Abstract
Mono-dispersed SiO(2)-CaO bioactive glass nanospheres (BGNS) were prepared by a two step sol-gel method in the absence of surfactant. The size of BGNS ranged from 200 to 350 nm in diameter and exhibited a rough surface texture. In vitro biomineralization tests showed that BGNS could...
|
PMID: 20725980
PDF is available here.
Abstract
Hollow protein nanospheres are prepared in aqueous solution by molecular self-assembly, and they show extraordinary capability to penetrate cell barriers in an energy-independent fashion.
|
PMID: 20848035
PDF is available here.
Abstract
Aqueous dispersions of fluorescent semiconducting polymer nanospheres (SPNs) have been synthesised by two methods; miniemulsion and micellar encapsulation. The colloidal and optical stability of SPNs synthesised by these two methods has been compared in order to assess the potential of these fluores...
|
PMID: 20585697
PDF is available here.
Abstract
Chirally functionalized hollow nanospheres with different surface properties were successfully synthesized by co-condensation of (2S,1'R,2'R)-N-tert-butyloxycarbonylpyrrolidine-2-carboxylic acid [2'-(4-trimethoxysilylbenzylamide)cyclohexyl] amide with 1,2-bis(trimethoxysilyl)ethane o...
|
PMID: 20509127
PDF is available here.
Abstract
Chirally functionalized hollow nanospheres with different surface properties were successfully synthesized by co-condensation of (2S,1'R,2'R)-N-tert-butyloxycarbonylpyrrolidine-2-carboxylic acid [2'-(4-trimethoxysilylbenzylamide)cyclohexyl] amide with 1,2-bis(trimethoxysilyl)ethane o...
|
PMID: 20509127
PDF is available here.
Abstract
We have fabricated opal photonic crystal structure, which is assembled from quantum dots-conjugated polystyrene spheres. We found that the quantum dots (QD) emission from QD-conjugated photonic crystal (PC) structure experienced not only shifting to shorter wavelength, but also an asymmetrical broad...
|
PMID: 20453286
PDF is available here.
Abstract
A pH-sensitive molecularly imprinted polymer (MIP) nanospheres/hydrogel composite exhibiting controlled release of dexamethasone-21 phosphate disodium (DXP) was developed as a potential coating for implantable biosensors to improve their biocompatibility. The molecularly imprinted pH-sensitive nanos...
|
PMID: 20346500
PDF is available here.
Abstract
We report a mechanistic study on a novel nanobelt structure that overcomes the drawback of sphere-shaped nanoparticles. Single-crystalline anatase TiO(2) nanobelts with two dominant surfaces of (101) facet exhibit enhanced photocatalytic activity over the nanosphere counterparts with an identical cr...
|
PMID: 20420405
PDF is available here.
Abstract
In this study, a facile and controllable synthetic route for the fabrication of mushroom nanostructures (Fe(x)O(y)@PSD-SiO(2)) and their hollow derivatives has been established. The synthesis consists of partial coating of Fe(x)O(y) (Fe(3)O(4) or Fe(2)O(3)) with polymer spheres, followed by attachin...
|
PMID: 20420374
PDF is available here.
Abstract
We investigate the thermodynamics of complexation of functionalized charged nanospheres with viral proteins. The physics of this problem is governed not only by electrostatic interaction between the proteins and the nanosphere cores (screened by salt ions), but also by configurational degrees of fre...
|
PMID: 20866273
PDF is available here.
Abstract
We report near-IR (NIR) light-inducible NF-kappaB downregulation through folate receptor-targeted hollow gold nanospheres carrying siRNA recognizing NF-kappaB p65 subunit. Using micro-positron emission tomography/computed tomography imaging, the targeted nanoconstructs exhibited significantly higher...
|
PMID: 20388791
PDF is available here.
Abstract
Different lanthanide chelates have been simultaneously embedded in a silica matrix yielding bright dual-mode lanthanide doped nanospheres which are uniform in size distribution, tunable, photostable, and leakage free. Depending on the chelate combination, two color emission with a single light sourc...
|
PMID: 20449329
PDF is available here.
Abstract
We report the use of a phosphatase to catalyze the formation of nanospheres from a hydrophobic compound (Ada-GFFY-OMe, 2) via a unique mechanism. The nanospheres were stable in aqueous solutions for two weeks. Their size could be controlled by both concentrations of the precursor (Ada-GFFY(p)-OMe, 1...
|
PMID: 20299724
PDF is available here.
Abstract
A novel electrochemical immunosensor for sensitive detection of cancer biomarker alpha-fetoprotein (AFP) is described that uses a graphene sheet sensor platform and functionalized carbon nanospheres (CNSs) labeled with horseradish peroxidase-secondary antibodies (HRP-Ab2). Greatly enhanced sensitivi...
|
PMID: 20201502
PDF is available here.
Abstract
Uniform, monodisperse calcium phosphate nanospheres (40 nm) were prepared using a simple co-precipitation method via the segregation crystallization imposed by hyaluronan molecules. The nanospheres exhibit excellent colloidal/storage stability in water due to the incorporated extracellular substance...
|
PMID: 20449276
PDF is available here.
Abstract
We demonstrate that photoselective bleaching creates beads with highly polarized fluorescence. First, the beads were immobilized in a PVA polymer. Second, the beads-doped PVA film was exposed to the illumination within the dye absorption band. A progressive decrease of absorption was observed. Next,...
|
PMID: 20389440
PDF is available here.
Abstract
Esterification of xylan with ibuprofen via activiation of the carboxylic acid with N,N'-carbonyldiimidazole (CDI) yields products of high drug loadings. Subsequent sulfation of xylan ibuprofen esters using the gentle agent SO(3)/DMF was successfully carried out in order to modify hyd...
|
PMID: 19904721
PDF is available here.
Abstract
Esterification of xylan with ibuprofen via activiation of the carboxylic acid with N,N'-carbonyldiimidazole (CDI) yields products of high drug loadings. Subsequent sulfation of xylan ibuprofen esters using the gentle agent SO(3)/DMF was successfully carried out in order to modify hyd...
|
PMID: 19904721
PDF is available here.
Abstract
Esterification of xylan with ibuprofen via activiation of the carboxylic acid with N,N'-carbonyldiimidazole (CDI) yields products of high drug loadings. Subsequent sulfation of xylan ibuprofen esters using the gentle agent SO(3)/DMF was successfully carried out in order to modify hyd...
|
PMID: 19904721
PDF is available here.
Abstract
We evaluated the effect of doxorubicin-conjugated single walled carbon nanotubes (CNT-Dox) and doxorubicin-conjugated spherical polyhydroxylated fullerenes or fullerenols (Ful-Dox) on angiogenesis. We report that CNTs exert a pro-angiogenic effect in vitro and in vivo. In contrast, the fullerenols o...
|
PMID: 20043662
PDF is available here.
Abstract
Biodegradable polymer particles present a promising approach for intracellular delivery of drugs, proteins, and nucleic acids. Poly-d,l-lactide-poly(ethylene glycol) (PELA) copolymers with different weight ratios of polyethylene glycol (PEG) were used as drug carriers in the present study. PELA part...
|
PMID: 20957117
PDF is available here.
Abstract
The aim of this study was to test the efficacy of a locally applied 8.5% nanostructured doxycycline (DOX) gel in preventing alveolar bone loss in experimental periodontal disease (EPD) in rats by using the tapping mode atomic force microscopy (AFM).
EPD was induced in...
|
PMID: 20835566
PDF is available here.
Abstract
We have hypothesized that polyproline repeat proteins exert their control over biological events such as mineral growth, plaque aggregation, or viscous adhesion by altering the length of their central repeat domain, resulting in dramatic changes in supramolecular assembly dimensions. In order to tes...
|
PMID: 20027208
PDF is available here.
Abstract
Functionalised nanoparticles have been proposed as potential agents for non-invasive therapies where an external source such as a laser or an electro-magnetic wave is used to heat targeted particles for either drug release or malignant cell damage. It is desirable to have intracellular reactions to...
|
PMID: 19848616
PDF is available here.
Abstract
The present study explored the transdermal permeation enhancing mechanism of non-ionic surfactant vesicles (proniosomes) of frusemide across rat skin. Fourier Transform Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), activation energy and histological examination were carried...
|
PMID: 20099518
PDF is available here.
Abstract
Although the potential benefits of gene therapy for the treatment of acquired and inherited genetic diseases have been demonstrated through preclinical studies, the results of human gene therapy trials have been disappointing. Recombinant viruses are the primary vectors of choice because of their ab...
|
PMID: 19780712
PDF is available here.
Abstract
Our study demonstrates feasibility of obtaining tunable optical bulk metamaterials based on smectic liquid crystal - nanoparticle composites....
|
PMID: 19997166
PDF is available here.
Abstract
A novel membrane-based lateral-flow immunodipstick assay was developed for the fast screening of aflatoxin B(2) (AFB(2)) as a model compound in food samples. The detector reagent consisted of magnetic nanogold microspheres (MnGMs) with nano-Fe(2)O(3) particles as core and gold nanoparticles as shell...
|
PMID: 19699076
PDF is available here.
Abstract
Optical nanosensors for such important analytes as oxygen, pH, temperature, etc. are manufactured in a simple way via precipitation. Lipophilic indicators are entrapped into nanobeads based on poly(methyl methacrylate), polystyrene, polyurethanes, ethylcellulose, and other polymers. Charged groups g...
|
PMID: 19635366
PDF is available here.
Abstract
We investigate dissipation mechanisms in such films experimentally and by finite-element method (FEM) calculations. Experimentally, we study the adsorption of globular proteins and virus particles to surfaces with various attachment geometries: direct adsorption to the surface, attachment via multip...
|
PMID: 19746972
PDF is available here.
Abstract
Calixarene-capped Co(32) clusters are constructed by a sodalite Co(II)(24) cage and an encapsulated Co(III)(8) cube. The spherical units are arranged into three isomeric structures, two of which are stacked by the bcc lattices and the third of which is assembled by the cubic closest packing of the s...
|
PMID: 19642699
PDF is available here.
Abstract
We found here that injection of the free AS-ON stimulates tumor growth independently of its sequence and that this stimulation is abolished in the presence of nanosphere-chitosan, which exerts with the oligonucleotides a specific inhibitory effect on tumor growth. The stimulation of tumor growth is...
|
PMID: 19732024
PDF is available here.
Abstract
This review reports the state of the art on innovative drug delivery strategies designed for antitubercular chemotherapeutics. The introduction contains the fundamental biological background concerning tuberculosis and a review of the current antitubercular therapy, and is followed by a critical rep...
|
PMID: 19678791
PDF is available here.
Abstract
A very simple strategy for the synthesis of superparamagnetic and fluorescent Fe(3)O(4)/ZnS hollow nanospheres is presented. These hollow nanospheres are not only nontoxic with a highly porous shell and have diameters of <100 nm but also exhibit very good magnetic resonance and fluorescence.
|
PMID: 19722639
PDF is available here.
Abstract
In fluid flow on hydrophobic surfaces, boundary slip occurs at the solid-liquid interface and nanobubbles on the surfaces are believed to be the reason for it. Boundary slip is of practical importance in micro/nanofluidics to reduce the drag force in fluid flow. However, nanobubbles tend to move und...
|
PMID: 19572534
PDF is available here.
Abstract
We developed a very simple, template-free, and environmentally friendly one-step chemical synthesis route to fabricate unagglomerated polypyrrole (PPy) nanospheres. The proposed new fabrication method enables the production of size-controlled unagglomerated PPy nanospheres without the help of any su...
|
PMID: 19719218
PDF is available here.
Abstract
The fabrications of sphere-like Au nanoparticles (NPs) on sapphire, GaN, and SiO(2) substrates through the irradiation of a few pulses of 266-nm laser onto Au thin films deposited on the substrates are demonstrated. The top-view diameter, contact angle on substrate, surface population density, and s...
|
PMID: 19654830
PDF is available here.
Abstract
A simple and general approach has been developed for the enhancement of random lasing based on the composite consisting of nanospheres and nanorods array. Due to the inherent nature of high refractive index, the selected nanorods act efficiently as scattering feedback centers, which can promote the...
|
PMID: 19654676
PDF is available here.
Abstract
We report our theoretical investigation onto the shape dependence of two-photon absorption (TPA) in semiconductor nanocrystals (NCs). Based on a four-band model under effective mass approximation, we have developed a simple analytical theory capable of providing a quantitative explanation of the rec...
|
PMID: 19654719
PDF is available here.
Abstract
Fe(2)O(3) and As(2)O(3)/Fe(2)O(3) particles were round with an average diameter of 20 nm and 100 nm as observed under transmission electron microscope. Upon exposure to an alternating magnetic field (AMF), the temperature of the suspension of magnetic particles increased to 41-51 degrees C, dependin...
|
PMID: 19554652
PDF is available here.
Abstract
Leishmania parasite resides mainly in the liver and the spleen and multiplies. Effective therapy of leishmaniasis could be achieved by delivering antileishmanial drugs to these sites. Present investigations were aimed at developing lipid nanospheres of amphotericin B (LN-A) anchored with mannose to a...
|
PMID: 19089691
PDF is available here.
Abstract
Spherical gold nanoparticles with diameters less than 8 nm have been prepared by the photoinduced reduction of hydrogen tetrachloroaurate via a one-step sol-gel process. The as-prepared Au nanoparticles are highly dispersed in a mesoporous TiO2 gel monolith and are exposed to the external ambient at...
|
PMID: 19417525
PDF is available here.
Abstract
We report studies of the adsorption of amelogenin onto self-assembled monolayers containing COOH end group functionality as well as single crystal fluoroapatite, a biologically relevant surface. We found that although our solutions contained only nanospheres of narrow size distribution, smaller stru...
|
PMID: 19025992
PDF is available here.
Abstract
We prepared molecularly imprinted polymers for the purpose of binding specifically to tocopherol (vitamin E) and its derivative, tocopherol acetate. Binding of the imprinted polymers to the template was found to be two times greater than that of the control, non-imprinted polymers, when using only 1...
|
PMID: 19701140
PDF is available here.
Abstract
Mice treated with intranasal Der f-CS nano-vaccine prior to challenge displayed an alleviated spectrum of symptoms including airway hyper-reactivity, lung inflammation and mucus production and had fewer eosinophilic cells in bronchoalveolar lavage fluid (BALF). Interestingly, the cytokine levels in...
|
PMID: 19494519
PDF is available here.
Abstract
We report the use of electrospraying for the synthesis of chitosan micro/nanospheres. The focus was to optimize the fabrication parameters involved in electrospraying for reproducible synthesis of chitosan based micro/nanospheres and to study their potential as delivery vehicles for bioactive agents...
|
PMID: 18386845
PDF is available here.
Abstract
All in all, the use of nanospheres in protein crystallization proved to be beneficial, both when screening new crystallization conditions to promote nucleation and when used as an additive to produce better quality crystals, faster. The polystyrene nanospheres are easy to use, commercially available...
|
PMID: 19145241
PDF is available here.
Abstract
These results suggest a possible stepwise interaction mechanism, starting with the N-terminus and followed by the C-terminus, leading to amelogenin nanosphere assembly....
|
PMID: 19086270
PDF is available here.
Abstract
Poly(D,L-lactide-co-glycolide) nanospheres incorporating flurbiprofen were prepared by the solvent displacement technique for purposes of assessing (i) drug-polymer physicochemical interactions, (ii) flurbiprofen release from the polymer matrix and (iii) eye permeation of the drug formulated in the...
|
PMID: 18425815
PDF is available here.
Abstract
These results might reflect that PAN may selectively accumulate onto solid tumors that are maintained above physiological temperature due to local hyperthermia....
|
PMID: 18721874
PDF is available here.
Abstract
We show that the adhesion strength between two spheres or between a sphere and a solid half-space actually exhibits a peak value at an optimal size. This optimal size arises owing to a transition between surface- and bulk-dominated interaction regimes at the nanoscale....
|
PMID: 18381255
PDF is available here.
Abstract
Reasonable agreement was obtained between the results of the analytic calculation and the experimental data for the various concentrations of nanoshells and laser outputs tested. This agreement was consistent for both the spatial and temporal domain. On average the disagreement between analytical ca...
|
PMID: 18951423
PDF is available here.
Abstract
A semi-analytical method for computing the electric field surrounding a finite linear chain of metal nanospheres and nanospheroids is described. In treating chains or clusters of spheres, a common approach is to use the spherical-harmonic addition theorem to relate the multipole expansion coefficien...
|
PMID: 18978855
PDF is available here.