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Optic Nerve Diseases (7):
Recent article
Optic Nerve Diseases
Abstract
The purpose of this study was to assess the characteristics of paranasal sinus mucoceles with ophthalmologic manifestations with a focus on optic neuropathy.
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PMID: 21819766
PDF is available here.
PDF is available here.
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Abstract
This study aimed to describe the Rarebit (RB) visual field and optic nerve size/morphology in patients treated with allogeneic stem-cell transplantation (SCT) in childhood, and to determine the impact of ocular status and conditioning regimens such as total body irradiation (TBI), ch...
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PMID: 20064124
PDF is available here.
PDF is available here.
Journal of Glaucoma (19)9 2010
Abstract
To evaluate the reproducibility of retinal nerve fiber layer (RNFL) thickness measurements in normal and glaucoma patients using the spectral optical coherence tomography (OCT)/scanning laser ophthalmosope (SLO).
One experienced operator measured peripapillary RNFL thickness 3 times in succession in...
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PMID: 20173650
PDF is available here.
PDF is available here.
Journal of Glaucoma (19)9 2010
Abstract
We determined whether there was a difference between the before and after assessments in the probability of a correct response for each of the fellows.
Loss of retinal thickness in the form of grooves and the resulting 3-dimensional nature of the RNFL defects were visualized on stereoscopic examinat...
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PMID: 20179626
PDF is available here.
PDF is available here.
Neurological Surgery (38)11 2010
Abstract
We should keep in mind that high MET uptake is frequently observed in nontumorous brain lesions. Although differentiation from tumorous lesions is usually possible by laboratory and morphological examinations, nontumorous lesions should be included in the differential diagnosis when encountering pat...
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PMID: 21081810
PDF is available here.
PDF is available here.
Abstract
Obstructive sleep apnea is a diagnosis that ophthalmologists can screen for when a patient presents with certain risk factors. Recent literature provides strong data for associations between sleep apnea and ocular disorders.
A potentially serious disorder, sleep apnea can lead to many systemic and o...
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PMID: 20811281
PDF is available here.
PDF is available here.
Abstract
Almost 100 years after its original description, sarcoidosis remains an enigmatic disease with unclear etiology and capricious symptomology, as well as a diagnostic challenge. This review coalesces current literature on the neuro-ophthalmic manifestations of sarcoidosis and discusses the epidemiolog...
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PMID: 20736834
PDF is available here.
PDF is available here.
Abstract
Abstract
The significant correlation between B/YP indices and OCT parameters in NTG patients suggests that the 2 tests detect similar areas or amounts of NTG damage and could be used for NTG early diagnosis....
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PMID: 20648075
PDF is available here.
PDF is available here.
Journal of Glaucoma (19)7 2010
Abstract
OCT image quality was reduced preoperatively in the eyes with cataracts and retinal nerve fiber layer thickness in the nasal sectors was increased in these eyes postoperatively. Cup depth, volume parameters, Glaucoma Progression Score, and the image quality of HRT measurements were all influenced by...
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PMID: 20051889
PDF is available here.
PDF is available here.
Journal of Glaucoma (19)7 2010
Abstract
ODDSS is a new method for assessing, recording, and sharing information about the clinical OD appearance. Our preliminary results show that it provides good sensitivity and specificity in glaucoma detection. The interobserver and intraobserver agreement ranged from fair to good....
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PMID: 20051883
PDF is available here.
PDF is available here.
Abstract
We investigated the mechanism of retinal ganglion cell (RGC) death in secondary degeneration of the optic nerve using a unique model that allows morphological separation between primary and secondary degeneration. A partial transection model was applied unilaterally in 110 Wistar rat eyes. The rate...
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PMID: 19951705
PDF is available here.
PDF is available here.
Abstract
The study demonstrates that those eyes with an optic disc pit have smaller back radius of corneal curvature compared with fellow eyes. Possibly, the embryological factors in the development of optic disc pit influence the development of cornea....
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PMID: 20562671
PDF is available here.
PDF is available here.
Abstract
Abstract
PURPOSE. To describe the association of retinal vascular tortuosity, measured quantitatively, with the neuroretinal rim. METHODS. A population-based, cross-sectional study was conducted in Malay persons aged 40 to 80 years residing in Singapore. Retinal vascular tortuosity was quantified by using a...
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PMID: 20207964
PDF is available here.
PDF is available here.
Nippon Ganka Gakkai zasshi (114)6 2010
Abstract
We report a patient with traumatic chiasmal syndrome caused by a severe traffic accident. CASE: A 25 year-old woman was referred for bitemporal visual field defects caused by a traffic accident two months before. Corrected visual acuity was 0.05 in the right eye and 1.2 in the left eye. Bilateral op...
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PMID: 20593659
PDF is available here.
PDF is available here.
Abstract
We report a case of a unilateral nasal hemianopia that was caused by compression of the left optic nerve by a sphenoid wing meningioma. Histological examination revealed that the pathology of the meningioma was consistent with that of an atypical meningioma, which carries a guarded prognosis with in...
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PMID: 20431487
PDF is available here.
PDF is available here.
Abstract
A 27-year-old man presented with rapid and severe visual loss in both eyes, together with pain behind the eyes. Visual acuities were light perception in both eyes. Pupillary constriction to light was minimal, and ophthalmoscopy results were normal. For a presumptive diagnosis of retrobulbar optic ne...
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PMID: 20414132
PDF is available here.
PDF is available here.
Abstract
Abstract
A 31-year-old woman with morning glory optic disc anomaly (MGDA) developed acute retrobulbar optic neuritis and a bullous macular detachment. MRI demonstrated truncation of the perineural space of the affected optic nerve as well as focal optic nerve enhancement. Optical coherence tomography (OCT) s...
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PMID: 20375849
PDF is available here.
PDF is available here.
Abstract
A 30-year-old woman developed acute visual loss and optic disc elevation in the left eye after breastfeeding her second son. The initial diagnosis was optic neuritis. However, MRI showed a lesion in left intraorbital and intracanalicular optic nerve and several cerebral lesions with imaging features...
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PMID: 20351573
PDF is available here.
PDF is available here.
Abstract
Bosnian journal of basic medical sciences / Udruzenje basicnih mediciniskih znanosti = Association of Basic Medical Sciences (10)2 2010
Abstract
Congenital abnormalities of the optic disc are not so rare. The etiology for the most of them is unknown. Visual acuity of affected eye may be minimally or severely affected, depending on the extent of lesion. All of these conditions can be unilateral or bilateral. Children who have unilateral optic...
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PMID: 20507293
PDF is available here.
PDF is available here.
Archives of Ophthalmology (128)5 2010
Abstract
People of AD have significantly worse performance than people of ED on all tests of visual function. Additional research using longitudinal data is needed to determine the cause of these small but significant ancestry differences in visual function....
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PMID: 20457975
PDF is available here.
PDF is available here.
Abstract
Paraneoplastic retinopathy including cancer-associated retinopathy (CAR) and melanoma-associated retinopathy (MAR), and paraneoplastic optic neuropathy (PON) are visual disorders associated with systemic cancer. Patients with CAR typically present with progressive loss of vision and photopsia, which...
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PMID: 20420177
PDF is available here.
PDF is available here.
Abstract
Three main features differentiating PARAO from NAON were identified on macular OCT. Complete inner retinal atrophy with loss of the normal stratification of the inner retinal layers, loss of the normal foveal depression, and marked thinning of the involved retina were characteristic findings of PARA...
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PMID: 19996826
PDF is available here.
PDF is available here.
Abstract
Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia (145)2 2010
Abstract
The results of the fundus examination were normal, showing no characteristics that might be considered typical of vitiligo. Sixteen patients had an altered VEP (9 with amplitude reduction, 7 with amplitude reduction and increased latency); 4 patients showed only an Arden Index (AI) > or =180; and 4...
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PMID: 20467388
PDF is available here.
PDF is available here.
Abstract
Abstract
We report the case of a cavernous hemangioma revealed by optic neuropathy in a 33-year-old female.
Copyright 2010 Elsevier Masson SAS. All rights reserved....
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PMID: 20347181
PDF is available here.
PDF is available here.
Abstract
The diagnosis of unilateral glaucoma essentially requires an etiologic investigation primarily to make sure that the deterioration is truly glaucomatous, thus specifically ruling out other optical neuropathies and papillary abnormality, such as tilted disc or drusen, which can mimic glaucomatous per...
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PMID: 20347180
PDF is available here.
PDF is available here.
Abstract
Purpose. Retrograde neurotrophic factor transport blockade has been implicated in the pathophysiology of glaucoma. Stem cell transplantation appears to ameliorate some neurodegenerative conditions in the brain and spinal cord, in part by neurotrophic factor secretion. The present study was conducted...
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PMID: 19933193
PDF is available here.
PDF is available here.
Neurosurgery (66)4 2010
Abstract
The actuarial 5- and 10-year overall rates of survival of tumor progression after GKRS were 93% and 88%, respectively. Similarly, the actuarial 5- and 10-year progression-free survival rates were 62% and 52%, respectively. Among 94 patients in whom visual function was evaluable after GKRS, only 3 pa...
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PMID: 20190668
PDF is available here.
PDF is available here.
Nippon Ganka Gakkai zasshi (114)3 2010
Abstract
We used ERGs to analyze the visual functions of animal models of human retinal and and optic nerve diseases. To investigate the contribution of the cone ON- and OFF-pathways to the mouse photopic ERGs, we studied the properties of the photopic ERGs of metabotropic glutamate receptor subtype 6-defici...
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PMID: 20387538
PDF is available here.
PDF is available here.
Abstract
Frequency-domain OCT (RTVue OCT) may offer comprehensive analysis for RNFL thickness and ONH, which showed good diagnostic ability in distinguishing normal from glaucomatous eyes....
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PMID: 19937335
PDF is available here.
PDF is available here.
Abstract
WE who have severe optic neuropathy, and lack of visual loss reversibility with thiamine treatment, led to the suspicion of coexisting Leber hereditary optic neuropathy (LHON), which was later confirmed when testing revealed the 14484 mitochondrial DNA mutation. Over the ensuing months, vision did n...
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PMID: 20182208
PDF is available here.
PDF is available here.
Journal of Glaucoma (19)3 2010
Abstract
Journal of Glaucoma (19)3 2010
Abstract
To investigate whether combining optic disc topography and short-wavelength automated perimetry (SWAP) data improves the diagnostic accuracy of relevance vector machine (RVM) classifiers for detecting glaucomatous eyes compared with using each test alone.
One eye of 144 glaucoma patients and 68 heal...
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PMID: 19528827
PDF is available here.
PDF is available here.
Journal of Glaucoma (19)3 2010
Abstract
We studied 32 patients with NTG and 32 with HTG. All patients had reliable 24-2 HVFs with a mean deviation of -10 dB or better, a glaucomatous optic disc and an abnormal HVF in at least 1 eye. Multifocal VEPs were obtained from each eye and probability plots created. The mfVEP and HVF probability pl...
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PMID: 19223786
PDF is available here.
PDF is available here.
Abstract
The primary open-angle glaucoma (POAG) is an optic neuropathy which is influenced by a number of different risk factors. Some of them can induce the transcriptional factor NF-kappaB, a nuclear protein which binds to specific areas of the DNA to stimulate different genes. NF-kappaB can be activated b...
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PMID: 20155656
PDF is available here.
PDF is available here.
Abstract
Autosomal dominant optic atrophy, the most common hereditary optic neuropathy, appears to have a more variable clinical presentation than previously thought. Acute visual loss, reversible visual loss, or visual loss associated with extraocular symptoms (deafness, extraocular ophthalmoplegia, multipl...
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PMID: 19915464
PDF is available here.
PDF is available here.
Abstract
In excitotoxicity and axotomy models retinal ganglion cell death has been shown to result from a complex interaction between retinal neurons and Müller glia, which release toxic molecules including tumor necrosis factor alpha. This counteracts neuroprotection by neurotrophins such as nerve growth f...
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PMID: 19915465
PDF is available here.
PDF is available here.
Journal of Glaucoma (19)2 2010
Abstract
High myopia, optic nerve head tilting, and parapapillary atrophy are likely associated with the increased susceptibility to damage of dependent axons. Axons outside of the area of tilt may be relatively protected. As young myopes are more likely to suffer from hypotony related complications after tr...
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PMID: 19661828
PDF is available here.
PDF is available here.
Abstract
IVIg can be considered an effective steroid-sparing agent in selected cases with steroid-dependent recurrent-relapsing autoimmune optic neuropathy....
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PMID: 20130715
PDF is available here.
PDF is available here.
Abstract
Laser photocoagulation of limbal and episcleral veins induces transient ocular hypertension in albino CD-1 mice. The ensuing retinal and optic nerve pathologic events recapitulated key features of glaucoma and placed ONH RGC axon responses as an early manifestation of damage. LIOH in albino mice may...
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PMID: 19815738
PDF is available here.
PDF is available here.
Abstract
Scan location matching may bridge the gap in RNFL thickness measurements between TD-OCT circular scan data and 3-D SD-OCT scan data, providing follow-up comparability across the two generations of OCTs....
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PMID: 19737886
PDF is available here.
PDF is available here.
Abstract
Further observations in respect of giant cell arteritis (GCA) as encountered in a local neuro-ophthalmology service established in Singapore ten years earlier are reported. The rarely seen occult form of the disease is described along with an illustrative case report concerning an 80-year-old woman....
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PMID: 20200780
PDF is available here.
PDF is available here.
Current Eye Research (35)1 2010
Abstract
Four individuals showed the p.Gln368X MYOC mutation, no other genetic variations were assessed. Two of these four siblings had glaucomatous optic disc changes with corresponding visual field losses and abnormal Heidelberg Retina Tomography results by the Moorfields regression analysis, one had abnor...
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PMID: 20021252
PDF is available here.
PDF is available here.
Abstract
Three patients with progressive visual loss, chronic alcoholism and tabagism were submitted to a complete neuro-ophthalmic examination and to retinal nerve fiber layer (RNFL) measurements using optical coherence tomography (OCT) scanning. Two patients showed marked RNFL loss in the temporal sector o...
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PMID: 20195038
PDF is available here.
PDF is available here.
Klinika oczna (112)1-3 2010
Abstract
Eye signs of the disease may be noticed in the most patients with NF 1. After 21th years of age ophthalmological symptoms are observed in all patients. The frequency of typical well known for NF 1 signs were different and characteristic for each age group....
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PMID: 20572503
PDF is available here.
PDF is available here.
Abstract
Children with ONH may develop CH over time, and surveillance thyroid function tests may be necessary as frequently as every four months....
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PMID: 20432806
PDF is available here.
PDF is available here.
Abstract
We must always be aware of beriberi even now, as far as we eat well-polished rice. 3) In 1972, we noticed a group of sporadic paraparesis in Kagoshima, which was 20 years later confirmed to be induced by human T lymphotropic virus type-I (HTLV-I). We named this disease as "HTLV-I associated myelopat...
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PMID: 20431261
PDF is available here.
PDF is available here.
Abstract
Stretch optic neuropathy presents initially as neuropraxia with temporary visual loss. Orbital decompression should be considered for treatment before permanent and irreversible visual loss ensues....
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PMID: 20037894
PDF is available here.
PDF is available here.
Abstract
Optic neuropathy (ON) is defined as the reduction of vision due to inflammatory lesion of the optic nerve. The patient with ON has to be evaluated clinically but also with complex techniques (magnetic resonance imaging, visual evoked potentials, cerebrospinal fluid examination) because ON could be t...
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PMID: 20540361
PDF is available here.
PDF is available here.
Abstract
The present paper is a revue of the basic terms related to the neuroprotection, an up-to-date on the pathophysiology of glaucoma. There are emphasized some of the main directions of evolution in the antiglaucomatous and neuroprotective treatment.
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PMID: 20827905
PDF is available here.
PDF is available here.
Abstract
We have performed RNFL measurements with the Stratus OCT twice in the same session. The differences between these measurements were used to calculate the test-retest variability (on clock hours, quadrants and the average RNFL thickness) using the formula: Test-retest variability = 1.96 x standard de...
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PMID: 21516872
PDF is available here.
PDF is available here.
Abstract
We report a patient with a recurrent adrenocorticotrophin secreting pituitary adenoma who received external beam irradiation after failing surgical and medical therapy. Sixteen months after radiotherapy, the patient was presented with declining visual acuity, and radiation-induced optic neuropathy w...
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PMID: 20688625
PDF is available here.
PDF is available here.
Ophthalmic Research (44)2 2010
Abstract
Ophthalmic Research (44)3 2010
Abstract
We suggest that mitochondrial dysfunction, as either a cause or consequence of injury, renders retinal ganglion cells sensitive to degeneration. Therapeutic approaches that target mitochondria and promote energy production may provide a general means of protecting aged retinal ganglion cells from de...
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PMID: 20829641
PDF is available here.
PDF is available here.
Otolaryngologia Polska (64)1 2010
Abstract
Graves' disease may result in significant proptosis that causes visual loss. This has been traditionally managed surgically by external bony skeleton decompression. Tran nasal endoscopic orbital decompression is as a new technique that avoids the need for cutaneous or gingival incisions. Decompressi...
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PMID: 20476592
PDF is available here.
PDF is available here.