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Ocular Hypertension (1):
Recent article
Ocular Hypertension
Archives of Ophthalmology (129)8 2011
Abstract
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Klinika oczna (113)4-6 2011
Abstract
Intravitreal injections are associated with a low incidence of serious adverse events. The most common ocular complication was subconjunctival hemorrhage. There was one case of serious complication--the culture-proven infectious endophthalmitis after Kenalog injection. Cataract formation and increas...
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PMID: 21913440
PDF is available here.
PDF is available here.
Journal of Glaucoma (19)9 2010
Abstract
To study the long-term course of primary angle closure (PAC) eyes after iridotomy.
Seventy-two eyes of 72 patients diagnosed as PAC, having occludable angles with evidence of closure, but no ocular hypertension, were studied. Laser iridotomy was carried out in all eyes at baseline. Standard achromat...
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PMID: 20164791
PDF is available here.
PDF is available here.
Nippon Ganka Gakkai zasshi (114)11 2010
Abstract
We investigated the effectiveness, safety and plasma concentration of long-acting carteolol hydrochloride 2% ophthalmic solution (LA) as compared with the original carteolol hydrochloride 2% ophthalmic solution(CA).
Patients with primary open angle glaucoma and ocular hypertension were randomized to...
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PMID: 21141077
PDF is available here.
PDF is available here.
Abstract
Although it is widely accepted that the Pascal dynamic contour tonometry (DCT) reading is higher than Goldmann applanation tonometry (GAT) in normal range of intraocular pressure (IOP), it remains unclear whether DCT reading is higher or lower than GAT in an eye with severely elevated IOP. This stud...
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PMID: 20652303
PDF is available here.
PDF is available here.
Abstract
Patients undergoing a PAT who did not have a subsequent short-term IOP rise had a lower risk of severe IOP spikes after IVTA compared with those patients receiving IVTA but not having undergone a PAT....
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PMID: 20847754
PDF is available here.
PDF is available here.
Abstract
CH was low in study and control patients and was correlated with severity of keratoconus/pellucid but not with glaucoma/glaucoma suspect or control status. Evidence of glaucoma was more common in study eyes than in controls but was present in both....
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PMID: 20517150
PDF is available here.
PDF is available here.
Journal of Glaucoma (19)7 2010
Abstract
All 3 prostaglandin/amide drugs are highly effective at lowering IOP. No differences in effect between the drugs or between members of different racial groups were detected, although the study sample size was too small to be certain to detect differences, if they existed....
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PMID: 20051890
PDF is available here.
PDF is available here.
Journal of Glaucoma (19)7 2010
Abstract
SWAP can detect subtle hemianopic field defects in patients with normal standard perimetry....
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PMID: 20841978
PDF is available here.
PDF is available here.
Abstract
In adult albino mice the effects of increased intraocular pressure on the outer retina and its circuitry was investigated at intervals ranging 3-14 weeks. Ocular hypertension (OHT) was induced by cauterizing the vessels draining the anterior part of the mice eye, as recently reported (Salinas-Navarr...
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PMID: 20650699
PDF is available here.
PDF is available here.
Abstract
To evaluate the variants of 10 genes for association with primary open-angle glaucoma (POAG) in a Chinese population.
A total of 405 unrelated patients with POAG (255 high-tension glaucoma [HTG], 100 normal-tension glaucoma [NTG], and 50 juvenile-onset open-angle glau...
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PMID: 20357201
PDF is available here.
PDF is available here.
Abstract
Abnormal elastic (reversible) increased distensibility in some KC corneas is consistent with reduced corneal rigidity (lower elastic modulus and/or thickness). Abnormal distending responses may be increased when IOP elevations are higher and/or longer and/or more frequent. The results suggest that a...
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PMID: 20489581
PDF is available here.
PDF is available here.
Pars plana anterior vitrectomy, hyaloido-zonulectomy, and iridectomy for aqueous humor misdirection.
Abstract
Aqueous misdirection refractory to medical treatment can be treated successfully with surgery consisting of partial pars plana vitrectomy, hyaloido-zonulectomy, and peripheral iridectomy.
2010 Elsevier Inc. All rights reserved....
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PMID: 20609709
PDF is available here.
PDF is available here.
Abstract
Younger postmenstrual age at laser treatment may be related to an increased risk of anterior segment complications, which should be recognized and managed appropriately.
2010 Elsevier Inc. All rights reserved....
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PMID: 20227677
PDF is available here.
PDF is available here.
Abstract
PURPOSE. To evaluate and compare rates of change in neuroretinal rim area (RA) and retinal nerve fiber layer thickness (RNFLT) measurements in glaucoma patients, those with suspected glaucoma, and normal subjects observed over time. METHODS. In this observational cohort study, patients recruited fro...
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PMID: 20207973
PDF is available here.
PDF is available here.
Abstract
PURPOSE. To evaluate the changes in aqueous humor dynamics and the efficacy and safety of the iStent (Glaukos Corp., Laguna Hills, CA), in combination with cataract surgery. METHODS. This investigation was a prospective, randomized, clinical study in patients with open-angle glaucoma or ocular hyper...
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PMID: 20207977
PDF is available here.
PDF is available here.
Abstract
OSD is prevalent among medically treated patients with glaucoma. The severity of OSD symptoms is positively correlated to the number of IOP-lowering medications used....
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PMID: 20386433
PDF is available here.
PDF is available here.
Archives of Ophthalmology (128)6 2010
Abstract
To evaluate the effect of partially attached posterior vitreous detachments (pPVDs) at the optic disc on retinal nerve fiber layer (RNFL) thickness as measured by optical coherence tomography.
A retrospective study was conducted using stored Stratus optical coherence...
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PMID: 20547945
PDF is available here.
PDF is available here.
Abstract
A single dose of a gene therapy vector carrying an inducible metalloproteinase human gene can both protect against the IOP increase produced by corticosteroid instillation in the sheep model and quickly reverse the IOP increase previously elicited by the corticosteroid. These results are a first ste...
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PMID: 20089869
PDF is available here.
PDF is available here.
Abstract
Pathomechanisms, resulting in secondary elevated intraocular pressure in patients with FHC and CAU, must be different as only in CAU patients was an association to corticosteroid therapy found....
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PMID: 20217637
PDF is available here.
PDF is available here.
Current Eye Research (35)5 2010
Abstract
The increased ratio of blood supply of peripheral retina was less than that of the central and middle retina at 3 h to 14 d following acute high intraocular pressure. The percent of retinal ganglion cell loss in the peripheral retina was clearly greater than that in the central and middle retina dur...
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PMID: 20450256
PDF is available here.
PDF is available here.
Archives of Ophthalmology (128)5 2010
Abstract
People of AD have significantly worse performance than people of ED on all tests of visual function. Additional research using longitudinal data is needed to determine the cause of these small but significant ancestry differences in visual function....
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PMID: 20457975
PDF is available here.
PDF is available here.
Abstract
The use of Combigan drops twice a day the day before and the day of injection in eyes scheduled for intravitreal injection of Lucentis is a safe and effective prophylaxis to reduce the acute IOP spikes of the post-injection period.
Copyright Georg Thieme Verlag KG Stuttgart . New York....
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PMID: 20408074
PDF is available here.
PDF is available here.
Abstract
Although the post-operative size of an intraocular gas bubble decreases progressively over time, problems with bubble expansion may still occur even at a late stage if meteorological factors, that may increase the bubble size, change.
Copyright Georg Thieme Verlag KG Stuttgart . New York....
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PMID: 20408083
PDF is available here.
PDF is available here.
Abstract
In TED, Friedenswald's equation explains the ultra-short term IOP increase observed when eyes deviate from their primary gaze position (eyeball compression by enlarged and infiltrated extra-ocular muscles). Goldmann's equation explains the long-term IOP increase seen in TED (episcleral venous pressu...
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PMID: 20408077
PDF is available here.
PDF is available here.
Abstract
Masquerade syndrome should always be considered in elderly uveitis. A correct diagnosis can be life-saving....
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PMID: 20370337
PDF is available here.
PDF is available here.
Abstract
The treatments of glaucoma or ocular hypertension are associated with numerous ocular surface changes. Similarly, these ocular surface modifications directly impact the effectiveness of these therapies. The management of patients with glaucoma or ocular hypertension also suffering from dry eye syndr...
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PMID: 20304521
PDF is available here.
PDF is available here.
Abstract
To compare retinal nerve fiber layer (RNFL) measurements taken with OCT in normal, ocular hypertensive, and glaucomatous eyes of children 4-18 years old.
The study included 181 eyes: 106 normal, 37 with ocular hypertension, and 38 with juvenile glaucoma. Diagnostic groups were classified based on in...
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PMID: 20304519
PDF is available here.
PDF is available here.
Abstract
The diagnosis of unilateral glaucoma essentially requires an etiologic investigation primarily to make sure that the deterioration is truly glaucomatous, thus specifically ruling out other optical neuropathies and papillary abnormality, such as tilted disc or drusen, which can mimic glaucomatous per...
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PMID: 20347180
PDF is available here.
PDF is available here.
Abstract
Abstract
Purpose. Retrograde neurotrophic factor transport blockade has been implicated in the pathophysiology of glaucoma. Stem cell transplantation appears to ameliorate some neurodegenerative conditions in the brain and spinal cord, in part by neurotrophic factor secretion. The present study was conducted...
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PMID: 19933193
PDF is available here.
PDF is available here.
Abstract
The analysis showed that after 3 months' treatment, between 58 and 83% of patients will have a > or =20% reduction in IOP and 70-93% of patients will have an absolute IOP <20 mmHg. Latanoprost and bimatoprost were found to produce significantly lower on-treatment IOP compared with timolol (p < 0.05)...
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PMID: 20014995
PDF is available here.
PDF is available here.
Abstract
Recent studies have shown that intracranial pressure is lower in patients with glaucoma and normal-tension glaucoma. Conversely, intracranial pressure appears to be elevated in patients with ocular hypertension. Early mathematical modeling studies have suggested that the counterbalance provided by i...
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PMID: 20040876
PDF is available here.
PDF is available here.
Abstract
Many articles in the literature demonstrate a modest, long-lasting decrease in IOP following phacoemulsification and posterior chamber intraocular lens implantation in patients with primary open-angle glaucoma and ocular hypertension. The mechanism of this average pressure-lowering effect has yet to...
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PMID: 20040874
PDF is available here.
PDF is available here.
Abstract
LALES is the largest prevalence survey of eye disease in Latinos of Mexican origin to date. This review discusses the findings of LALES, including data that demonstrate specific risk factors and manifestations of open-angle glaucoma in this rapidly growing population. SUMMARY: The LALES data on ocul...
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PMID: 20040873
PDF is available here.
PDF is available here.
Journal of Glaucoma (19)3 2010
Abstract
Journal of Glaucoma (19)3 2010
Abstract
To investigate long-term resource consumption and clinical outcome of patients with early primary open-angle glaucoma or ocular hypertension treated with prostaglandins in clinical practice in France.
Thirty-four geographically spread specialized hospitals and private practices enrolled consecutive...
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PMID: 19661825
PDF is available here.
PDF is available here.
Journal of Glaucoma (19)3 2010
Abstract
We studied 32 patients with NTG and 32 with HTG. All patients had reliable 24-2 HVFs with a mean deviation of -10 dB or better, a glaucomatous optic disc and an abnormal HVF in at least 1 eye. Multifocal VEPs were obtained from each eye and probability plots created. The mfVEP and HVF probability pl...
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PMID: 19223786
PDF is available here.
PDF is available here.
Abstract
In 287 patients with CSC, the mean age was 56.8 years and 207 (72.1%) were men. In the control group of 235, the mean age was 59.5 years and 168 (71.5%) were men. Glaucoma was found in 10 of 287 patients (3.4%) with CSC and in 20 of 235 control subjects (8.5%, P = 0.014, odds ratio = 0.39, 95% confi...
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PMID: 19996820
PDF is available here.
PDF is available here.
Current Eye Research (35)2 2010
Abstract
These results strongly suggest that the anatomical losses of retinal neurons in local areas of the retina or optic nerve head are a cause of the reduction in the amplitude of the focal photopic negative response in open angle glaucoma....
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PMID: 20136426
PDF is available here.
PDF is available here.
Journal of Glaucoma (19)2 2010
Abstract
Repeatability of GDx-VCC and GDx-ECC is similar, and is satisfactory for clinical purposes; it is only minimally influenced by pharmacological mydriasis. However, repeatability of the measurement decreases with increasing severity of glaucoma. This characteristic is better detectable with GDx-ECC th...
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PMID: 19528821
PDF is available here.
PDF is available here.
Journal of Glaucoma (19)2 2010
Abstract
Both the GDx VCC and StratusOCT demonstrate increasing RNFL loss with advanced glaucomatous damage and were comparable in the diagnosis of perimetric glaucoma. Preperimetric glaucomatous damage may be better assessed by StratusOCT....
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PMID: 19373100
PDF is available here.
PDF is available here.
Abstract
Findings of this study provide new insights into tissue oxygen transport in the inner retina and optic nerve head through the regulated expression of Hb in macroglia and RGCs. Upregulation of Hb expression appears to be an intrinsic protective mechanism to facilitate cellular oxygenation and may als...
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PMID: 19741249
PDF is available here.
PDF is available here.
Abstract
The results demonstrated that the ECM of the inner basal lamina is neither necessary nor sufficient to prevent migration of transplanted cells into the neural retina. In contrast, glial reactivity was associated with poor graft migration. Targeted disruption of glial reactivity dramatically improved...
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PMID: 19850833
PDF is available here.
PDF is available here.
Abstract
An Eph-ephrin signaling network is activated at the ONH after LIOH in CD-1 mice, either before or coincident with the initial morphologic signs of RGC axon damage reported previously. Of note, ephrin-B reverse signaling was transiently upregulated in RGC axons at the ONH early in their response to I...
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PMID: 19815726
PDF is available here.
PDF is available here.
Abstract
Laser photocoagulation of limbal and episcleral veins induces transient ocular hypertension in albino CD-1 mice. The ensuing retinal and optic nerve pathologic events recapitulated key features of glaucoma and placed ONH RGC axon responses as an early manifestation of damage. LIOH in albino mice may...
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PMID: 19815738
PDF is available here.
PDF is available here.
Klinika oczna (112)7-9 2010
Abstract
To compare the intraocular pressure (P), values obtained with the ICare rebound tonometer with the Goldmann applanation tonometer (GAT), and to evaluate the influence of central comeal thickness (CCT), and radius of the corneal curvature (R) on IOP measurements.
Eighty four eyes of 48 subjects (65 e...
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PMID: 21121124
PDF is available here.
PDF is available here.
Abstract
Five infants with significant congenital corneal haze had increased measured intraocular pressure that remained high despite drug treatment and surgery to decrease intraocular pressure. The clinical diagnosis of recessive congenital hereditary endothelial dystrophy without glaucoma was made based on...
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PMID: 20128551
PDF is available here.
PDF is available here.
Abstract
VFI values were "stable or with low progression" in 100% of OHT patients, 88% of early POAG, 38.5% of moderate POAG, 33% of advanced POAG. Progression during the first half period (mean of 3 years) of follow-up could be extrapolated for the second half period in 97% of OHT patients, 76% of early POA...
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PMID: 20005005
PDF is available here.
PDF is available here.
Seminars in Ophthalmology (25)1-2 2010
Abstract
The purpose is to report a case and management of secondary Pigment Dispersion (PD) with severe elevation of the Intraocular Pressure (IOP) after bilateral uncomplicated phacoemulsification with implantation "within the capsular bag" of hydrophobic acrylic intra-ocular lenses (HAIOLs). The patient,...
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PMID: 20507195
PDF is available here.
PDF is available here.
Abstract
Diseases with nonmendelian, complex, polygenic or multifactorial heredity are defined as disorders that do not exhibit a classic mendelian inheritance attributable to a single gene but are determined by a number of genetic and environmental factors. Glaucoma forms having a multifacto...
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PMID: 21516857
PDF is available here.
PDF is available here.
Abstract
We detected perimetric progression as it follows: 15 eyes by the GPA analysis and 19 eyes by the manual method. Concurrency rate between the two methods reached 87%. Associated factors with perimetric progression were: pseudoexfoliation, thin cornea, older age and cardiovascular diseases....
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PMID: 21516870
PDF is available here.
PDF is available here.
BMC Ophthalmology (10) 2010
Abstract
Our purpose was to obtain efficacy and safety information from a cohort of subjects exposed to latanoprost/timolol fixed combination (FC) for ≥18 months using a prospective, observational design.
In all, 577 office-based ophthalmologists in Germany switched 2339 patients with glaucoma or ocular hy...
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PMID: 20825668
PDF is available here.
PDF is available here.
Value in Health (13)4 2010
Abstract
The model performed well in all validity tests. Analyses of hypothetical treatment strategies took about 30 minutes per cohort and lead to plausible health-economic outcomes. CONCLUSION: There is added value of DES models in complex treatment strategies such as glaucoma. Achieving transparency in mo...
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PMID: 20659272
PDF is available here.
PDF is available here.
Journal of Glaucoma (19)1 2010
Abstract
To understand the factors that influence glaucoma treatment adherence with medication taking, prescription refills, and appointment keeping to develop an intervention for a specific population.
In-depth interviews were conducted with 80 individuals diagnosed with open-angle glaucoma, glaucoma suspec...
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PMID: 20075676
PDF is available here.
PDF is available here.
Journal of Glaucoma (19)1 2010
Abstract
Digital ocular massage has a useful role to play in the management of the hypertensive phase after Ahmed glaucoma drainage device surgery. In this series 50% of patients achieved a 20% drop in IOP with massage....
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PMID: 20075672
PDF is available here.
PDF is available here.
Abstract
These data support a novel and flexible model of modest ocular hypertension with axon loss. The maximal duration of IOP elevation will be further characterized in future studies....
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PMID: 19850836
PDF is available here.
PDF is available here.
Abstract
The results show that contralateral eyes exhibit similar mechanical behavior and suggest that local mechanical stress and strain within the LC are correlate highly with local laminar CTVF. These simulations emphasize the importance of developing both high-resolution imaging of the LC microarchitectu...
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PMID: 19696175
PDF is available here.
PDF is available here.
Journal of Glaucoma (18)9 2009
Abstract
Brimonidine and NAC supplementation provide antioxidative properties to retina and decrease retinal damage induced by ocular hypertension....
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PMID: 20010244
PDF is available here.
PDF is available here.
Journal of Glaucoma (18)9 2009
Abstract
Although some intermethod variability differences were identified, all 3 methods in this study demonstrated clinically acceptable measurement repeatability and reproducibility. This result, in conjunction with the finding that variability was not different between eyes, examiners, or measurement set...
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PMID: 20010245
PDF is available here.
PDF is available here.