Abstract
We present 3 cases, including 2 with unique ophthalmic ultrasound images of ocular plasmacytoma.
Three patients with ocular manifestations of multiple myeloma are described. All were noted to have known synchronous systemic disease. In this study, patients presented with epibulbar (n...
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PMID: 21193351
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Abstract
Our patient responded quickly to propanolol, with a clinical response within few days. Literature describes reduced size and changes in the colour of hemangiomas within 24-48 hours. Our experience is in line with that reported in the literature. Propanolol treatment of this patient group has only be...
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PMID: 20882080
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Abstract
There is increasing evidence of a significant association between HIV seropositivity and OSSN. The role of HPV as contributing to the cause of OSSN is being investigated. SUMMARY: Patients with conjunctival cancer in sub-Saharan Africa are typically younger and more than 50% have underlying HIV infe...
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PMID: 20639761
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Abstract
We had described a prefabricated superficial temporal fascia island flap and used this technique in >50 enucleation patients with severe socket contraction ending in excellent or good results for 28 years (Altindas- 1 procedure). However, the flap was not suitable for the exenteration patients with...
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PMID: 20606580
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Abstract
Ocular adnexal lymphomas comprise 1% to 2% of all non-Hodgkin lymphomas and about 8% of extranodal lymphomas. They are a heterogeneous group of malignancies, the majority of which are primary extranodal lymphoma with most (up to 80%) of the marginal zone of mucosa associated lymphoid tissue type (MA...
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PMID: 20574170
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Abstract
In a 3-year study with mass lesions related to ophthalmology 30 cases arising from ocular tissue, ocular adenaxae and orbit were subjected to fine needle aspiration biopsy. Of these 27 cases were further subjected to detailed histopathological examination. Fine needle aspiration biopsy revealed defi...
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PMID: 21192503
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Abstract
The NEI-VFQ-25 (National Eye Institute Visual Function Questionnaire) was extended by several questions taking account of aesthetic and cosmetic aspects in addition to the mere visual function aspects. This amended questionnaire, named NEI-VQF +, was used to evaluate the perceived overall success of...
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PMID: 20645231
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Abstract
In recent years, infectious agents have been increasingly recognised as an important pathogenetic factor for various malignant tumours of the ocular adnexa. Many of these viruses and bacteria affect the cell cycle and physiological apoptosis. Ocular adnexal lymphoma (OAL), especially extranodal marg...
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PMID: 20535664
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Abstract
A 3-day-old, male red deer (Cervus elaphus) with bilateral microphthalmia was found dead in the Western Alps in northern Italy. No other gross alterations were present. Ocular globes were formalin fixed and processed for histology. In both eyes, a large cyst, filled with keratin and lined by squamou...
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PMID: 20688706
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Abstract
We present the successful use of interstitial photodynamic therapy in the treatment of lacrimal gland mantle cell lymphoma associated with cervical and axillary lymphadenopathy in a 59-year-old female.
(c) 2009 Elsevier B.V. All rights reserved.
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PMID: 20510310
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Abstract
There have been some notable changes in survival that can be linked to epidemiological and clinical factors in different countries over time. Time-varying proportions of the major histological subtypes might however have affected the survival estimates for a number of the cancer forms reviewed here....
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PMID: 20192877
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Abstract
Medical records of 53 cattle undergoing enucleation (1998-2006) were reviewed. Assessments of the outcomes were done via client surveys. Descriptive statistics were generated on the affected population, the underlying disease, the complications, and the length of retention within the herd. Hereford...
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PMID: 20808572
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Abstract
This article describes 11 cases of neuronal embryonal neoplasia in captive adult teleost fish. Neoplasms were located within 1 or both eyes of 8 fish and the skin of 3 other fish. Ocular neoplasms most often presented as unilateral or bilateral exophthalmia. Seven ocular and 1 cutaneous mass were co...
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PMID: 20351360
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Abstract
Proton beam therapy (PT) offers improved sparing of normal tissue, thus potentially reducing the risk for treatment related late sequelae and induction of secondary cancer. In addition, it can be an instrument for intensification of local therapy ("dose escalation") for disease currently not suffici...
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PMID: 20514614
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Abstract
Although there are no randomised trials directly comparing topical chemotherapeutic agents mitomycin-C, 5-fluorouracil, and interferon-alpha2b, published studies indicate equal efficacy of these agents for treatment of non-invasive ocular surface squamous neoplasia (80%-88%). 5-Fluorouracil may be p...
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PMID: 19776089
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Abstract
AIM To report the outcome of treatment of non-invasive ocular surface squamous neoplasia (or conjunctival-corneal intra-epithelial neoplasia (CCIN)) where topical mitomycin C (MMC) has been used in the treatment regimen. DESIGN Prospective, non-comparative interventional case series. PARTICIPANTS 91...
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PMID: 20447963
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Abstract
BACKGROUND/AIMS Diagnostic pars plana vitrectomy is a useful technique in the diagnosis of intraocular lymphoma (IOL); however, the role of transconjunctival sutureless vitrectomy (TSV) has not been fully explored for this indication. The purpose of this study was to review our experience with 25-ga...
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PMID: 20447965
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Abstract
We analysed specific mTOR pathway effectors using immunohistochemical analysis of 30 uvea and eight conjunctiva melanoma samples. We assessed the association with prognostic clinical-pathological features, and performed mutational analysis on the BRAF and NRAS genes. None of the cases had mutations...
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PMID: 20173664
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Abstract
This case highlights the development of 2 ocular malignancies in the same eye of an HIV-positive patient, at different CD4 counts, allowing the authors to speculate on additional factors involved in the development of the second malignancy....
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PMID: 20370336
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Abstract
Mechanisms that maintain ocular immune privilege may contribute to ocular tumor progression by inhibiting tumoricidal immune responses. Consistent with that notion are observations from transplantable tumor models in mice demonstrating that the tumoricidal activity of CD8(+) cytolytic T lymphocytes...
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PMID: 20370332
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Abstract
Masquerade syndrome should always be considered in elderly uveitis. A correct diagnosis can be life-saving....
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PMID: 20370337
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Abstract
Repeat MRI of the brain and orbits at this time revealed a 0.8 x 2.4-cm lesion of the left choroid plexus. LP revealed rare atypical B cells. The patient rapidly deteriorated and died a month later. CONCLUSION: Recognition of the potential for rapid progression and mortality in patients with PIOL is...
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PMID: 20370335
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Abstract
The clinical efficacy of rituximab therapy in systemic mucosa-associated lymphoid tissue (MALT) lymphoma with both periocular and intraocular involvement is described. Ophthalmic examination and radiologic imaging demonstrated tumor with bilateral periorbital, lacrimal, and subconjunctival infiltrat...
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PMID: 20370339
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Abstract
Improved medical and surgical treatment of conditions that lead to end-stage eye disease have led to a decrease in total enucleated globes. This is particularly evident for glaucoma. Changing demographics in Los Angeles and referral patterns are most likely responsible for the increase in retinoblas...
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PMID: 20016910
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Abstract
Cancer is regarded as the abnormal cellular multiplication; it is not controlled by the organism; and its cells present a differentiated DNA. Initially, the disease does not show clinical signs, but it can be diagnosed by laboratorial examinations. When tumors are present in the maxillofacial area,...
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PMID: 20186076
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Abstract
We have applied a new design of orbicularis oculi musculocutaneous flap for the anterior wall reconstruction in 7 cases. In all cases, flap survived without any complications. In the design proposed in the article, the flap was raised from the lateral orbital region and the pivot point was placed ar...
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PMID: 20179476
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Abstract
We conclude that the down-regulation of p21, p27 and cathepsin in epithelial cells of macular dystrophy corneas may be related to defense mechanisms against apoptotic cell death....
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PMID: 20054800
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Abstract
Nine patients between the ages of 52 and 83 were referred with a diagnosis of primary intraocular lymphoma but were ultimately diagnosed with sarcoidosis. The most common clinical signs found in these patients that are atypical for primary intraocular lymphoma but common in sarcoidosis were multifoc...
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PMID: 20175273
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Abstract
Surgical removal of left congenital limbo corneal mass by peripheral lamellar keratoplasty (LKP) using preserved remaining corneasclera graft from other recipient was effective for the treatment of limbocorneal fibroma. A case of 17 year old Chinese girl with a corneal mass since her...
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PMID: 21409939
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Abstract
Bevacizumab is used in the treatment of cancer where it inhibits tumor growth by blocking the formation of new blood vessels (blocking angiogenesis). The purpose of this paper is to evaluate the short-term safety and effectiveness of Avastin injected into the eyeball in cases with intraocular tumors...
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PMID: 20827913
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Abstract
Angiogenesis, fundamental process that consists in the formation of new vessels, is essential physiologically in the tissue maintenance and of the homeostasis, having in this sense a few positive and negative regulators. Vascular endothelial growth factor and other angiogenical prote...
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PMID: 21516858
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Abstract
We report an extremely rare case of vitreous and retinal metastasis from gastric cancer. Ophthalmologists and oncologists should be aware that gastrointestinal cancer can cause intraocular metastasis in the form of vitreous seeds and retinal infiltration....
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PMID: 20037908
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Abstract
Vitreous infiltration without uveoretinal involvement can be an unusual manifestation of intraocular NK/T-cell lymphoma. Clinician awareness of possible ocular involvement may assist in the diagnosis of disseminated NK/T-cell lymphoma....
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PMID: 19882515
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Abstract
Patients who will undergo orbital exenteration should be warned about possible difficulties with social interactions. Healthcare personnel should be trained to help patients and family members prepare for such difficulties....
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PMID: 20090478
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Abstract
Epithelial tumors of the lacrimal gland account for 50% of the expansive lesions of the lacrimal fossa. Pleomorphic adenomas have a good prognosis if surgery achieves en bloc removal distant from the tumoral capsule. Nevertheless, despite more severe treatment, the average survival remains limited f...
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PMID: 20303130
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Abstract
This report describes a 7-year-old boy with multiple endocrine neoplasia type 2B who presented to the ophthalmology department because of peripheral corneal changes. In addition to prominent corneal nerves and eyelid neuromas, the patient was found to have substantial corneoscleral limbal thickening...
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PMID: 19645382
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Abstract
We present a patient with only ocular relaps and without evidence of bone marrow progression after ASCT. Ig A kappa myeloma, stage IIIA was diagnosed in a 53-year-old man, according to Kyle-Greipp and Durie Salmon. He was treated with three courses of VAD therapy. Then he received high dose melphala...
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PMID: 21384738
PDF is available here.
Abstract
We present 10 patients with intraocular medulloepithelioma. In 7 of these patients the eye had to be enucleated. Metastasis did not occur, but epiretinal tumor seeding did occur in one patient. In one of the 3 not enucleated eyes, ruthenium-106 brachytherapy could salvage the tumor containing eye.
C...
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PMID: 20108196
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Abstract
Presence and interplay of microbial flora at the ocular surface reveal dynamic and evolving interactions with implications for both ocular surface health and disease. Data in this area are scarce or non-existent. The purpose of this review is to provide a snapshot of new and emerging...
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PMID: 19620859
PDF is available here.
Abstract
Expression of COX-2 was detected in all but 5 globes, all of which contained neoplasms. Expression of COX-2 was detected in regions infiltrated by neoplasia in 21 globes; however, definitive labeling of tumor cells was detected in only 2 of those. In the remaining 19 globes, COX-2 expression was det...
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PMID: 19795944
PDF is available here.
Abstract
We report on a 68-year-old female patient. Lamellar keratectomy was performed combined with brachytherapy with strontium-90 for a total dose of 120 Gy (single daily dose: 10 Gy). Two months after treatment, a regression of neovascularization was noted. During 3.5 years of follow-up, no rubeosis of t...
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PMID: 19806383
PDF is available here.
Abstract
OSSN has become the most frequent malignant ocular tumour in the south of Malawi. The incidence of OSSN seems to have increased dramatically from 1989 to 2006--in parallel to increasing HIV infection rates....
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PMID: 18781308
PDF is available here.
Abstract
CLINIC REPORT: A 3-year-old boy presented with an intermediate uveitis. Complete ophthalmic exam, ocular ultrasonography, magnetic resonance imaging and computerized tomography of the orbit were inconclusive. Determination of the aqueous humor/serum rate of Lactate dehydrogenase (LDH) was the key fo...
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PMID: 19809928
PDF is available here.