered pressur...
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PMID: 21568393
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
We describe the laboratory implementation of Infinium whole genome genotyping (WGG) technology for whole genome association studies and copy number studies. Briefly, the Infinium WGG assay employs a single tube whole genome amplification reaction to amplify the entire genome; genomic loci of interes...
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PMID: 19381978
PDF is available here.
PDF is available here.
Abstract
: To examine the efficacy and safety of an intravitreal cell-based production of glucagon-like peptide-1 (GLP-1) by intravitreally implanted and encapsulated cells.
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PMID: 21836406
PDF is available here.
PDF is available here.
Abstract
The need for bone tissue engineering has increased as the world population ages. The objectives of this study were to (1) develop a novel human umbilical cord mesenchymal stem cell (hUCMSC)-encapsulating, fiber-reinforced injectable calcium phosphate cement (CPCF) scaffold, and (2) i...
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PMID: 21091340
PDF is available here.
PDF is available here.
Abstract
The objective of the present investigation was to prepare mucoadhesive microspheres of ketorolac for nasal administration by means of a solvent evaporation technique using carbopol (CP), polycarbophil (PL) and chitosan (CS) as mucoadhesive polymers. The prepared microspheres were cha...
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PMID: 21612151
PDF is available here.
PDF is available here.
Vojnosanitetski pregled (68)4 2011
Abstract
Selective intraarterial radionuclide therapy (SIRT) with Yttrium-90 (Y-90) microspheres is also known as radioembolization and delivers high doses of radiation to hepatic tumors with minimum healthy liver exposure. The aim of this study was to present our preliminary experience in the role of liver d...
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PMID: 21627019
PDF is available here.
PDF is available here.
Abstract
Hydroxyapatite and hybrid gelatine/hydroxyapatite microspheres were obtained through a water in oil emulsion of a calcium phosphate cement (CPC). The setting reaction of the CPC, in this case the hydrolysis of α-tricalcium phosphate, was responsible for the consolidation of the micr...
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PMID: 21290594
PDF is available here.
PDF is available here.
Abstract
We use a near-infrared (NIR) light responsive polymer-nanorod composite whose glass transition temperature (T(g)) is in the range of body temperature to control and enhance the release of a small-molecule drug (<800 Da). In addition to increased temperature and resulting changes in molecule diffusio...
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PMID: 21384864
PDF is available here.
PDF is available here.
Biofabrication (3)1 2011
Abstract
Biomaterials for scaffolds and scaffold fabrication techniques are two key elements in scaffold-based tissue engineering. Nanocomposites that consist of biodegradable polymers and osteoconductive bioceramic nanoparticles and advanced scaffold manufacturing techniques, such as rapid p...
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PMID: 21245522
PDF is available here.
PDF is available here.
Abstract
Abstract
We evaluated effects of rotating bioreactor culture on the extracellular matrix production and proliferation of human annulus fibrosus (AF) cells. AF cells were embedded into alginate beads, and then cultured up to 3 weeks in a rotating wall vessel bioreactor or a static vessel. By real-time RT-PCR,...
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PMID: 21303231
PDF is available here.
PDF is available here.
Abstract
We measured Brownian displacements of microspheres exposed to light of varying intensities and wavelengths. Displacements were consistently diminished in an intensity-dependent and wavelength-dependent fashion, and center-to-center distances between microspheres were shifted to higher values. We con...
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PMID: 21287689
PDF is available here.
PDF is available here.
Abstract
We show that a short 15-60 min predigestion with a protease such as LysC (modified on-bead digest termed protease elution) increases the elution efficiency 2- to 3-fold compared to standard acid elution protocols. While longer incubation periods-as performed in standard on-bead digestion-led to part...
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PMID: 21043528
PDF is available here.
PDF is available here.
Abstract
Human placenta-derived mesenchymal stem cells (hPMSCs) represent a promising source of stem cells. The application of hPMSCs in cartilage tissue engineering, however, was less reported. In this study, hPMSCs were grown in a three-dimensional (3D) environment for cartilage tissue form...
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PMID: 21284540
PDF is available here.
PDF is available here.
Abstract
We report on novel cross-validating optoacoustic methods for measuring the frequency response of wideband acoustic sensors. The approach developed does not require pre-calibrated hydrophones and therefore can be readily adopted in any existing optoacoustic measurement configuration. The methods are...
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PMID: 21342817
PDF is available here.
PDF is available here.
Abstract
Poly(lactide-co-glycolide) (PLGA) beads have been widely studied as a potential drug/protein carrier. The main shortcomings of PLGA beads are that they lack bioactivity and controllable drug-delivery ability, and their acidic degradation by-products can lead to pH decrease in the vic...
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PMID: 21210517
PDF is available here.
PDF is available here.
Abstract
To study the effect of circulating cell-free oxyhemoglobin (FHb) on intestinal microcirculation and intestinal epithelial injury in a rat model.
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PMID: 21245994
PDF is available here.
PDF is available here.
Abstract
The objective of this study was to prepare gliclazide-chitosan microparticles with tripolyphosphate by ionic crosslinking.
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PMID: 21235580
PDF is available here.
PDF is available here.
Hämostaseologie (31)2 2011
Abstract
Comparability of instruments was excellent (r = 0.98). Coefficients of variation of total imprecision measurements ranged from 2.2 to 3.4%. Linearity was excellent over the range tested (12-121% FXIII). Analytical sensitivity was 0.51% FXIII on BCS XP and 0.44% FXIII on Sysmex CA-1500, respectively....
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PMID: 21246161
PDF is available here.
PDF is available here.
Abstract
We show that the yield, rate, and robustness of prion conversion and the sensitivity of prion detection are significantly improved by a simple modification of the PMCA format. Conducting PMCA reactions in the presence of Teflon beads (PMCAb) increased the conversion of PrP(C) into PrP(Sc) from ∼10...
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PMID: 21347353
PDF is available here.
PDF is available here.
Abstract
We present the first stage of development of an assay incorporating cadmium selenide quantum dots (QDs) for the detection of mycobacterial surface antigens. The principle of the assay is the separation of bacterial cells using magnetic beads coupled with genus-specific polyclonal antibodies and mono...
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PMID: 21637746
PDF is available here.
PDF is available here.
Abstract
The objective of present investigation was to evaluate the entrapment efficiency of the anti-HIV drug, zidovudine, using two Eudragit polymers of different permeability characteristics and to study the effect of this entrapment on the drug release properties. In order to increase the entrapment effic...
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PMID: 21648196
PDF is available here.
PDF is available here.
Abstract
The objective of this work was to develop and evaluate reconstitutable suspensions of ibuprofen-loaded microspheres prepared with an acrylic polymer (Eudragit RS-PM). The microspheres were prepared by the quasi-emulsion solvent diffusion technique. To prepare reconstitutable suspension formulation, t...
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PMID: 21796942
PDF is available here.
PDF is available here.
Abstract
The study of macromolecular structure has become critical to the elucidation of molecular mechanisms and function. There are several limited, but important bioinstruments capable of testing the force dependence of structural features in proteins. Scale has been a limiting parameter o...
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PMID: 21445050
PDF is available here.
PDF is available here.
Abstract
We have developed a high throughput screening test for assessing enzymatic resistance of the HIV-1 RT in plasma to 3TC/FTC and NNRTIs. The test uses the sensitive "Amp-RT" assay with a newly-developed real-time PCR format to screen biochemically for drug resistance in single reactions containing eit...
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PMID: 21799767
PDF is available here.
PDF is available here.
Abstract
Serum cystatin B (CSTB) concentrations have been reported to be increased in patients with hepatocellular carcinoma compared to concentrations seen in normal subjects. In this study, we developed a "fluorescent microsphere immunoassay" (FMI) capable of specifically detecting CSTB in serum.
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PMID: 20961191
PDF is available here.
PDF is available here.
Abstract
We have identified a probiotic bacteria-derived soluble protein, p40, from Lactobacillus rhamnosus GG (LGG), which prevents cytokine-induced apoptosis in intestinal epithelial cells. In the current study, we analyzed the mechanisms by which p40 regulates cellular responses in intestinal epithelial c...
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PMID: 21606592
PDF is available here.
PDF is available here.
Abstract
Mouse embryonic stem cells (mESCs) were first derived and cultured almost 30 years ago and ever since have been valuable tools for creating knockout mice and for studying early mammalian development. More recently (1998), human embryonic stem cells (hESCs) have been derived from blastocysts, and num...
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PMID: 21042983
PDF is available here.
PDF is available here.
Abstract
A large-scale stirred culture system for the expansion of mouse embryonic stem cells (mESCs) in spinner flasks under serum-free conditions was established using macroporous microcarriers for cell attachment and growth. This type of microcarrier was chosen as it potentially offers more protection to...
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PMID: 21042989
PDF is available here.
PDF is available here.
Abstract
We have shown that several techniques for measurement or illustration of immune responses in a hematopoietic murine CD4(k/o) mice transplantation model might be beneficial to get new insight into in vivo behavior of transplanted stem cells. Subjected to the transplantation setups (allogeneic, syngen...
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PMID: 21043002
PDF is available here.
PDF is available here.
Abstract
The preparation and characterization of heparin-immobilized microspheres which were used to bind acidic fibroblast growth factor (aFGF), vascular endothelial growth factor (VEGF), monocyte chemoattractant protein 1 (MCP-1/CCL2), and regulation upon activation normal T cell express se...
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PMID: 20827464
PDF is available here.
PDF is available here.
Acta Biomaterialia (7)1 2011
Abstract
We have utilized atomic force microscopy to characterize the microelastic properties of decellularized cell-derived matrix from human pulmonary fibroblasts. This heterogeneous three-dimensional matrix had an average thickness of 5 ± 0.4 μm and a Young's modulus of 105 ± 14 Pa. Ascorbate treatment...
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PMID: 20656080
PDF is available here.
PDF is available here.
Acta Biomaterialia (7)1 2011
Abstract
Macroporous hydrogels may have direct applications in regenerative medicine as scaffolds to support tissue formation. Hydrogel microspheres may be used as drug-delivery vehicles or as building blocks to assemble modular scaffolds. A variety of techniques exist to produce macroporous...
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PMID: 20659596
PDF is available here.
PDF is available here.
Genipin-crosslinked microcarriers mediating hepatocellular aggregates formation and functionalities.
Abstract
We culture human liver carcinoma cell line (HepG2) cells on genipin-crosslinked gelatin microspheres of two different sizes. Results suggest that both microcarriers support cell adhesion, proliferation, and spontaneous formation of hepatocellular aggregates, among which the spheres with bigger size...
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PMID: 21105169
PDF is available here.
PDF is available here.
Abstract
Development of micro technologies based approach for express diagnostics of toxigenic C. diphtheriae strains.
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PMID: 21598618
PDF is available here.
PDF is available here.
British Journal of Radiology (83)989 2010
Abstract
We concluded that in our rabbit model of liver tumours the combination of cisplatin-eluting GMSs and flavopiridol was effective....
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PMID: 20019172
PDF is available here.
PDF is available here.
Abstract
We present the focused development of a novel structure that combines the biomimetic properties of nanofibers with the robust mechanical aspects of the sintered microsphere scaffold to produce a composite scaffold that demonstrates an ability to mimic the mechanical environment of trabecular bone wh...
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PMID: 20878987
PDF is available here.
PDF is available here.
Lab On a Chip (10)23 2010
Abstract
Low frequency alternating current insulator-based dielectrophoresis is a novel technique that allows for highly controlled manipulation of particles. By varying the shape of an AC voltage applied across a microchannel containing an array of insulating cylindrical structures it was possible to concen...
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PMID: 20936247
PDF is available here.
PDF is available here.
Lab On a Chip (10)22 2010
Abstract
Our approach yields a detection limit of 800 cells mL(-1), one of the highest-sensitivity immunosensors to date....
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PMID: 20862443
PDF is available here.
PDF is available here.
Lab On a Chip (10)22 2010
Abstract
A compact microfluidic device with 96 microchambers allocated within four circular units was designed and examined for cell distribution. In each unit, cells were distributed to the surrounding chambers radially from the center. The circular arrangement of the chambers makes the design simple and co...
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PMID: 20871882
PDF is available here.
PDF is available here.
Lab On a Chip (10)22 2010
Abstract
We have demonstrated that 0.4 and 1 μm beads conjugated with antibodies can be rapidly assembled into the microwells by applying a pulsed electric field across the chamber. By assembling step-wise a mixture of fluorescently labeled antibody-conjugated microbeads, we incorporated both spatial and fl...
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PMID: 20820631
PDF is available here.
PDF is available here.
Abstract
Well uniform microspheres of phase pure Covellite were synthesized through a simple hydrothermal approach using poly vinyl pyrrolidone (PVP) as surfactant. The micro-spheres were constituted of numerous self-organized knitted nano-ribbons of ∼ 30 nm thickness. The effect of conc. PVP in the hydrot...
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PMID: 20830395
PDF is available here.
PDF is available here.
Macromolecular Bioscience (10)11 2010
Abstract
We focus on biomaterial scaffolds designed to mediate the development and maturation of vascular networks, by immobilized growth factors. The interactive effects of multiple vasculogenic factors are discussed in the context of cardiac tissue engineering....
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PMID: 20857391
PDF is available here.
PDF is available here.
Drug Delivery (17)8 2010
Abstract
Proteins and peptides are complex macromolecules that are prone to change in their native structure during storage, which causes undesired side-effects after their administration. During past decades, bioactive carriers have played an important role in stabilization of proteins. Incorporation of the...
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PMID: 20879837
PDF is available here.
PDF is available here.
Abstract
Autologous fat is the ideal soft-tissue filler; however, its widespread application is limited because of variable clinical results and poor survival. Engineered fillers have the potential to maximize survival. Alginate is a hydrogel copolymer that can be engineered into spheres of <200 μm, thus fa...
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PMID: 20842001
PDF is available here.
PDF is available here.
Proteomics (10)22 2010
Abstract
We attempt to summarize the most recent advancements in the proteomic study of microbial phagosomes, especially those originating from mouse or human cells. We also briefly describe the proteomics of latex bead-containing phagosomes because they are often used as model phagosomes for study. We provi...
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PMID: 21080496
PDF is available here.
PDF is available here.
Abstract
We present dynamic saturation optical microscopy (DSOM)--a new technique that monitors the temporal decay of the excited singlet state due to a dark state formation. By mapping the intensity dependent decay kinetics, enhanced resolution images can be obtained. Generally, any dark state of fluorescen...
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PMID: 20721375
PDF is available here.
PDF is available here.
Abstract
We synthesized a fluorescent monomer composed of glucose-recognition sites, a fluorogenic site, spacers, and polymerization sites. The spacers are designed to be long and hydrophilic for increasing opportunities to bind glucose molecules; consequently, the fluorescent monomers enable high-intensive...
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PMID: 20921374
PDF is available here.
PDF is available here.
Abstract
Anti-TNF-α antibody encapsulated into highly porous microspheres was released in a controlled manner and exhibited biological activity against TNF-α. The technique used to produce TIPS microspheres is rapid and provides high encapsulation efficiency. This technique could also be applied to other t...
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PMID: 19886803
PDF is available here.
PDF is available here.
Abstract
We have developed an immunomicroarray for systematic studies of the binding properties of 10 different micro-/nano-sized streptavidin-functionalized beads to a biotin substrate immobilized on SiO(2) with or without surface modification. SiO(2) surface cleaning, immobilized substrate concentration an...
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PMID: 20417734
PDF is available here.
PDF is available here.