Abstract
Congenital cranial dysinnervation disorders (CCDDs) are developmental abnormalities involving the hypoplasia or aplasia of the cranial nerves with muscle dysinnervation. This study aimed to determine if congenital superior oblique palsy with superior oblique hypoplasia also can be classified as a CC...
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PMID: 20570358
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Abstract
Mitochondrial diseases comprise a group of complex and heterogeneous genetic disorders. Variable clinical features present a major challenge in pediatric diagnoses. From January 1984-June 2009, 69 patients were diagnosed with either syndromic mitochondrial diseases or nonsyndromic mitochondrial dise...
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PMID: 20691940
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Abstract
We report two clinical cases of unusual injury mechanisms, which we discuss with reference to the available literature....
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PMID: 20694547
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Abstract
The rate of improvement is more rapid for clinical signs (NPC and PFV) than for symptoms in children undergoing treatment for CI. OBVAT results in a more rapid improvement in symptoms, NPC and PFV, and a greater percentage of patients reaching pre-determined criteria of success when compared with HB...
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PMID: 20543758
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Abstract
PURPOSE. To investigate the general morphology, fiber type content, and myosin heavy chain (MyHC) composition of extraocular muscles (EOMs) from postmortem donors with amyotrophic lateral sclerosis (ALS) and to evaluate whether EOMs are affected or truly spared in this disease. METHODS. EOM and limb...
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PMID: 20181843
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Abstract
Bartonella henselae is the causative agent of cat scratch disease, a human infection usually characterized by persistent regional lymphadenopathy. It is transmitted to humans by cat scratches or bites. Cats are the major reservoir for this bacterium thus B. henselae has a worldwide distribution. The...
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PMID: 20042306
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Abstract
We report a case of Fisher syndrome accompanied by ocular flutter. A 19-year-old man presented with diplopia and vertigo, associated with preceding symptoms of common cold. Since symmetric weakness of abduction in both eyes, truncal ataxia, diminution of tendon reflexes, and gaze nystagmus were note...
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PMID: 20593660
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Abstract
A 51-year-old woman with breast cancer presented with progressive diplopia. Neuro-ophthalmologic examination revealed right gaze palsy and peripheral facial nerve palsy. Brain magnetic resonance imaging (MRI) was normal. However, two months later a repeat brain MRI revealed an enhancing round nodula...
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PMID: 20532149
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Abstract
A 44-year-old man with progressive ataxia, facial weakness, bilateral adduction deficits, and abducting nystagmus was initially misdiagnosed and treated for multiple sclerosis because a midbrain anatomic cleft had been overlooked on brain MRI. Six cases of "midbrain (or mesencephalic) cleft" or "key...
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PMID: 20393349
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Abstract
We report five children, belonging to independent families, with JS: they shared the same typical MRI abnormality, known as molar tooth sign, but had an otherwise quite variable phenotype, regarding mostly their cognitive performance, visual abilities and extra-neurological compromise....
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PMID: 20464299
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Abstract
PLT is an autogenous tissue that allowed for controlled weakening of the superior oblique tendon, with minimal complications observed in four patients. More studies comparing PLT tendon expansion with other published methods are warranted.
Copyright 2010 American Association for Pediatric Ophthalmol...
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PMID: 20451856
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Abstract
We report the anesthetic management in a 13-year-old girl with Joubert syndrome, scheduled for cauterization of nasal mucosa under general anesthesia. She had episodes of tachypnea and apnea. Oral midazolam 10 mg and famotidine 20 mg were administered 30 min before surgery. Anesthesia was induced an...
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PMID: 20229761
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Abstract
Twenty-four patients with a mean age of 46.4 years and a mean follow-up of 14.6 months were included. Treatment options included intravitreal antibiotics, vitrectomy, evisceration, and systemic antibiotics. Optimal structural outcome was achieved in 6 (25%) eyes. A total of 70.8% eyes had no light p...
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PMID: 19996830
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Abstract
We present an unexpected complication of frontal mucocele, abducens nerve paralysis, and its treatment....
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PMID: 20489468
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Abstract
A case of acquired Brown syndrome caused by surgical repair of medial orbital wall fracture is reported in the present paper. A 23-year-old man presented at the hospital with right periorbital trauma. Although the patient did not complain of any diplopia, the imaging study revealed a blow-out fractu...
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PMID: 20157416
PDF is available here.
Abstract
We report a 13-year-old girl with positive mycoplasma immunoglobulin (Ig)M and IgG serology who presented with one-sided horizontal gaze palsy, ataxia, areflexia, and bulbar palsy. Her cranial magnetic resonance imaging was normal and blood serum was negative for anti-GQ1b IgG antibodies....
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PMID: 20718193
PDF is available here.
Abstract
Aim of the study was to evaluate effectiveness of intraoperative identification of oculomotor nerves (OMN) in resection of skull base tumors invading superior orbital fissure and cavernous sinus.
69 patients with cranioorbital tumors operated in Burdenko Neurosurgical Institute (Moscow, Russia) sinc...
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PMID: 21254574
PDF is available here.
Abstract
We report a case of a young woman with schizophrenia who presented with tardive OGC related to amisulpride....
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PMID: 20935407
PDF is available here.
Abstract
We describe a 52-year-old man with a history of increasing fatigability and gait disturbances that were first attributed to hypothyroidism. On examination, he had bilateral pseudo-internuclear ophthalmoplegia with weakness of adduction and abducting nystagmus. Convergence was also impaired and he sh...
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PMID: 20046005
PDF is available here.
Abstract
We compared the variability of gaze positional errors relative to the target with the microstructural integrity of white matter tracts as measured by the fractional anisotropy (FA) parameter of diffusion tensor imaging. Gaze error variability was significantly correlated with the mean FA values of t...
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PMID: 20611047
PDF is available here.
Abstract
The white-eyed orbital floor blowout fracture is most commonly seen in children and adolescents. The orbital floor is the most common fracture location with entrapment of inferior orbital contents and/or the inferior rectus muscle in a "trapdoor" fashion. Other sites may also be fractured either sim...
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PMID: 20090487
PDF is available here.
Abstract
Both the GAT and the Tono-Pen XL can be used to establish IOP in patients with restrictive TED....
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PMID: 20090483
PDF is available here.
Abstract
Statistical correlation were found between results of all ocular-motor tests outcome in MS patients and control group. In smooth pursuit test most often second degree (35.0%), in OKN test first degree (28.3%) and in saccades the third degree (31.6%) of dysfunction was observed. The higher the values...
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PMID: 20731203
PDF is available here.
Xian Yang,
Koki Yamada,
Bradley Katz,
Hongzai Guan,
Lifei Wang,
Caroline Andrews,
Guiqiu Zhao,
Elizabeth C Engle,
Haoyu Chen,
Zongzhong Tong,
Jie Kong,
Cong Hu,
Qinglan Kong,
Guiyun Fan,
Ze Wang,
Meizhen Ning,
Shaoyan Zhang,
Jinling Xu and
Kang Zhang
Abstract
Two Chinese families (XT and YT) with congenital fibrosis of the extraocular muscles (CFEOM) were identified. The purpose of this study was to determine if previously described Homo sapiens kinesin family member 21A (KIF21A) mutations were responsible for CFEOM in these two Chinese pedigrees.
Clinic...
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PMID: 21042561
PDF is available here.
Abstract
Traumatic rupture of the superior oblique tendon is a rare cause of acquired Brown's syndrome. This report describes a case of traumatic rupture of the superior oblique tendon, distal to the trochlea, after injury with a plant hook. The ruptured tendon was reapproximated. Postoperatively, asymptomat...
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PMID: 20507002
PDF is available here.
Abstract
We report a 67-year-old Japanese woman with ataxia with oculomotor apraxia type 2 (AOA2). She was born to consanguineous parents and showed a teenage onset, a slowly progressive cerebellar ataxia and sensory-motor neuropathy and an elevated level of serum alpha-fetoprotein (AFP). All of these clinic...
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PMID: 19893583
PDF is available here.
Abstract
We could demonstrate by diffusion tensor imaging: (1) An anterior displacement of the transverse pontine fibers; (2) Posterior clumping of the corticospinal, medial lemniscus and central tegmental tracts and of the medial and dorsal longitudinal fasciculi complex; (3) Absent decussation of superior...
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PMID: 20069218
PDF is available here.
Abstract
A patient with congenital fibrosis of the extraocular muscles may show alternatively either synergistic divergence or adduction, which has not been documented before....
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PMID: 19826317
PDF is available here.
Abstract
We recommend myectomy of the superior oblique muscle combined with resection of the trochlea if symptoms of SOM recur after a prior superior oblique tenectomy. Based on this small series with long follow-up, the procedure also may be considered as the primary operation for SOM that fails medical man...
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PMID: 19570521
PDF is available here.
Abstract
We sought to examine whether electrical injury subjects demonstrate abnormal patterns of brain activation during working memory and procedural learning tasks. Fourteen electrical injury subjects and fifteen demographically matched healthy control subjects performed a spatial working memory paradigm...
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PMID: 19323610
PDF is available here.
Abstract
The German BMBF (German Ministry of Education and Research) has decided to establish an Integrated Center for Research and Treatment of Vertigo, Balance and Ocular Motor Disorders (IFB(LMU)) in Munich in 2010. After funding over a 10-year period, the long-term continuation of the IFB(LMU) by the med...
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PMID: 19662450
PDF is available here.
Abstract
CASE REPORT: A 20 year-old woman was submitted to resection of an ependymome of the fourth ventricle. After surgery the patient began to refer diplopia and oscillopsia. WEBINO syndrome (wall-eyed bilateral internuclear ophthalmoplegia), vertical nystagmus and skew deviation were diagnosed. DISCUSSIO...
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PMID: 19728243
PDF is available here.
Abstract
A 7-year-old boy presented with vertical double images. A paediatric examination and magnetic resonance imaging of the head did not show any pathological findings. The diagnosis was an acquired click syndrome of the superior oblique muscle. In cases with inflammatory and systemic origin the underlyi...
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PMID: 19593572
PDF is available here.
Abstract
A total of 22 patients having MED were seen. Out of these 50% were males (N = 11) and 50% females (N = 11). Twelve (54.54%) had MED in the left eye and 10 (45.45%) had MED in the right eye. Ptosis was present in the eye affected with MED in 16 (72.72%) patients. Pseudoptosis was seen in 4 (18.18%) p...
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PMID: 19757696
PDF is available here.
Abstract
Hemineglect is a complicated disorder that poses challenges to treatment. A paucity of clinical trial evidence limits our ability to extrapolate experimental mediation of hemineglect to globally improved functioning. Nonetheless, many treatment approaches appear promising. Underlying neuroscience ma...
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PMID: 19590378
PDF is available here.
Abstract
Co-incidence of sensorineural hearing loss and ophthalmic abnormalities has a tremendous influence on development of children. This study was done to determine the nature and prevalence of ophthalmic disturbances in children with congenital sensorineural hearing loss. In a descriptive cross-sectiona...
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PMID: 18839196
PDF is available here.
Abstract
We present a 38-year-old male FD patient with a prior history of six different episodes of stroke and newly developing ocular disorders. He presented with nystagmus with different wave forms and directions and blepharospasm as well as cornea verticillata....
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PMID: 19499232
PDF is available here.
Abstract
Purpose: The range of monocular excursions can be determined by several different methods, including the Aimark Perimeter, Synoptophore and Modified Goldman Perimeter. However the relationship between these tests is poorly understood.
Methods: This is a prospective, cross-sectional stud...
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PMID: 19301190
PDF is available here.
Abstract
We are presenting this rare complication with the hope of elucidating further on clinical course of illness and literature review on the possible pathophysiological mechanism....
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PMID: 19225782
PDF is available here.
Abstract
BOLD signal increases were observed in the visual association area of both hemispheres (BA19) (MT/V5), primary visual cortex (BA17) of the right hemisphere, bilateral superior parietal lobules (BA7), and bilateral frontal eye fields (BA6). Decreases of BOLD signals were observed in the PIVC bilatera...
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PMID: 19116795
PDF is available here.
Abstract
Examiner bias did not affect the CISS scores for subjects with NBV in our prior study. The CISS continues to be a valid instrument for quantifying symptoms in 9 to <18-year-old children. These results also confirm the validity of a cut-point of > or = 16 in distinguishing children with symptomatic C...
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PMID: 19289977
PDF is available here.
Abstract
This is the first study to identify abnormalities of fixation in MND and these results indicate that ocular fixation instabilities may be a marker of the sub-clinical frontal lobe dysfunction in MND. A longitudinal study to examine if saccadic intrusion amplitude deteriorates with time would be of i...
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PMID: 19306041
PDF is available here.
Abstract
Tube shunts are typically used in eyes with refractory glaucoma. There is increased interest in studying the efficacy of GDDs. Most of the attention has been focused on comparing trabeculectomy with the Baerveldt implant (Advanced Medical Optics, Inc., Santa Anna, California, USA). The other leading...
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PMID: 19240545
PDF is available here.
Abstract
The associated ocular motor findings in our patients indicate that paroxysmal ipsiversive OTR in mesodiencephalic lesions is caused by intermittent hyperactivity of partially damaged ipsilesional riMLF or INC....
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PMID: 19038407
PDF is available here.
Jacob A S Vorstman,
Bruce I Turetsky,
Monique E J Sijmens-Morcus,
Monique G de Sain,
Bert Dorland,
Mirjam Sprong,
Eric F Rappaport,
Frits A Beemer,
Beverly S Emanuel,
René S Kahn,
Herman van Engeland and
Chantal Kemner
Abstract
We hypothesized an interaction between the COMT(158) genotype and proline, predicting the strongest negative effect of high proline on brain function to occur in 22q11DS children who are carriers of the COMT(met) allele. Of the three physiological measures, only SPEM and PPI were abnormal in the pat...
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PMID: 18769474
PDF is available here.
Abstract
Changes in visual functions were analyzed in 427 patients with pituitary adenomas after endoscopic endonasal transsphenoidal tumor removal. The analysis indicated that not only the specific features of tumor growth and size and the baseline function, but also the efficacy of surgery and a patient's...
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PMID: 19824443
PDF is available here.
Abstract
Ocular tilt reaction (OTR) includes skew deviation, eye torsion and head tilt. It is usually accompanied by a tilt in the subjective visual vertical. OTR seems to reflect an otolithic dysfunction. This case report shows an OTR of central origin as a result of simultaneous paramedial thalamic and mes...
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PMID: 19909722
PDF is available here.